Chemical-Free Technique to Study the Ultrastructure of Primary Cilium.

abstract：:Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cellular homeostasis; however, mitochondria are still required for migration and metastasis. Taking advantage of the metabolic flexibility of TNBC MDA-MB-231 cells to generate subpopulations with glycolytic or oxidative p...

journal_title：Scientific reports

authors： Urra FA,Muñoz F,Córdova-Delgado M,Ramírez MP,Peña-Ahumada B,Rios M,Cruz P,Ahumada-Castro U,Bustos G,Silva-Pavez E,Pulgar R,Morales D,Varela D,Millas-Vargas JP,Retamal E,Ramírez-Rodríguez O,Pessoa-Mahana H,Pavani M,Fer

更新日期：2018-09-04 00:00:00

abstract：:Various folk remedies employ certain odorous compounds with analgesic effects. In fact, linalool, a monoterpene alcohol found in lavender extracts, has been found to attenuate pain responses via subcutaneous, intraperitoneal, intrathecal, and oral administration. However, the analgesic effects of odorous compounds med...

journal_title：Scientific reports

authors： Tashiro S,Yamaguchi R,Ishikawa S,Sakurai T,Kajiya K,Kanmura Y,Kuwaki T,Kashiwadani H

更新日期：2016-11-15 00:00:00

abstract：:Ultrasound-enhanced drug delivery has shown great promise in providing targeted burst release of drug at the site of the disease. Yet current solid ultrasound-responsive particles are non-degradable with limited potential for drug-loading. Here, we report on an ultrasound-responsive multi-cavity poly(lactic-co-glycoli...

journal_title：Scientific reports

authors： Su X,Thomas RG,Bharatula LD,Kwan JJ

更新日期：2019-07-03 00:00:00

abstract：:We performed a systematic investigation on the dynamic behavior of conduction filaments (CFs) in WO₃-x-based devices. It was found that the electric forming produced an electric structure consisted of a conductive channel (virtual cathode) started from cathode and an insulating band surrounding anode. Both the virtual...

journal_title：Scientific reports

authors： Hong DS,Chen YS,Li Y,Yang HW,Wei LL,Shen BG,Sun JR

更新日期：2014-02-11 00:00:00

abstract：:The structure of bonds in biomolecules, such as base pairs in RNA chains or native interactions in proteins, can be presented in the form of a chord diagram. A given biomolecule is then characterized by the genus of an auxiliary two-dimensional surface associated to such a diagram. In this work we introduce the notion...

journal_title：Scientific reports

authors： Zając S,Geary C,Andersen ES,Dabrowski-Tumanski P,Sulkowska JI,Sułkowski P

更新日期：2018-12-03 00:00:00

abstract：:Correlations between fluctuations in resting state BOLD fMRI signals are interpreted as measures of functional connectivity (FC), but the neural basis of their origins and their relationships to specific features of underlying electrophysiologic activity, have not been fully established. In particular, the dependence ...

journal_title：Scientific reports

authors： Shi Z,Wilkes DM,Yang PF,Wang F,Wu R,Wu TL,Chen LM,Gore JC

更新日期：2019-06-20 00:00:00

abstract：:Biomass burning aerosols mainly consist of black carbon (BC) and organic aerosols (OAs), and some of OAs are brown carbon (BrC). This study simulates the colors of BrC, BC and their mixture with scattering OAs in the ambient atmosphere by using a combination of light scattering simulations, a two-stream radiative tran...

journal_title：Scientific reports

authors： Liu C,Chung CE,Zhang F,Yin Y

更新日期：2016-06-16 00:00:00

abstract：:The persistent public health threat of animal to human transmission of influenza A virus (IAV) has stimulated interest in rapid and accurate detection of all IAV subtypes in clinical specimens of animal origin. In this study, a new set of primers and probes was designed for one-step pan-IAV reverse-transcription fluor...

journal_title：Scientific reports

authors： Luan L,Sun Z,Kaltenboeck B,Huang K,Li M,Peng D,Xu X,Ye J,Li J,Guo W,Wang C

更新日期：2016-07-22 00:00:00

abstract：:Colors of crystals, pigments, metals, salt solutions and bioluminescence occur in nature due to the optical properties of electrons in atoms and molecules. However, colors can also result from interference effects on nanostructures. In contrast to artificial coloration, which are caused by well-defined regular structu...

journal_title：Scientific reports

authors： Zyla G,Kovalev A,Grafen M,Gurevich EL,Esen C,Ostendorf A,Gorb S

更新日期：2017-12-15 00:00:00

abstract：:Drug repositioning strategies have improved substantially in recent years. At present, two advances are poised to facilitate new strategies. First, the LINCS project can provide rich transcriptome data that reflect the responses of cells upon exposure to various drugs. Second, machine learning algorithms have been app...

