Abstract:
:People who used illicit drugs (PWUDs) represent an important population group for acquisition and viral dispersion. In Brazil, high rates of the human T lymphotropic virus 1 (HTLV-1) and 2 (HTLV-2) have been reported in epidemiological studies. However, the epidemiological scenario of HTLV-1/2 infections in PWUDs is still poorly understood. Thus, this cross-sectional study determined the prevalence, frequency of subtypes and factors associated with HTLV-1/2 infections among PWUDs in the Brazilian state of Pará, an area considered endemic for this virus and with poor health services. Among 826 PWUDs, 53 (6.4%) presented anti-HTLV-1/2 antibodies by EIA and 44 (5.3%) presented proviral DNA by PCR. HTLV-1 and HTLV-2 were detected in 25 (3.0%) and 19 (2.3%) PWUDs, respectively. Subtypes 1a (25/44), transcontinental (23/44) and Japanese subgroups (2/44), 2b (6/44) and 2c (13/44) were identified. Involvement in illicit/criminal activity, daily use of illicit drugs, illicit drug use over 12 years, unprotected sex with other PWUDs, changes in genitalia (including ulcers and wounds), and more than 12 sexual partners were associated with HTLV-1/2 in PWUDs. This high prevalence and intense circulation of subtypes and subgroups of HTLV-1/2 is very worrying, and indicate the need for urgent actions for its control, prevention and treatment.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Oliveira-Filho AB,Araújo APS,Souza APC,Gomes CM,Silva-Oliveira GC,Martins LC,Fischer B,Machado LFA,Vallinoto ACR,Ishak R,Lemos JAR,Kupek Edoi
10.1038/s41598-019-51383-7subject
Has Abstractpub_date
2019-10-14 00:00:00pages
14750issue
1issn
2045-2322pii
10.1038/s41598-019-51383-7journal_volume
9pub_type
杂志文章abstract::The visual magnocellular system is thought to play a crucial role in learning to read. Here therefore, we examined whether magnocellular based training could improve reading in children with visual reading problems. The participants were 24 male primary school students aged between 9-11 (Mean = 9.76, SD = 0.59) with s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37753-7
更新日期:2019-02-04 00:00:00
abstract::Real-time quantitative polymerase chain reaction (qPCR) data are found to display periodic patterns in the fluorescence intensity as a function of sample number for fixed cycle number. This behavior is seen for technical replicate datasets recorded on several different commercial instruments; it occurs in the baseline...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38951
更新日期:2016-12-13 00:00:00
abstract::Krüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. We previously identified KLF6 as mediator of hepatocyte glucose and lipid homeostasis. The loss or reduction of KLF6 is linked to the progression of hepatocellular carcinoma, but its contribution to liver regeneration and repair in acute live...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08680-w
更新日期:2017-08-14 00:00:00
abstract::GABA counteracts wide range of stresses through regulation of GABA shunt pathway in plants. Although, GABA assisted tolerance against As toxicity in plants is still unexplored. We have examined GABA induced tolerance in rice seedlings with two exposure periods of GABA i.e., short term and long term. Results showed tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09428-2
更新日期:2017-08-18 00:00:00
abstract::Bending light in a controllable way is desired in various applications such as beam steering, navigating and cloaking. Different from the conventional way to bend light by refractive index gradient, transformation optics or special beams through wavefront design such as Airy beams and surface plasmons, we proposed a m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15805
更新日期:2015-10-29 00:00:00
abstract::Machine learning algorithms have recently shown their precision and potential in many different use cases and fields of medicine. Most of the algorithms used are supervised and need a large quantity of labeled data to achieve high accuracy. Also, most applications of machine learning in medicine are attempts to mimic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73902-7
更新日期:2020-10-12 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-44657-7
更新日期:2019-06-05 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-22369-8
更新日期:2018-03-06 00:00:00
abstract::Most bacterial cells are stressed, and as a result, some become tolerant to antibiotics by entering a dormant state known as persistence. The key intracellular metabolite that has been linked to this persister state is guanosine tetraphosphate (ppGpp), the alarmone that was first linked to nutrient stress. In Escheric...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20519
更新日期:2016-02-03 00:00:00
abstract::The extreme miniaturization of biological and chemical assays in aqueous-droplet compartments enables spatiotemporal control for large-scale parallel experimentation and can thus permit new capabilities for "digitizing" directed molecular evolution methodologies. We report a remarkably facile bulk method to generate m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26257
更新日期:2016-05-20 00:00:00
abstract::Metal-organic frameworks (MOFs) are intriguing host materials in composite electrolytes due to their ability for tailoring host-guest interactions by chemical tuning of the MOF backbone. Here, we introduce particularly high sodium ion conductivity into the zeolitic imidazolate framework ZIF-8 by impregnation with the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60198-w
更新日期:2020-02-26 00:00:00
abstract::Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04946-5
更新日期:2017-07-05 00:00:00
abstract::GABAergic and glutamatergic dysfunction in the dorsolateral prefrontal cortex (DLPFC) are thought to be the core pathophysiological mechanisms of schizophrenia. Recently, we have established a method to index these functions from the DLPFC using the paired transcranial magnetic stimulation (TMS) paradigms of short int...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17052-3
更新日期:2017-12-06 00:00:00
abstract::Epigenetics alternation of non-genetic variation and genome-wide association study proven allelic variants may associate with insulin secretion in type 2 diabetes (T2D) development. We analyzed promoter DNA methylation array to evaluate the associated with increased susceptibility to T2D (30 cases, 10 controls) and fo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71336-9
