Targeting human embryonic stem cells with quantum dot-conjugated phages.

Abstract:

:Targeting embryonic stem cells (ESCs) is important for ESC labeling, drug delivery and cell fate control. In this study, we identified twenty-two phage clones that bind specifically to the hESC cell line X-01, which was derived from human blastocysts of Chinese origin. One phage (H178), which displays the sequence VGGEAWSSPTDL, showed higher binding affinity to hESCs than to a monkey ES cell line (RS366.4) and two mouse ES cell lines (R1 and E14). Using quantum dots (QDs) conjugated to the H178 phage, we demonstrate that the phage can specifically bind to hESCs in vitro. Our results suggest a possible interaction between the selected peptide and the stem cell extracellular matrix (ECM). The selection method described here allows rapid and efficient screening of unique phage clones and targeting cells. The phages displaying peptides identified by this study have potential applications for cargo delivery and receptor studies.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhao W,Jin L,Yuan H,Tan Z,Zhou C,Li LS,Ma L

doi

10.1038/srep03134

subject

Has Abstract

pub_date

2013-11-05 00:00:00

pages

3134

issn

2045-2322

pii

srep03134

journal_volume

3

pub_type

杂志文章
  • Soil microbial community composition does not predominantly determine the variance of heterotrophic soil respiration across four subtropical forests.

    abstract::To explore the importance of soil microbial community composition on explaining the difference in heterotrophic soil respiration (R(h)) across forests, a field investigation was conducted on Rh and soil physiochemical and microbial properties in four subtropical forests in southern China. We observed that Rh differed ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07854

    authors: Wei H,Xiao G,Guenet B,Janssens IA,Shen W

    更新日期:2015-01-19 00:00:00

  • Fabrication of laser printed microfluidic paper-based analytical devices (LP-µPADs) for point-of-care applications.

    abstract::Microfluidic paper-based analytical devices (µPADs) have provided a breakthrough in portable and low-cost point-of-care diagnostics. Despite their significant scope, the complexity of fabrication and reliance on expensive and sophisticated tools, have limited their outreach and possibility of commercialization. Herein...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44455-1

    authors: Ghosh R,Gopalakrishnan S,Savitha R,Renganathan T,Pushpavanam S

    更新日期:2019-05-27 00:00:00

  • Enhanced Capacitance of Hybrid Layered Graphene/Nickel Nanocomposite for Supercapacitors.

    abstract::In this work, Ni nanoparticles were directly decorated on graphene (G) nanosheets via mechanical ball milling. Based on transmission electron microscopy observations, the Ni nanoparticles were well dispersed and attached to the G nanosheet without any agglomerations. Electrochemical results showed that the capacitance...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32082

    authors: Mohd Zaid NA,Idris NH

    更新日期:2016-08-24 00:00:00

  • Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury.

    abstract::Although protein-folding stress at the endoplasmic reticulum (ER) is emerging as a driver of neuronal dysfunction in models of spinal cord injury and neurodegeneration, the contribution of this pathway to peripheral nerve damage remains poorly explored. Here we targeted the unfolded protein response (UPR), an adaptive...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21709

    authors: Oñate M,Catenaccio A,Martínez G,Armentano D,Parsons G,Kerr B,Hetz C,Court FA

    更新日期:2016-02-24 00:00:00

  • Human T-lymphotropic virus 1 and 2 among people who used illicit drugs in the state of Pará, northern Brazil.

    abstract::People who used illicit drugs (PWUDs) represent an important population group for acquisition and viral dispersion. In Brazil, high rates of the human T lymphotropic virus 1 (HTLV-1) and 2 (HTLV-2) have been reported in epidemiological studies. However, the epidemiological scenario of HTLV-1/2 infections in PWUDs is s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51383-7

    authors: Oliveira-Filho AB,Araújo APS,Souza APC,Gomes CM,Silva-Oliveira GC,Martins LC,Fischer B,Machado LFA,Vallinoto ACR,Ishak R,Lemos JAR,Kupek E

    更新日期:2019-10-14 00:00:00

  • Deglycosylation of Tropheryma whipplei biofilm and discrepancies between diagnostic results during Whipple's disease progression.

    abstract::Whipple's disease is a systemic infectious disease associated with the bacterium Tropheryma whipplei. Numerous reports have presented puzzling discrepancies between diagnosis methods. We addressed this confusion using fluorescent in situ hybridization and immunofluorescence assays to evaluate 34 duodenal biopsies and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23883

    authors: Audoly G,Fenollar F,Lagier JC,Lepidi H,Raoult D

    更新日期:2016-03-30 00:00:00

  • Impact of the severity of restrictive spirometric pattern on nutrition, physical activity, and quality of life: results from a nationally representative database.

