Abstract:
:Targeting embryonic stem cells (ESCs) is important for ESC labeling, drug delivery and cell fate control. In this study, we identified twenty-two phage clones that bind specifically to the hESC cell line X-01, which was derived from human blastocysts of Chinese origin. One phage (H178), which displays the sequence VGGEAWSSPTDL, showed higher binding affinity to hESCs than to a monkey ES cell line (RS366.4) and two mouse ES cell lines (R1 and E14). Using quantum dots (QDs) conjugated to the H178 phage, we demonstrate that the phage can specifically bind to hESCs in vitro. Our results suggest a possible interaction between the selected peptide and the stem cell extracellular matrix (ECM). The selection method described here allows rapid and efficient screening of unique phage clones and targeting cells. The phages displaying peptides identified by this study have potential applications for cargo delivery and receptor studies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhao W,Jin L,Yuan H,Tan Z,Zhou C,Li LS,Ma Ldoi
10.1038/srep03134subject
Has Abstractpub_date
2013-11-05 00:00:00pages
3134issn
2045-2322pii
srep03134journal_volume
3pub_type
杂志文章abstract::To explore the importance of soil microbial community composition on explaining the difference in heterotrophic soil respiration (R(h)) across forests, a field investigation was conducted on Rh and soil physiochemical and microbial properties in four subtropical forests in southern China. We observed that Rh differed ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07854
更新日期:2015-01-19 00:00:00
abstract::Microfluidic paper-based analytical devices (µPADs) have provided a breakthrough in portable and low-cost point-of-care diagnostics. Despite their significant scope, the complexity of fabrication and reliance on expensive and sophisticated tools, have limited their outreach and possibility of commercialization. Herein...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44455-1
更新日期:2019-05-27 00:00:00
abstract::In this work, Ni nanoparticles were directly decorated on graphene (G) nanosheets via mechanical ball milling. Based on transmission electron microscopy observations, the Ni nanoparticles were well dispersed and attached to the G nanosheet without any agglomerations. Electrochemical results showed that the capacitance...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32082
更新日期:2016-08-24 00:00:00
abstract::Although protein-folding stress at the endoplasmic reticulum (ER) is emerging as a driver of neuronal dysfunction in models of spinal cord injury and neurodegeneration, the contribution of this pathway to peripheral nerve damage remains poorly explored. Here we targeted the unfolded protein response (UPR), an adaptive...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21709
更新日期:2016-02-24 00:00:00
abstract::People who used illicit drugs (PWUDs) represent an important population group for acquisition and viral dispersion. In Brazil, high rates of the human T lymphotropic virus 1 (HTLV-1) and 2 (HTLV-2) have been reported in epidemiological studies. However, the epidemiological scenario of HTLV-1/2 infections in PWUDs is s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51383-7
更新日期:2019-10-14 00:00:00
abstract::Whipple's disease is a systemic infectious disease associated with the bacterium Tropheryma whipplei. Numerous reports have presented puzzling discrepancies between diagnosis methods. We addressed this confusion using fluorescent in situ hybridization and immunofluorescence assays to evaluate 34 duodenal biopsies and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23883
更新日期:2016-03-30 00:00:00
abstract::The general disease burden associated with the restrictive spirometric pattern (RSP) is substantial. However, the impact of RSP by its severity on general health problems and quality of life has not been well elucidated. This study aimed to analyse nutrition, physical activity, and quality of life in subjects who part...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76777-w
更新日期:2020-11-12 00:00:00
abstract::Malaria surveillance data provide opportunity to develop forecasting models. Seasonal variability in environmental factors correlate with malaria transmission, thus the identification of transmission patterns is useful in developing prediction models. However, with changing seasonal transmission patterns, either due t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02560-z
更新日期:2017-06-01 00:00:00
abstract::Understanding and mitigating decoherence is a key challenge for quantum science and technology. The main source of decoherence for solid-state spin systems is the uncontrolled spin bath environment. Here, we demonstrate quantum control of a mesoscopic spin bath in diamond at room temperature that is composed of electr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00382
更新日期:2012-01-01 00:00:00
abstract::The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnologies play an important role. Here, it is demonstrated that the Radio Electric Asymmetric Conveyer (REAC), an in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35719
更新日期:2016-10-24 00:00:00
abstract::Fundamental cell signaling mechanisms that regulate dynamic remodeling of the extracellular matrix (ECM) in mechanically loaded tissues are not yet clearly understood. Trabecular meshwork (TM) tissue in the eye is under constant mechanical stress and continuous remodeling of ECM is crucial to maintain normal aqueous h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00845-x
更新日期:2017-04-11 00:00:00
abstract::Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissecti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31298-5
更新日期:2018-08-29 00:00:00
abstract::Both chronic Obstruction Pulmonary Disease (COPD) and lung cancer are leading causes of death globally. Although COPD and lung cancer coexist frequently, it is unknown whether lung cancer patients with COPD harbor distinct genomic characteristics compared to those without COPD. In this study, we retrospectively analyz...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02405-9
更新日期:2017-05-18 00:00:00
abstract::Energy metabolism, involving the ATP-dependent AMPK-PgC-Ppar pathway impacts metabolic health immensely, in that its impairment can lead to obesity, giving rise to disease. Based on observations that individuals with Gilbert's syndrome (GS; UGT1A1(*)28 promoter mutation) are generally lighter, leaner and healthier tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30051
