Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration.


:Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many investigations. In this study, we used genetic and pharmacological approaches to explore the role of the inflammasome in a mouse model of retinal degeneration. We identify that Casp1/11-/- mice have better-preserved retinal function, reduced inflammation and increased photoreceptor survivability. While Nlrp3-/- mice display some level of preservation of retinal function compared to controls, pharmacological inhibition of NLRP3 did not protect against photoreceptor cell death. Further, Aim2-/-, Nlrc4-/-, Asc-/-, and Casp11-/- mice show no substantial retinal protection. We propose that CASP-1-associated photoreceptor cell death occurs largely independently of NLRP3 and other established inflammasome sensor proteins, or that inhibition of a single sensor is not sufficient to repress the inflammatory cascade. Therapeutic targeting of CASP-1 may offer a more promising avenue to delay the progression of retinal degenerations.


Sci Rep


Scientific reports


Wooff Y,Fernando N,Wong JHC,Dietrich C,Aggio-Bruce R,Chu-Tan JA,Robertson AAB,Doyle SL,Man SM,Natoli R




Has Abstract


2020-02-10 00:00:00












  • Profiling the impact of medium formulation on morphology and functionality of primary hepatocytes in vitro.

    abstract::The characterization of fully-defined in vitro hepatic culture systems requires testing of functional and morphological variables to obtain the optimal trophic support, particularly for cell therapeutics including bioartificial liver systems (BALs). Using serum-free fully-defined culture medium formulations, we measur...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Nelson LJ,Treskes P,Howie AF,Walker SW,Hayes PC,Plevris JN

    更新日期:2013-01-01 00:00:00

  • Return to different climate states by reducing sulphate aerosols under future CO2 concentrations.

    abstract::It is generally believed that anthropogenic aerosols cool the atmosphere; therefore, they offset the global warming resulting from greenhouse gases to some extent. Reduction in sulphate, a primary anthropogenic aerosol, is necessary for mitigating air pollution, which causes atmospheric warming. Here, the changes in t...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Takemura T

    更新日期:2020-12-10 00:00:00

  • The androgen receptor expression and its activity have different relationships with prognosis in hepatocellular carcinoma.

    abstract::The role of the Androgen Receptor (AR) expression and its activity in the prognosis of hepatocellular carcinoma (HCC) remains inconclusive. The aim of this study is to analyze the role of the AR expression and its activity as prognostic biomarkers in HCC. Three-hundred and thirty-seven patients from The Cancer Genome ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Acosta-Lopez S,Diaz-Bethencourt D,Concepción-Massip T,Martin-Fernandez de Basoa MC,Plata-Bello A,Gonzalez-Rodriguez A,Perez-Hernandez F,Plata-Bello J

    更新日期:2020-12-16 00:00:00

  • A tongue for all seasons: extreme phenotypic flexibility in salamandrid newts.

    abstract::Many organisms faced with seasonally fluctuating abiotic and biotic conditions respond by altering their phenotype to account for the demands of environmental changes. Here we discovered that newts, which switch seasonally between an aquatic and terrestrial lifestyle, grow a complex adhesive system on their tongue pad...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Heiss E,Handschuh S,Aerts P,Van Wassenbergh S

    更新日期:2017-04-21 00:00:00

  • Complex societies and the growth of the law.

    abstract::While many informal factors influence how people interact, modern societies rely upon law as a primary mechanism to formally control human behaviour. How legal rules impact societal development depends on the interplay between two types of actors: the people who create the rules and the people to which the rules poten...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Katz DM,Coupette C,Beckedorf J,Hartung D

    更新日期:2020-10-30 00:00:00

  • Nature and characteristics of temperature background effect for interactive respiration process.

    abstract::Indoor air quality (IAQ) is much more crucial to human health than its atmospheric air quality counterpart. Improving indoor air environment requires investigating how different indoor air stability affects airflow trajectory. By presenting both manikin experiment and Computational Fluid Dynamics (CFD) simulation, we ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gong G,Deng X

    更新日期:2017-08-17 00:00:00

  • Short tryptophan- and arginine-rich peptide shows efficacy against clinical methicillin-resistant Staphylococcus aureus strains isolated from skin and soft tissue infections.

