当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Linoleic and palmitoleic acid block streptokinase-mediated plasminogen activation and reduce severity of invasive group A streptococcal infection.

Linoleic and palmitoleic acid block streptokinase-mediated plasminogen activation and reduce severity of invasive group A streptococcal infection.

Abstract：

:In contrast to mild infections of Group A Streptococcus (GAS) invasive infections of GAS still pose a serious health hazard: GAS disseminates from sterile sites into the blood stream or deep tissues and causes sepsis or necrotizing fasciitis. In this case antibiotics do not provide an effective cure as the bacteria are capable to hide from them very quickly. Therefore, new remedies are urgently needed. Starting from a myxobacterial natural products screening campaign, we identified two fatty acids isolated from myxobacteria, linoleic and palmitoleic acid, specifically blocking streptokinase-mediated activation of plasminogen and thereby preventing streptococci from hijacking the host's plasminogen/plasmin system. This activity is not inherited by other fatty acids such as oleic acid and is not attributable to the killing of streptococci. Moreover, both fatty acids are superior in their inhibitory properties compared to two clinically used drugs (tranexamic or ε-amino caproic acid) as they show 500-1000 fold lower IC50 values. Using a humanized plasminogen mouse model mimicking the clinical situation of a local GAS infection that becomes systemic, we demonstrate that these fatty acids ameliorate invasive GAS infection significantly. Consequently, linoleic and palmitoleic acid are possible new options to combat GAS invasive diseases.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Rox K,Jansen R,Loof TG,Gillen CM,Bernecker S,Walker MJ,Chhatwal GS,Müller R

doi

10.1038/s41598-017-11276-z

subject

Has Abstract

pub_date

2017-09-18 00:00:00

pages

11798

issue

1

issn

2045-2322

pii

10.1038/s41598-017-11276-z

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Genome-wide patterns of local adaptation in Western European Drosophila melanogaster natural populations.

    abstract：:Signatures of spatially varying selection have been investigated both at the genomic and transcriptomic level in several organisms. In Drosophila melanogaster, the majority of these studies have analyzed North American and Australian populations, leading to the identification of several loci and traits under selection...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34267-0

    authors： Mateo L,Rech GE,González J

    更新日期：2018-11-01 00:00:00

  • Effect of in situ VSi2 and SiC phases on the sintering behavior and the mechanical properties of HfB2-based composites.

    abstract：:In situ HfB2-SiC-VSi2 composite was fabricated by reactive pressureless sintering at the temperature of 2150 °C for 4 h under a vacuum atmosphere. In situ SiC and VSi2 reinforcements were formed using VC and Si powders as starting materials according to the following reaction: VC + 3Si = SiC + VSi2. Microstructural st...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73295-7

    authors： Ghadami S,Taheri-Nassaj E,Baharvandi HR,Ghadami F

    更新日期：2020-10-06 00:00:00

  • FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation.

    abstract：:Protein tyrosine kinase (PTK) activity has been implicated in pro-inflammatory gene expression following tumor necrosis factor-α (TNF-α) or interkeukin-1β (IL-1β) stimulation. However, the identity of responsible PTK(s) in cytokine signaling have not been elucidated. To evaluate which PTK is critical to promote the cy...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44098-2

    authors： Murphy JM,Jeong K,Rodriguez YAR,Kim JH,Ahn EE,Lim SS

    更新日期：2019-05-20 00:00:00

  • Neuronal imaging with ultrahigh dynamic range multiphoton microscopy.

    abstract：:Multiphoton microscopes are hampered by limited dynamic range, preventing weak sample features from being detected in the presence of strong features, or preventing the capture of unpredictable bursts in sample strength. We present a digital electronic add-on technique that vastly improves the dynamic range of a multi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06065-7

    authors： Yang R,Weber TD,Witkowski ED,Davison IG,Mertz J

    更新日期：2017-07-19 00:00:00

  • Low-dimensional behavior of Kuramoto model with inertia in complex networks.

    abstract：:Low-dimensional behavior of large systems of globally coupled oscillators has been intensively investigated since the introduction of the Ott-Antonsen ansatz. In this report, we generalize the Ott-Antonsen ansatz to second-order Kuramoto models in complex networks. With an additional inertia term, we find a low-dimens...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04783

    authors： Ji P,Peron TK,Rodrigues FA,Kurths J

    更新日期：2014-05-02 00:00:00

  • Adiponectin improves long-term potentiation in the 5XFAD mouse brain.