更新日期:2020-09-30 00:00:00
abstract::The pathophysiological implications of plasminogen activator inhibitor-1 (PAI-1) in HCV infection remain obscure. This prospective study evaluated 669 HCV patients, of whom 536 had completed a course of anti-HCV therapy and had pre-, peri- and post-therapy measurements of various profiles, including PAI-1 levels. Mult...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42503
更新日期:2017-02-13 00:00:00
abstract::Antimicrobial peptides (AMPs) are an important part of the human innate immune system for protection against bacterial infections, however the AMPs display varying degrees of activity against Staphylococcus aureus. Previously, we showed that inactivation of the ATP synthase sensitizes S. aureus towards the AMP antibio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68146-4
更新日期:2020-07-09 00:00:00
abstract::Spin-coated self-assemblies of colloidal particles have been developed recently as an attractive close-packed monolayer of the particles for a variety of applications, but they are limited by the small area of their monolayers, especially given their low uniformity and monolayer coverage on large-area substrates. We r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47990-z
更新日期:2019-08-07 00:00:00
abstract::miR1444s are functionally significant miRNAs targeting polyphenol oxidase (PPO) genes for cleavage. MIR1444 genes were reported only in Populus trichocarpa. Through the computational analysis of 215 RNA-seq data, four whole genome sequences of Salicaceae species and deep sequencing of six P. trichocarpa small RNA libr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39740
更新日期:2017-01-10 00:00:00
abstract::Oysters are unusual among bivalves in that they possess chambers, often filled with soft, chalky calcite, that are irregularly scattered throughout the shell. Because the function of these so-called chalky deposits is still unclear, evaluating the growth and distribution of chalk is important for elucidating the ecolo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68726-4
更新日期:2020-07-21 00:00:00
abstract::Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our res...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37612
更新日期:2016-11-22 00:00:00
abstract::Polarization sensitive and insensitive color filters have important applications in the area of nano-spectroscopy and CCD imaging applications. Metallic nanostructures provide an efficient way to design and engineer ultrathin color filters. These nanostructures have capability to split the white light into fundamental...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07986-z
更新日期:2017-08-14 00:00:00
abstract::Biological invasions are a major threat to biodiversity and ecosystem functioning. Successful invasions depend on the interplay of multiple abiotic and biotic factors, however, the process of the invasion itself is often overlooked. The temporal variation of environmental factors suggests that a 'window of opportunity...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44737-8
更新日期:2019-06-05 00:00:00
abstract::Novel activated boron nitride (BN) as an effective adsorbent for pollutants in water and air has been reported in the present work. The activated BN was synthesized by a simple structure-directed method that enabled us to control the surface area, pore volume, crystal defects and surface groups. The obtained BN exhibi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03208
更新日期:2013-11-13 00:00:00
abstract::Transformation optics (TO) concept well known for its huge possibility in patterning the path of electromagnetic waves is exploited to design a beam steering lens. The broadband directive in-phase emission in a desired off-normal direction from an array of equally fed radiators is numerically and experimentally report...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18819
更新日期:2016-01-05 00:00:00
abstract::A clinical study was designed to record a wide range of physiological values from patients undergoing haemodialysis treatment in the Renal Unit of the Churchill Hospital in Oxford. Video was recorded for a total of 84 dialysis sessions from 40 patients during the course of 1 year, comprising an overall video recording...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75152-z
更新日期:2020-10-28 00:00:00
abstract::Unnatural chiral α-amino acids are widely used in fields of organic chemistry, biochemistry and medicinal chemistry, and their synthesis has attracted extensive attention. Although the asymmetric synthesis provides some efficient protocols, noble and elaborate catalysts, ligands and additives are usually required whic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26161
更新日期:2016-05-17 00:00:00
abstract::Driven diffusive systems have been a paradigm for modelling many physical, chemical, and biological transport processes. In the systems, spatial correlation plays an important role in the emergence of a variety of nonequilibrium phenomena and exhibits rich features such as pronounced oscillations. However, the lack of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19652
更新日期:2016-01-25 00:00:00
abstract::Correlations between fluctuations in resting state BOLD fMRI signals are interpreted as measures of functional connectivity (FC), but the neural basis of their origins and their relationships to specific features of underlying electrophysiologic activity, have not been fully established. In particular, the dependence ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45404-8
更新日期:2019-06-20 00:00:00
abstract::Transposition mutagenesis is a powerful tool to identify the function of genes, reveal essential genes and generally to unravel the genetic basis of living organisms. However, transposon-mediated mutagenesis has only been successfully applied to a limited number of archaeal species and has never been reported in Therm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36711
更新日期:2016-11-08 00:00:00
abstract::Osteosarcoma pulmonary metastases are typically treated with resection and/or chemotherapy. We hypothesize that stereotactic radiosurgery (SRS) can be an alternative to surgery that can achieve high rates of local control with limited toxicity. From January 2005 to December 2013, 73 patients who developed pulmonary me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14521-7
更新日期:2017-12-12 00:00:00