Abstract：
:As variations in the chromosome number are recognized to be of evolutionary interest but are also widely debated in the literature, we aimed to quantitatively test for possible relationships among the chromosome number, plant traits, and environmental factors. In particular, the chromosome number and drivers of its variation were examined in 801 Italian endemic vascular plants, for a total of 1364 accessions. We estimated phylogenetic inertia and adaptation in chromosome number - based on an Ornstein-Uhlenbeck process - and related chromosome numbers with other plant traits and environmental variables. Phylogenetic effects in chromosome number varied among the examined clades but were generally high. Chromosome numbers were poorly related to large scale climatic conditions, while a stronger relationship with categorical variables was found. Specifically, open, disturbed, drought-prone habitats selected for low chromosome numbers, while perennial herbs, living in shaded, stable environments were associated with high chromosome numbers. Altogether, our findings support an evolutionary role of chromosome number variation, and we argue that environmental stability favours higher recombination rates in comparison to unstable environments. In addition, by comparing the results of models testing for the evolvability of 2n and of x, we provide insight into the presumptive ecological significance of polyploidy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Carta A,Bedini G,Peruzzi Ldoi
10.1038/s41598-018-32515-xsubject
Has Abstractpub_date
2018-09-24 00:00:00pages
14258issue
1issn
2045-2322pii
10.1038/s41598-018-32515-xjournal_volume
8pub_type
杂志文章abstract：:Huntington's disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although HD is monogenic, its molecular manifestation appears highly complex and involves multiple cellular processes. The recent application of high throughput platforms such as mic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05224-0
更新日期：2017-07-12 00:00:00
abstract：:A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-22153-8
更新日期：2018-03-06 00:00:00
abstract：:The phosphatidylinositol (PI) cycle is central to eukaryotic cell signaling. Its complexity, due to the number of reactions and lipid and inositol phosphate intermediates involved makes it difficult to analyze experimentally. Computational modelling approaches are seen as a way forward to elucidate complex biological ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70215-7
更新日期：2020-08-06 00:00:00
abstract：:The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We foun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29479
更新日期：2016-07-05 00:00:00
abstract：:Amphibian oocytes have been extensively used for heterologous expression of membrane proteins for studying their biochemical and biophysical properties. So far, Xenopus laevis is the main amphibian used as oocytes source to express aquaglyceroporins in order to assess water and solutes permeability. However, this well...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37069-6
更新日期：2019-01-10 00:00:00
abstract：:Changes in the stability, hydrogen diffusion, and mechanical properties of the NbH phases from Ni-doping was studied by using first-principles methods. The calculation results reveal that the single H atom adsorption is energetically favorable at the tetrahedral interstitial site (TIS) and octahedral interstitial site...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06658-2
更新日期：2017-07-26 00:00:00
abstract：:Acquisition of nutrients during intra-vacuolar growth of L. pneumophila within macrophages or amoebae is poorly understood. Since many genes of L. pneumophila are acquired by inter-kingdom horizontal gene transfer from eukaryotic hosts, we examined the presence of human solute carrier (SLC)-like transporters in the L....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26782-x
更新日期：2018-05-29 00:00:00
abstract：:Seagrass meadows are threatened by coastal development and global change. In the face of these pressures, molecular techniques such as reverse transcription quantitative real-time PCR (RT-qPCR) have great potential to improve management of these ecosystems by allowing early detection of chronic stress. In RT-qPCR, the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17051
更新日期：2015-11-23 00:00:00
abstract：:The need for sensitive, robust, portable, and inexpensive biosensing platforms is of significant interest in clinical applications for disease diagnosis and treatment monitoring at the point-of-care (POC) settings. Rapid, accurate POC diagnostic assays play a crucial role in developing countries, where there are limit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08719
更新日期：2015-03-06 00:00:00
abstract：:Global warming is projected to continue, leading to intense fluctuations in precipitation and heat waves and thereby affecting the productivity and the relevant biological processes of grassland ecosystems. Here, we determined the functional responses to warming and altered precipitation in both typical and desert ste...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34801
更新日期：2016-10-10 00:00:00
abstract：:The Near-infrared Fluorescence (NIRF) molecular imaging of cancer is known to be superior in sensitivity, deeper penetration, and low phototoxicity compared to other imaging modalities. In view of an increased need for efficient and targeted imaging agents, we synthesized a NAD(P)H quinone oxidoreductase 1 (NQO1)-acti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44111-8
更新日期：2019-06-12 00:00:00
abstract：:We report the transient memory device by means of a water soluble SSG (solid sodium with glycerine) paper. This material has a hydroscopic property hence it can be soluble in water. In terms of physical security of memory devices, prompt abrogation of a memory device which stored a large number of data is crucial when...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38324
更新日期：2016-12-05 00:00:00