    abstract::The general disease burden associated with the restrictive spirometric pattern (RSP) is substantial. However, the impact of RSP by its severity on general health problems and quality of life has not been well elucidated. This study aimed to analyse nutrition, physical activity, and quality of life in subjects who part...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76777-w

    authors: Chung SJ,Kim HI,Yang B,Kim T,Sim YS,Kang HK,Kim SH,Yoon HJ,Choi H,Lee H

    更新日期:2020-11-12 00:00:00

  • Using remote sensing environmental data to forecast malaria incidence at a rural district hospital in Western Kenya.

    abstract::Malaria surveillance data provide opportunity to develop forecasting models. Seasonal variability in environmental factors correlate with malaria transmission, thus the identification of transmission patterns is useful in developing prediction models. However, with changing seasonal transmission patterns, either due t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02560-z

    authors: Sewe MO,Tozan Y,Ahlm C,Rocklöv J

    更新日期:2017-06-01 00:00:00

  • Controlling the quantum dynamics of a mesoscopic spin bath in diamond.

    abstract::Understanding and mitigating decoherence is a key challenge for quantum science and technology. The main source of decoherence for solid-state spin systems is the uncontrolled spin bath environment. Here, we demonstrate quantum control of a mesoscopic spin bath in diamond at room temperature that is composed of electr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00382

    authors: de Lange G,van der Sar T,Blok M,Wang ZH,Dobrovitski V,Hanson R

    更新日期:2012-01-01 00:00:00

  • REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer's disease mouse model.

    abstract::The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnologies play an important role. Here, it is demonstrated that the Radio Electric Asymmetric Conveyer (REAC), an in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35719

    authors: Lorenzini L,Giuliani A,Sivilia S,Baldassarro VA,Fernandez M,Lotti Margotti M,Giardino L,Fontani V,Rinaldi S,Calzà L

    更新日期:2016-10-24 00:00:00

  • TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma.

    abstract::Fundamental cell signaling mechanisms that regulate dynamic remodeling of the extracellular matrix (ECM) in mechanically loaded tissues are not yet clearly understood. Trabecular meshwork (TM) tissue in the eye is under constant mechanical stress and continuous remodeling of ECM is crucial to maintain normal aqueous h...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00845-x

    authors: Tellios N,Belrose JC,Tokarewicz AC,Hutnik C,Liu H,Leask A,Motolko M,Iijima M,Parapuram SK

    更新日期:2017-04-11 00:00:00

  • High prevalence of ventricular repolarization abnormalities in people carrying TGFβR2 mutations.

    abstract::Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissecti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31298-5

    authors: Extramiana F,Milleron O,Elbitar S,Uccellini A,Langeois M,Spentchian M,Delorme G,Arnoult F,Denjoy I,Bouleti C,Fressart V,Iserin F,Maison-Blanche P,Abifadel M,Leenhardt A,Boileau C,Jondeau G

    更新日期:2018-08-29 00:00:00

  • Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD.

    abstract::Both chronic Obstruction Pulmonary Disease (COPD) and lung cancer are leading causes of death globally. Although COPD and lung cancer coexist frequently, it is unknown whether lung cancer patients with COPD harbor distinct genomic characteristics compared to those without COPD. In this study, we retrospectively analyz...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02405-9

    authors: Xiao D,Li F,Pan H,Liang H,Wu K,He J

    更新日期:2017-05-18 00:00:00

  • Features of an altered AMPK metabolic pathway in Gilbert's Syndrome, and its role in metabolic health.

    abstract::Energy metabolism, involving the ATP-dependent AMPK-PgC-Ppar pathway impacts metabolic health immensely, in that its impairment can lead to obesity, giving rise to disease. Based on observations that individuals with Gilbert's syndrome (GS; UGT1A1(*)28 promoter mutation) are generally lighter, leaner and healthier tha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30051

    authors: Mölzer C,Wallner M,Kern C,Tosevska A,Schwarz U,Zadnikar R,Doberer D,Marculescu R,Wagner KH

    更新日期:2016-07-21 00:00:00

  • In vitro cytotoxicity and anticancer effects of citral nanostructured lipid carrier on MDA MBA-231 human breast cancer cells.

    abstract::Very recently, we postulated that the incorporation of citral into nanostructured lipid carrier (NLC-Citral) improves solubility and delivery of the citral without toxic effects in vivo. Thus, the objective of this study is to evaluate anti-cancer effects of NLC-Citral in MDA MB-231 cells in vitro through the Annexin ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-38214-x

    authors: Nordin N,Yeap SK,Rahman HS,Zamberi NR,Abu N,Mohamad NE,How CW,Masarudin MJ,Abdullah R,Alitheen NB

