Abstract：
:Adherence to cardioprotective medications following myocardial infarction (MI) is commonly assessed using a binary threshold of 80%. We investigated the relationship between medication adherence as a continuous measure and outcomes in MI survivors using restricted cubic splines (RCS). We identified all patients aged ≥65 years hospitalised for MI from 2003-2008 who survived one-year post-discharge (n = 5938). Adherence to statins, beta-blockers, renin angiotensin system inhibitors (RASI) and clopidogrel was calculated using proportion of days covered to one-year post-discharge (landmark date). Outcomes were 1-year all-cause death and major adverse cardiac events (MACE) after the landmark date. Adherence-outcome associations were estimated from RCS Cox regression models. RCS analyses indicated decreasing risk for both outcomes above 60% adherence for statins, RASI and clopidogrel, with each 10% increase in adherence associated with a 13.9%, 12.1% and 18.0% decrease respectively in adjusted risk of all-cause death (all p < 0.02). Similar results were observed for MACE (all p < 0.03). Beta-blockers had no effect on outcomes at any level of adherence. In MI survivors, increasing adherence to statins, RASI, and clopidogrel, but not beta blockers, is associated with a decreasing risk of death/MACE with no adherence threshold beyond 60%. Medication adherence should be considered as a continuous measure in outcomes analyses.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Greenland M,Knuiman MW,Hung J,Nedkoff L,Arnet I,Rankin JM,Kilkenny MF,Sanfilippo FMdoi
10.1038/s41598-020-60799-5subject
Has Abstractpub_date
2020-03-09 00:00:00pages
4315issue
1issn
2045-2322pii
10.1038/s41598-020-60799-5journal_volume
10pub_type
杂志文章abstract：:Multipotential stromal cells (MSCs) demonstrate strong immunomodulation capabilities following culture expansion. We have previously demonstrated that human cancellous bone fragments (CBFs) clinically used as viable allografts for spinal fusion have resident MSCs that exhibit T cell immunomodulation after monolayer ex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31979-1
更新日期：2018-09-10 00:00:00
abstract：:Elucidating arbuscular mycorrhizal (AM) fungal responses to elevation changes is critical to improve understanding of microbial function in ecosystems under global asymmetrical climate change scenarios. Here we examined AM fungal community in a two-year reciprocal translocation of vegetation-intact soil blocks along a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36606
更新日期：2016-11-09 00:00:00
abstract：:The tunneled central venous catheter (CVC) plays an important role for hemodialysis patients, but CVC-related thrombosis in the central veins remain problematic. This study is the first try to numerically find out what hemodynamic parameters are predisposed to the initiation and formation of thrombus after CVC inserti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12456-7
更新日期：2017-11-21 00:00:00
abstract：:Genotyping-by-sequencing (GBS) or restriction-site associated DNA marker sequencing (RAD-seq) is a practical and cost-effective method for analysing large genomes from high diversity species. This method of sequencing, coupled with methylation-sensitive enzymes (often referred to as methylation-sensitive restriction e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19655-w
更新日期：2018-02-01 00:00:00
abstract：:Ricco's area (the largest area of visual space in which stimulus area and intensity are inversely proportional at threshold) has previously been hypothesised to be a result of centre/surround antagonism in retinal ganglion cell receptive fields, but recent evidence suggests a sizeable cortical contribution. Here, Ricc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21620-6
更新日期：2018-03-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-71840-y
更新日期：2020-09-01 00:00:00
abstract：:We describe the realization and characterization of a compact, autonomous fiber laser system that produces the optical frequencies required for laser cooling, trapping, manipulation, and detection of 87Rb atoms - a typical atomic species for emerging quantum technologies. This device, a customized laser system from th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59971-8
更新日期：2020-02-24 00:00:00
abstract：:The objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18944-0
更新日期：2018-01-11 00:00:00
abstract：:Intracellular ion channels are involved in multiple signaling processes, including such crucial ones as regulation of cellular motility and fate. With 95% of the cellular membrane belonging to intracellular organelles, it is hard to overestimate the importance of intracellular ion channels. Multiple studies have been ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13968-y
更新日期：2017-10-26 00:00:00
abstract：:Genome-wide studies on high-altitude adaptation have received increased attention as a classical case of organismal evolution under extreme environment. However, the current genetic understanding of high-altitude adaptation emanated mainly from autosomal analyses. Only a few earlier genomic studies paid attention to t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35004
更新日期：2016-10-07 00:00:00
abstract：:The abnormal wing discs (awd) gene encodes the Drosophila homolog of NME1/NME2 metastasis suppressor genes. Awd acts in multiple tissues where its function is critical in establishing and maintaining epithelial integrity. Here, we analysed awd gene function in Drosophila epithelial cells using transgene-mediated RNA i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17217-0
更新日期：2017-12-04 00:00:00
abstract：:Spirotetramat is employed worldwide to fight insect pests due to its high efficiency. This chemical is quickly metabolized by plants into spirotetramat-enol, so current regulations establish that both compounds must be determined in foodstuffs for monitoring purposes. Nowadays, immunochemical methods constitute rapid ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81432-z
更新日期：2021-01-19 00:00:00
abstract：:TRPV1 is a polymodal nociceptor for diverse physical and chemical stimuli that interact with different parts of the channel protein. Recent cryo-EM studies revealed detailed channel structures, opening the door for mapping structural elements mediating activation by each stimulus. Towards this goal, here we have combi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33827
更新日期：2016-09-26 00:00:00
