Abstract：
:Candida glabrata CCTCC M202019 as an industrial yeast strain that is widely used to produce α-oxocarboxylic acid. Strain M202019 has been proven to have a higher pyruvate-producing capacity than the reference strain CBS138. To characterize the genotype of the M202019 strain, we generated a draft sequence of its genome, which has a size of 12.1 Mbp and a GC content of 38.47%. Evidence accumulated during genome annotation suggests that strain M202019 has strong capacities for glucose transport and pyruvate biosynthesis, defects in pyruvate catabolism, as well as variations in genes involved in nutrient and dicarboxylic acid transport, oxidative phosphorylation, and other relevant aspects of carbon metabolism, which might promote pyruvate accumulation. In addition to differences in its central carbon metabolism, a genomic analysis revealed genetic differences in adhesion metabolism. Forty-nine adhesin-like proteins of strain M202019 were identified classified into seven subfamilies. Decreased amounts of adhesive proteins, and deletions or changes of low-complexity repeats and functional domains might lead to lower adhesion and reduced pathogenicity. Further virulence experiments validated the biological safety of strain M202019. Analysis of the C. glabrata CCTCC M202019 genome sequence provides useful insights into its genetic context, physical characteristics, and potential metabolic capacity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xu N,Ye C,Chen X,Liu J,Liu L,Chen Jdoi
10.1038/srep34893subject
Has Abstractpub_date
2016-10-07 00:00:00pages
34893issn
2045-2322pii
srep34893journal_volume
6pub_type
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pub_type： 杂志文章
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更新日期：2019-12-18 00:00:00
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pub_type： 杂志文章
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更新日期：2018-08-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-11-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-03-22 00:00:00
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更新日期：2017-05-18 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-10-07 00:00:00
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更新日期：2016-07-18 00:00:00
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更新日期：2016-09-08 00:00:00
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更新日期：2016-10-26 00:00:00
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更新日期：2017-08-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-09-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
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更新日期：2016-12-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2014-09-26 00:00:00
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journal_title：Scientific reports
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更新日期：2017-05-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-018-31590-4
更新日期：2018-09-10 00:00:00
