Mitochondria-targeted antioxidants as highly effective antibiotics.

abstract：:Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epigenetic marks at promoter or enhancer regions keeps genes expressed at low levels but poised for rapid activation. Typically, DNA at bivalent promoters is only lowly methylated i...

journal_title：Scientific reports

authors： Bernhart SH,Kretzmer H,Holdt LM,Jühling F,Ammerpohl O,Bergmann AK,Northoff BH,Doose G,Siebert R,Stadler PF,Hoffmann S

更新日期：2016-11-23 00:00:00

abstract：:Altering mechanical compliance in load carriage structures has shown to reduce metabolic cost and accelerative forces of carrying weight. Currently, modifications to load carriage structures have been primarily targeted at vertical motion of the carried mass. No study to date has investigated altering load carriage co...

journal_title：Scientific reports

authors： Martin JP,Li Q

更新日期：2018-09-13 00:00:00

abstract：:We have employed a model system, inspired by SNARE proteins, to facilitate membrane fusion between Giant Unilamellar Vesicles (GUVs) and Large Unilamellar Vesicles (LUVs) under physiological conditions. In this system, two synthetic lipopeptide constructs comprising the coiled-coil heterodimer-forming peptides K4, (KI...

journal_title：Scientific reports

authors： Mora NL,Boyle AL,Kolck BJV,Rossen A,Pokorná Š,Koukalová A,Šachl R,Hof M,Kros A

更新日期：2020-02-20 00:00:00

abstract：:Hookworms are one of the most prevalent and important parasites, infecting ~500 million people worldwide. Hookworm disease is among the leading causes of iron-deficiency anemia in the developing world and is associated with significant growth stunting and malnutrition. In humans, hookworms appear to impair memory and ...

journal_title：Scientific reports

authors： Pan SC,Ward DV,Yin Y,Hu Y,Elfawal MA,Clark RE,Aroian RV

更新日期：2019-05-27 00:00:00

abstract：:Neuregulin 4 (NRG4), an epidermal growth factor-like signaling molecule, plays an important role in cell-to-cell communication during tissue development. Its function to regulate energy metabolism has recently been reported. This current study was designed to assess the preventive and therapeutic effects of NRG4 overe...

journal_title：Scientific reports

authors： Ma Y,Gao M,Liu D

更新日期：2016-05-17 00:00:00

abstract：:Implantable 3D engineered vascular tissue constructs can be formed by co-culturing endothelial and fibroblast cells on macroporous scaffolds. Here we show that these constructs can be used for studying the dynamics of neovascular formation in-vitro by a combination of live confocal imaging and an array of image proces...

journal_title：Scientific reports

authors： Blinder YJ,Freiman A,Raindel N,Mooney DJ,Levenberg S

更新日期：2015-12-09 00:00:00

abstract：:Advances in lab-on-a-chip (LOC) devices have led to significant improvements in the on-chip manipulation, separation, sorting, and isolation of particles and cells. Among various LOC-based approaches such as inertia-based methods, acoustophoresis, and magnetophoresis, the planar-slanted-electrode dielectrophoresis (DE...

journal_title：Scientific reports

authors： Dalili A,Taatizadeh E,Tahmooressi H,Tasnim N,Rellstab-Sánchez PI,Shaunessy M,Najjaran H,Hoorfar M

更新日期：2020-07-16 00:00:00

abstract：:By means of extensive ab initio calculations, a new two-dimensional (2D) atomic material tin selenide monolayer (coined as tinselenidene) is predicted to be a semiconductor with an indirect gap (~1.45 eV) and a high hole mobility (of order 10000 cm(2)V(-1)S(-1)), and will bear an indirect-direct gap transition under a...

journal_title：Scientific reports

authors： Zhang LC,Qin G,Fang WZ,Cui HJ,Zheng QR,Yan QB,Su G

更新日期：2016-02-01 00:00:00

abstract：:We aim to evaluate the association of systolic and diastolic blood pressure (SBP and DBP) with estimated urinary sodium (Na) and potassium(K) excretions, and their gram-to-gram Na/K ratio across various salt-diet regions during 2005-2009 in China. A prospective cohort study was conducted to recruit 46,285 participants...

journal_title：Scientific reports

authors： Yin L,Deng G,Mente A,Sun Y,Liu X,Zhang X,Wang X,Wang Y,Bo J,Chen H,Liu X,Gao N,Bai X,Rangarajan S,Li W

更新日期：2018-04-30 00:00:00

abstract：:Bone is the most common site of distant relapse in breast cancer, leading to severe complications which dramatically affect the patients' quality of life. It is believed that the crosstalk between metastatic breast cancer cells and osteoclasts is critical for breast cancer-induced osteolysis. In this study, the effect...

