Mitochondria-targeted antioxidants as highly effective antibiotics.

abstract：:Mitofusins are large transmembrane GTPases of the dynamin-related protein family, and are required for the tethering and fusion of mitochondrial outer membranes. Their full-length structures remain unknown, which is a limiting factor in the study of outer membrane fusion. We investigated the structure and dynamics of ...

journal_title：Scientific reports

authors： De Vecchis D,Cavellini L,Baaden M,Hénin J,Cohen MM,Taly A

更新日期：2017-08-31 00:00:00

abstract：:Systemic antioxidative status has been implicated in glaucoma pathogenesis. Additionally, corneal hysteresis (CH) may contribute to glaucoma progression. Here, we evaluated the relationship between biological antioxidant potential (BAP) and CH. This study included 103 patients with open-angle glaucoma (OAG). We used a...

journal_title：Scientific reports

authors： Uchida K,Himori N,Hashimoto K,Shiga Y,Tsuda S,Omodaka K,Nakazawa T

更新日期：2020-01-17 00:00:00

abstract：:Bacterial communities in wastewater treatment plants (WWTPs) affect plant functionality through their role in the removal of pollutants from wastewater. Bacterial communities vary extensively based on plant operating conditions and influent characteristics. The capacity of WWTPs can also affect the bacterial community...

journal_title：Scientific reports

authors： Kim YK,Yoo K,Kim MS,Han I,Lee M,Kang BR,Lee TK,Park J

更新日期：2019-10-15 00:00:00

abstract：:Haloarchaea are unique microorganism's resistant to environmental and osmotic stresses and thrive in their habitats despite extreme fluctuating salinities. In the present study, haloarchaea were isolated from hypersaline thalossohaline salterns of Bhandup, Mumbai, India and were identified as Haloferax prahovense, Hal...

journal_title：Scientific reports

authors： Thombre RS,Shinde VD,Oke RS,Dhar SK,Shouche YS

更新日期：2016-05-27 00:00:00

abstract：:Subsea hypersaline anoxic brine pools are among the most extreme habitable environments on Earth that offer clues to life on other planets. Brine is toxic to macrofauna as remotely operated vehicles commonly observe dead and preserved remains in brine pools. While brine pools are often assumed to be stable stratified ...

journal_title：Scientific reports

authors： Sawyer DE,Mason RA,Cook AE,Portnov A

更新日期：2019-01-15 00:00:00

abstract：:Despite the fact that 2015 was the international year of light, no mention was made of the fact that radiation contains entropy as well as energy, with different spectral distributions. Whereas the energy function has been vastly studied, the radiation entropy distribution has not been analysed at the same speed. The ...

journal_title：Scientific reports

authors： Delgado-Bonal A

更新日期：2017-05-10 00:00:00

abstract：:Frataxin is a highly conserved protein encoded by the frataxin (FXN) gene. The full-length 210-amino acid form of protein frataxin (1-210; isoform A) expressed in the cytosol of cells rapidly translocates to the mitochondria, where it is converted to the mature form (81-210) by mitochondrial processing peptidase. Matu...

journal_title：Scientific reports

authors： Guo L,Wang Q,Weng L,Hauser LA,Strawser CJ,Mesaros C,Lynch DR,Blair IA

更新日期：2018-11-19 00:00:00

abstract：:Metastasis causes approximately 90% of breast cancer-related deaths in women. Previously, we have demonstrated that 2-dodecyl-6-methoxycyclohexa-2,5-diene- 1,4-dione (DMDD) remarkably inhibited the growth of human breast cancer cells with little toxicity. In this study, we investigated the toxicity and efficacy of DMD...

journal_title：Scientific reports

authors： Chen C,Nong Z,Xie Q,He J,Cai W,Tang X,Chen X,Huang R,Gao Y

更新日期：2017-07-27 00:00:00

abstract：:Tissue damage induces rapid recruitment of leukocytes and changes in the transcriptional landscape that influence wound healing. However, the cell-type specific transcriptional changes that influence leukocyte function and tissue repair have not been well characterized. Here, we employed translating ribosome affinity ...

journal_title：Scientific reports

authors： Houseright RA,Rosowski EE,Lam PY,Tauzin SJM,Mulvaney O,Dewey CN,Huttenlocher A

更新日期：2020-09-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Escobar-Zepeda A,Godoy-Lozano EE,Raggi L,Segovia L,Merino E,Gutiérrez-Rios RM,Juarez K,Licea-Navarro AF,Pardo-Lopez L,Sanchez-Flores A