    abstract::In recent years methicillin-resistant Staphylococcus aureus has posed a challenge in treating skin and soft tissue infections. Finding new antimicrobial agents has therefore become imperative. We evaluated the in vitro antimicrobial activity of a synthetic peptide, P6, against multidrug resistant clinical strains of S...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Bacalum M,Dragulescu EC,Necula G,Codita I,Radu M

    更新日期:2019-11-20 00:00:00

  • Concurrent guiding of light and heat by transformation optics and transformation thermodynamics via soft matter.

    abstract::Controlling light and heat via metamaterials has presented interesting technological applications using transformation optics (TO) and transformation thermodynamics (TT). However, such devices are commonly mono-physics and mono-purpose, because the used metamaterial is designed to deal with one type of physical mechan...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Barros WKP,Pereira E

    更新日期:2018-07-30 00:00:00

  • Epidemiological and geospatial profile of the prescription opioid crisis in Ohio, United States.

    abstract::The underlying reasons behind the unprecedented increase of the mortality rates due to the opioid epidemics in the United States are still not fully uncovered. Most efforts have been focused on targeting opioids, but there is little information about vulnerable populations at high risk of opioid abuse and death. In th...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Hernandez A,Branscum AJ,Li J,MacKinnon NJ,Hincapie AL,Cuadros DF

    更新日期:2020-03-09 00:00:00

  • Engineering of Baeyer-Villiger monooxygenase-based Escherichia coli biocatalyst for large scale biotransformation of ricinoleic acid into (Z)-11-(heptanoyloxy)undec-9-enoic acid.

    abstract::Baeyer-Villiger monooxygenases (BVMOs) are able to catalyze regiospecific Baeyer-Villiger oxygenation of a variety of cyclic and linear ketones to generate the corresponding lactones and esters, respectively. However, the enzymes are usually difficult to express in a functional form in microbial cells and are rather u...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Seo JH,Kim HH,Jeon EY,Song YH,Shin CS,Park JB

    更新日期:2016-06-17 00:00:00

  • Analysis of genome-wide variants through bulked segregant RNA sequencing reveals a major gene for resistance to Plasmodiophora brassicae in Brassica oleracea.

    abstract::Two cabbage (Brassica oleracea) cultivars 'Tekila' and 'Kilaherb' were identified as resistant to several pathotypes of Plasmodiophora brassicae. In this study, we identified a clubroot resistance gene (Rcr7) in 'Tekila' for resistance to pathotype 3 of P. brassicae from a segregating population derived from 'Tekila' ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dakouri A,Zhang X,Peng G,Falk KC,Gossen BD,Strelkov SE,Yu F

    更新日期:2018-12-05 00:00:00

  • Lactobacillus casei reduces susceptibility to type 2 diabetes via microbiota-mediated body chloride ion influx.

    abstract::Gut microbiota mediated low-grade inflammation is involved in the onset of type 2 diabetes (T2DM). In this study, we used a high fat sucrose (HFS) diet-induced pre-insulin resistance and a low dose-STZ HFS rat models to study the effect and mechanism of Lactobacillus casei Zhang in protecting against T2DM onset. Hyper...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhang Y,Guo X,Guo J,He Q,Li H,Song Y,Zhang H

    更新日期:2014-07-18 00:00:00

  • Author Correction: Localization and function of neurosecretory protein GM, a novel small secretory protein, in the chicken hypothalamus.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Shikano K,Bessho Y,Kato M,Iwakoshi-Ukena E,Taniuchi S,Furumitsu M,Tachibana T,Bentley GE,Kriegsfeld LJ,Ukena K

    更新日期:2018-04-13 00:00:00

  • Multigene phylogeny of root-knot nematodes and molecular characterization of Meloidogyne nataliei Golden, Rose & Bird, 1981 (Nematoda: Tylenchida).

    abstract::The root-knot nematodes of the genus Meloidogyne are highly adapted, obligate plant parasites, consisting of nearly one hundred valid species, and are considered the most economically important group of plant-parasitic nematodes. Six Meloidogyne species: M. arenaria, M. hapla, M. incognita, M. microtyla, M. naasi and ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Álvarez-Ortega S,Brito JA,Subbotin SA

    更新日期:2019-08-13 00:00:00

  • Mean Bias in Seasonal Forecast Model and ENSO Prediction Error.