journal_title：Scientific reports

authors： Xie L,He S,Wen Y,Bo X,Zhang Z

更新日期：2017-08-02 00:00:00

abstract：:The food supply is being increasingly challenged by climate change and water scarcity. However, incremental changes in traditional cropping systems have achieved only limited success in meeting these multiple challenges. In this study, we applied a systematic approach, using model simulation and data from two groups o...

journal_title：Scientific reports

authors： Meng Q,Wang H,Yan P,Pan J,Lu D,Cui Z,Zhang F,Chen X

更新日期：2017-02-03 00:00:00

abstract：:Although nearly one fifth of all human cancers have an infectious aetiology, the causes for the majority of cancers remain unexplained. Despite the enormous data output from high-throughput shotgun sequencing, viral DNA in a clinical sample typically constitutes a proportion of host DNA that is too small to be detecte...

journal_title：Scientific reports

authors： Vinner L,Mourier T,Friis-Nielsen J,Gniadecki R,Dybkaer K,Rosenberg J,Langhoff JL,Cruz DF,Fonager J,Izarzugaza JM,Gupta R,Sicheritz-Ponten T,Brunak S,Willerslev E,Nielsen LP,Hansen AJ

更新日期：2015-08-19 00:00:00

abstract：:Peak heat flow occurs at mid-ocean ridges and decreases with the age of the oceanic lithosphere. Several plate models, including the Parsons and Sclater (PSM) model, Global Depth and Heat (GDH1) model and Constant Heat flow Applied on the Bottom Lithospheric Isotherm (CHABLIS) model, have been used to predict heat flo...

journal_title：Scientific reports

authors： Qiuming C

更新日期：2016-01-13 00:00:00

abstract：:Optical fibers have been utilized in various fields owing to their superior guiding performance. However, the modification of optical properties and light manipulation in fibers are restricted by the limitation of the core and cladding materials. In addition, the spot size of the light is constrained by the diffractio...

journal_title：Scientific reports

authors： Kim M,Kim S

更新日期：2020-12-01 00:00:00

abstract：:Immobilized preys are routinely used in agro-ecological exposure studies to quantify predation of pests under field conditions, but this method has not been validated. Our purpose was to determine the validity of using immobilized adults of the major rice pest Nilaparvata lugens, brown plant hopper (BPH), as sentinels...

journal_title：Scientific reports

authors： Zou Y,de Kraker J,Bianchi FJ,van Telgen MD,Xiao H,van der Werf W

更新日期：2017-02-17 00:00:00

abstract：:Climate change is the greatest threat to coral reef ecosystems. In particular, increasing ocean temperatures are causing severe and widespread coral bleaching, contributing to extensive coral loss and degradation of coral reef habitats globally. Effects of coral bleaching are not however, equally apportioned among dif...

journal_title：Scientific reports

authors： Pisapia C,Burn D,Pratchett MS

更新日期：2019-06-10 00:00:00

abstract：:DNA methylation is an essential epigenetic marker associated with the silencing of gene expression. Although various genome-wide studies revealed aberrantly methylated gene targets as molecular biomarkers for early detection, the survival rate of lung cancer patients is still poor. In order to identify methylation-dri...

journal_title：Scientific reports

authors： Lenka G,Tsai MH,Lin HC,Hsiao JH,Lee YC,Lu TP,Lee JM,Hsu CP,Lai LC,Chuang EY

更新日期：2017-02-15 00:00:00

abstract：:Next generation sequencing (NGS) data analysis is highly compute intensive. In-memory computing, vectorization, bulk data transfer, CPU frequency scaling are some of the hardware features in the modern computing architectures. To get the best execution time and utilize these hardware features, it is necessary to tune ...

journal_title：Scientific reports

authors： Kathiresan N,Temanni R,Almabrazi H,Syed N,Jithesh PV,Al-Ali R

更新日期：2017-08-22 00:00:00

abstract：:Recent research in filamentous fungi has revealed that the motility of an endocytic organelle early endosome (EE) has a versatile role in many physiological functions. Here, to further examine the motility of EEs in the industrially important fungus Aspergillus oryzae, we visualized these organelles via the Rab5 homol...

journal_title：Scientific reports

authors： Togo Y,Higuchi Y,Katakura Y,Takegawa K

更新日期：2017-11-17 00:00:00

abstract：:This study measured the effects of vitamin D (VD) supplementation on the underlying molecular pathways involved in renal and testicular damage induced by lead (Pb) toxicity. Thirty two adult male Wistar rats were divided equally into four groups that were treated individually or simultaneously, except the negative con...

