Abstract：
:Dentin sialoprotein (DSP) is a dentin extracellular matrix protein. It is involved in dental mesenchymal cell lineages and dentin formation through regulation of its target gene expression. DSP mutations cause dentin genetic diseases. However, mechanisms of DSP in controlling dental mesenchymal cell differentiation are unknown. Using DSP as bait, we screened a protein library from mouse odontoblastic cells and found that DSP is a ligand and binds to cell surface receptor, occludin. Further study identified that the C-terminal DSP domainaa 363-458 interacts with the occludin extracellular loop 2aa 194-241. The C-terminal DSP domain induced phosphorylation of occludin Ser490 and focal adhesion kinase (FAK) Ser722 and Tyr576. Coexpression of DSP, occludin and FAK was detected in dental mesenchymal cells during tooth development. Occludin physically interacts with FAK, and occludin and FAK phosphorylation can be blocked by DSP and occludin antibodies. This DSP domain facilitates dental mesenchymal cell differentiation and mineralization. Furthermore, transplantation and pulp-capping procedures revealed that this DSP domain induces endogenous dental pulp mesenchymal cell proliferation, differentiation and migration, while stimulating blood vessel proliferation. This study elucidates the mechanism of DSP in dental mesenchymal lineages and implies that DSP may serve as a therapeutic agent for dentin-pulp complex regeneration in dental caries.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li W,Chen L,Chen Z,Wu L,Feng J,Wang F,Shoff L,Li X,Donly KJ,MacDougall M,Chen Sdoi
10.1038/s41598-017-00339-wsubject
Has Abstractpub_date
2017-03-22 00:00:00pages
300issue
1issn
2045-2322pii
10.1038/s41598-017-00339-wjournal_volume
7pub_type
杂志文章abstract：:In recent and future synchrotron radiation facilities, relativistic electron bunches with increasingly high charge density are needed for producing brilliant light at various wavelengths, from X-rays to terahertz. In such conditions, interaction of electron bunches with their own emitted electromagnetic fields leads t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45024-2
更新日期：2019-07-17 00:00:00
abstract：:The time evolution of the distribution and shareability of quantum coherence of a tripartite system in a non-Markovian environment is examined. The total coherence can be decomposed into various contributions, ranging from local, global bipartite and global tripartite, which characterize the type of state. We identify...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39027-2
更新日期：2019-02-20 00:00:00
abstract：:Changes in land cover have become key components of global environmental change and represent the impact of human activity. To better understand the fundamental processes of land transition characteristics before and after the implementation of ecological programmes, we determined the dominant systematic changes in la...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44496
更新日期：2017-03-21 00:00:00
abstract：:The visual magnocellular system is thought to play a crucial role in learning to read. Here therefore, we examined whether magnocellular based training could improve reading in children with visual reading problems. The participants were 24 male primary school students aged between 9-11 (Mean = 9.76, SD = 0.59) with s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37753-7
更新日期：2019-02-04 00:00:00
abstract：:The biological processes involved in a drug's mechanisms of action are oftentimes dynamic, complex and difficult to discern. Time-course gene expression data is a rich source of information that can be used to unravel these complex processes, identify biomarkers of drug sensitivity and predict the response to a drug. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74725-2
更新日期：2020-10-19 00:00:00
abstract：:Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positive Bacillus subtilis, Mycobac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00802-8
更新日期：2017-05-03 00:00:00
abstract：:Identifying patients at risk of poor outcome after mild traumatic brain injury (MTBI) is essential to aid prognostics and treatment. Diffuse axonal injury (DAI) may be the primary pathologic feature of MTBI but is normally not detectable by conventional imaging technology. This lack of sensitivity of clinical imaging ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13628-1
更新日期：2017-10-23 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60498-1
更新日期：2020-02-27 00:00:00
abstract：:High efficiency polymer:fullerene photovoltaic device layers self-assemble with hierarchical features from ångströms to 100's of nanometers. The feature size, shape, composition, orientation, and order all contribute to device efficiency and are simultaneously difficult to study due to poor contrast between carbon bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30915
更新日期：2016-08-08 00:00:00
abstract：:Powdery mildew, a common cereal disease caused by the fungus Blumeria graminis, is a major limiting factor of barley production and genetic resistance is the most appropriate protection against it. To aid the breeding of new cultivars and their marketing, resistance genes can be postulated in homogeneous accessions. A...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75978-7
更新日期：2020-11-03 00:00:00
abstract：:The carrier transport characteristics of Sb2Se2Te topological insulators were investigated, after exposure to different levels of nitrogen gas. The magnetoresistance (MR) slope for the Sb2Se2Te crystal increased by approximately 100% at 10 K after 2-days of exposure. The Shubnikov-de Haas (SdH) oscillation amplitude i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05369-y
更新日期：2017-07-11 00:00:00
abstract：:Serratia marcescens is one of the important nosocomial pathogens which rely on quorum sensing (QS) to regulate the production of biofilm and several virulence factors. Hence, blocking of QS has become a promising approach to quench the virulence of S. marcescens. For the first time, QS inhibitory (QSI) and antibiofilm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16507-x
更新日期：2017-11-27 00:00:00
abstract：:Dermal papilla cells (DPCs) are important components of hair follicles and play a critical role in hair follicle development. However, the mechanisms by which DPCs induce hair follicle development remain unclear. In the present study, we identified the mitotic arrest deficient protein MAD2B as a modifier of DPCs. Over...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10350-w
更新日期：2017-09-15 00:00:00
abstract：:The vast majority of proteins do not form functional interactions in physiological conditions. We have considered several sets of protein pairs from S. cerevisiae with no functional interaction reported, denoted as non-interacting pairs, and compared their 3D structures to available experimental complexes. We identifi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40419