journal_title：Scientific reports

authors： Feng MX,Hong JX,Wang Q,Fan YY,Yuan CT,Lei XH,Zhu M,Qin A,Chen HX,Hong D

更新日期：2016-01-08 00:00:00

abstract：:The aim of this study was to estimate the influence of regenerated tobacco on the extraction of Cd from two acidic soils as well as to address the problem of how to deal with contaminated leaves following phytoextraction. Results showed that a coppicing tobacco led to a decline in Cd concentration in regenerated leave...

journal_title：Scientific reports

authors： Yang Y,Ge Y,Zeng H,Zhou X,Peng L,Zeng Q

更新日期：2017-08-03 00:00:00

abstract：:Tau is a microtubule-associated protein whose C-terminal domain consisting of four repeat regions R1, R2, R3 and R4 binds to microtubules to stabilize them. In several neurodegenerative diseases, tau detaches from microtubules to form insoluble aggregates leading to tauopathy. Microtubules are made up of αβ tubulin su...

journal_title：Scientific reports

authors： Bhandare VV,Kumbhar BV,Kunwar A

更新日期：2019-07-25 00:00:00

abstract：:A series of nanocomposites of cobalt embedded in N-doped nanoporous carbons, carbon nanotubes or hollow carbon onions have been synthesized by a one-step carbonization of metal-organic-framework ZIF-67. The effect of the carbonization temperature on the structural evolution of the resulting nanocomposites has been inv...

journal_title：Scientific reports

authors： Chen B,Ma G,Zhu Y,Xia Y

更新日期：2017-07-13 00:00:00

abstract：:Structural materials used for safety critical applications require high strength and simultaneously high resistance against crack growth, referred to as damage tolerance. However, the two properties typically exclude each other and research efforts towards ever stronger materials are hampered by drastic loss of fractu...

journal_title：Scientific reports

authors： Hohenwarter A,Völker B,Kapp MW,Li Y,Goto S,Raabe D,Pippan R

更新日期：2016-09-14 00:00:00

abstract：:In this population-based retrospective study, we aimed to investigate the association between age at diagnosis and prognosis of pancreatic cancer (PC) patients using data from the National Cancer Institute's Surveillance, Epidemiology, and the End Results database. Different factors for stratification, like race, sex,...

journal_title：Scientific reports

authors： Wang H,Liu J,Xia G,Lei S,Huang X,Huang X

更新日期：2020-04-27 00:00:00

abstract：:Enterovirus 71 (EV71) is the predominant causative pathogen of hand-foot-and-mouth disease (HFMD). Contrary to other HFMD-causing enterovirus, EV71 can lead to severe neurological complications, even death. MicroRNAs (miRNAs) are small non-coding RNAs that constitute the largest family of gene regulators participating...

journal_title：Scientific reports

authors： Zheng C,Zheng Z,Sun J,Zhang Y,Wei C,Ke X,Liu Y,Deng L,Wang H

更新日期：2017-11-27 00:00:00

abstract：:Balance disorders have been poorly investigated and somewhat neglected in people infected with the human immunodeficiency virus, especially in children, whose have intrinsic and extrinsic risk factors that may compromise the balance. To evaluate the foot plantar pressures and the balance in children with acquired immu...

journal_title：Scientific reports

authors： da Silva Pontes L,Callegari B,Magno L,Moraes A,Silva BG,Manso K,Barros B,Araújo AP,Silva MC,Dias GA,Vasconcelos BH,Costa E Silva A,Libonati RM,Souza GS

更新日期：2019-03-13 00:00:00

abstract：:We report a method to promote photoluminescence emission in graphene materials by enhancing carrier scattering instead of directly modifying band structure in multilayer reduced graphene oxide (rGO) nanospheres. We intentionally curl graphene layers to form nanospheres by reducing graphene oxide with spherical polymer...

journal_title：Scientific reports

authors： Chen Q,Zhang C,Xue F,Zhou Y,Li W,Wang Y,Tu W,Zou Z,Wang X,Xiao M

更新日期：2013-01-01 00:00:00

abstract：:With about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte nucleus. How viral cccDNA gene expression is regulated by its chromatin structure; more importa...

journal_title：Scientific reports

authors： Alarcon V,Hernández S,Rubio L,Alvarez F,Flores Y,Varas-Godoy M,De Ferrari GV,Kann M,Villanueva RA,Loyola A

更新日期：2016-05-13 00:00:00

abstract：:We here describe the dc magnetic field over the human head produced by healthy hair follicles when the scalp is lightly pressed. This phenomenon was briefly reported decades earlier, where a double-planar SQUID (Superconducting Quantum Interference Devices) gradiometer at a single location was used. We here perform a ...

