Increased alpha-synuclein tear fluid levels in patients with Parkinson's disease.

Abstract:

:The objective of the study was to estimate if altered levels of alpha-synuclein can be detected in tear fluid of patients with Parkinson's disease (PD). Therefore, tear fluid samples of 75 PD patients, 75 control subjects and 31 atypical Parkinsonian patients were collected and analyzed in triplicates using an ultra-sensitive single molecule array (SIMOA) system and applying a human alpha-synuclein immunoassay. In PD, levels of total soluble alpha-synuclein were significantly increased compared to control subjects (p = 0.03; AUC PD vs. controls 0.60). There was no difference comparing PD patients stratified by Hoehn & Yahr stages and atypical Parkinsonian syndromes stratified by tauopathies and non-PD-synucleinopathies against each other (p > 0.05). In conclusion, alpha-synuclein can be detected and quantified in tear fluid, revealing small but significant differences in total alpha-synuclein levels between PD and control subjects. Tear fluid can be collected non-invasively and risk-free, therefore presenting a promising source for further biomarker research.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Maass F,Rikker S,Dambeck V,Warth C,Tatenhorst L,Csoti I,Schmitz M,Zerr I,Leha A,Bähr M,Lingor P

doi

10.1038/s41598-020-65503-1

subject

Has Abstract

pub_date

2020-05-22 00:00:00

pages

8507

issue

1

issn

2045-2322

pii

10.1038/s41598-020-65503-1

journal_volume

10

pub_type

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