    abstract：:Adiponectin is an adipokine that regulates apoptosis, glucose and lipid metabolism, and insulin sensitivity in metabolic diseases. As recent studies have associated changes in adipokines and other metabolites in the central nervous system with a risk for Alzheimer's disease (AD), we investigated the effects of adipone...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45509-0

    authors： Wang M,Jo J,Song J

    更新日期：2019-06-20 00:00:00

  • Systematic assessment of prescribed medications and short-term risk of myocardial infarction - a pharmacopeia-wide association study from Norway and Sweden.

    abstract：:Wholesale, unbiased assessment of Scandinavian electronic health-care databases offer a unique opportunity to reveal potentially important undiscovered drug side effects. We examined the short-term risk of acute myocardial infarction (AMI) associated with drugs prescribed in Norway or Sweden. We identified 24,584 and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44641-1

    authors： Sen A,Vardaxis I,Lindqvist BH,Brumpton BM,Strand LB,Bakken IJ,Vatten LJ,Romundstad PR,Ljung R,Mukamal KJ,Janszky I

    更新日期：2019-06-04 00:00:00

  • Analysis of the metabolome of Anopheles gambiae mosquito after exposure to Mycobacterium ulcerans.

    abstract：:Infection with Mycobacterium ulcerans causes Buruli Ulcer, a neglected tropical disease. Mosquito vectors are suspected to participate in the transmission and environmental maintenance of the bacterium. However, mechanisms and consequences of mosquito contamination by M. ulcerans are not well understood. We evaluated ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09242

    authors： Hoxmeier JC,Thompson BD,Broeckling CD,Small P,Foy BD,Prenni J,Dobos KM

    更新日期：2015-03-18 00:00:00

  • New insights into the origin of remote PPG signals in visible light and infrared.

    abstract：:Remote photoplethysmography (PPG) is an optical measurement technique with established applications in vital signs monitoring. Recently, the consensual understanding of blood volume variations (BVVs) as the origin of PPG signals was challenged, raising validity concerns about the remote SpO2 methodology. Recognizing t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26068-2

    authors： Moço AV,Stuijk S,de Haan G

    更新日期：2018-05-31 00:00:00

  • Substantial blue carbon in overlooked Australian kelp forests.

    abstract：:Recognition of the potential for vegetated coastal ecosystems to store and sequester carbon has led to their increasing inclusion into global carbon budgets and carbon offset schemes. However, kelp forests have been overlooked in evaluations of this 'blue carbon', which have been limited to tidal marshes, mangrove for...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69258-7

    authors： Filbee-Dexter K,Wernberg T

    更新日期：2020-07-23 00:00:00

  • Dependency of Queensland and the Great Barrier Reef's tropical fisheries on reef-associated fish.

    abstract：:Coral reefs have been subject to mass coral bleaching, potentially causing rapid and widespread degradation of ecosystem services that depend on live coral cover, such as fisheries catch. Fisheries species in tropical waters associate with a wide range of habitats, so assessing the dependency of fisheries on coral ree...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74652-2

    authors： Brown CJ,Taylor W,Wabnitz CCC,Connolly RM

    更新日期：2020-10-20 00:00:00

  • Publisher Correction: Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-62065-0

    authors： An T,Fan T,Zhang XQ,Liu YF,Huang J,Liang C,Lv BH,Wang YQ,Zhao XG,Liu JX,Fu YH,Jiang GJ

    更新日期：2020-04-22 00:00:00

  • Estimating the nutrient thresholds of a typical tributary in the Liao River basin, Northeast China.

    abstract：:Estimating regional nutrient criteria for streams and rivers is a key step toward protecting river water quality and restoring the health of aquatic ecosystems. Using a multivariable statistical analysis technique, nutrients were identified as the main factor influencing the degradation of the benthic macroinvertebrat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22128-9

    authors： Chen J,Li F,Wang Y,Kong Y

    更新日期：2018-02-28 00:00:00

  • Circulating long non-coding RNAs HOTAIR, Linc-p21, GAS5 and XIST expression profiles in diffuse large B-cell lymphoma: association with R-CHOP responsiveness.

    abstract：:The reliable identification of diffuse large B-cell lymphoma (DLBCL)-specific targets owns huge implications for its diagnosis and treatment. Long non-coding RNAs (lncRNAs) are implicated in DLBCL pathogenesis; however, circulating DLBCL-related lncRNAs are barely investigated. We investigated plasma lncRNAs; HOTAIR, ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81715-5

    authors： Senousy MA,El-Abd AM,Abdel-Malek RR,Rizk SM

    更新日期：2021-01-22 00:00:00

  • The First 250 ms of Auditory Processing: No Evidence of Early Processing Negativity in the Go/NoGo Task.

