Abstract：
:The control of Salmonella from farm to fork is challenging due to the emergence of antimicrobial-resistant isolates and the limited effects of current control methods. Advanced chemical technologies have made accessible a wide range of uncharacterized small molecules (SMs) with encouraging chemical properties for antimicrobial treatment. Of the 4,182 SMs screened in vitro, four cidal SMs were effective at 10 µM and higher against several serotypes, antibiotic-resistant, and biofilm embedded Salmonella enterica subsp. enterica serotype Typhimurium by altering cell membrane integrity. The four SMs displayed synergistic effects with ciprofloxacin, meropenem and cefeprime against Salmonella. Further, the SMs were not pernicious to most eukaryotic cells at 200 μM and cleared internalized Salmonella in infected Caco-2, HD11, and THP-1 cells at 6.25 µM and higher. The SMs also increased the longevity of Salmonella-infected Galleria mellonella larvae and reduced the population of internalized Salmonella Typhimurium. Two of the SMs (SM4 and SM5) also reduced S. Typhimurium load in infected chicken ceca as well as its systemic translocation into other tissues, with minimal impact on the cecal microbiota. This study demonstrated that SMs are a viable source of potential antimicrobials applicable in food animal production against Salmonella.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Deblais L,Helmy YA,Kathayat D,Huang HC,Miller SA,Rajashekara Gdoi
10.1038/s41598-018-31249-0subject
Has Abstractpub_date
2018-09-06 00:00:00pages
13381issue
1issn
2045-2322pii
10.1038/s41598-018-31249-0journal_volume
8pub_type
杂志文章abstract：:The Langendorff-perfused heart technique has become the model of choice for multiparametric optical mapping of cardiac function and electrophysiology. However, photon scattering in tissues represents a significant drawback of the optical imaging approach, fundamentally limiting its mapping capacity to the heart surfac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32317-1
更新日期：2018-09-20 00:00:00
abstract：:Acute traumatic intraparenchymal hematoma (tICH) expansion is a devastating neurological complication that is associated with poor outcome after cerebral contusion. This study aimed to develop and validate a novel noncontrast computed tomography (CT) (NCCT) multihematoma fuzzy sign to predict acute tICH expansion. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81685-8
更新日期：2021-01-21 00:00:00
abstract：:Successful communication is critical to the fitness of individuals and maintenance of populations, but less is known regarding the social contexts and reactions to scent marking by other individuals in solitary carnivores, including pumas. We evaluated the responses of resident male pumas to visitation and scent marki...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27257
更新日期：2016-06-02 00:00:00
abstract：:A comprehensive understanding of the charge/discharge behaviour of high-capacity anode active materials, e.g., Si and Li, is essential for the design and development of next-generation high-performance Li-based batteries. Here, we demonstrate the in situ scanning electron microscopy (in situ SEM) of Si anodes in a con...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36153
更新日期：2016-10-26 00:00:00
abstract：:Differentiating recurrent brain tumor from radiation necrosis is often difficult. This study aims to investigate the efficacy of 11C-methionine (MET)-PET radiomics for distinguishing recurrent brain tumor from radiation necrosis, as compared with conventional tumor-to-normal cortex (T/N) ratio evaluation. We enrolled ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-52279-2
更新日期：2019-10-30 00:00:00
abstract：:Sampling various compartments within the lower airways to examine human bronchial epithelial cells (HBEC) is essential for understanding numerous lung diseases. Conventional methods to identify HBEC in bronchoalveolar lavage (BAL) and wash (BW) have throughput limitations in terms of efficiency and ensuring adequate c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42214
更新日期：2017-02-06 00:00:00
abstract：:FMS-like Tyrosine Kinase 3 (FLT3) is a clinically validated target for acute myeloid leukemia (AML). Inhibitors targeting FLT3 have been evaluated in clinical studies and have exhibited potential to treat FLT3-driven AML. A frequent, clinical limitation is FLT3 selectivity, as concomitant inhibition of FLT3 and c-KIT ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21839-3
更新日期：2018-02-27 00:00:00
abstract：:Metabolomics was applied to a C57BL/6N mouse model of chronic unpredictable mild stress (CMS). Such mice were treated with two antidepressants from different categories: fluoxetine and imipramine. Metabolic profiling of the hippocampus was performed using gas chromatography-mass spectrometry analysis on samples prepar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08890
更新日期：2015-03-09 00:00:00
abstract：:Hirschsprung disease (HSCR) is a common cause of functional colonic obstruction in children. The currently available genetic testing is often inadequate as it mainly focuses on RET and several other genes, accounting for only 15-20% of cases. To identify novel, potentially pathogenic variants, we isolated a panel of g...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-14835-6
更新日期：2017-11-01 00:00:00
abstract：:Ammonia borane (AB) is among the most promising precursors for the large-scale synthesis of hexagonal boron nitride (h-BN) by chemical vapour deposition (CVD). Its non-toxic and non-flammable properties make AB particularly attractive for industry. AB decomposition under CVD conditions, however, is complex and hence h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14663-8
更新日期：2017-10-30 00:00:00
abstract：:This study investigated lead concentrations in the hairs of radiographers working in the radiological departments of general hospitals that used lead shielding for radiation protection. We collected scalp hair samples from 32 radiographers working in four radiology departments with lead shielding and 18 administration...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80721-3
更新日期：2021-01-08 00:00:00
abstract：:The majority of genes encoding photosynthesis-associated proteins in the nucleus are induced by light during photomorphogenesis, allowing plants to establish photoautotrophic growth. Therefore, optimizing the protein import apparatus of plastids, designated as the translocon at the outer and inner envelope membranes o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76939-w
更新日期：2020-11-20 00:00:00
abstract：:Up to now, full tunability of waveforms was possible only in electronics, up to radio-frequencies. Here we propose a new concept of producing few-cycle terahertz (THz) pulses with widely tunable waveforms. It is based on control of the phase delay between different parts of the THz wavefront using linear diffractive o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43852-w