journal_title：Scientific reports

authors： Khan S,Cohen D

更新日期：2019-10-30 00:00:00

abstract：:Circular Dichroism data are often decomposed into their constituent spectra to quantify the secondary structure of peptides or proteins but the estimation of the secondary structure content fails when light scattering leads to spectral distortion. If peptide-induced liposome self-association occurs, subtracting contro...

journal_title：Scientific reports

authors： Vermeer LS,Marquette A,Schoup M,Fenard D,Galy A,Bechinger B

更新日期：2016-12-22 00:00:00

abstract：:Two decades ago, a phenomenon resembling Landau damping was described in the synchronization of globally coupled oscillators: the evidence of a regime where the order parameter decays when linear theory predicts neutral stability for the incoherent state. We here show that such an effect is far more generic, as soon a...

journal_title：Scientific reports

authors： Qiu T,Zhang Y,Liu J,Bi H,Boccaletti S,Liu Z,Guan S

更新日期：2015-12-14 00:00:00

abstract：:Recent studies have elucidated the crucial role for microRNAs in peripheral nerve myelination by ablating components of the microRNA synthesis machinery. Few studies have focused on the role of individual microRNAs. To fill this gap, we focused this study on miR-138, which was shown to be drastically reduced in Dicer1...

journal_title：Scientific reports

authors： Lin HP,Oksuz I,Svaren J,Awatramani R

更新日期：2018-02-28 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in guiding development and maintaining function of the human heart. Dysregulation of miRNAs has been linked to various congenital heart diseases including Tetralogy of Fallot (TOF), which represents the most common cyanotic heart malformation in humans. Several studies have id...

journal_title：Scientific reports

authors： Grunert M,Appelt S,Dunkel I,Berger F,Sperling SR

更新日期：2019-12-13 00:00:00

abstract：:Toll-like receptor 9 (TLR9) is crucial to the host immune response against fungi, such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, but its importance in Cryptococcus gattii infection is unknown. Our study aimed to understand the role of TLR9 during the course of experimental C. gattii infec...

journal_title：Scientific reports

authors： da Silva-Junior EB,Firmino-Cruz L,Guimarães-de-Oliveira JC,De-Medeiros JVR,de Oliveira Nascimento D,Freire-de-Lima M,de Brito-Gitirana L,Morrot A,Previato JO,Mendonça-Previato L,Decote-Ricardo D,de Matos Guedes HL,Freire-de-Lima

更新日期：2021-01-14 00:00:00

abstract：:Estimating regional nutrient criteria for streams and rivers is a key step toward protecting river water quality and restoring the health of aquatic ecosystems. Using a multivariable statistical analysis technique, nutrients were identified as the main factor influencing the degradation of the benthic macroinvertebrat...

journal_title：Scientific reports

authors： Chen J,Li F,Wang Y,Kong Y

更新日期：2018-02-28 00:00:00

abstract：:Cryo-electron microscopy (cryo-EM) has become a leading technology for determining protein structures. Recent advances in this field have allowed for atomic resolution. However, predicting the backbone trace of a protein has remained a challenge on all but the most pristine density maps (<2.5 Å resolution). Here we in...

journal_title：Scientific reports

authors： Si D,Moritz SA,Pfab J,Hou J,Cao R,Wang L,Wu T,Cheng J

更新日期：2020-03-09 00:00:00

abstract：:Rhythm is an essential element of dancing and music. To investigate the neural mechanisms underlying how rhythm is learned, we recorded electroencephalographic (EEG) data during a rhythm-reproducing task that asked participants to memorize an auditory stimulus and reproduce it via tapping. Based on the behavioral resu...

journal_title：Scientific reports

authors： Edagawa K,Kawasaki M

更新日期：2017-02-22 00:00:00

abstract：:Recent studies have linked appearance of Paneth cells in colorectal adenomas to adenoma burden and male gender. However, the clinical importance of Paneth cells' associations with synchronous advanced adenoma (AA) and colorectal carcinoma (CRC) is currently unclear. We performed a comprehensive case-control study usin...

journal_title：Scientific reports

authors： Mahon M,Xu J,Yi X,Liu X,Gao N,Zhang L

更新日期：2016-05-18 00:00:00

abstract：:Although biophysical yield responses to local warming have been studied, we know little about how crop yield growth-a function of climate and technology-responds to global temperature and socioeconomic changes. Here, we present the yield growth of major crops under warming conditions from preindustrial levels as simul...

journal_title：Scientific reports

authors： Iizumi T,Furuya J,Shen Z,Kim W,Okada M,Fujimori S,Hasegawa T,Nishimori M

更新日期：2017-08-10 00:00:00