    abstract：:Past evidence of an early Processing Negativity in auditory Go/NoGo event-related potential (ERP) data suggests that young adults proactively process sensory information in two-choice tasks. This study aimed to clarify the occurrence of Go/NoGo Processing Negativity and investigate the ERP component series related to ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-020-61060-9

    authors： Fogarty JS,Barry RJ,Steiner GZ

    更新日期：2020-03-04 00:00:00

  • Diabetic cats have decreased gut microbial diversity and a lack of butyrate producing bacteria.

    abstract：:Obesity and inactivity are major risk factors of feline diabetes mellitus (FDM) and human type II diabetes mellitus (T2DM). In recent years, changes in the gut microbiota have been suggested as a contributing factor to T2DM. Whether the gut microbiota (GM) composition plays a role in FDM remains unknown. The aim of th...

    journal_title：Scientific reports

    pub_type： 杂志文章,多中心研究

    doi：10.1038/s41598-019-41195-0

    authors： Kieler IN,Osto M,Hugentobler L,Puetz L,Gilbert MTP,Hansen T,Pedersen O,Reusch CE,Zini E,Lutz TA,Bjørnvad CR

    更新日期：2019-03-18 00:00:00

  • Metabolic response induced by parasitic plant-fungus interactions hinder amino sugar and nucleotide sugar metabolism in the host.

    abstract：:Infestation by the biotrophic pathogen Gymnosporangium asiaticum can be devastating for plant of the family Rosaceae. However, the phytopathology of this process has not been thoroughly elucidated. Using a metabolomics approach, we discovered the intrinsic activities that induce disease symptoms after fungal invasion ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37434

    authors： Lee DK,Ahn S,Cho HY,Yun HY,Park JH,Lim J,Lee J,Kwon SW

    更新日期：2016-11-28 00:00:00

  • Role of PARP1-mediated autophagy in EGFR-TKI resistance in non-small cell lung cancer.

    abstract：:Resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has become the main clinical challenge of advanced lung cancer. This research aimed to explore the role of PARP1-mediated autophagy in the progression of TKI therapy. PARP1-mediated autophagy was evaluated in vitro by CCK-8 assay, cl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-77908-z

    authors： Zhang Z,Lian X,Xie W,Quan J,Liao M,Wu Y,Yang ZZ,Wang G

    更新日期：2020-12-01 00:00:00

  • Profiling the neutralizing antibody response in chronically HIV-1 CRF07_BC-infected intravenous drug users naïve to antiretroviral therapy.

    abstract：:Characterizing neutralizing antibody (NAb) responses in individuals infected with diverse HIV-1 strains is necessary to reveal the novel targets for regional preventive and therapeutic strategies development. We evaluated the prevalence, breadth, and potency of NAb responses in 98 CRF07_BC-infected individuals using a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46308

    authors： Hu X,Hu Y,Zhao C,Gao H,Greene KM,Ren L,Ma L,Ruan Y,Sarzotti-Kelsoe M,Montefiori DC,Hong K,Shao Y

    更新日期：2017-04-07 00:00:00

  • Bile signalling promotes chronic respiratory infections and antibiotic tolerance.

    abstract：:Despite aggressive antimicrobial therapy, many respiratory pathogens persist in the lung, underpinning the chronic inflammation and eventual lung decline that are characteristic of respiratory disease. Recently, bile acid aspiration has emerged as a major comorbidity associated with a range of lung diseases, shaping t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29768

    authors： Reen FJ,Flynn S,Woods DF,Dunphy N,Chróinín MN,Mullane D,Stick S,Adams C,O'Gara F

    更新日期：2016-07-19 00:00:00

  • An Aqueous-Based Approach for Fabrication of PVDF/MWCNT Porous Composites.

    abstract：:In this paper, we demonstrate the fabrication of conductive porous polymers based on foaming of an aqueous dispersion of polymeric particles and multi-walled carbon nanotubes (CNT). By tuning the surface energy of the constituents, we direct their preferential adsorption at the air-liquid (bubble) interface or within ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01770-9

    authors： Rezvantalab H,Ghazi N,Ambrusch MJ,Infante J,Shojaei-Zadeh S

    更新日期：2017-05-11 00:00:00

  • Harmonic radar tracking reveals random dispersal pattern of bumblebee (Bombus terrestris) queens after hibernation.

