Mitochondria-targeted antioxidants as highly effective antibiotics.


:Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positive Bacillus subtilis, Mycobacterium sp. and Staphylococcus aureus and Gram-negative Photobacterium phosphoreum and Rhodobacter sphaeroides in submicromolar and micromolar concentrations. SkQ1 exhibited less antibiotic activity towards Escherichia coli due to the presence of the highly effective multidrug resistance pump AcrAB-TolC. E. coli mutants lacking AcrAB-TolC showed similar SkQ1 sensitivity, as B. subtilis. Lowering of the bacterial membrane potential by SkQ1 might be involved in the mechanism of its bactericidal action. No significant cytotoxic effect on mammalian cells was observed at bacteriotoxic concentrations of SkQ1. Therefore, SkQ1 may be effective in protection of the infected mammals by killing invading bacteria.


Sci Rep


Scientific reports


Nazarov PA,Osterman IA,Tokarchuk AV,Karakozova MV,Korshunova GA,Lyamzaev KG,Skulachev MV,Kotova EA,Skulachev VP,Antonenko YN




Has Abstract


2017-05-03 00:00:00












  • A membrane-inserted structural model of the yeast mitofusin Fzo1.

    abstract::Mitofusins are large transmembrane GTPases of the dynamin-related protein family, and are required for the tethering and fusion of mitochondrial outer membranes. Their full-length structures remain unknown, which is a limiting factor in the study of outer membrane fusion. We investigated the structure and dynamics of ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: De Vecchis D,Cavellini L,Baaden M,Hénin J,Cohen MM,Taly A

    更新日期:2017-08-31 00:00:00

  • The association between oxidative stress and corneal hysteresis in patients with glaucoma.

    abstract::Systemic antioxidative status has been implicated in glaucoma pathogenesis. Additionally, corneal hysteresis (CH) may contribute to glaucoma progression. Here, we evaluated the relationship between biological antioxidant potential (BAP) and CH. This study included 103 patients with open-angle glaucoma (OAG). We used a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Uchida K,Himori N,Hashimoto K,Shiga Y,Tsuda S,Omodaka K,Nakazawa T

    更新日期:2020-01-17 00:00:00

  • The capacity of wastewater treatment plants drives bacterial community structure and its assembly.

    abstract::Bacterial communities in wastewater treatment plants (WWTPs) affect plant functionality through their role in the removal of pollutants from wastewater. Bacterial communities vary extensively based on plant operating conditions and influent characteristics. The capacity of WWTPs can also affect the bacterial community...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kim YK,Yoo K,Kim MS,Han I,Lee M,Kang BR,Lee TK,Park J

    更新日期:2019-10-15 00:00:00

  • Biology and survival of extremely halophilic archaeon Haloarcula marismortui RR12 isolated from Mumbai salterns, India in response to salinity stress.

    abstract::Haloarchaea are unique microorganism's resistant to environmental and osmotic stresses and thrive in their habitats despite extreme fluctuating salinities. In the present study, haloarchaea were isolated from hypersaline thalossohaline salterns of Bhandup, Mumbai, India and were identified as Haloferax prahovense, Hal...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Thombre RS,Shinde VD,Oke RS,Dhar SK,Shouche YS

    更新日期:2016-05-27 00:00:00

  • Submarine Landslides Induce Massive Waves in Subsea Brine Pools.

    abstract::Subsea hypersaline anoxic brine pools are among the most extreme habitable environments on Earth that offer clues to life on other planets. Brine is toxic to macrofauna as remotely operated vehicles commonly observe dead and preserved remains in brine pools. While brine pools are often assumed to be stable stratified ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Sawyer DE,Mason RA,Cook AE,Portnov A

    更新日期:2019-01-15 00:00:00

  • Entropy of radiation: the unseen side of light.

    abstract::Despite the fact that 2015 was the international year of light, no mention was made of the fact that radiation contains entropy as well as energy, with different spectral distributions. Whereas the energy function has been vastly studied, the radiation entropy distribution has not been analysed at the same speed. The ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Delgado-Bonal A

