Abstract:
:The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnologies play an important role. Here, it is demonstrated that the Radio Electric Asymmetric Conveyer (REAC), an innovative technology platform for neuro- and bio-modulation, used according to the neuro-regenerative protocol (RGN-N), significantly increases astroglial reaction around the amyloid plaques in an AD mouse model, as evaluated by GFAP-immunoreactivity, and reduces microglia-associated neuroinflammation markers, as evaluated by Iba1-immunoreactivity and mRNA expression level of inflammatory cytokines TREM. IL1beta, iNOS and MRC1 were not affected neither by the genotype or by REAC RGN-N treatment. Also observed was an increase in locomotion in treated animals. The study was performed in 24-month-old male Tg2576 mice and age-matching wild-type animals, tested for Y-maze, contextual fear conditioning and locomotion immediately after the end of a specific REAC treatment administered for 15 hours/day for 15 days. These results demonstrated that REAC RGN-N treatment modifies pathological neuroinflammation, and mitigates part of the complex motor behaviour alterations observed in very old Tg2576 mice.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lorenzini L,Giuliani A,Sivilia S,Baldassarro VA,Fernandez M,Lotti Margotti M,Giardino L,Fontani V,Rinaldi S,Calzà Ldoi
10.1038/srep35719subject
Has Abstractpub_date
2016-10-24 00:00:00pages
35719issn
2045-2322pii
srep35719journal_volume
6pub_type
杂志文章abstract::Prion-like behaviour is attracting much attention due to the growing evidences that amyloid-like self-assembly may reach beyond neurodegeneration and be a conserved functional mechanism. The best characterized functional prions correspond to a subset of yeast proteins involved in translation or transcription. Their co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09714-z
更新日期:2017-09-21 00:00:00
abstract::Resin composites containing reinforcing inert glass fillers combined with bioactive glass (BG) can aid in the prevention of secondary caries, which is a major cause of failure of contemporary composite restorations. A series of previous studies on experimental resin composites filled with BG 45S5 has demonstrated that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54035-y
更新日期:2019-11-21 00:00:00
abstract::Rhegmatogenous retinal detachment (RRD) is an ophthalmic emergency, which usually requires prompt surgery to prevent further detachment and restore sensory function. Although several individual factors have been suggested, a systems level understanding of molecular pathomechanisms underlying this severe eye disorder i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80005-w
更新日期:2021-01-13 00:00:00
abstract::The present study evaluated the effects of exposing liquid-stored boar semen to different red light LED regimens on sperm quality and reproductive performance. Of all of the tested photo-stimulation procedures, the best pattern consisted of 10 min light, 10 min rest and 10 min of further light (10-10-10 pattern). This...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22569
更新日期:2016-03-02 00:00:00
abstract::Computational determination of peptide conformations is challenging as it is a problem of finding minima in a high-dimensional space. The "divide and conquer" approach is promising for reliably reducing the search space size. A random forest learning model is proposed here to expand the scope of applicability of the "...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27167-w
更新日期:2018-06-11 00:00:00
abstract::Developed through evolution, brain neural system self-organizes into an economical and dynamic network structure with the modulation of repetitive neuronal firing activities through synaptic plasticity. These highly variable electric activities inevitably produce a spontaneous magnetic field, which also significantly ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46104-z
更新日期:2019-07-04 00:00:00
abstract::Unlike mammals, in palmipedes de novo lipogenesis from diet takes place mostly in the liver. The French Landes Goose is famous for its high capacity and susceptibility to fatty liver production. While miRNAs play a critical role in the posttranscriptional regulation of gene expression, miRNAs that are involved in the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16632-7
更新日期:2017-11-24 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. KCa3.1 ion channels play a critical role in TGFβ1-dependent pro-fibrotic responses in human lung myofibroblasts. We aimed to develop a human lung parenchymal model of fibrogenesis and test the efficacy of t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18555-9
更新日期:2018-01-10 00:00:00
abstract::We demonstrate a novel route to achieving highly efficient and strongly confined spoof surface plasmon polaritons (SPPs) waveguides at subwavelength scale enabled by planar staggered plasmonic waveguides (PSPWs). The structure of these new waveguides consists of an ultrathin metallic strip with periodic subwavelength ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38528
更新日期:2016-12-05 00:00:00
abstract::Capacitation is the final maturation step spermatozoa undergo prior to fertilisation. The efflux of cholesterol from the sperm membrane to the extracellular environment is a crucial step during capacitation but current methods to quantify this process are suboptimal. In this study, we validate the use of a BODIPY-chol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45831-7
更新日期:2019-07-08 00:00:00
abstract::In this paper, we demonstrate a novel dual-pump approach to generate robust optical frequency comb with varying free spectral range (FSR) spacing in a CMOS-compatible high-Q micro-ring resonator (MRR). The frequency spacing of the comb can be tuned by an integer number FSR of the MRR freely in our dual-pump scheme. Th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28501
更新日期:2016-06-24 00:00:00
abstract::We identify graphene layer on a disordered substrate as a system where localization of phonons can be observed. Generally, observation of localization for scattering waves is not simple, because the Rayleigh scattering is inversely proportional to a high power of wavelength. The situation is radically different for th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34426-3
更新日期:2018-11-02 00:00:00
abstract::Cardiopulmonary resuscitation (CPR) training and its quality are critical in improving the survival rate of cardiac arrest. This randomized controlled study investigated the efficacy of a newly developed CPR training program for the public in a Taiwanese setting. A total of 832 adults were randomized to either a tradi...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-67193-1
更新日期:2020-06-22 00:00:00
