NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes.

abstract：:Identifying the occurrence mechanism of drug-induced side effects (SEs) is critical for design of drug target and new drug development. The expression of genes in biological processes is regulated by transcription factors(TFs) and/or microRNAs. Most of previous studies were focused on a single level of gene or gene se...

journal_title：Scientific reports

authors： Jia X,Jin Q,Liu X,Bian X,Wang Y,Liu L,Ma H,Tan F,Gu M,Chen X

更新日期：2017-07-20 00:00:00

abstract：:Caenorhabditis elegans presents functioning, biologically relevant phenotypes and is frequently used as a bioindicator of toxicity. However, most C. elegans in vivo effect-assessment methods are laborious and time consuming. Therefore, we developed a novel method to measure the oxygen consumption rate of C. elegans as...

journal_title：Scientific reports

authors： Preez GD,Fourie H,Daneel M,Miller H,Höss S,Ricci C,Engelbrecht G,Zouhar M,Wepener V

更新日期：2020-03-06 00:00:00

abstract：:In this paper, an electrically tunable metasuface is designed for visible regime. The device mainly consists of a V-shaped metallic metasurface, an ITO film, an electro-optic (EO) dielectric and a metal layer fabricated on a silica substrate. A continuous electrical modulation of resonant wavelength has been theoretic...

journal_title：Scientific reports

authors： Guo J,Tu Y,Yang L,Zhang R,Wang L,Wang B

更新日期：2017-10-26 00:00:00

abstract：:Activities involving observation of wild organisms (e.g. wildlife watching, tidepooling) can provide recreational and learning opportunities, with biologically diverse animal assemblages expected to be more stimulating to humans. In turn, more diverse communities may enhance human interest and facilitate provisioning ...

journal_title：Scientific reports

authors： Fairchild TP,Fowler MS,Pahl S,Griffin JN

更新日期：2018-10-15 00:00:00

abstract：:Antibody humanization is a key step in the preclinical phase of the development of therapeutic antibodies, originally developed and tested in non-human models (most typically, in mouse). The standard technique of Complementarity-Determining Regions (CDR) grafting into human Framework Regions of germline sequences has ...

journal_title：Scientific reports

authors： Clavero-Álvarez A,Di Mambro T,Perez-Gaviro S,Magnani M,Bruscolini P

更新日期：2018-10-04 00:00:00

abstract：:Manual count of mitotic figures, which is determined in the tumor region with the highest mitotic activity, is a key parameter of most tumor grading schemes. It can be, however, strongly dependent on the area selection due to uneven mitotic figure distribution in the tumor section. We aimed to assess the question, how...

journal_title：Scientific reports

authors： Aubreville M,Bertram CA,Marzahl C,Gurtner C,Dettwiler M,Schmidt A,Bartenschlager F,Merz S,Fragoso M,Kershaw O,Klopfleisch R,Maier A

更新日期：2020-10-05 00:00:00

abstract：:In this work we revisit the important and controversial concept of quantum weak values, aiming to provide a simplified understanding to its associated physics and the origin of anomaly. Taking the Stern-Gerlach setup as a working system, we base our analysis on an exact treatment in terms of quantum Bayesian approach....

journal_title：Scientific reports

authors： Qin L,Feng W,Li XQ

更新日期：2016-02-03 00:00:00

abstract：:The mammalian retina encodes the visual world in action potentials generated by 20-50 functionally and anatomically-distinct types of retinal ganglion cell (RGC). Individual RGC types receive synaptic input from distinct presynaptic circuits; therefore, their responsiveness to specific features in the visual scene ari...

journal_title：Scientific reports

authors： Shi Q,Gupta P,Boukhvalova AK,Singer JH,Butts DA

更新日期：2019-06-18 00:00:00

abstract：:Biomass waste treatment and detrimental dye adsorption are two of the crucial environmental issues nowadays. In this study, we investigate to simultaneously resolve the aforementioned issues by synthesizing chitosan sponges as adsorbents toward rose bengal (RB) dye adsorption. Through a temperature-controlled freeze-c...

journal_title：Scientific reports

authors： Wang M,Ma Y,Sun Y,Hong SY,Lee SK,Yoon B,Chen L,Ci L,Nam JD,Chen X,Suhr J

更新日期：2017-12-22 00:00:00

abstract：:Investigation of non-covalent interaction of hydrophobic surfaces with the protein G (PrG) is necessary due to their frequent utilization in immunosensors and ELISA. It has been confirmed that surfaces, including carbonous-nanostructures (CNS) could orient proteins for a better activation. Herein, PrG interaction with...

