Abstract：
:Targeting embryonic stem cells (ESCs) is important for ESC labeling, drug delivery and cell fate control. In this study, we identified twenty-two phage clones that bind specifically to the hESC cell line X-01, which was derived from human blastocysts of Chinese origin. One phage (H178), which displays the sequence VGGEAWSSPTDL, showed higher binding affinity to hESCs than to a monkey ES cell line (RS366.4) and two mouse ES cell lines (R1 and E14). Using quantum dots (QDs) conjugated to the H178 phage, we demonstrate that the phage can specifically bind to hESCs in vitro. Our results suggest a possible interaction between the selected peptide and the stem cell extracellular matrix (ECM). The selection method described here allows rapid and efficient screening of unique phage clones and targeting cells. The phages displaying peptides identified by this study have potential applications for cargo delivery and receptor studies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhao W,Jin L,Yuan H,Tan Z,Zhou C,Li LS,Ma Ldoi
10.1038/srep03134subject
Has Abstractpub_date
2013-11-05 00:00:00pages
3134issn
2045-2322pii
srep03134journal_volume
3pub_type
杂志文章abstract：:Nano-scale investigations of bainitic structures formed at temperatures below 350 °C have shown that the bainitic ferrite lattice is super-saturated in carbon. A high density of intrinsic defects would be playing a part in the carbon-supersaturation levels detected. In this work, the role of C-vacancy complexes on car...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57469-x
更新日期：2020-01-16 00:00:00
abstract：:Organic carbon (OC) stability in tropical soils is strongly interlinked with multivalent cation interaction and mineral association. Low molecular weight organic acids (LMWOAs) represent the readily biodegradable OC. Therefore, investigating retention mechanisms of LMWOAs in mineral-cation-LMWOAs systems is critical t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26127
更新日期：2016-05-23 00:00:00
abstract：:Alterations in the gut microbiota play a crucial role in host physiology and metabolism; however, the molecular pathways underlying these changes in diet-induced obesity are unclear. Mechanistic target of rapamycin (mTOR) signaling pathway is associated with metabolic disorders such as obesity and type 2 diabetes (T2D...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30887
更新日期：2016-07-29 00:00:00
abstract：:Wavelength, polarization and orbital angular momentum of light are important degrees of freedom for processing and encoding information in optical communication. Over the years, the generation and conversion of orbital angular momentum in nonlinear optical media has found many novel applications in the context of opti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45424-4
更新日期：2019-06-19 00:00:00
abstract：:Bee-pollinated plants face a dilemma in that bees both passively transport pollen grains among conspecific flowers and actively collect pollen to feed their larvae. Therefore, mechanisms that reduce pollen collection by bees have evolved in melittophilous plants. Malvaceae pollen is uncollectable for corbiculate bees ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41262-6
更新日期：2019-03-18 00:00:00
abstract：:The association between choline uptake and androgen receptor (AR) expression is suggested by the upregulation of choline kinase-alpha in prostate cancer. Recently, detection of AR aberration in cell-free DNA as well as early 18F-fluorocholine positron emission tomography/computed tomography (FCH-PET/CT) were associate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15928-y
更新日期：2017-11-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-05-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12515-z
更新日期：2017-09-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27488
更新日期：2016-06-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27023-x
更新日期：2018-06-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-10-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15002
更新日期：2015-10-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11111
更新日期：2015-06-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08138-z
更新日期：2017-08-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05025
更新日期：2014-05-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40777-2
更新日期：2019-03-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42241
更新日期：2017-02-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25484-8
更新日期：2018-05-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07389
更新日期：2014-12-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-55524-w
更新日期：2019-12-18 00:00:00
abstract：:The proinflammatory cytokine Interleukin 17A (hereafter named IL-17A) or IL-17A producing cells are elevated in breast tumors environment and correlate with poor prognosis. Increased IL-17A is associated with ER(-) or triple negative tumors and reduced Disease Free Survival. However, the pathophysiological role of IL-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03456
更新日期：2013-12-09 00:00:00
abstract：:In this paper, we propose an angle- and polarization-insensitive metamaterial absorber. We design a metamaterial unit cell that is based on a split ring cross resonator (SRCR). We observe that the absorption frequency and absorption ratio are insensitive to incident angles when a via array surrounds the SRR. We demons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39686
更新日期：2016-12-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79567-6
更新日期：2021-01-08 00:00:00
abstract：:In typical numerical simulations, the space-charge force is calculated by slicing a beam into many longitudinal segments and by solving the two-dimensional Poisson equation in each segment. This method neglects longitudinal leakage of the space-charge force to nearby segments owing to its longitudinal spread over 1/γ....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30960-2
更新日期：2018-08-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40573-y
更新日期：2019-03-11 00:00:00
abstract：:Inositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation orchestrates adaptive responses, including lipid anabolism, metabolic reprogramming, increases i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16662-1
更新日期：2017-11-28 00:00:00
abstract：:For the application of formic acid as a liquid organic hydrogen carrier, development of efficient catalysts for dehydrogenation of formic acid is a challenging topic, and most studies have so far focused on the composition of metals and supports, the size effect of metal nanoparticles, and surface chemistry of support...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33502
更新日期：2016-09-26 00:00:00
abstract：:Fragmentation of thin layers of materials is mediated by a network of cracks on its surface. It is commonly seen in dehydrated paintings or asphalt pavements and even in graphene or other two-dimensional materials, but is also observed in the characteristic polygonal pattern on a crocodile's head. Here, we build a sim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04966
更新日期：2014-05-27 00:00:00
abstract：:Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson's disease (PD). It is one of the most important proteins, which constitute Lewy body in PD patient. However, how this well folded highly soluble protein presents in this proteinaceous aggregate is still unclear. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44558
更新日期：2017-03-16 00:00:00
abstract：:Non-homologous end joining (NHEJ) is a major DNA double-strand break (DSB) repair mechanism. We characterized here a series of plasmid-based DSB templates that were repaired in Xenopus egg extracts via the canonical, Ku-dependent NHEJ pathway. We showed that the template with compatible ends was efficiently repaired w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27797
更新日期：2016-06-21 00:00:00