abstract：:Present study, for the first time, reports the development of a nanohybridized baculovirus based stent that can locally promote vascular re-endothelialization by efficient delivery of pro-angiogenic vascular endothelial growth factor (Vegf) genes. In vitro data demonstrated rapid expression of functionally active Vegf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02366
更新日期：2013-01-01 00:00:00
abstract：:To understand the mechanisms of male sterility in cotton (Gossypium spp.), combined histological, biochemical and transcription analysis using RNA-Seq was carried out in the anther of the single-gene recessive genic male sterility system of male sterile line 1355A and male fertile line 1355B, which are near-isogenic l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09608
更新日期：2015-06-05 00:00:00
abstract：:Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo. However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia. Therefore, the aim of this study was to investigate the ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep17438
更新日期：2015-12-01 00:00:00
abstract：:Inosine-5'-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mechanisms of regulation remain largely unknown. Using the enzyme from the industria...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02805-x
更新日期：2017-06-01 00:00:00
abstract：:The current standard of care for head and neck cancer includes surgical resection of the tumor followed by targeted head and neck radiation. This radiotherapy results in a multitude of negative side effects in adjacent normal tissues. Autophagy is a cellular mechanism that could be targeted to ameliorate these side ef...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05206
更新日期：2014-06-06 00:00:00
abstract：:This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabol...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/s41598-018-33843-8
更新日期：2018-10-31 00:00:00
abstract：:Somatic copy number alterations (SCNAs) affecting oncogenic drivers have a firmly established role in promoting cancer. However, no agreed-upon standard exists for calling locus-specific amplifications and deletions in each patient sample. Here, we report the correlative analysis of copy number amplitude and length wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19649
更新日期：2016-01-20 00:00:00
abstract：:The celebrated Jordan-Wigner transformation provides an efficient mapping between spin chains and fermionic systems in one dimension. Here we extend this spin-fermion mapping to arbitrary tree structures, which enables mapping between fermionic and spin systems with nearest-neighbor coupling. The mapping is achieved w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38128-8
更新日期：2019-02-22 00:00:00
abstract：:We examined the associations of age and serum magnesium, iron, lead, copper, and zinc levels with bone mineral density (BMD) in 2412 children under 3 years of age in order to find a tool to monitor BMD in children without the use of expensive imaging techniques. One-way ANOVA and chi-square tests were used to determin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81501-3
更新日期：2021-01-21 00:00:00
abstract：:Rubber dams are widely used for landscaping in urban rivers and they retain large amounts of sediments. The sediments are rich in phosphorus (P) which can cause river eutrophication. Little is known about P release in rubber dams. We investigated the potential of sediment P release by isotherm experiment in an urban r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59493-3
更新日期：2020-02-17 00:00:00
abstract：:Impulsivity is a naturally occurring behavior that, when accentuated, can be found in a variety of neuropsychiatric disorders. The expression of trait impulsivity has been shown to change with a variety of factors, such as age and sex, but the existing literature does not reflect widespread consensus regarding the inf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35537-7
更新日期：2018-12-05 00:00:00
abstract：:Profiling immune repertoires by high throughput sequencing enhances our understanding of immune system complexity and immune-related diseases in humans. Previously, cloning and Sanger sequencing identified limited numbers of T cell receptor (TCR) nucleotide sequences in rhesus monkeys, thus their full immune repertoir...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10092
更新日期：2015-05-11 00:00:00
abstract：:Multiple sequence alignment (MSA) is an integral part of molecular biology. But handling massive number of large sequences is still a bottleneck for most of the state-of-the-art software tools. Knowledge driven algorithms utilizing features of input sequences, such as high similarity in case of DNA sequences, can help...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42966-5
更新日期：2019-04-29 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-017-16210-x
更新日期：2017-11-23 00:00:00
abstract：:In this study, we identified a CD105+CD90.1-CD133-CD55- (CD133-CD55-) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133-CD55- common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors sugges...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38632
更新日期：2016-12-08 00:00:00
abstract：:The dynamics of networks of neuronal cultures has been recently shown to be strongly dependent on the network geometry and in particular on their dimensionality. However, this phenomenon has been so far mostly unexplored from the theoretical point of view. Here we reveal the rich interplay between network geometry and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28236-w
更新日期：2018-07-02 00:00:00
abstract：:Heme-copper oxygen reductases are terminal respiratory enzymes, catalyzing the reduction of dioxygen to water and the translocation of protons across the membrane. Oxygen consumption is inhibited by various substances. Here we tested the relatively unknown inhibition of cytochrome c oxidase (CcO) with isocyanate. In c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60801-0
更新日期：2020-03-02 00:00:00
abstract：:Chronic inflammation can be a major driver of the failure of a variety of organs, including chronic kidney disease (CKD). The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease model. Nuclear factor erythroid 2-related factor 2 (Nrf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08054-2
更新日期：2017-08-18 00:00:00