    更新日期:2017-05-10 00:00:00

  • Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes.

    abstract::Frataxin is a highly conserved protein encoded by the frataxin (FXN) gene. The full-length 210-amino acid form of protein frataxin (1-210; isoform A) expressed in the cytosol of cells rapidly translocates to the mitochondria, where it is converted to the mature form (81-210) by mitochondrial processing peptidase. Matu...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Guo L,Wang Q,Weng L,Hauser LA,Strawser CJ,Mesaros C,Lynch DR,Blair IA

    更新日期:2018-11-19 00:00:00

  • 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione inhibits the growth and metastasis of breast carcinoma in mice.

    abstract::Metastasis causes approximately 90% of breast cancer-related deaths in women. Previously, we have demonstrated that 2-dodecyl-6-methoxycyclohexa-2,5-diene- 1,4-dione (DMDD) remarkably inhibited the growth of human breast cancer cells with little toxicity. In this study, we investigated the toxicity and efficacy of DMD...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chen C,Nong Z,Xie Q,He J,Cai W,Tang X,Chen X,Huang R,Gao Y

    更新日期:2017-07-27 00:00:00

  • Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage.

    abstract::Tissue damage induces rapid recruitment of leukocytes and changes in the transcriptional landscape that influence wound healing. However, the cell-type specific transcriptional changes that influence leukocyte function and tissue repair have not been well characterized. Here, we employed translating ribosome affinity ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Houseright RA,Rosowski EE,Lam PY,Tauzin SJM,Mulvaney O,Dewey CN,Huttenlocher A

    更新日期:2020-09-24 00:00:00

  • Author Correction: Analysis of sequencing strategies and tools for taxonomic annotation: Defining standards for progressive metagenomics.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Escobar-Zepeda A,Godoy-Lozano EE,Raggi L,Segovia L,Merino E,Gutiérrez-Rios RM,Juarez K,Licea-Navarro AF,Pardo-Lopez L,Sanchez-Flores A

    更新日期:2020-03-03 00:00:00

  • Aspirin upregulates αB-Crystallin to protect the myocardium against heat stress in broiler chickens.

    abstract::We established in vivo and in vitro models to investigate the role of αB-Crystallin (CryAB) and assess the ability of aspirin (ASA) to protect the myocardium during prolonged heat stress. Thirty-day-old chickens were divided into three groups (n = 90): heat stress (HS, 40±1 °C); ASA(-)HS(+), 1 mg/kg ASA orally 2 h bef...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Tang S,Yin B,Song E,Chen H,Cheng Y,Zhang X,Bao E,Hartung J

    更新日期:2016-11-18 00:00:00

  • Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger.

    abstract::Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction. Intranasal insulin is a promising tool to investigate central insulin action in humans. We evaluated the acute effects of 160 U intranasal insulin on resting-state brain functional connectivity in healthy young adults. Twenty-...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章


    authors: Kullmann S,Heni M,Veit R,Scheffler K,Machann J,Häring HU,Fritsche A,Preissl H

    更新日期:2017-05-09 00:00:00

  • MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function.

    abstract::Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a hallmark of many genetic diseases and plays a key role in tumor progression. The essential role of mitochondria, added to their recently documented capacity to transfer from cell to cell, obviously contributes to their curr...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Caicedo A,Fritz V,Brondello JM,Ayala M,Dennemont I,Abdellaoui N,de Fraipont F,Moisan A,Prouteau CA,Boukhaddaoui H,Jorgensen C,Vignais ML

    更新日期:2015-03-13 00:00:00

  • Single cell profiling of capillary blood enables out of clinic human immunity studies.

    abstract::An individual's immune system is driven by both genetic and environmental factors that vary over time. To better understand the temporal and inter-individual variability of gene expression within distinct immune cell types, we developed a platform that leverages multiplexed single-cell sequencing and out-of-clinic cap...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dobreva T,Brown D,Park JH,Thomson M