更新日期：2020-03-03 00:00:00

abstract：:We established in vivo and in vitro models to investigate the role of αB-Crystallin (CryAB) and assess the ability of aspirin (ASA) to protect the myocardium during prolonged heat stress. Thirty-day-old chickens were divided into three groups (n = 90): heat stress (HS, 40±1 °C); ASA(-)HS(+), 1 mg/kg ASA orally 2 h bef...

journal_title：Scientific reports

authors： Tang S,Yin B,Song E,Chen H,Cheng Y,Zhang X,Bao E,Hartung J

更新日期：2016-11-18 00:00:00

abstract：:Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction. Intranasal insulin is a promising tool to investigate central insulin action in humans. We evaluated the acute effects of 160 U intranasal insulin on resting-state brain functional connectivity in healthy young adults. Twenty-...

journal_title：Scientific reports

authors： Kullmann S,Heni M,Veit R,Scheffler K,Machann J,Häring HU,Fritsche A,Preissl H

更新日期：2017-05-09 00:00:00

abstract：:Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a hallmark of many genetic diseases and plays a key role in tumor progression. The essential role of mitochondria, added to their recently documented capacity to transfer from cell to cell, obviously contributes to their curr...

journal_title：Scientific reports

authors： Caicedo A,Fritz V,Brondello JM,Ayala M,Dennemont I,Abdellaoui N,de Fraipont F,Moisan A,Prouteau CA,Boukhaddaoui H,Jorgensen C,Vignais ML

更新日期：2015-03-13 00:00:00

abstract：:An individual's immune system is driven by both genetic and environmental factors that vary over time. To better understand the temporal and inter-individual variability of gene expression within distinct immune cell types, we developed a platform that leverages multiplexed single-cell sequencing and out-of-clinic cap...

journal_title：Scientific reports

authors： Dobreva T,Brown D,Park JH,Thomson M

更新日期：2020-11-25 00:00:00

abstract：:Septic shock is associated with multiple injuries to organs and tissues. These events may induce the regenerative response of adult stem cells. However, little is known about how endogenous stem cells are modulated by sepsis. This study analyzed the circulation of hematopoietic stem cells (HSCs), endothelial progenito...

journal_title：Scientific reports

authors： Skirecki T,Mikaszewska-Sokolewicz M,Godlewska M,Dołęgowska B,Czubak J,Hoser G,Kawiak J,Zielińska-Borkowska U

更新日期：2019-03-01 00:00:00

abstract：:Elevated emissions of sulfur dioxide, nitrogen oxides and ammonia in China have resulted in high levels of sulfur and nitrogen deposition, being contributors to soil acidification, especially in and near large cities. However, knowledge gaps still exist in the way that large cities shape spatial patterns of acid depos...

journal_title：Scientific reports

authors： Du E,de Vries W,Liu X,Fang J,Galloway JN,Jiang Y

更新日期：2015-07-27 00:00:00

abstract：:In wild animal conservation, knowing the age of an individual animal is extremely beneficial. However, estimating the age is difficult for many species. Recently, epigenetics-based methods of estimating age have been reported. These studies were predominantly on humans with few reports on other animals, especially wil...

journal_title：Scientific reports

authors： Ito H,Udono T,Hirata S,Inoue-Murayama M

更新日期：2018-07-03 00:00:00

abstract：:We discovered a technical solution of such outstanding importance that it can trigger new approaches in silicon wet etching processing and, in particular, photovoltaic cell manufacturing. The so called inverted pyramid arrays, outperforming conventional pyramid textures and black silicon because of their superior ligh...

journal_title：Scientific reports

authors： Wang Y,Yang L,Liu Y,Mei Z,Chen W,Li J,Liang H,Kuznetsov A,Xiaolong D

更新日期：2015-06-02 00:00:00

abstract：:To evaluate the performance of computed high b value diffusion-weighted images (DWI) in prostate cancer detection. 97 consecutive patients who had undergone multiparametric MRI of the prostate followed by biopsy were reviewed. Five radiologists independently scored 138 lesions on native high b-value images (b = 1200 s...

journal_title：Scientific reports

authors： Ning P,Shi D,Sonn GA,Vasanawala SS,Loening AM,Ghanouni P,Obara P,Shin LK,Fan RE,Hargreaves BA,Daniel BL