更新日期：2017-01-13 00:00:00
abstract：:Post-operative atrial fibrillation (POAF) is postulated as a complex interaction of different pathogenic factors, suggesting inflammatory processes as a main trigger of this particular type of atrial fibrillation. Therefore, the study sought to assess the impact of cellular immunity on the development of POAF. Compari...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-28046-0
更新日期：2018-06-25 00:00:00
abstract：:The development of novel small molecule inhibitors of the cancer-associated tropomyosin 3.1 (Tpm3.1) provides the ability to examine the metabolic function of specific actin filament populations. We have determined the ability of these anti-Tpm (ATM) compounds to regulate glucose metabolism in mice. Acute treatment (1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22946-x
更新日期：2018-03-15 00:00:00
abstract：:3D printing has produced many beneficial applications for surgery. The technique´s applicability in replicating nasal cavity anatomy for clinical use has not been studied. Our aim was to determine whether 3D printing could realistically replicate the nasal cavities and the airflow passing through them from a clinical ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57537-2
更新日期：2020-01-16 00:00:00
abstract：:Scleroderma is a refractory autoimmune skin fibrotic disorder. Alterations of microRNAs in lesional skin could be a new approach to treating the disease. Here, we found that expression of miR-155 was up regulated in lesional skin tissue from patients with either systemic or localized scleroderma, and correlated with f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20314
更新日期：2016-02-01 00:00:00
abstract：:Though carbon (C): nitrogen (N) stoichiometry has been widely studied in terrestrial ecosystems, little is known about its variation following afforestation. By synthesizing the results of 53 studies, we examined temporal and spatial variation in C: N ratios and in N-C scaling relationships of both the organic and the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19117
更新日期：2016-01-08 00:00:00
abstract：:Humans bargaining over money tend to reject unfair offers, whilst chimpanzees bargaining over primary rewards of food do not show this same motivation to reject. Whether such reciprocal fairness represents a predominantly human motivation has generated considerable recent interest. We induced either moderate or severe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00593
更新日期：2012-01-01 00:00:00
abstract：:Metabolites detectible in human biofluids are attractive biomarkers for the diagnosis of early Lyme disease (ELD), a vector-borne infectious disease. Urine represents an easily obtained clinical sample that can be applied for diagnostic purposes. However, few studies have explored urine for biomarkers of ELD. In this ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29713-y
更新日期：2018-08-15 00:00:00
abstract：:Bacterial biofilms are particularly problematic since they become resistant to most available antibiotics. Hence, novel potential antagonists to inhibit biofilm formation are urgent. Here the influences of two natural products, ursolic acid and resveratrol, on biofilm of the clinical methicillin-resistant Staphylococc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05467
更新日期：2014-06-27 00:00:00
abstract：:High content of organic matter in the downstream of watersheds underscored the severity of non-point source (NPS) pollution. The major objectives of this study were to characterize and quantify dissolved organic matter (DOM) in watersheds affected by NPS pollution, and to apply self-organizing map (SOM) and parallel f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16079
更新日期：2015-11-03 00:00:00
abstract：:Hematopoietic stem/progenitor cells (HSPC) in zebrafish emerge from the aortic hemogenic endothelium (HE) and migrate towards the caudal hematopoietic tissue (CHT), where they expand and differentiate during definitive hematopoiesis. Phospholipase C gamma 1 (Plcγ1) has been implicated for hematopoiesis in vivo and in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36338-8
更新日期：2019-01-21 00:00:00
abstract：:Association of a high-serum ferritin with poor outcome showed that iron might play a detrimental role in the brain after intracerebral hemorrhage (ICH). Here, we investigated changes in serum iron, ferritin, transferrin (Tf) and ceruloplasmin (CP) in patients with ICH (n = 100) at day 1 (admission), 3, 7, 14 and 21 an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21970
更新日期：2016-02-22 00:00:00
abstract：:We present a novel, non-invasive magnetic resonance imaging (MRI) technique to assess real-time dynamic vasomodulation of the microvascular bed. Unlike existing perfusion imaging techniques, our method is sensitive only to blood volume and not flow velocity. Using graded gas challenges and a long-life, blood-pool T 1-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06983-6
更新日期：2017-08-07 00:00:00
abstract：:Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence in pediatric IBD remains unknown. We carried out a cross-sectional study in 63 children with Crohn's disease (CD) and 48 with ulcerative colitis (UC) to assess the prevalence of vitamin K deficiency and to searc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04768
更新日期：2014-04-24 00:00:00
abstract：:Human papillomavirus (HPV) is the most common sexually transmitted infection in the world and the main cause of cervical cancer. Nowadays, the virus-like particles (VLPs) based on L1 proteins have been considered as the best candidate for vaccine development against HPV infections. Two commercial HPV (Gardasil and Cer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51679-8
更新日期：2019-10-23 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is a common health problem during pregnancy and its prevalence is increasing globally, especially in China. The aim of this study was to investigate socioeconomic, environmental and lifestyle factors associated with GDM in Chinese women. A matched pair case-control study was conduct...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26412-6
更新日期：2018-05-25 00:00:00
abstract：:High Resolution Melt (HRM) is a versatile and rapid post-PCR DNA analysis technique primarily used to differentiate sequence variants among only a few short amplicons. We recently developed a one-vs-one support vector machine algorithm (OVO SVM) that enables the use of HRM for identifying numerous short amplicon seque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19218
更新日期：2016-01-18 00:00:00
