Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD.

abstract：:The objective was to establish and evaluate a method for manufacture of custom trays for edentulous jaws using computer aided design and fused deposition modeling (FDM) technologies. A digital method for design the custom trays for edentulous jaws was established. The tissue surface data of ten standard mandibular ede...

journal_title：Scientific reports

authors： Chen H,Yang X,Chen L,Wang Y,Sun Y

更新日期：2016-01-14 00:00:00

abstract：:Nicotine was not included in previous efforts to identify the most important toxicants of tobacco smoke. A health risk assessment of nicotine for smokers of cigarettes was conducted using the margin of exposure (MOE) approach and results were compared to literature MOEs of various other tobacco toxicants. The MOE is d...

journal_title：Scientific reports

authors： Baumung C,Rehm J,Franke H,Lachenmeier DW

更新日期：2016-10-19 00:00:00

abstract：:An empirical approach was taken to screen a novel synthetic compound library designed to be active against Gram-positive bacteria. We obtained five compounds that were active against spores from the model organism Bacillus subtilis and the food-borne pathogen Bacillus cereus during our population based experiments. Us...

journal_title：Scientific reports

authors： Omardien S,Ter Beek A,Vischer N,Montijn R,Schuren F,Brul S

更新日期：2018-06-14 00:00:00

abstract：:Thyroid hormone (TH) has long been believed to play a minor role in male reproduction. However, evidences from experimental model of thyrotoxicosis or hypothyroidism suggests its role in spermatogenesis. Cellular action of TH requires membrane transport via specific transporters such as monocarboxylate transporter 8 (...

journal_title：Scientific reports

authors： Bae HS,Jin YK,Ham S,Kim HK,Shin H,Cho GB,Lee KJ,Lee H,Kim KM,Koo OJ,Jang G,Lee JM,Lee JY

更新日期：2020-07-07 00:00:00

abstract：:Gelatin, derived from collagen, has both the mechanical properties required for tissue growth, as well the functional domains required for cell binding. In its natural state, gelatin derives its properties from a network of structured, intertwined, triple helical chains, which is stabilized by hydrogen bonds at temper...

journal_title：Scientific reports

authors： Marmorat C,Arinstein A,Koifman N,Talmon Y,Zussman E,Rafailovich M

更新日期：2016-05-05 00:00:00

abstract：:The AMP-activated kinase (AMPK) is a major energy sensor metabolic enzyme that is activated early during T cell immune responses but its role in the generation of effector T cells is still controversial. Using both in vitro and in vivo models of T cell proliferation, we show herein that AMPK is dispensable for early T...

journal_title：Scientific reports

authors： Lepez A,Pirnay T,Denanglaire S,Perez-Morga D,Vermeersch M,Leo O,Andris F

更新日期：2020-12-10 00:00:00

abstract：:Early microvascular damage in diabetes (e.g. capillary nonperfusion and ischemia) can now be assessed and quantified with optical coherence tomography-angiography (OCT-A). The morphology of vascular tissue is indeed affected by different factors; however, there is a paucity of data examining whether OCT-A metrics are ...

journal_title：Scientific reports

authors： Tang FY,Ng DS,Lam A,Luk F,Wong R,Chan C,Mohamed S,Fong A,Lok J,Tso T,Lai F,Brelen M,Wong TY,Tham CC,Cheung CY

更新日期：2017-05-31 00:00:00

abstract：:Plant-based proteins are increasingly being used in aquafeeds, but one of the limitations is taurine deficiency that can be especially detrimental for carnivorous fish. In this study, taurine supplementation in high plant protein diets (low fish meal, 15%) was investigated on the growth performance and fillet organole...

journal_title：Scientific reports

authors： Kotzamanis Y,Tsironi T,Brezas A,Grigorakis K,Ilia V,Vatsos I,Romano N,van Eys J,Kumar V

更新日期：2020-07-23 00:00:00

abstract：:Regular exercise elicits advantageous metabolic adaptations in skeletal muscle, such as improved insulin sensitivity. However, the underpinning molecular mechanisms and the effect of diet on muscle exercise training benefits are unclear. We therefore characterized the skeletal muscle proteome following exercise traini...

journal_title：Scientific reports

authors： Kleinert M,Parker BL,Jensen TE,Raun SH,Pham P,Han X,James DE,Richter EA,Sylow L

更新日期：2018-07-16 00:00:00

abstract：:A practical quantum computer must be capable of performing high fidelity quantum gates on a set of quantum bits (qubits). In the presence of noise, the realization of such gates poses daunting challenges. Geometric phases, which possess intrinsic noise-tolerant features, hold the promise for performing robust quantum ...

