A novel 96well-formatted micro-gap plate enabling drug response profiling on primary tumour samples.

abstract：:The thermal field theory is applied to fermionic superfluids by doubling the degrees of freedom of the BCS theory. We construct the two-mode states and the corresponding Bogoliubov transformation to obtain the BCS thermal vacuum. The expectation values with respect to the BCS thermal vacuum produce the statistical ave...

journal_title：Scientific reports

authors： Hou XY,Huang Z,Guo H,He Y,Chien CC

更新日期：2018-08-10 00:00:00

abstract：:The endosymbiotic bacterium Wolbachia spreads rapidly through populations of Aedes aegypti mosquitoes, and strongly inhibits infection with key human pathogens including the dengue and Zika viruses. Mosquito control programs aimed at limiting transmission of these viruses are ongoing in multiple countries, yet there i...

journal_title：Scientific reports

authors： Dutra HLC,Rodrigues SL,Mansur SB,de Oliveira SP,Caragata EP,Moreira LA

更新日期：2017-11-16 00:00:00

abstract：:The kynurenine pathway (KP) is dysregulated in neuroinflammatory diseases including Alzheimer's disease (AD), however has not been investigated in preclinical AD characterized by high neocortical amyloid-β load (NAL), prior to cognitive impairment. Serum KP metabolites were measured in the cognitively normal KARVIAH c...

journal_title：Scientific reports

authors： Chatterjee P,Goozee K,Lim CK,James I,Shen K,Jacobs KR,Sohrabi HR,Shah T,Asih PR,Dave P,ManYan C,Taddei K,Lovejoy DB,Chung R,Guillemin GJ,Martins RN

更新日期：2018-05-22 00:00:00

abstract：:Single-walled carbon nanotubes (SWCNTs) have been modified with ester groups using typical organic radical chemistry. Consequently, traps for mobile excitons have been created, which enhanced the optical properties of the material. The proposed methodology combines the benefits of mainstream approaches to create lumin...

journal_title：Scientific reports

authors： Przypis L,Krzywiecki M,Niidome Y,Aoki H,Shiraki T,Janas D

更新日期：2020-11-16 00:00:00

abstract：:Hypertension is a public health issue in Iran. The study aimed to estimate the prevalence, awareness, treatment, and control of hypertension, and to explore their determinants among 10,040 Kurdish adults from Ravansar Non-Communicable Disease (RaNCD) cohort study in Iran. Univariate, and multivariate analyses were use...

journal_title：Scientific reports

authors： Rajati F,Hamzeh B,Pasdar Y,Safari R,Moradinazar M,Shakiba E,Bazargan-Hejazi S,Karim H,Najafi F

更新日期：2019-08-27 00:00:00

abstract：:Precision Medicine in Oncology requires tailoring of therapeutic strategies to individual cancer patients. Due to the limited quantity of tumor samples, this proves to be difficult, especially for early stage cancer patients whose tumors are small. In this study, we exploited a 2.4 × 2.4 centimeters polydimethylsiloxa...

journal_title：Scientific reports

authors： Wong AH,Li H,Jia Y,Mak PI,Martins RPDS,Liu Y,Vong CM,Wong HC,Wong PK,Wang H,Sun H,Deng CX

更新日期：2017-08-22 00:00:00

abstract：:Molecular taxonomy often uncovers cryptic species, reminding us that taxonomic incompleteness is even more severe than previous thought. The importance of cryptic species for conservation is poorly understood. Although some cryptic species may be seriously threatened or otherwise important, they are rarely included in...

journal_title：Scientific reports

authors： Delić T,Trontelj P,Rendoš M,Fišer C

更新日期：2017-06-13 00:00:00

abstract：:To date, only bar/pat gene derived from Streptomyces has been used to generate the commercial PPT-resistant crops currently available in the market. The limited source of bar/pat gene is probably what has caused the decrease in PPT-tolerance, which has become the main concern of those involved in field management prog...

journal_title：Scientific reports

authors： Tian YS,Xu J,Zhao W,Xing XJ,Fu XY,Peng RH,Yao QH

更新日期：2015-10-23 00:00:00

abstract：:Unlike the constant nature of elastic coefficients of isotropic bulk materials, the Young's (E) and shear (μ) moduli of nano-structured (NS) gyroid metamaterials change with relative density (ρ), but at different rates depending on the cell size of the structure. These elastic behaviors displayed by E and μ cause cros...

journal_title：Scientific reports

authors： Park JH,Lee JC

更新日期：2017-09-05 00:00:00

abstract：:Amyloid-beta (Aβ)-induced neurotoxicity is a major contributor to the pathologies associated with Alzheimer's disease (AD). The formation of reactive oxygen species (ROS), an early response induced by the peptide and oligomeric derivatives of Aβ, plays a significant role in effecting cellular pathogenesis. Here we emp...