    abstract::This study uses retrospective forecasts made using an APEC Climate Center seasonal forecast model to investigate the cause of errors in predicting the amplitude of El Niño Southern Oscillation (ENSO)-driven sea surface temperature variability. When utilizing Bjerknes coupled stability (BJ) index analysis, enhanced err...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kim ST,Jeong HI,Jin FF

    更新日期:2017-07-20 00:00:00

  • Selection of a novel DNA aptamer against OFA/iLRP for targeted delivery of doxorubicin to AML cells.

    abstract::The standard treatment for most acute myeloid leukemia (AML) is chemotherapy, which is often associated with severe adverse effects. One strategy to reduce the adverse effects is targeted therapy that can selectively deliver anticancer drugs to tumor cells. Immature laminin receptor protein (OFA/iLRP) is a potential t...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: An Y,Hu Y,Li X,Li Z,Duan J,Yang XD

    更新日期:2019-05-14 00:00:00

  • Drug screening of cancer cell lines and human primary tumors using droplet microfluidics.

    abstract::Precision Medicine in Oncology requires tailoring of therapeutic strategies to individual cancer patients. Due to the limited quantity of tumor samples, this proves to be difficult, especially for early stage cancer patients whose tumors are small. In this study, we exploited a 2.4 × 2.4 centimeters polydimethylsiloxa...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wong AH,Li H,Jia Y,Mak PI,Martins RPDS,Liu Y,Vong CM,Wong HC,Wong PK,Wang H,Sun H,Deng CX

    更新日期:2017-08-22 00:00:00

  • Picosecond supercontinuum generation in large mode area photonic crystal fibers for coherent anti-Stokes Raman scattering microspectroscopy.

    abstract::We perform a detailed theoretical and experimental investigation of supercontinuum generation in large-mode-area photonic crystal fibers pumped by a high-energy, high-repetition rate picosecond Nd:YVO4 laser, with the goal of using it as the Stokes beam in coherent anti-Stokes Raman scattering setup. We analyze the in...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Shen Y,Voronin AA,Zheltikov AM,O'Connor SP,Yakovlev VV,Sokolov AV,Scully MO

    更新日期:2018-06-22 00:00:00

  • Factors affecting dural sinus density in non-contrast computed tomography of brain.

    abstract::The possibility of changing the intracranial vasculature computed tomography (CT) attenuation under the influence of variable factors is a long-held unestablished belief. The purpose of this study is to evaluate factors affecting dural sinus density in non-contrast computed tomography of the brain. Patients presented ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Akhavan R,Abbasi B,Kheirollahi M,Ghamari Khameneh A,Hashemi J,Khoei S,Darban Hosseini Amirkhiz G

    更新日期:2019-08-19 00:00:00

  • Integrated transcriptomic and metabolomic analyses reveal the effects of callose deposition and multihormone signal transduction pathways on the tea plant-Colletotrichum camelliae interaction.

    abstract::Colletotrichum infects diverse hosts, including tea plants, and can lead to crop failure. Numerous studies have reported that biological processes are involved in the resistance of tea plants to Colletotrichum spp. However, the molecular and biochemical responses in the host during this interaction are unclear. Cuttin...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lu Q,Wang Y,Xiong F,Hao X,Zhang X,Li N,Wang L,Zeng J,Yang Y,Wang X

    更新日期:2020-07-30 00:00:00

  • Akting up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions.

    abstract::Accumulating evidence implies that both AKT1 and GABAA receptor (GABAAR) subunit genes are involved in schizophrenia pathogenesis. Activated Akt promotes GABAergic neuron differentiation and increases GABAAR expression on the plasma membrane. To elucidate the role of Akt1 in modulating GABAergic functions and schizoph...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chang CY,Chen YW,Wang TW,Lai WS

    更新日期:2016-09-12 00:00:00

  • Electrical detection of dengue biomarker using egg yolk immunoglobulin as the biological recognition element.

    abstract::Nonstructural protein 1 (NS1) is secreted by dengue virus in the first days of infection and acts as an excellent dengue biomarker. Here, the direct electrical detection of NS1 from dengue type 2 virus has been achieved by the measurement of variations in open circuit potential (OCP) between a reference electrode and ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Figueiredo A,Vieira NC,dos Santos JF,Janegitz BC,Aoki SM,Junior PP,Lovato RL,Nogueira ML,Zucolotto V,Guimarães FE