journal_title：Scientific reports

authors： Zhang J,Kyaw TH,Tong DM,Sjöqvist E,Kwek LC

更新日期：2015-12-21 00:00:00

abstract：:We analyze the entire publication database of the American Physical Society generating longitudinal (50 years) citation networks geolocalized at the level of single urban areas. We define the knowledge diffusion proxy, and scientific production ranking algorithms to capture the spatio-temporal dynamics of Physics know...

journal_title：Scientific reports

authors： Zhang Q,Perra N,Gonçalves B,Ciulla F,Vespignani A

更新日期：2013-01-01 00:00:00

abstract：:The pollination syndrome concept has provided powerful utility in understanding the evolution and adaptation of floral traits. However, the utility of this conception has been questioned on the grounds that flowers usually attract a broader spectrum of visitors than one might expect. Furthermore, the relationship betw...

journal_title：Scientific reports

authors： Wang X,Wen M,Qian X,Pei N,Zhang D

更新日期：2020-08-18 00:00:00

abstract：:Motor symptoms are defining traits in the diagnosis of Parkinson's disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive affere...

journal_title：Scientific reports

authors： Vinding MC,Tsitsi P,Piitulainen H,Waldthaler J,Jousmäki V,Ingvar M,Svenningsson P,Lundqvist D

更新日期：2019-02-22 00:00:00

abstract：:Bimetallic Pd1-x Pt x solid-solution nanoparticles (NPs) display charging/discharging of hydrogen gas, which has relevance for fuel cell technologies; however, the constituent elements are immiscible in the bulk phase. We examined these material systems using high-energy synchrotron X-ray diffraction, X-ray absorption...

journal_title：Scientific reports

authors： Kumara LSR,Sakata O,Kobayashi H,Song C,Kohara S,Ina T,Yoshimoto T,Yoshioka S,Matsumura S,Kitagawa H

更新日期：2017-11-06 00:00:00

abstract：:Cancer cachexia is a complex multi-organ syndrome characterized by body weight loss, weakness, muscle atrophy and fat depletion. With a prevalence of 1 million people in Europe and only limited therapeutic options, there is a high medical need for new approaches to treat cachexia. Our latest results highlighted microb...

journal_title：Scientific reports

authors： Pötgens SA,Brossel H,Sboarina M,Catry E,Cani PD,Neyrinck AM,Delzenne NM,Bindels LB

更新日期：2018-08-17 00:00:00

abstract：:Single molecule microarrays have been used in quantitative proteomics, in particular, single cell analysis requiring high sensitivity and ultra-low limits of detection. In this paper, several image analysis methods are evaluated for their ability to accurately enumerate single molecules bound to a microarray spot. Cru...

journal_title：Scientific reports

authors： Salehi-Reyhani A

更新日期：2017-12-20 00:00:00

abstract：:Somatic copy number alterations (SCNAs) affecting oncogenic drivers have a firmly established role in promoting cancer. However, no agreed-upon standard exists for calling locus-specific amplifications and deletions in each patient sample. Here, we report the correlative analysis of copy number amplitude and length wi...

journal_title：Scientific reports

authors： Roszik J,Wu CJ,Siroy AE,Lazar AJ,Davies MA,Woodman SE,Kwong LN

更新日期：2016-01-20 00:00:00

abstract：:Empathetic verbal feedback from others has been shown to alleviate the intensity of experimental pain. To investigate the brain changes associated with this effect, we conducted 3T-fMRI measurements in 30 healthy subjects who received painful thermal stimuli on their left hand while overhearing empathetic, neutral or ...

journal_title：Scientific reports

authors： Fauchon C,Faillenot I,Quesada C,Meunier D,Chouchou F,Garcia-Larrea L,Peyron R

更新日期：2019-06-10 00:00:00

abstract：:The plasmodial CTP:phosphocholine cytidylyltransferase (PfCCT) is a promising antimalarial target, which can be inhibited to exploit the need for increased lipid biosynthesis during the erythrocytic life stage of Plasmodium falciparum. Notable structural and regulatory differences of plasmodial and mammalian CCTs offe...

journal_title：Scientific reports

authors： Marton L,Hajdú F,Nagy GN,Kucsma N,Szakács G,Vértessy BG

更新日期：2018-06-12 00:00:00

abstract：:Tau is a Microtubule-associated protein that induces and stabilizes the formation of the Microtubule cytoskeleton and plays an important role in neurodegenerative diseases. The Microtubules binding region of Tau has been determined for a long time but where and how Tau binds to its partner still remain a topic of deba...

