Abstract：
:Recent studies have linked appearance of Paneth cells in colorectal adenomas to adenoma burden and male gender. However, the clinical importance of Paneth cells' associations with synchronous advanced adenoma (AA) and colorectal carcinoma (CRC) is currently unclear. We performed a comprehensive case-control study using 1,900 colorectal adenomas including 785 from females, and 1,115 from males. We prospectively reviewed and recorded Paneth cell status in the colorectal adenomas consecutively collected between February 2014 and June 2015. Multivariable logistic regression analyses revealed that, in contrast to the adenomas without Paneth cells, the Paneth cell-containing adenomas at distal colorectum were inversely associated with presence of a synchronous AA or CRC (odds ratio [OR] 0.39, P = 0.046), whereas no statistical significance was reached for Paneth cell-containing proximal colorectal adenomas (P = 0.33). Synchronous AA and CRC were significantly associated with older age (60 + versus <60 years, OR 1.60, P = 0.002), male gender (OR 1.42, P = 0.021), and a history of AA or CRC (OR 2.31, P < 0.001). However, synchronous CRC was not associated with Paneth cell status, or a history of AA or CRC. Paneth cell presence in the adenomas of distal colorectum may be a negative indicator for synchronous AA and CRC, and seems to warrant further studies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mahon M,Xu J,Yi X,Liu X,Gao N,Zhang Ldoi
10.1038/srep26129subject
Has Abstractpub_date
2016-05-18 00:00:00pages
26129issn
2045-2322pii
srep26129journal_volume
6pub_type
杂志文章abstract：:Loss of stromal Caveolin-1 (CAV1) expression is associated with poor prognosis in various cancers. We evaluated the prognostic value of CAV1 expression of both cancer cells and stromal cells in colorectal liver metastases (CRLM) in patients undergoing hepatectomy. In this retrospective study, 109 patients were enrolle...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02251-9
更新日期：2017-05-17 00:00:00
abstract：:There has been much interest recently in the discovery of thermally induced magnetisation switching using femtosecond laser excitation, where a ferrimagnetic system can be switched deterministically without an applied magnetic field. Experimental results suggest that the reversal occurs due to intrinsic material prope...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03262
更新日期：2013-11-20 00:00:00
abstract：:Why lightning sometimes has multiple discharges to ground is an unanswered question. Recently, the observation of small plasma structures on positive leaders re-ignited the search. These small plasma structures were observed as pulsing radio sources along the positive leader length and were named "needles". Needles ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74597-6
更新日期：2020-10-15 00:00:00
abstract：:As it is altered by ionizing radiation, the vascular network is considered as a prime target in limiting normal tissue damage and improving tumor control in radiation therapy. Irradiation activates endothelial cells which then participate in the recruitment of circulating cells, especially by overexpressing cell adhes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05563-y
更新日期：2017-07-13 00:00:00
abstract：:The number of magnetoelectric multiferroic materials reported to date is scarce, as magnetic structures that break inversion symmetry and induce an improper ferroelectric polarization typically arise through subtle competition between different magnetic interactions. The (NH4)2[FeCl5(H2O)] compound is a rare case wher...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14475
更新日期：2015-09-29 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62436-7
更新日期：2020-04-16 00:00:00
abstract：:Lipases are interfacially activated enzymes that catalyze the hydrolysis of ester bonds and constitute prime candidates for industrial and biotechnological applications ranging from detergent industry, to chiral organic synthesis. As a result, there is an incentive to understand the mechanisms underlying lipase activi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52539-1
更新日期：2019-11-07 00:00:00
abstract：:P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remains relatively unexplored. We charac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71753-w
更新日期：2020-09-24 00:00:00
abstract：:Aerosol nanoparticle injectors are fundamentally important for experiments where container-free sample handling is needed to study isolated nanoparticles. The injector consists of a nebuliser, a differential pumping unit, and an aerodynamic lens to create and deliver a focused particle beam to the interaction point in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45120-3
更新日期：2019-06-20 00:00:00
abstract：:The current economics of the fish protein industry demand rapid, accurate and expressive prediction algorithms at every step of protein production especially with the challenge of global climate change. This help to predict and analyze functional and nutritional quality then consequently control food allergies in hype...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10890-1
更新日期：2017-09-07 00:00:00
abstract：:Psychopathy is a personality disorder characterised by atypical moral behaviour likely rooted in atypical affective/motivational processing, as opposed to an inability to judge the wrongness of an action. Guilt is a moral emotion believed to play a crucial role in adherence to moral and social norms, but the mechanism...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36273
更新日期：2016-11-03 00:00:00
abstract：:We fabricated multi-layered graphene/MoS2 heterostructured devices by positioning mechanically exfoliated bulk graphite and single-crystalline 2H-MoS2 onto Au metal pads on a SiO2/Si substrate via a contamination-free dry transfer technique. We also studied the electrical transport properties of Au/MoS2 junction devic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13743
更新日期：2015-09-03 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-48627-x
更新日期：2019-08-28 00:00:00
abstract：:Peripheral artery disease (PAD) is a major cause of acute and chronic illness, with extremely poor prognosis that remains underdiagnosed and undertreated. Trimethylamine-N-Oxide (TMAO), a gut derived metabolite, has been associated with atherosclerotic burden. We determined plasma levels of TMAO by mass spectrometry a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52082-z
更新日期：2019-10-30 00:00:00