journal_title：Scientific reports

authors： Ebrahim-Habibi MB,Ghobeh M,Mahyari FA,Rafii-Tabar H,Sasanpour P

更新日期：2019-02-04 00:00:00

abstract：:Drug-based treatments are the most widely used interventions for cancer management. Personalized drug response profiling remains inherently challenging with low cell count harvested from tumour sample. We present a 96well-formatted microfluidic plate with built-in micro-gap that preserves up to 99.2% of cells during m...

journal_title：Scientific reports

authors： Ma WY,Hsiung LC,Wang CH,Chiang CL,Lin CH,Huang CS,Wo AM

更新日期：2015-04-13 00:00:00

abstract：:The present study tested whether the LPS/TLR4 signal pathway in endometrial stromal cells is essential for the pathogenesis of adenomyosis. We tested the expression of TLR4, MD2 in the endometrium without adenomyosis (CE), the eutopic endometrium with adenomyosis (EuE) and the ectopic endometrium with adenomyosis (EE)...

journal_title：Scientific reports

authors： Guo J,Chen L,Luo N,Li C,Chen R,Qu X,Liu M,Kang L,Cheng Z

更新日期：2016-02-22 00:00:00

abstract：:Considering environmental concerns regarding air pollution which is induced by burning fossil fuels to generate electrical power, utilizing solar energy as a green and sustainable energy source is of great interest. This study proposes a novel framework to determine the optimal location for constructing solar photovol...

journal_title：Scientific reports

authors： Mokarram M,Mokarram MJ,Khosravi MR,Saber A,Rahideh A

更新日期：2020-05-18 00:00:00

abstract：:The large and complex genome of Pseudomonas aeruginosa, which consists of significant portions (up to 20%) of transferable genetic elements contributes to the rapid development of antibiotic resistance. The whole genome sequences of 22 strains isolated from eye and cystic fibrosis patients in Australia and India betwe...

journal_title：Scientific reports

authors： Subedi D,Vijay AK,Kohli GS,Rice SA,Willcox M

更新日期：2018-10-23 00:00:00

abstract：:Antimonite [Sb(III)]-oxidizing bacteria can transform the toxic Sb(III) into the less toxic antimonate [Sb(V)]. Recently, the cytoplasmic Sb(III)-oxidase AnoA and the periplasmic arsenite [As(III)] oxidase AioAB were shown to responsible for bacterial Sb(III) oxidation, however, disruption of each gene only partially ...

journal_title：Scientific reports

authors： Li J,Yang B,Shi M,Yuan K,Guo W,Wang Q,Wang G

更新日期：2017-03-02 00:00:00

abstract：:The impact of ctDNA changes after chemotherapy on the clinical outcomes of patients with metastatic colorectal cancer (mCRC) remains unclear. The present study evaluated the clinical implications of the early change in ctDNA levels as a predictor of objective response and clinical outcome in mCRC patients who received...

journal_title：Scientific reports

authors： Osumi H,Shinozaki E,Yamaguchi K,Zembutsu H

更新日期：2019-11-22 00:00:00

abstract：:Afforestation is an important approach to mitigate global warming. Its complex interactions with the climate system, however, makes it controversial. Afforestation is expected to be effective in the tropics where biogeochemical and biogeophysical effects act in concert; however, its potential in the large semi-arid re...

journal_title：Scientific reports

authors： Yosef G,Walko R,Avisar R,Tatarinov F,Rotenberg E,Yakir D

更新日期：2018-01-17 00:00:00

abstract：:Exposure to silica can cause lung fibrosis and cancer. Identification of molecular targets is important for the intervention and/or prevention of silica-induced lung diseases. Telomeres consist of tandem repeats of DNA sequences at the end of chromosomes, preventing chromosomal fusion and degradation. Regulator of tel...

journal_title：Scientific reports

authors： Shoeb M,Joseph P,Kodali V,Mustafa G,Farris BY,Umbright C,Roberts JR,Erdely A,Antonini JM

更新日期：2017-12-11 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are highly prevalent inflammatory cells that play a key role in tumor development and are considered therapeutic targets. MDSCs promote tumor growth by blocking T-cell-mediated anti-tumoral immune response through depletion of arginine that is essential for T-cell proliferation...

journal_title：Scientific reports

authors： Najac C,Chaumeil MM,Kohanbash G,Guglielmetti C,Gordon JW,Okada H,Ronen SM

更新日期：2016-08-10 00:00:00

abstract：:Why lightning sometimes has multiple discharges to ground is an unanswered question. Recently, the observation of small plasma structures on positive leaders re-ignited the search. These small plasma structures were observed as pulsing radio sources along the positive leader length and were named "needles". Needles ma...