abstract：:Since the hemorrhage in severe dengue seems to be primarily related to the defect of the platelet, the possibility that dengue virus (DENV) is selectively tropic for one of its surface receptors was investigated. Flow cytometric data of DENV-infected megakaryocytic cell line superficially expressing human glycoprotein...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20914-z
更新日期：2018-02-09 00:00:00
abstract：:K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to understand how it alters the regulation of its dynamics. Here, we present local changes in K-Ras structure, conformation and dynamics upon G12D ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48029-z
更新日期：2019-08-13 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-59906-3
更新日期：2020-02-13 00:00:00
abstract：:The mechanism by which chronic metabolic acidosis (CMA) regulates sodium (Na(+))-chloride (Cl(-)) cotransporter (NCC) in the renal distal convoluted tubules remains unexplored. We examined the role of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and with-no-lysine kinase 4 (WNK4) on expression of NCC in mouse...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18360
更新日期：2016-01-05 00:00:00
abstract：:A hybrid optoplasmonic amplifier, injection-seeded by an internally-generated Raman signal and operating in the visible (563-675 nm), is proposed and evidence for amplification is presented. Comprising a gain medium tethered to a whispering gallery mode (WGM) resonator with a protein, and a plasmonic surface, the opti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06168
更新日期：2014-08-26 00:00:00
abstract：:Airports can affect birds by hindering acoustic communication. Here, we investigated the impacts of aircraft events on vocal behavior in wood thrush (Hylocichla mustelina) breeding one mile from an airport in Ithaca, NY, USA. We identified the number of wood thrush songs between 0500 and 0800 h at various distances fr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80380-4
更新日期：2021-01-13 00:00:00
abstract：:Lateral flow strip tests are a cost-effective method for detecting specific proteins in biological samples, which can be performed in the field without specialized expertise. While most recognizable in the pregnancy tests, there are many other applications for lateral flow strip technology. The pest control industry h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70200-0
更新日期：2020-08-07 00:00:00
abstract：:Optical antennas can be used to manipulate the direction and polarization of radiation from an emitter. Usually, these metallic nanostructures utilize localized plasmon resonances to generate highly directional and strongly polarized emission, which is determined predominantly by the antenna geometry alone, and is thu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06456
更新日期：2014-09-24 00:00:00
abstract：:Concurrent generation and mixing phenomenon of thermoacoustic (TA) and magnetoacoustic (MA) waves in water are predicted and observed. A theory unifying TA and MA is further put forward to analyze it. By scaling down the radio frequency in thermoacoustics to the low mega Hertz range and by incorporating appropriately ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11489
更新日期：2015-06-26 00:00:00
abstract：:Papillary thyroid carcinoma (PTC) displays strong but so far largely uncharacterized heritability. Here we studied genetic predisposition in a family with six affected individuals. We genotyped all available family members and conducted whole exome sequencing of blood DNA from two affected individuals. Haplotype analy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10566
更新日期：2015-07-02 00:00:00
abstract：:CRISPR/Cas9-based gene knockout in animal cells, particularly in teleosts, has proven to be very efficient with regards to mutation rates, but the precise insertion of exogenous DNA or gene knock-in via the homology-directed repair (HDR) pathway has seldom been achieved outside of the model organisms. Here, we succeed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79409-5
更新日期：2020-12-17 00:00:00
abstract：:We use satellite gravity measurements in the Gravity Recovery and Climate Experiment (GRACE) to estimate terrestrial water storage (TWS) change in the continental United States (US) from 2003 to 2012, and establish a GRACE-based Hydrological Drought Index (GHDI) for drought monitoring. GRACE-inferred TWS exhibits oppo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19909
更新日期：2016-01-27 00:00:00
abstract：:Scanning micro-mirror actuators are silicon-based oscillatory micro-electro-mechanical systems (MEMS). They enable laser distance measurements for automotive LIDAR applications as well as projection modules for the consumer market. For MEMS applications, the geometric structure is typically designed to serve a number ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40377-0
更新日期：2019-03-08 00:00:00
abstract：:The domain wall-related change in the anisotropic magnetoresistance in L-shaped permalloy nanowires is measured as a function of the magnitude and orientation of the applied magnetic field. The magnetoresistance curves, compiled into so-called domain wall magnetoresistance state space maps, are used to identify highly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06045
更新日期：2014-08-13 00:00:00
abstract：:Modern megaherbivore community richness is limited by bottom-up controls, such as resource limitation and resultant dietary competition. However, the extent to which these same controls impacted the richness of fossil megaherbivore communities is poorly understood. The present study investigates the matter with refere...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51709-5
更新日期：2019-10-28 00:00:00
abstract：:It is our contention that for multiscale modelling of infectious disease systems to evolve and expand in scope, it needs to be founded on a theory. Such a theory would improve our ability to describe infectious disease systems in terms of their scales and levels of organization, and their inter-relationships. In this ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52820-3
更新日期：2019-11-08 00:00:00
abstract：:Extracorporeal membrane oxygenation (ECMO) is used for rescue in severe respiratory and/or circulatory failure. The patient's blood is pumped over artificial surfaces in the ECMO circuit. A platelet activation model was applied to study the potential thrombogenicity of ECMO circuit components: the centrifugal blood pu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32247-y
更新日期：2018-09-18 00:00:00