    更新日期:2019-02-07 00:00:00

  • Relationship between lumbar lordosis and the ratio of the spinous process height to the anterior spinal column height.

    abstract::Purpose Global sagittal imbalance with lumbar hypo-lordosis leads to various problems in elderly populations and is often treated with long-segment fusion and osteotomy. These highly invasive procedures result in a wide range of rigid spines with a high rate of complications. Although some reports have mentioned the p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63648-7

    authors: Inanami H,Iwai H,Kaneko T,Oshina M,Manabe N,Takano Y,Yuzawa Y,Segawa T,Yanagisawa K,Hirai S,Saiki F,Fukushima M,Oka H,Matsudaira K,Oshima Y,Koga H

    更新日期:2020-04-21 00:00:00

  • The Tie2-agonist Vasculotide rescues mice from influenza virus infection.

    abstract::Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administered early and may induce viral resistance. Thus, targeting the host response directly has been proposed as a nov...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11030

    authors: Sugiyama MG,Armstrong SM,Wang C,Hwang D,Leong-Poi H,Advani A,Advani S,Zhang H,Szaszi K,Tabuchi A,Kuebler WM,Van Slyke P,Dumont DJ,Lee WL

    更新日期:2015-06-05 00:00:00

  • The Potential of Alkyl Amides as Novel Biomarkers and Their Application to Paleocultural Deposits in China.

    abstract::A series of alkyl amides was detected and identified in the sedimentary record from an archaeological site at Yuchisi, Mengcheng, Anhui, China. The alkyl amides profiles change abruptly at the depth corresponding to the transition between two prehistoric cultures, which also corresponds to an abrupt change in the fatt...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15371-z

    authors: Wang J,Simoneit BRT,Sheng G,Chen L,Xu L,Wang X,Wang Y,Sun L

    更新日期:2017-11-07 00:00:00

  • Comparative Analysis of Gene Expression Profiles of Human Dental Fluorosis and Kashin-Beck Disease.

    abstract::To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their pe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18519-z

    authors: Zhang Q,Ma J,Liu H,He D,Chen L,Wu H,Jiang H,Lu Q,Bai S

    更新日期:2018-01-09 00:00:00

  • On the Hydrogen Bond Strength and Vibrational Spectroscopy of Liquid Water.

    abstract::In the present work, we introduce two new metrics i.e. hydrogen-bond strength and charge-transfer between the donor/acceptor water molecules as a measure of hydrogen-bond rearrangement dynamics. Further, we also employ a simple model based on energy flux through the donor-acceptor water pairs to quantify the extent of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35357-9

    authors: Ojha D,Karhan K,Kühne TD

    更新日期:2018-11-15 00:00:00

  • Protecting maize from rootworm damage with the combined application of arbuscular mycorrhizal fungi, Pseudomonas bacteria and entomopathogenic nematodes.

    abstract::Diabrotica virgifera virgifera LeConte, the western corn rootworm (WCR), is the most destructive pest of maize in North America, and has recently spread across central Europe. Its subterranean larval stages are hard to reach with pesticides and it has evolved resistance to conventional management practices. The applic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39753-7

    authors: Jaffuel G,Imperiali N,Shelby K,Campos-Herrera R,Geisert R,Maurhofer M,Loper J,Keel C,Turlings TCJ,Hibbard BE

    更新日期:2019-02-28 00:00:00

  • ABCC8 mRNA expression is an independent prognostic factor for glioma and can predict chemosensitivity.

    abstract::Glioma is the most common primary intracranial tumor and is associated with very low survival rates. The development of reliable biomarkers can help to elucidate the molecular mechanisms involved in glioma development. Here the expression of ABCC8 mRNA, clinical characteristics, and survival information based on 1893 ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69676-7

    authors: Zhou K,Liu Y,Zhao Z,Wang Y,Huang L,Chai R,Li G,Jiang T

    更新日期:2020-07-29 00:00:00

  • Correlated clusters of closed reaction centers during induction of intact cells of photosynthetic bacteria.

    abstract::Antenna systems serve to absorb light and to transmit excitation energy to the reaction center (RC) in photosynthetic organisms. As the emitted (bacterio)chlorophyll fluorescence competes with the photochemical utilization of the excitation, the measured fluorescence yield is informed by the migration of the excitatio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70966-3

    authors: Maróti P,Kovács IA,Kis M,Smart JL,Iglói F

    更新日期:2020-08-19 00:00:00

  • Identification and Prediction of Tuberculosis in Eastern China: Analyses from 10-year Population-based Notification Data in Zhejiang Province, China.