    更新日期:2020-11-25 00:00:00

  • Mobilization of Stem and Progenitor Cells in Septic Shock Patients.

    abstract::Septic shock is associated with multiple injuries to organs and tissues. These events may induce the regenerative response of adult stem cells. However, little is known about how endogenous stem cells are modulated by sepsis. This study analyzed the circulation of hematopoietic stem cells (HSCs), endothelial progenito...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Skirecki T,Mikaszewska-Sokolewicz M,Godlewska M,Dołęgowska B,Czubak J,Hoser G,Kawiak J,Zielińska-Borkowska U

    更新日期:2019-03-01 00:00:00

  • Spatial boundary of urban 'acid islands' in southern China.

    abstract::Elevated emissions of sulfur dioxide, nitrogen oxides and ammonia in China have resulted in high levels of sulfur and nitrogen deposition, being contributors to soil acidification, especially in and near large cities. However, knowledge gaps still exist in the way that large cities shape spatial patterns of acid depos...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Du E,de Vries W,Liu X,Fang J,Galloway JN,Jiang Y

    更新日期:2015-07-27 00:00:00

  • Estimation of chimpanzee age based on DNA methylation.

    abstract::In wild animal conservation, knowing the age of an individual animal is extremely beneficial. However, estimating the age is difficult for many species. Recently, epigenetics-based methods of estimating age have been reported. These studies were predominantly on humans with few reports on other animals, especially wil...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ito H,Udono T,Hirata S,Inoue-Murayama M

    更新日期:2018-07-03 00:00:00

  • Maskless inverted pyramid texturization of silicon.

    abstract::We discovered a technical solution of such outstanding importance that it can trigger new approaches in silicon wet etching processing and, in particular, photovoltaic cell manufacturing. The so called inverted pyramid arrays, outperforming conventional pyramid textures and black silicon because of their superior ligh...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang Y,Yang L,Liu Y,Mei Z,Chen W,Li J,Liang H,Kuznetsov A,Xiaolong D

    更新日期:2015-06-02 00:00:00

  • The impact of computed high b-value images on the diagnostic accuracy of DWI for prostate cancer: A receiver operating characteristics analysis.

    abstract::To evaluate the performance of computed high b value diffusion-weighted images (DWI) in prostate cancer detection. 97 consecutive patients who had undergone multiparametric MRI of the prostate followed by biopsy were reviewed. Five radiologists independently scored 138 lesions on native high b-value images (b = 1200 s...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ning P,Shi D,Sonn GA,Vasanawala SS,Loening AM,Ghanouni P,Obara P,Shin LK,Fan RE,Hargreaves BA,Daniel BL

    更新日期:2018-02-21 00:00:00

  • Graft revascularization is essential for non-invasive monitoring of transplanted islets with radiolabeled exendin.

    abstract::Islet transplantation is a novel promising strategy to cure type 1 diabetes. However, the long-term outcome is still poor, because both function and survival of the transplant decline over-time. Non-invasive imaging methods have the potential to enable monitoring of islet survival after transplantation and the effects...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Eter WA,Bos D,Frielink C,Boerman OC,Brom M,Gotthardt M

    更新日期:2015-10-22 00:00:00

  • Structure-Activity Analysis of Gram-positive Bacterium-producing Lasso Peptides with Anti-mycobacterial Activity.

    abstract::Lariatin A, an 18-residue lasso peptide encoded by the five-gene cluster larABCDE, displays potent and selective anti-mycobacterial activity. The structural feature is an N-terminal macrolactam ring, through which the C-terminal passed to form the rigid lariat-protoknot structure. In the present study, we established ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Inokoshi J,Koyama N,Miyake M,Shimizu Y,Tomoda H

    更新日期:2016-07-26 00:00:00

  • Association of BRCA1 promoter methylation with sporadic breast cancers: Evidence from 40 studies.