abstract::The metal-free nitrogen-doped graphitic-carbon@graphene (Ng-C@G) is prepared from a composite of polyaniline and graphene by a facile polymerization following by pyrolysis for electrochemical oxygen reduction reaction (ORR). Pyrolysis creates a sponge-like with ant-cave-architecture in the polyaniline derived nitrogen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68260-3
更新日期:2020-07-24 00:00:00
abstract::Fibrin polymerization is a necessary part of hemostasis but clots can obstruct blood vessels and cause heart attacks and strokes. The polymerization reactions are specific and controlled, involving strong knob-into-hole interactions to convert soluble fibrinogen into insoluble fibrin. It has long been assumed that clo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00879
更新日期:2012-01-01 00:00:00
abstract::The DNA methyltransferase DNMT3A R882H mutation is observed in 25% of all AML patients. DNMT3A is active as tetramer and the R882H mutation is located in one of the subunit/subunit interfaces. Previous work has reported that formation of mixed wildtype/R882H complexes leads to a strong loss of catalytic activity obser...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31635-8
更新日期:2018-09-05 00:00:00
abstract::Selenium and selenium nanoparticles (SeNPs) are extensively used in biomedicine, electronics and some other industrial applications. The bioproduction of SeNPs is gaining interest as a green method to manufacture these biotechnologically relevant products. Several microorganisms have been used for the production of Se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16252-1
更新日期:2017-11-22 00:00:00
abstract::Measurements of skeletal muscle cross-sectional area, index, and radiation attenuation utilizing clinical computed tomography (CT) scans are used in assessments of sarcopenia, the loss of skeletal muscle mass and function associated with aging. To classify individuals as sarcopenic, sex-specific cutoffs for 'low' valu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29825-5
更新日期:2018-07-27 00:00:00
abstract::The placenta forms a maternal-fetal junction that supports many physiological functions such as the supply of nutrition and exchange of gases and wastes. Establishing an in vitro culture model of human and non-human primate trophoblast stem/progenitor cells is important for investigating the process of early placental...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63602-7
更新日期:2020-04-22 00:00:00
abstract::The presence of missing values (MVs) in label-free quantitative proteomics greatly reduces the completeness of data. Imputation has been widely utilized to handle MVs, and selection of the proper method is critical for the accuracy and reliability of imputation. Here we present a comparative study that evaluates the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81279-4
更新日期:2021-01-19 00:00:00
abstract::Severe sepsis and septic shock are life-threatening conditions, with Gram-negative organisms responsible for most sepsis mortality. Systemic administration of compounds that block the action of lipopolysaccharide (LPS), a constituent of the Gram-negative outer cell membrane, is hampered by their hydrophobicity and cat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29739
更新日期:2016-07-14 00:00:00
abstract::Transition metal cobalt (Co) nanoparticle was designed as catalyst to promote the conversion reaction of Sn to SnO2 during the delithiation process which is deemed as an irreversible reaction. The designed nanocomposite, named as SnO2/Co3O4/reduced-graphene-oxide (rGO), was synthesized by a simple two-step method comp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09164
更新日期:2015-03-17 00:00:00
abstract::The mechanism of immune tolerance is to be further understood. The present study aims to investigate the role of the Cardiac endothelial cell (CEC)-derived exosomes in the induction of regulatory B cells. In this study, CECs were isolated from the mouse heart. Exosomes were purified from the culture supernatant of the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07583
更新日期:2014-12-23 00:00:00
abstract::Sixty norovirus outbreaks that occurred in Pudong District, Shanghai in 2017 and affected 959 people were summarised. Of the outbreaks, 29 (48.3%), 27 (45.0%), and 4 (6.7%) occurred in kindergartens, primary schools, and middle schools, respectively. Although the total number of outbreaks peaked in March (13/60, 21.7%...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33724-0
更新日期:2018-10-15 00:00:00
abstract::Ovarian cancer is the second most common gynaecologic malignancy and the main cause of death from gynaecologic cancer, due to late diagnosis and chemoresistance. Studies have reported the role of cysteine in cancer, by contributing for hydrogen sulphide (H2S) generation and as a precursor of glutathione (GSH). However...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27753-y
更新日期:2018-06-22 00:00:00
abstract::The Hauraki Gulf, a shallow embayment in north-eastern New Zealand, provides an interesting environment for ecological soundscape research. It is situated on a tectonic plate boundary, contains one of the busiest ports in the southern hemisphere and is home to a diverse range of soniferous animals. The underwater soun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06347-0
更新日期:2017-07-18 00:00:00
abstract::The spinal dorsal horn (SDH) is comprised of distinct neuronal populations that process different somatosensory modalities. Somatostatin (SST)-expressing interneurons in the SDH have been implicated specifically in mediating mechanical pain. Identifying the transcriptomic profile of SST neurons could elucidate the uni...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25110-7
更新日期:2018-05-01 00:00:00
abstract::While impressive improvements have been achieved in T-ALL therapy, current treatment approaches fail in approximately 25% of patients and these patients have limited treatment options. Another significant group of patients is being overtreated, which causes long-lasting side effects. Identification of molecules contro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15200-3
更新日期:2017-11-07 00:00:00
abstract::The electrohydrodynamic (EHD) jet spraying process is a good method for making quantum dot (QD) layers in light-emitting diodes (LEDs). However, controlling the morphology and large-scale fabrication of the QD layers are critical for realizing all-solution-processed QD-LEDs with high performance. Three spraying techni...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50181-5
更新日期:2019-09-25 00:00:00
abstract::Fine-motor impairment (FMI) is progressively expressed in early Parkinson's Disease (PD) patients and is now known to be evident in the immediate prodromal stage of the condition. The clinical techniques for detecting FMI may not be robust enough and here, we show that the subtle FMI of early PD patients can be effect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69369-1
更新日期:2020-07-28 00:00:00