Abstract:
:Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ERβ activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor β-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17β-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERβ in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ERβ-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sasayama D,Sugiyama N,Yonekubo S,Pawlak A,Murasawa H,Nakamura M,Hayashi M,Ogawa T,Moro M,Washizuka S,Amano N,Hongo K,Ohnota Hdoi
10.1038/s41598-017-04946-5subject
Has Abstractpub_date
2017-07-05 00:00:00pages
4663issue
1issn
2045-2322pii
10.1038/s41598-017-04946-5journal_volume
7pub_type
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