更新日期:2016-07-21 00:00:00
abstract::Very recently, we postulated that the incorporation of citral into nanostructured lipid carrier (NLC-Citral) improves solubility and delivery of the citral without toxic effects in vivo. Thus, the objective of this study is to evaluate anti-cancer effects of NLC-Citral in MDA MB-231 cells in vitro through the Annexin ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38214-x
更新日期:2019-02-07 00:00:00
abstract::Purpose Global sagittal imbalance with lumbar hypo-lordosis leads to various problems in elderly populations and is often treated with long-segment fusion and osteotomy. These highly invasive procedures result in a wide range of rigid spines with a high rate of complications. Although some reports have mentioned the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63648-7
更新日期:2020-04-21 00:00:00
abstract::Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administered early and may induce viral resistance. Thus, targeting the host response directly has been proposed as a nov...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11030
更新日期:2015-06-05 00:00:00
abstract::A series of alkyl amides was detected and identified in the sedimentary record from an archaeological site at Yuchisi, Mengcheng, Anhui, China. The alkyl amides profiles change abruptly at the depth corresponding to the transition between two prehistoric cultures, which also corresponds to an abrupt change in the fatt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15371-z
更新日期:2017-11-07 00:00:00
abstract::To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their pe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18519-z
更新日期:2018-01-09 00:00:00
abstract::In the present work, we introduce two new metrics i.e. hydrogen-bond strength and charge-transfer between the donor/acceptor water molecules as a measure of hydrogen-bond rearrangement dynamics. Further, we also employ a simple model based on energy flux through the donor-acceptor water pairs to quantify the extent of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35357-9
更新日期:2018-11-15 00:00:00
abstract::Diabrotica virgifera virgifera LeConte, the western corn rootworm (WCR), is the most destructive pest of maize in North America, and has recently spread across central Europe. Its subterranean larval stages are hard to reach with pesticides and it has evolved resistance to conventional management practices. The applic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39753-7
更新日期:2019-02-28 00:00:00
abstract::Glioma is the most common primary intracranial tumor and is associated with very low survival rates. The development of reliable biomarkers can help to elucidate the molecular mechanisms involved in glioma development. Here the expression of ABCC8 mRNA, clinical characteristics, and survival information based on 1893 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69676-7
更新日期:2020-07-29 00:00:00
abstract::Antenna systems serve to absorb light and to transmit excitation energy to the reaction center (RC) in photosynthetic organisms. As the emitted (bacterio)chlorophyll fluorescence competes with the photochemical utilization of the excitation, the measured fluorescence yield is informed by the migration of the excitatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70966-3
更新日期:2020-08-19 00:00:00
abstract::Tuberculosis, a severe infectious disease caused by the Mycobacterium tuberculosis, arouses huge concerns globally. In this study, a total of 331,594 TB cases in Zhejiang Province were notified during the period of 2009-2018 with the gender ratio of male to female 2.16:1. The notified TB incidences demonstrated a cont...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64387-5
更新日期:2020-05-04 00:00:00
abstract::An evaluation of energy thresholding and acquisition mode for metal artifact reduction in Photon-counting detector CT (PCD-CT) compared to conventional energy-integrating detector CT (EID-CT) was performed. Images of a hip prosthesis phantom placed in a water bath were acquired on a scanner with PCD-CT and EID-CT (tub...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77904-3
更新日期:2020-12-03 00:00:00
abstract::Birgus latro (coconut crab) is an edible crustacean that has experienced serious overharvesting throughout its whole habitat range; however, the negative effects of overharvesting on the genetic diversity within B. latro populations have not been elucidated. Here, we report sex ratio, body size, and genetic diversity ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66712-4
更新日期:2020-06-22 00:00:00
abstract::The newly sequenced mitochondrial genomes of 107 Asian swamp buffalo (Bubalus bubalis carabensis) allowed the reconstruction of the matrilineal divergence since ~900 Kya. Phylogenetic trees and Bayesian skyline plots suggest a role of the glacial periods in the demographic history of swamp buffalo. The ancestral swamp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04830-2
更新日期:2017-07-05 00:00:00
abstract::The control of Salmonella from farm to fork is challenging due to the emergence of antimicrobial-resistant isolates and the limited effects of current control methods. Advanced chemical technologies have made accessible a wide range of uncharacterized small molecules (SMs) with encouraging chemical properties for anti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31249-0
更新日期:2018-09-06 00:00:00
abstract::Rising temperatures in the Arctic cause accelerated mass loss from the Greenland Ice Sheet and reduced sea ice cover. Tidewater outlet glaciers represent direct connections between glaciers and the ocean where melt rates at the ice-ocean interface are influenced by ocean temperature and circulation. However, few measu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05089-3
更新日期:2017-07-10 00:00:00
abstract::Autism is a common and often severe neurodevelopmental disorder for which diverse pathophysiological processes have been proposed. Recent gene expression data comparing autistic and control brains suggest that the normal differential gene expression between frontal and temporal cortex is attenuated in autistic brains....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01831
更新日期:2013-01-01 00:00:00