abstract：:Rapid urbanization is a global phenomenon that has altered many ecosystems, generating ecological risks such as causing a decline in many ecosystem services. In this study, ecosystem service oriented risk assessment combined with PSR were quantifying how urbanization influences the ecosystem services about Beijing-Tia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52719-z
更新日期：2019-11-14 00:00:00
abstract：:Growth factors have great therapeutic potential for various disease therapy and tissue engineering applications. However, their clinical efficacy is hampered by low bioavailability, rapid degradation in vivo and non-specific biodistribution. Nanoparticle based delivery systems are being evaluated to overcome these lim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14040-5
更新日期：2017-10-30 00:00:00
abstract：:The neuropathology of Parkinson's disease (PD) involves the frontal-subcortical circuit, an area responsible for processing affective theory of mind (ToM). Patients with PD are expected to experience deficits in the affective ToM. This study aims to investigate whether the ability to infer emotion in others is affecte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33988-6
更新日期：2018-10-30 00:00:00
abstract：:The manuscript highlights the efficacy of silver ions to act as a unique probe for the detection of bacterial contamination in water samples. The bacterial cell membrane adherence property of the silver ions was employed to develop two different bacterial detection assays employing colorimetric and electrochemical tec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68803-8
更新日期：2020-07-20 00:00:00
abstract：:To date there are thirteen species validly assigned to the genus Anaerococcus. Most of the species in this genus are anaerobic and of human origin. Anaerococcus urinimassiliensis sp. nov., strain Marseille-P2143T is member of family Peptoniphilaceae, which was isolated from the urine of a 17-year-old boy affected by a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82420-z
更新日期：2021-01-29 00:00:00
abstract：:Many behaviors of cancer, such as progression, metastasis and drug resistance etc., cannot be fully understood by genetic mutations or intracellular signaling alone. Instead, they are emergent properties of the cell community which forms a tumor. Studies of tumor heterogeneity reveal that many cancer behaviors critica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09307-w
更新日期：2017-08-18 00:00:00
abstract：:A single-institution series using a (neo)adjuvant chemotherapy and interdigitated hyperfractionated split-course radiation therapy (CRT) treatment protocol for soft tissue sarcoma was reviewed. Our specific aims were to study recurrence rates and long-term toxicity. Between 1998 and 2016, 89 patients with non-metastat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43794-3
更新日期：2019-05-13 00:00:00
abstract：:Urothelial carcinoma (UC) is a common disease causing significant morbidity and mortality as well as considerable costs for health systems. Extensive aberrant methylation of DNA is broadly documented in early UC, contributing to genetic instability, altered gene expression and tumor progression. However the triggers i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60796-8
更新日期：2020-03-02 00:00:00
abstract：:Melimine and Mel4 are chimeric cationic peptides with broad-spectrum antimicrobial activity. They have been shown to be highly biocompatible in animal models and human clinical trials. The current study examined the mechanism of action of these two antimicrobial peptides against P. aeruginosa. The effect of the peptid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42440-2
更新日期：2019-05-08 00:00:00
abstract：:The variation in mortality-to-incidence ratios (MIRs) among countries reflects the clinical outcomes and the available interventions for colorectal cancer treatments. The association between MIR of prostate cancer and cancer care disparities among countries is an interesting issue that is rarely investigated. For the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40003
更新日期：2017-01-04 00:00:00
abstract：:The most obvious method to observe transplanted islets in the liver is direct biopsy, but the distribution and location of the best biopsy site in the recipient's liver are poorly understood. Islets transplanted into the whole liver of five diabetic cynomolgus monkeys that underwent insulin-independent survival for an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57701-8
更新日期：2020-01-21 00:00:00
abstract：:Estradiol derived from neural aromatization of testosterone plays a key role in the organization and activation of neural structures underlying male behaviors. This study evaluated the contribution of the estrogen receptor (ER) β in estradiol-induced modulation of social and mood-related behaviors by using mice lackin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63427-4
更新日期：2020-04-10 00:00:00
abstract：:Three-dimensional (3D) spheroidal cell cultures are now recognised as better models of cancers as compared to traditional cell cultures. However, established 3D cell culturing protocols and techniques are time-consuming, manually laborious and often expensive due to the excessive consumption of reagents. Microfluidics...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72952-1
更新日期：2020-09-28 00:00:00
abstract：:FAS rs2234767 (-1377 G>A), rs1800682 (-670 A>G) and FASLG rs763110 (-844 C>T) promoter polymorphisms can influence transcriptional activities of the genes and thus multiple tumors susceptibility. To investigate their association with risk of colorectal cancer (CRC), the three SNPs were genotyped in 878 cases and 884 c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19229
更新日期：2016-01-13 00:00:00
abstract：:After the accident at the Fukushima Daiichi Nuclear Power Plant run by Tokyo Electric Power Company in 2011, breast milk samples obtained from volunteers living in Fukushima and neighboring prefectures were examined and small amounts of I-131 (2.2-36.3 Bq/kg) were detected in some samples. In this work, the I-131 conc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12426
更新日期：2015-07-22 00:00:00
abstract：:The concept of parity-time (PT) symmetry in SPPs is proposed and confirmed for the first time in this work. By introducing periodic modulation of the effective refractive index in SPP system, the asymmetric propagation is theoretically predicted and numerically demonstrated. After validation of this concept, we apply ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14981
更新日期：2015-10-08 00:00:00