    abstract：:The dispersal of animals from their birth place has profound effects on the immediate survival and longer-term persistence of populations. Molecular studies have estimated that bumblebee colonies can be established many kilometers from their queens' natal nest site. However, little is known about when and how queens d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40355-6

    authors： Makinson JC,Woodgate JL,Reynolds A,Capaldi EA,Perry CJ,Chittka L

    更新日期：2019-03-20 00:00:00

  • Micro-gun based on laser pulse propulsion.

    abstract：:This paper proposes a novel "micro-gun" structure for laser pulse propulsion. The "micro-bullets" (glass microspheres) are irradiated by a laser pulse with a 10 ns duration in a dynamic process. Experimental parameters such as the microsphere diameter and the laser pulse energy are varied to investigate their influenc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16400-7

    authors： Yu H,Li H,Cui L,Liu S,Yang J

    更新日期：2017-11-24 00:00:00

  • Solution-Processed Phosphorescent Organic Light-Emitting Diodes with Ultralow Driving Voltage and Very High Power Efficiency.

    abstract：:To realize power efficient solution-processed phosphorescent organic light-emitting diodes (s-PhOLEDs), the corresponding high driving voltage issue should be well solved. To solve it, efforts have been devoted to the exploitation of novel host or interfacial materials. However, the issues of charge trapping of phosph...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12487

    authors： Wang S,Wang X,Yao B,Zhang B,Ding J,Xie Z,Wang L

    更新日期：2015-07-24 00:00:00

  • Dissecting the structural basis of MEIG1 interaction with PACRG.

    abstract：:The product of the meiosis-expressed gene 1 (MEIG1) is found in the cell bodies of spermatocytes and recruited to the manchette, a structure unique to elongating spermatids, by Parkin co-regulated gene (PACRG). This complex is essential for targeting cargo to the manchette during sperm flagellum assembly. Here we show...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18278

    authors： Li W,Walavalkar NM,Buchwald WA,Teves ME,Zhang L,Liu H,Bilinovich S,Peterson DL,Strauss JF 3rd,Williams DC Jr,Zhang Z

    更新日期：2016-01-04 00:00:00

  • Elevation of autophagy markers in Sjögren syndrome dry eye.

    abstract：:Autophagy is known to be implicated in the pathogenesis of Sjögren syndrome (SS), but evidences are limited. We aimed to examine the levels of autophagy markers in tear film and conjunctival epithelial cells from SS dry eye patients, and analyze their correlations with clinical features. Patients with SS dry eye exhib...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17128-0

    authors： Byun YS,Lee HJ,Shin S,Chung SH

    更新日期：2017-12-08 00:00:00

  • Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine.

    abstract：:Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined the effects of DG and venlafaxine (VLX) in a chronic social defeat stress model...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10391-1

    authors： Bai S,Zhang X,Chen Z,Wang W,Hu Q,Liang Z,Shen P,Gui S,Zeng L,Liu Z,Chen J,Xie X,Huang H,Han Y,Wang H,Xie P

    更新日期：2017-08-29 00:00:00

  • Early prediction of neoadjuvant chemotherapy response for advanced breast cancer using PET/MRI image deep learning.

    abstract：:This study aimed to investigate the predictive efficacy of positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) for the pathological response of advanced breast cancer to neoadjuvant chemotherapy (NAC). The breast PET/MRI image deep learning model was introduced and compared w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-77875-5

    authors： Choi JH,Kim HA,Kim W,Lim I,Lee I,Byun BH,Noh WC,Seong MK,Lee SS,Kim BI,Choi CW,Lim SM,Woo SK

    更新日期：2020-12-03 00:00:00

  • The number of key carcinogenic events can be predicted from cancer incidence.

    abstract：:The widely accepted multiple-hit hypothesis of carcinogenesis states that cancers arise after several successive events. However, no consensus has been reached on the quantity and nature of these events, although "driver" mutations or epimutations are considered the most probable candidates. By using the largest publi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12448-7

    authors： Belikov AV

    更新日期：2017-09-22 00:00:00

  • A physiological role of cyclic electron transport around photosystem I in sustaining photosynthesis under fluctuating light in rice.

    abstract：:Plants experience a highly variable light environment over the course of the day. To reveal the molecular mechanisms of their photosynthetic response to fluctuating light, we examined the role of two cyclic electron flows around photosystem I (CEF-PSI)--one depending on PROTON GRADIENT REGULATION 5 (PGR5) and one on N...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20147

    authors： Yamori W,Makino A,Shikanai T

    更新日期：2016-02-02 00:00:00