    abstract::Breast cancer susceptibility gene 1 (BRCA1) located at chromosome 17q12-21 is a classic tumor suppressor gene, and has been considered as a significant role in hereditary breast cancers. Moreover, numerous studies demonstrated the methylation status of CpG islands in the promoter regions of BRCA1 gene was aberrant in ...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析


    authors: Zhang L,Long X

    更新日期:2015-12-08 00:00:00

  • Top down and bottom up selection drives variations in frequency and form of a visual signal.

    abstract::The frequency and form of visual signals can be shaped by selection from predators, prey or both. When a signal simultaneously attracts predators and prey selection may favour a strategy that minimizes risks while attracting prey. Accordingly, varying the frequency and form of the silken decorations added to their web...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yeh CW,Blamires SJ,Liao CP,Tso IM

    更新日期:2015-03-30 00:00:00

  • Enhanced segregation of concurrent sounds with similar spectral uncertainties in individuals with autism spectrum disorder.

    abstract::When acoustic signals from different sound sources are mixed upon arrival at the ears, the auditory system organizes these acoustic elements by their features. This study shows that individuals with autism spectrum disorder (ASD) performed better in terms of hearing a target sequence among distractors that had similar...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lin IF,Yamada T,Komine Y,Kato N,Kashino M

    更新日期:2015-05-22 00:00:00

  • Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals.

    abstract::The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Scaduto P,Sequeira A,Vawter MP,Bunney W,Limon A

    更新日期:2020-05-25 00:00:00

  • Dyschloremia is associated with failure to restore renal function in survivors with acute kidney injury: an observation retrospective study.

    abstract::Dyschloremia is common in critically ill patients. However, little is known about the effects of dyschloremia on renal function in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). A total of 483 patients who received CRRT for AKI were selected and divided into three groups...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kee YK,Jeon HJ,Oh J,Shin DH

    更新日期:2020-11-12 00:00:00

  • Experimental demonstration of plasmon enhanced energy transfer rate in NaYF4:Yb(3+),Er(3+) upconversion nanoparticles.

    abstract::Energy transfer upconversion (ETU) is known to be the most efficient frequency upconversion mechanism. Surface plasmon can further enhance the upconversion process, opening doors to many applications. However, ETU is a complex process involving competing transitions between multiple energy levels and it has been diffi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lu D,Mao C,Cho SK,Ahn S,Park W

    更新日期:2016-01-07 00:00:00

  • Analysis of repetitive element expression in the blood and skin of patients with Parkinson's disease identifies differential expression of satellite elements.

    abstract::Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with the observation of aberrant expression of RE posing a mut...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Billingsley KJ,Lättekivi F,Planken A,Reimann E,Kurvits L,Kadastik-Eerme L,Kasterpalu KM,Bubb VJ,Quinn JP,Kõks S,Taba P

    更新日期:2019-03-13 00:00:00

  • Elucidation of microstructural changes in leaves during senescence using spectral domain optical coherence tomography.

    abstract::Leaf senescence provides a unique window to explore the age-dependent programmed degradation at organ label in plants. Here, spectral domain optical coherence tomography (SD-OCT) has been used to study in vivo senescing leaf microstructural changes in the deciduous plant Acer serrulatum Hayata. Hayata leaves show autu...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Anna T,Chakraborty S,Cheng CY,Srivastava V,Chiou A,Kuo WC

    更新日期:2019-02-04 00:00:00

  • Network pharmacology based virtual screening of active constituents of Prunella vulgaris L. and the molecular mechanism against breast cancer.

    abstract::Prunella vulgaris L, a perennial herb widely used in Asia in the treatment of various diseases including cancer. In vitro studies have demonstrated the therapeutic effect of Prunella vulgaris L. against breast cancer through multiple pathways. However, the nature of the biological mechanisms remains unclear. In this s...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhang X,Shen T,Zhou X,Tang X,Gao R,Xu L,Wang L,Zhou Z,Lin J,Hu Y

    更新日期:2020-09-25 00:00:00