journal_title：Scientific reports

authors： BaSalamah MA,Abdelghany AH,El-Boshy M,Ahmad J,Idris S,Refaat B

更新日期：2018-03-19 00:00:00

abstract：:Novel mesoporous silicas rolled with silica sheets with 2D regular spacing were prepared using a self-assembled graphene oxide (GO) template formed by mixing GO with Pluronic123 (P123). Self-assembled GO templated mesoporous silicas (SGT-PMS) showed well-developed X-ray diffraction peaks with d-spacings of 9.8-10.8 nm...

journal_title：Scientific reports

authors： Park KW,Kwon OY

更新日期：2020-04-10 00:00:00

abstract：:Globally, lung cancer accounts for approximately 20% of all cancer related deaths. Five-year survival is poor and rates have remained unchanged for the past four decades. There is an urgent need to identify markers of lung carcinogenesis and new targets for therapy. Given the recent successes of immune modulators in c...

journal_title：Scientific reports

authors： Baird AM,Gray SG,Richard DJ,O'Byrne KJ

更新日期：2016-01-13 00:00:00

abstract：:Polarization of macrophages is regulated through complex signaling networks. Correlating miRNA and mRNA expression over time after macrophage polarization has not yet been investigated. We used paired RNA-Seq and miRNA-Seq experiments to measure the mRNA and miRNA expression in bone marrow-derived macrophages over a t...

journal_title：Scientific reports

authors： Lu L,McCurdy S,Huang S,Zhu X,Peplowska K,Tiirikainen M,Boisvert WA,Garmire LX

更新日期：2016-12-16 00:00:00

abstract：:Green reduction of graphene oxide (GO) by phytochemicals was explored using the aqueous extract of kaffir lime peels. The research methods included preparation of extracts, preparation of GO, preparation and characterization of reduced-GO (RGO) using Fourier Transform Infrared (FTIR), X-ray diffraction (XRD), and UV-V...

journal_title：Scientific reports

authors： Wijaya R,Andersan G,Permatasari Santoso S,Irawaty W

更新日期：2020-01-20 00:00:00

abstract：:We demonstrate fluorescent Fe embedded magnetic nanodiamonds by ion implantation and two-step annealing. The diamond characteristics with a highly ordered core and a graphite surface layer are maintained after the implantation process. After the two-step annealing process, a bright red fluorescence associated with nit...

journal_title：Scientific reports

authors： Lin BR,Kunuku S,Chen CH,Chen TY,Hsiao TY,Yu HK,Chang YJ,Liao LC,Niu H,Lee CP

更新日期：2019-02-04 00:00:00

abstract：:Here, water flow inside large radii semi-infinite carbon nanotubes is investigated. Permeable wall taking into account the molecular interactions between water and a nanotube, and the slip boundary condition will be considered. Furthermore, interactions among molecules are approximated by the continuum approximation. ...

journal_title：Scientific reports

authors： Chan Y,Lee SL,Chen W,Zheng L,Shi Y,Ren Y

更新日期：2019-08-20 00:00:00

abstract：:Single-cell RNA-seq has been established as a reliable and accessible technique enabling new types of analyses, such as identifying cell types and studying spatial and temporal gene expression variation and change at single-cell resolution. Recently, single-cell RNA-seq has been applied to developing embryos, which of...

journal_title：Scientific reports

authors： Ilsley GR,Suyama R,Noda T,Satoh N,Luscombe NM

更新日期：2020-03-18 00:00:00

abstract：:Gapmer antisense oligonucleotides cleave target RNA effectively in vivo, and is considered as promising therapeutics. Especially, gapmers modified with locked nucleic acid (LNA) shows potent knockdown activity; however, they also cause hepatotoxic side effects. For developing safe and effective gapmer drugs, a deeper ...

journal_title：Scientific reports

authors： Kasuya T,Hori S,Watanabe A,Nakajima M,Gahara Y,Rokushima M,Yanagimoto T,Kugimiya A

更新日期：2016-07-27 00:00:00

abstract：:Glioblastoma multiforme (GBM) is a highly invasive and chemoradioresistant brain malignancy. Temozolomide (TMZ), a DNA-alkylating agent, is effective against GBM and has become the standard first-line drug. However, the mechanism by which TMZ regulates the progression of GBM remains elusive. Here, we demonstrate that ...

journal_title：Scientific reports

authors： Yamaki T,Suenaga Y,Iuchi T,Alagu J,Takatori A,Itami M,Araki A,Ohira M,Inoue M,Kageyama H,Yokoi S,Saeki N,Nakagawara A

更新日期：2013-01-01 00:00:00

abstract：:In this study, we analyze the role of different structural variants of proteins in the speciation processes. We separate human and mouse proteomes (taken as a reference) into three previously defined variants of disorder: ordered proteins (ORDPs), structured proteins with intrinsically disordered protein regions (IDPR...

journal_title：Scientific reports

authors： Forcelloni S,Giansanti A

更新日期：2020-03-11 00:00:00