    abstract::Tuberculosis, a severe infectious disease caused by the Mycobacterium tuberculosis, arouses huge concerns globally. In this study, a total of 331,594 TB cases in Zhejiang Province were notified during the period of 2009-2018 with the gender ratio of male to female 2.16:1. The notified TB incidences demonstrated a cont...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64387-5

    authors: Liu K,Li T,Vongpradith A,Wang F,Peng Y,Wang W,Chai C,Chen S,Zhang Y,Zhou L,Chen X,Bian Q,Chen B,Wang X,Jiang J

    更新日期:2020-05-04 00:00:00

  • A semi-automated quantitative comparison of metal artifact reduction in photon-counting computed tomography by energy-selective thresholding.

    abstract::An evaluation of energy thresholding and acquisition mode for metal artifact reduction in Photon-counting detector CT (PCD-CT) compared to conventional energy-integrating detector CT (EID-CT) was performed. Images of a hip prosthesis phantom placed in a water bath were acquired on a scanner with PCD-CT and EID-CT (tub...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77904-3

    authors: Do TD,Sawall S,Heinze S,Reiner T,Ziener CH,Stiller W,Schlemmer HP,Kachelrieß M,Kauczor HU,Skornitzke S

    更新日期:2020-12-03 00:00:00

  • Evaluating the effect of overharvesting on genetic diversity and genetic population structure of the coconut crab.

    abstract::Birgus latro (coconut crab) is an edible crustacean that has experienced serious overharvesting throughout its whole habitat range; however, the negative effects of overharvesting on the genetic diversity within B. latro populations have not been elucidated. Here, we report sex ratio, body size, and genetic diversity ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66712-4

    authors: Yorisue T,Iguchi A,Yasuda N,Yoshioka Y,Sato T,Fujita Y

    更新日期:2020-06-22 00:00:00

  • Whole Mitogenomes Reveal the History of Swamp Buffalo: Initially Shaped by Glacial Periods and Eventually Modelled by Domestication.

    abstract::The newly sequenced mitochondrial genomes of 107 Asian swamp buffalo (Bubalus bubalis carabensis) allowed the reconstruction of the matrilineal divergence since ~900 Kya. Phylogenetic trees and Bayesian skyline plots suggest a role of the glacial periods in the demographic history of swamp buffalo. The ancestral swamp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04830-2

    authors: Wang S,Chen N,Capodiferro MR,Zhang T,Lancioni H,Zhang H,Miao Y,Chanthakhoun V,Wanapat M,Yindee M,Zhang Y,Lu H,Caporali L,Dang R,Huang Y,Lan X,Plath M,Chen H,Lenstra JA,Achilli A,Lei C

    更新日期:2017-07-05 00:00:00

  • Novel Imidazole and Methoxybenzylamine Growth Inhibitors Affecting Salmonella Cell Envelope Integrity and its Persistence in Chickens.

    abstract::The control of Salmonella from farm to fork is challenging due to the emergence of antimicrobial-resistant isolates and the limited effects of current control methods. Advanced chemical technologies have made accessible a wide range of uncharacterized small molecules (SMs) with encouraging chemical properties for anti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31249-0

    authors: Deblais L,Helmy YA,Kathayat D,Huang HC,Miller SA,Rajashekara G

    更新日期:2018-09-06 00:00:00

  • Sea ice breakup and marine melt of a retreating tidewater outlet glacier in northeast Greenland (81°N).

    abstract::Rising temperatures in the Arctic cause accelerated mass loss from the Greenland Ice Sheet and reduced sea ice cover. Tidewater outlet glaciers represent direct connections between glaciers and the ocean where melt rates at the ice-ocean interface are influenced by ocean temperature and circulation. However, few measu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05089-3

    authors: Bendtsen J,Mortensen J,Lennert K,K Ehn J,Boone W,Galindo V,Hu YB,Dmitrenko IA,Kirillov SA,Kjeldsen KK,Kristoffersen Y,G Barber D,Rysgaard S

    更新日期:2017-07-10 00:00:00

  • Patterning of regional gene expression in autism: new complexity.

    abstract::Autism is a common and often severe neurodevelopmental disorder for which diverse pathophysiological processes have been proposed. Recent gene expression data comparing autistic and control brains suggest that the normal differential gene expression between frontal and temporal cortex is attenuated in autistic brains....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01831

    authors: Ginsberg MR,Rubin RA,Natowicz MR

    更新日期:2013-01-01 00:00:00