journal_title：Scientific reports

authors： Martinho M,Allegro D,Huvent I,Chabaud C,Etienne E,Kovacic H,Guigliarelli B,Peyrot V,Landrieu I,Belle V,Barbier P

更新日期：2018-09-14 00:00:00

abstract：:To compare the efficacy and safety of triple therapy combining intravitreal injection of anti-vascular endothelial growth factor, trabeculectomy, and pan-retinal photocoagulation via binocular indirect ophthalmoscopy, with that of transscleral cyclophotocoagulation (TCP) to treat neovascular glaucoma in the angle-clos...

journal_title：Scientific reports

authors： Hong Y,Hu Y,Dou H,Wang C,Zhang C,Ma Z

更新日期：2018-05-04 00:00:00

abstract：:The interaction of a mechanical oscillator with the operation actions and environment fields will give rise to the splitting of normal modes. In this study, we investigate the normal mode splitting behaviour of a moving-particles-pumped single-span clamped-hinged elastic homogeneous beam based on the proposed multi-oc...

journal_title：Scientific reports

authors： Sun Z

更新日期：2018-06-28 00:00:00

abstract：:It well-known that mental training improves skill performance. Here, we evaluated skill acquisition and consolidation after physical or motor imagery practice, by means of an arm pointing task requiring speed-accuracy trade-off. In the main experiment, we showed a significant enhancement of skill after both practices ...

journal_title：Scientific reports

authors： Ruffino C,Truong C,Dupont W,Bouguila F,Michel C,Lebon F,Papaxanthis C

更新日期：2021-01-27 00:00:00

abstract：:A fast Endospore Germinability Assay (EGA) was validated with traditional plate counts to enumerate single endospore germination events for monitoring surface sterilization. The assay is based on a time-gated luminescence microscopy technique enabling visualization and enumeration of individual germinating endospores....

journal_title：Scientific reports

authors： Yung PT,Lester E,Ponce A

更新日期：2020-01-16 00:00:00

abstract：:Causal Structure Discovery (CSD) is the problem of identifying causal relationships from large quantities of data through computational methods. With the limited ability of traditional association-based computational methods to discover causal relationships, CSD methodologies are gaining popularity. The goal of the st...

journal_title：Scientific reports

authors： Shen X,Ma S,Vemuri P,Simon G,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-02-19 00:00:00

abstract：:Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNA...

journal_title：Scientific reports

authors： Yan L,Cao R,Liu Y,Wang L,Pan B,Lv X,Jiao H,Zhuang Q,Sun X,Xiao R

更新日期：2016-09-06 00:00:00

abstract：:Unimolecular dual agonists for the glucagon-like peptide 1 receptor (GLP1R) and glucagon receptor (GCGR) are emerging as a potential new class of important therapeutics in type 2 diabetes (T2D). Reliable and quantitative assessments of in vivo occupancy on each receptor would improve the understanding of the efficacy ...

journal_title：Scientific reports

authors： Eriksson O,Haack T,Hijazi Y,Teichert L,Tavernier V,Laitinen I,Berglund JE,Antoni G,Velikyan I,Johansson L,Pierrou S,Wagner M,Tillner J

更新日期：2020-10-07 00:00:00

abstract：:Glioblastoma (grade IV glioma) is the most common and aggressive adult brain tumor. A better understanding of the biology of glioblastoma cells is crucial to identify molecular targets stimulating cell death. NPM1 (nucleophosmin) is a multifunctional chaperone that plays an important role in cancer development. Herein...

journal_title：Scientific reports

authors： Holmberg Olausson K,Elsir T,Moazemi Goudarzi K,Nistér M,Lindström MS

更新日期：2015-11-12 00:00:00

abstract：:The neural substrates by which speech sounds are perceptually segregated into distinct streams are poorly understood. Here, we recorded high-density scalp event-related potentials (ERPs) while participants were presented with a cyclic pattern of three vowel sounds (/ee/-/ae/-/ee/). Each trial consisted of an adaptatio...

journal_title：Scientific reports

authors： Alain C,Arsenault JS,Garami L,Bidelman GM,Snyder JS

更新日期：2017-01-19 00:00:00

abstract：:BiFeO3 is one of the most promising multiferroic materials but undergoes two major drawbacks: low dielectric susceptibility and high dielectric loss. Here we report high in-plane dielectric permittivity (ε' ∼2500) and low dielectric loss (tan δ < 0.01) obtained on Bi0.95Y0.05FeO3 films epitaxially grown on SrTiO3 (001...

journal_title：Scientific reports

authors： Scarisoreanu ND,Craciun F,Birjega R,Ion V,Teodorescu VS,Ghica C,Negrea R,Dinescu M

更新日期：2016-05-09 00:00:00