journal_title：Scientific reports

authors： Saba MMF,de Paiva AR,Concollato LC,Warner TA,Schumann C

更新日期：2020-10-15 00:00:00

abstract：:We report efficient detection of alpha radiation on highly textured and vertically aligned along (002) Gallium-doped Zinc Oxide (ZnO:Ga) nanorods on a glass substrate with an average diameter ~150 ± 10 nm. Photoluminescence measurement showed near band emission 393 nm, in agreement with the bandgap value ~3.22 eV, mea...

journal_title：Scientific reports

authors： Sahani RM,Kumari C,Pandya A,Dixit A

更新日期：2019-08-06 00:00:00

abstract：:A single-institution series using a (neo)adjuvant chemotherapy and interdigitated hyperfractionated split-course radiation therapy (CRT) treatment protocol for soft tissue sarcoma was reviewed. Our specific aims were to study recurrence rates and long-term toxicity. Between 1998 and 2016, 89 patients with non-metastat...

journal_title：Scientific reports

authors： Nevala R,Tukiainen E,Tarkkanen M,Böhling T,Blomqvist C,Sampo M

更新日期：2019-05-13 00:00:00

abstract：:Agricultural land is typically managed based on visible plant life at the expense of the belowground majority. However, microorganisms mediate processes sustaining plant life and the soil environment. To understand the role of microbes we first must understand what controls soil microbial community assembly. We assess...

journal_title：Scientific reports

authors： Kaminsky R,Trouche B,Morales SE

更新日期：2017-03-28 00:00:00

abstract：:Features from Electrovestibulography (EVestG) recordings have been used to classify and measure the severity of both persistent post-concussion syndrome (PCS) and major depressive disorder. Herein, we examined the effect of comorbid depression on the detection of persistent PCS using EVestG. To validate our previously...

journal_title：Scientific reports

authors： Suleiman A,Lithgow B,Mansouri B,Moussavi Z

更新日期：2018-09-27 00:00:00

abstract：:Computational predictions of double gene knockout effects by flux balance analysis (FBA) have been used to characterized genome-wide patterns of epistasis in microorganisms. However, it is unclear how in silico predictions are related to in vivo epistasis, as FBA predicted only a minority of experimentally observed ge...

journal_title：Scientific reports

authors： Alzoubi D,Desouki AA,Lercher MJ

更新日期：2019-08-14 00:00:00

abstract：:This paper presents a study of noise in room-temperature THz radiometers that use THz-to-optical upconversion followed by optical detection of thermal radiation. Despite some undesired upconverted thermal noise, no noise is intrinsically introduced by efficient electro-optic modulation via a sum-frequency-generation p...

journal_title：Scientific reports

authors： Santamaría-Botello G,Popovic Z,Abdalmalak KA,Segovia-Vargas D,Brown ER,García Muñoz LE

更新日期：2020-06-10 00:00:00

abstract：:Tinnitus (phantom auditory perception associated with hearing loss) can seriously affect wellbeing. Its neural substrate is unknown however it has been linked with abnormal activity in auditory pathways. Though no cure currently exists, repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce tinni...

journal_title：Scientific reports

authors： Mulders WH,Vooys V,Makowiecki K,Tang AD,Rodger J

更新日期：2016-12-01 00:00:00

abstract：:Exosomes are nano-sized endosome-derived small intraluminal vesicles, which are important facilitators of intercellular communication by transporting contents, such as protein, mRNA, and microRNAs, between neighboring cells, such as in the tumor microenvironment. The purpose of this study was to understand the mechani...

journal_title：Scientific reports

authors： Su MJ,Aldawsari H,Amiji M

更新日期：2016-07-22 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Sykora-Bodie ST,Bezy V,Johnston DW,Newton E,Lohmann KJ

更新日期：2018-04-19 00:00:00

abstract：:In adipose tissue, agonists of the β3-adrenergic receptor (ADRB3) regulate lipolysis, lipid oxidation, and thermogenesis. The deficiency in the thermogenesis induced by neuroblast differentiation-associated protein AHNAK in white adipose tissue (WAT) of mice fed a high-fat diet suggests that AHNAK may stimulate energy...

journal_title：Scientific reports

authors： Shin JH,Lee SH,Kim YN,Kim IY,Kim YJ,Kyeong DS,Lim HJ,Cho SY,Choi J,Wi YJ,Choi JH,Yoon YS,Bae YS,Seong JK

更新日期：2016-03-18 00:00:00