Abstract：
:Telomerase activation and telomere maintenance are critical for cellular immortalization and transformation. PIN2/TERF1-interacting telomerase inhibitor 1 (PinX1) is a telomerase regulator and the aberrant expression of PinX1 causes telomere shortening. Identifying PinX1-interacting proteins is important for understanding telomere maintenance. We found that PinX1 directly interacts with nucleophosmin (NPM), a protein that has been shown to positively correlate with telomerase activity. We further showed that PinX1 acts as a linker in the association between NPM and hTERT, the catalytic subunit of telomerase. Additionally, the recruitment of NPM by PinX1 to the telomerase complex could partially attenuate the PinX1-mediated inhibition on telomerase activity. Taken together, our data reveal a novel mechanism that regulates telomerase activation through the interaction between NPM, PinX1 and the telomerase complex.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cheung DH,Ho ST,Lau KF,Jin R,Wang YN,Kung HF,Huang JJ,Shaw PCdoi
10.1038/srep43650subject
Has Abstractpub_date
2017-03-03 00:00:00pages
43650issn
2045-2322pii
srep43650journal_volume
7pub_type
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