    更新日期:2015-01-19 00:00:00

  • RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity.

    abstract::Mitochondria act as a platform for antiviral innate immunity, and the immune system depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLR) signaling pathway via an adaptor molecule, mitochondrial antiviral signaling. We report that RLR-mediated antiviral innate immunity requires oxida...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yoshizumi T,Imamura H,Taku T,Kuroki T,Kawaguchi A,Ishikawa K,Nakada K,Koshiba T

    更新日期:2017-07-14 00:00:00

  • Phonon-electron interactions in piezoelectric semiconductor bulk acoustic wave resonators.

    abstract::This work presents the first comprehensive investigation of phonon-electron interactions in bulk acoustic standing wave (BAW) resonators made from piezoelectric semiconductor (PS) materials. We show that these interactions constitute a significant energy loss mechanism and can set practical loss limits lower than anha...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gokhale VJ,Rais-Zadeh M

    更新日期:2014-07-08 00:00:00

  • Speeding up GW Calculations to Meet the Challenge of Large Scale Quasiparticle Predictions.

    abstract::Although the GW approximation is recognized as one of the most accurate theories for predicting materials excited states properties, scaling up conventional GW calculations for large systems remains a major challenge. We present a powerful and simple-to-implement method that can drastically accelerate fully converged ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gao W,Xia W,Gao X,Zhang P

    更新日期:2016-11-11 00:00:00

  • Climatic factors control the geospatial distribution of active ingredients in Salvia miltiorrhiza Bunge in China.

    abstract::Climate change profoundly influences the geospatial distribution of secondary metabolites and causes the geographical migration of plants. We planted seedlings of the same species in eighteen ecological regions along a latitudinal gradient in eastern and western China, in order to explore the regulation of multi-clima...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhang C,Yang D,Liang Z,Liu J,Yan K,Zhu Y,Yang S

    更新日期:2019-01-29 00:00:00

  • Characterization and Comparative Genomic Analyses of Pseudomonas aeruginosa Phage PaoP5: New Members Assigned to PAK_P1-like Viruses.

    abstract::As a potential alternative to antibiotics, phages can be used to treat multi-drug resistant bacteria. As such, the biological characteristics of phages should be investigated to utilize them as effective antimicrobial agents. In this study, phage PaoP5, a lytic virus that infects Pseudomonas aeruginosa PAO1, was isola...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Shen M,Le S,Jin X,Li G,Tan Y,Li M,Zhao X,Shen W,Yang Y,Wang J,Zhu H,Li S,Rao X,Hu F,Lu S

    更新日期:2016-09-23 00:00:00

  • A high-precision and high-order error model for airborne distributed POS transfer alignment.

    abstract::Distributed position and orientation systems (DPOSs) can provide abundant time-spatial information for interferometric synthetic aperture radar (InSAR) in airborne earth observation systems. However, some key error terms have not been taken into consideration in the traditional low-order error model, which suppresses ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gu B,Ye W,Teng Z,Chen H,Wang G

    更新日期:2020-11-24 00:00:00

  • Universal roles of hydrogen in electrochemical performance of graphene: high rate capacity and atomistic origins.

    abstract::Atomic hydrogen exists ubiquitously in graphene materials made by chemical methods. Yet determining the effect of hydrogen on the electrochemical performance of graphene remains a significant challenge. Here we report the experimental observations of high rate capacity in hydrogen-treated 3-dimensional (3D) graphene n...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ye J,Ong MT,Heo TW,Campbell PG,Worsley MA,Liu Y,Shin SJ,Charnvanichborikarn S,Matthews MJ,Bagge-Hansen M,Lee JR,Wood BC,Wang YM

    更新日期:2015-11-05 00:00:00

  • Fuzzy Union to Assess Climate Suitability of Annual Ryegrass (Lolium multiflorum), Alfalfa (Medicago sativa) and Sorghum (Sorghum bicolor).

    abstract::The Law of the Minimum is often implemented using t-norm or fuzzy intersection. We propose the use of t-conorm or fuzzy union for climate suitability assessment of a grass species using annual ryegrass (Lolium multiflorum Lam.) as an example and evaluate the performance for alfalfa (Medicago sativa L.) and sorghum (So...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kim H,Hyun SW,Hoogenboom G,Porter CH,Kim KS

    更新日期:2018-07-05 00:00:00