更新日期：2018-02-21 00:00:00

abstract：:Islet transplantation is a novel promising strategy to cure type 1 diabetes. However, the long-term outcome is still poor, because both function and survival of the transplant decline over-time. Non-invasive imaging methods have the potential to enable monitoring of islet survival after transplantation and the effects...

journal_title：Scientific reports

authors： Eter WA,Bos D,Frielink C,Boerman OC,Brom M,Gotthardt M

更新日期：2015-10-22 00:00:00

abstract：:Lariatin A, an 18-residue lasso peptide encoded by the five-gene cluster larABCDE, displays potent and selective anti-mycobacterial activity. The structural feature is an N-terminal macrolactam ring, through which the C-terminal passed to form the rigid lariat-protoknot structure. In the present study, we established ...

journal_title：Scientific reports

authors： Inokoshi J,Koyama N,Miyake M,Shimizu Y,Tomoda H

更新日期：2016-07-26 00:00:00

abstract：:Breast cancer susceptibility gene 1 (BRCA1) located at chromosome 17q12-21 is a classic tumor suppressor gene, and has been considered as a significant role in hereditary breast cancers. Moreover, numerous studies demonstrated the methylation status of CpG islands in the promoter regions of BRCA1 gene was aberrant in ...

journal_title：Scientific reports

authors： Zhang L,Long X

更新日期：2015-12-08 00:00:00

abstract：:The frequency and form of visual signals can be shaped by selection from predators, prey or both. When a signal simultaneously attracts predators and prey selection may favour a strategy that minimizes risks while attracting prey. Accordingly, varying the frequency and form of the silken decorations added to their web...

journal_title：Scientific reports

authors： Yeh CW,Blamires SJ,Liao CP,Tso IM

更新日期：2015-03-30 00:00:00

abstract：:When acoustic signals from different sound sources are mixed upon arrival at the ears, the auditory system organizes these acoustic elements by their features. This study shows that individuals with autism spectrum disorder (ASD) performed better in terms of hearing a target sequence among distractors that had similar...

journal_title：Scientific reports

authors： Lin IF,Yamada T,Komine Y,Kato N,Kashino M

更新日期：2015-05-22 00:00:00

abstract：:The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue...

journal_title：Scientific reports

authors： Scaduto P,Sequeira A,Vawter MP,Bunney W,Limon A

更新日期：2020-05-25 00:00:00

abstract：:Dyschloremia is common in critically ill patients. However, little is known about the effects of dyschloremia on renal function in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). A total of 483 patients who received CRRT for AKI were selected and divided into three groups...

journal_title：Scientific reports

authors： Kee YK,Jeon HJ,Oh J,Shin DH

更新日期：2020-11-12 00:00:00

abstract：:Energy transfer upconversion (ETU) is known to be the most efficient frequency upconversion mechanism. Surface plasmon can further enhance the upconversion process, opening doors to many applications. However, ETU is a complex process involving competing transitions between multiple energy levels and it has been diffi...

journal_title：Scientific reports

authors： Lu D,Mao C,Cho SK,Ahn S,Park W

更新日期：2016-01-07 00:00:00

abstract：:Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with the observation of aberrant expression of RE posing a mut...

journal_title：Scientific reports

authors： Billingsley KJ,Lättekivi F,Planken A,Reimann E,Kurvits L,Kadastik-Eerme L,Kasterpalu KM,Bubb VJ,Quinn JP,Kõks S,Taba P

更新日期：2019-03-13 00:00:00

abstract：:Leaf senescence provides a unique window to explore the age-dependent programmed degradation at organ label in plants. Here, spectral domain optical coherence tomography (SD-OCT) has been used to study in vivo senescing leaf microstructural changes in the deciduous plant Acer serrulatum Hayata. Hayata leaves show autu...

journal_title：Scientific reports

authors： Anna T,Chakraborty S,Cheng CY,Srivastava V,Chiou A,Kuo WC

更新日期：2019-02-04 00:00:00

abstract：:Prunella vulgaris L, a perennial herb widely used in Asia in the treatment of various diseases including cancer. In vitro studies have demonstrated the therapeutic effect of Prunella vulgaris L. against breast cancer through multiple pathways. However, the nature of the biological mechanisms remains unclear. In this s...

journal_title：Scientific reports

authors： Zhang X,Shen T,Zhou X,Tang X,Gao R,Xu L,Wang L,Zhou Z,Lin J,Hu Y

更新日期：2020-09-25 00:00:00