更新日期：2019-05-15 00:00:00
abstract：:Coastal wetlands are important carbon sinks globally, but their ability to store carbon hinges on their nitrogen (N) supply and N uptake dynamics of dominant plant species. In terrestrial ecosystems, uptake of nitrate (NO3-) and ammonium (NH4+) through roots can strongly influence N acquisition rates and their respons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23349-8
更新日期：2018-03-29 00:00:00
abstract：:Using single-trial cortical signals calculated by weighted minimum norm solution estimation (WMNE), the present study explored a feature extraction method based on rhythm entropy to classify the scalp electroencephalography (EEG) signals of error response from that of correct response during performing auditory-track ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24535-4
更新日期：2018-04-17 00:00:00
abstract：:Myopia is the commonest eye disorder in the world. High myopes are predisposed to ocular pathologies. The vasoactive intestinal peptide receptor 2 (VIPR2) gene was identified as a myopia susceptibility locus by our group and another group. We continued to fine-map this locus. A case-control study was performed in 4 se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54619-8
更新日期：2019-12-03 00:00:00
abstract：:Hibernation in mammals is a remarkable state of heterothermy wherein metabolic rates are reduced, core body temperatures reach ambient levels, and key physiological functions are suspended. Typically, hibernation is observed in cold-adapted mammals, though it has also been documented in tropical species and even prima...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01768
更新日期：2013-01-01 00:00:00
abstract：:A feasibility study is presented on the performance parameters of a novel on-chip antenna based on metasurface technology at terahertz band. The proposed metasurface on-chip antenna is constructed on an electrically thin high-permittivity gallium arsenide (GaAs) substrate layer. Metasurface is implemented by engraving...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68105-z
更新日期：2020-07-03 00:00:00
abstract：:A new extraordinary application of deoxyribonucleic acid (DNA) thin-solid-film was experimentally explored in the field of ultrafast nonlinear photonics. Optical transmission was investigated in both linear and nonlinear regimes for two types of DNA thin-solid-films made from DNA in aqueous solution and DNA-cetyltrime...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41480
更新日期：2017-01-27 00:00:00
abstract：:Lipidomic analyses address the problem of characterizing the lipid components of given cells, tissues and organisms by means of chromatographic separations coupled to high-resolution, tandem mass spectrometry analyses. A number of software tools have been developed to help in the daunting task of mass spectrometry sig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70259-9
更新日期：2020-08-07 00:00:00
abstract：:Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in hum...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08267-5
更新日期：2017-08-15 00:00:00
abstract：:Many reports have demonstrated that radiation stimulates reactive oxygen species (ROS) production by mitochondria for a few hours to a few days after irradiation. However, these studies were performed using cell lines, and there is a lack of information about redox homeostasis in irradiated animals and humans. Blood r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25650-y
更新日期：2018-05-09 00:00:00
abstract：:Oxidative stress and mitochondrial dysfunction are implicated in aging-related neurodegenerative disorders. 8-Oxoguanine (8-oxoG), a common oxidised base lesion, is often highly accumulated in brains from patients with neurodegenerative disorders. MTH1 hydrolyses 8-oxo-2'-deoxyguanosine triphosphate (8-oxo-dGTP) to 8-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22086
更新日期：2016-02-25 00:00:00
abstract：:We identify graphene layer on a disordered substrate as a system where localization of phonons can be observed. Generally, observation of localization for scattering waves is not simple, because the Rayleigh scattering is inversely proportional to a high power of wavelength. The situation is radically different for th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34426-3
更新日期：2018-11-02 00:00:00
abstract：:Atomic Fermi gases have been an ideal platform for simulating conventional and engineering exotic physical systems owing to their multiple tunable control parameters. Here we investigate the effects of mixed dimensionality on the superfluid and pairing phenomena of a two-component ultracold atomic Fermi gas with a sho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13321-3
更新日期：2017-10-11 00:00:00
abstract：:Intrahepatic cholestasis represents a frequent manifestation of drug-induced liver injury; however, the mechanisms underlying such injuries are poorly understood. In this study of human HepaRG and primary hepatocytes, we found that bile canaliculi (BC) underwent spontaneous contractions, which are essential for bile a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24709
更新日期：2016-05-12 00:00:00
abstract：:Arctic and alpine environments present extreme, but different, challenges to survival. We therefore studied the ecological adaptation of the arctic-alpine fritillary Boloria napaea in northern Sweden and compared these results with the eastern Alps. Using mark-release-recapture, we analysed phenology, mobility, activi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40508-7
更新日期：2019-03-07 00:00:00
abstract：:Development of new antimicrobial agents is required against the causative agent for listeriosis, Listeria monocytogenes, as the number of drug resistant strains continues to increase. A promising target is the β-ketoacyl-acyl carrier protein synthase FabF, which participates in the catalysis of fatty acid synthesis an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39277
更新日期：2017-01-03 00:00:00
abstract：:Learning to successfully navigate social environments is a critical developmental goal, predictive of long-term wellbeing. However, little is known about how people learn to adjust to different social environments, and how this behaviour emerges across development. Here, we use a series of economic games to assess how...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78546-1
更新日期：2020-12-10 00:00:00
abstract：:Abnormalities in actin cytoskeleton have been linked to Friedreich's ataxia (FRDA), an inherited peripheral neuropathy characterised by an early loss of neurons in dorsal root ganglia (DRG) among other clinical symptoms. Despite all efforts to date, we still do not fully understand the molecular events that contribute...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62050-7
更新日期：2020-03-23 00:00:00