journal_title：Scientific reports

authors： Giordano CR,Terlecky LJ,Bollig-Fischer A,Walton PA,Terlecky SR

更新日期：2014-05-15 00:00:00

abstract：:The electrowetting lenses has attracted researchers in many fields, such as biology, beam shaping, and drug delivery. Previous research on electrowetting lens has focused on neither expanding the dynamic focal length range nor reducing the wavefront aberration. However, the properties with large numerical aperture and...

journal_title：Scientific reports

authors： Song X,Zhang H,Li D,Jia D,Liu T

更新日期：2020-10-01 00:00:00

abstract：:Amplification and sequencing of 16S amplicons are widely used for profiling the structure of oral microbiota. However, it remains not clear whether and to what degree DNA extraction and targeted 16S rRNA hypervariable regions influence the analysis. Based on a mock community consisting of five oral bacterial species i...

journal_title：Scientific reports

authors： Teng F,Darveekaran Nair SS,Zhu P,Li S,Huang S,Li X,Xu J,Yang F

更新日期：2018-11-05 00:00:00

abstract：:Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases, and adult-targeted SIA strategies are being considered. This st...

journal_title：Scientific reports

authors： Chong KC,Zhang C,Jia KM,Zee BCY,Luo T,Wang L,Tam GCH,Sun R,Wang MH,Guan X

更新日期：2018-10-31 00:00:00

abstract：:Evaluations of restoration success usually focus on the structural aspects of ecosystems. Pollination, as an important functional aspect, is often overlooked. Here, the shifts in pollinator assemblage and pollen limitation in the desert shrub Caragana microphylla were examined along a restoration gradient in Horqin Sa...

journal_title：Scientific reports

authors： Pan CC,Qu H,Feng Q,Liu LD,Zhao HL,Li YL,Li YQ,Zhang TH,Liu XP

更新日期：2017-12-04 00:00:00

abstract：:Calcified marine organisms typically experience increased oxidative stress and changes in mineralization in response to ocean acidification and warming conditions. These effects could hinder the potency of animal weapons, such as the mantis shrimp's raptorial appendage. The mechanical properties of this calcified weap...

journal_title：Scientific reports

authors： deVries MS,Webb SJ,Tu J,Cory E,Morgan V,Sah RL,Deheyn DD,Taylor JR

更新日期：2016-12-15 00:00:00

abstract：:The Przewalski's gazelle (Procapra przewalskii) is one of the most endangered ungulates in the world, with fewer than 2,000 individuals surviving in nine habitat fragments on the Qinghai-Tibet Plateau and isolated by human settlements and infrastructure. In particular, the Qinghai-Tibet railway, which crosses the larg...

journal_title：Scientific reports

authors： Yu H,Song S,Liu J,Li S,Zhang L,Wang D,Luo SJ

更新日期：2017-12-21 00:00:00

abstract：:PCR-mediated chromosome splitting (PCS) was developed in the yeast Saccharomyces cerevisiae. It is based on homologous recombination and enables division of a chromosome at any point to form two derived and functional chromosomes. However, because of low homologous recombination activity, PCS is limited to a single si...

journal_title：Scientific reports

authors： Sasano Y,Nagasawa K,Kaboli S,Sugiyama M,Harashima S

更新日期：2016-08-17 00:00:00

abstract：:Rare individuals remain cognitively intact despite the presence of neuropathology usually associated with fully symptomatic Alzheimer's disease (AD), which we refer to as Non-Demented with Alzheimer's disease Neuropathology (NDAN). Understanding the involved mechanism(s) of their cognitive resistance may reveal novel ...

journal_title：Scientific reports

authors： Briley D,Ghirardi V,Woltjer R,Renck A,Zolochevska O,Taglialatela G,Micci MA

更新日期：2016-06-14 00:00:00

abstract：:Identifying similarities and differences in choice behavior across species is informative about how basic mechanisms give rise to more complex processes. In the present study, we compared pre- and post-choice latencies between rats and humans under two paradigms. In Experiment 1, we used a cued choice paradigm where s...

journal_title：Scientific reports

authors： Fam J,Westbrook F,Arabzadeh E

更新日期：2016-02-10 00:00:00

abstract：:The overuse of antibiotics results in the development of antibiotic resistance and limits the useful life of these drugs in fighting bacteria, including Aeromonas hydrophila, a well-known opportunistic pathogen that causes serious infections in fish and other animals. In this study, we investigated the adaptive resist...

journal_title：Scientific reports

authors： Yao Z,Li W,Lin Y,Wu Q,Yu F,Lin W,Lin X

更新日期：2016-12-19 00:00:00

abstract：:As variations in the chromosome number are recognized to be of evolutionary interest but are also widely debated in the literature, we aimed to quantitatively test for possible relationships among the chromosome number, plant traits, and environmental factors. In particular, the chromosome number and drivers of its va...

journal_title：Scientific reports

authors： Carta A,Bedini G,Peruzzi L

更新日期：2018-09-24 00:00:00

abstract：:A primary cilium is a hair-like structure with a width of approximately 200 nm. Over the past few decades, the main challenge in the study of the ultrastructure of cilia has been the high sensitivity of cilia to chemical fixation, which is required for many imaging techniques. In this report, we demonstrate a combined...

journal_title：Scientific reports

authors： Mohieldin AM,AbouAlaiwi WA,Gao M,Nauli SM

更新日期：2015-11-02 00:00:00

abstract：:Targetting the ubiquitin pathway is an attractive strategy for cancer therapy. The inhibitor of the ubiquitin-like molecule NEDD8 pathway, MLN4924 (Pevonedistat) is in Phase II clinical trials. Protection of healthy cells from the induced toxicity of the treatment while preserving anticancer efficacy is a highly antic...

journal_title：Scientific reports

authors： Malhab LJ,Descamps S,Delaval B,Xirodimas DP

更新日期：2016-11-30 00:00:00

abstract：:In a 250-kyr transient simulation of the Community Earth System Model (CESM), we identified a precessional forced seesaw of the summer middle-upper tropospheric eddy temperature between Asia and the North Pacific as the paleo-APO (Asian-Pacific oscillation). The paleo-APO variability is out of phase with the precessio...

journal_title：Scientific reports

authors： Wang Y,Jian Z,Zhao P,Xiao D,Chen J

更新日期：2016-07-06 00:00:00

abstract：:Chemotherapy is widely used in cancer treatments. However, non-specific distribution of chemotherapeutic agents to healthy tissues and normal cells in the human body always leads to adverse side effects and disappointing therapeutic outcomes. Therefore, the main aim of this study was to develop a targeted drug deliver...

journal_title：Scientific reports

authors： Gan BK,Rullah K,Yong CY,Ho KL,Omar AR,Alitheen NB,Tan WS

更新日期：2020-10-08 00:00:00

abstract：:Species are chronically exposed to ionizing radiation, a natural phenomenon which can be enhanced by human activities. The induced toxicity mechanisms still remain unclear and seem depending on the mode of exposure, i.e. acute and chronic. To better understand these phenomena, studies need to be conducted both at the ...

journal_title：Scientific reports

authors： Dubois C,Lecomte C,Ruys SPD,Kuzmic M,Della-Vedova C,Dubourg N,Galas S,Frelon S

更新日期：2018-07-27 00:00:00

abstract：:Renewable natural resources, such as solar radiation, rainfall, wind, and geothermal heat, together with ecosystem services, provide the elementary supports for the sustainable development of human society. To improve regional sustainability, we studied the spatial distributions and quantities of renewable natural res...

journal_title：Scientific reports

authors： Wang C,Zhang S,Yan W,Wang R,Liu J,Wang Y

更新日期：2016-11-18 00:00:00

abstract：:Antimicrobial resistant infections are a serious public health threat worldwide. Whole genome sequencing approaches to rapidly identify pathogens and predict antibiotic resistance phenotypes are becoming more feasible and may offer a way to reduce clinical test turnaround times compared to conventional culture-based m...

journal_title：Scientific reports

authors： Nguyen M,Brettin T,Long SW,Musser JM,Olsen RJ,Olson R,Shukla M,Stevens RL,Xia F,Yoo H,Davis JJ

更新日期：2018-01-11 00:00:00

abstract：:Charge density wave (CDW), the periodic modulation of the electronic charge density, will open a gap on the Fermi surface that commonly leads to decreased or vanishing conductivity. On the other hand superconductivity, a commonly believed competing order, features a Fermi surface gap that results in infinite conductiv...

journal_title：Scientific reports

authors： Zhu X,Ning W,Li L,Ling L,Zhang R,Zhang J,Wang K,Liu Y,Pi L,Ma Y,Du H,Tian M,Sun Y,Petrovic C,Zhang Y

更新日期：2016-06-02 00:00:00

abstract：:Pathological links between neurodegenerative disease and cancer are emerging. LRRK2 overactivity contributes to Parkinson's disease, whereas our previous analyses of public cancer patient data revealed that decreased LRRK2 expression is associated with lung adenocarcinoma (LUAD). The clinical and functional relevance ...

journal_title：Scientific reports

authors： Lebovitz C,Wretham N,Osooly M,Milne K,Dash T,Thornton S,Tessier-Cloutier B,Sathiyaseelan P,Bortnik S,Go NE,Halvorsen E,Cederberg RA,Chow N,Dos Santos N,Bennewith KL,Nelson BH,Bally MB,Lam WL,Gorski SM

更新日期：2021-01-22 00:00:00