Abstract：
:Loss of stromal Caveolin-1 (CAV1) expression is associated with poor prognosis in various cancers. We evaluated the prognostic value of CAV1 expression of both cancer cells and stromal cells in colorectal liver metastases (CRLM) in patients undergoing hepatectomy. In this retrospective study, 109 patients were enrolled. CAV1 expression was studied by immunohistochemistry. The staining was scored semiquantitatively as weak or strong. Disease-free survival (DFS) and overall survival (OS) were calculated using both Kaplan-Meier and multivariate Coxregression methods. Weak stromal CAV1 expression was associated with decreased DFS and OS in univariate and in multivariate analysis (HR 2.00; 95% CI, 1.24-3.22; P = 0.004, and HR 2.47; 95% CI, 1.28-4.76; P = 0.007, respectively). Cancer cell CAV1 expression was not associated with DFS and OS. Five-year DFS and OS rates were 13% and 43%, respectively, in patients with weak stromal CAV1 expression and 40% and 71%, respectively, in patients with strong stromal CAV1 expression. In this study, we indicate that weak stromal CAV1 expression in CRLM is an adverse prognostic factor in patients who undergo liver resection for liver-only colorectal metastases. We suggest validation of this finding in an independent cohort and consideration of risk stratification for post-hepatectomy adjuvant follow-up and therapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Neofytou K,Pikoulis E,Petrou A,Agrogiannis G,Petrides C,Papakonstandinou I,Papalambros A,Aggelou A,Kavatzas N,Liakakos T,Felekouras Edoi
10.1038/s41598-017-02251-9subject
Has Abstractpub_date
2017-05-17 00:00:00pages
2058issue
1issn
2045-2322pii
10.1038/s41598-017-02251-9journal_volume
7pub_type
杂志文章abstract：:The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared to conventional CT for pulmonary imaging. A custom-made lung phantom, including nodules of different sizes and shapes, was scanned with a preclinical SPCCT and a conventional CT in standard and high-resolu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35888-1
更新日期：2018-11-26 00:00:00
abstract：:From 2010 to 2012, large outbreaks of EV-A71-related- hand foot and mouth disease (HFMD) occurred annually in China. Some cases had neurological complications and were closely associated with fatal cardiopulmonary collapse, but not all children with central nervous system (CNS) involvement demonstrated a poor prognosi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23444
更新日期：2016-03-22 00:00:00
abstract：:The Pregnane X Receptor (PXR) is a ligand-activated transcription factor belonging to the nuclear receptor family. PXR can bind diverse drugs and environmental toxicants with different binding modes, making it an intriguing target for drug discovery. Here we investigated the binding mechanism of the SR12813 ligand to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34373-z
更新日期：2018-11-01 00:00:00
abstract：:The human pyruvate dehydrogenase complex (PDC) comprises four multidomain components, E1, E3, E2 and an E3-binding protein (E3BP), the latter two forming the core as E2·E3BP sub-complex. Pyruvate flux through PDC is regulated via phosphorylation (inactivation) at E1 by four PDC kinases (PDKs), and reactivation by two ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42760
更新日期：2017-02-23 00:00:00
abstract：:Sterility mosaic disease (SMD) is one of the serious production constraints that may lead to complete yield loss in pigeonpea. Three mapping populations including two recombinant inbred lines and one F2, were used for phenotyping for SMD resistance at two locations in three different years. Genotyping-by-sequencing ap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01535-4
更新日期：2017-05-12 00:00:00
abstract：:Due to the limitations of current imaging techniques, visualization of lymphatic capillaries within tissue in vivo has been challenging. Here, we present a label-free high resolution optical coherence tomography (OCT) based lymphangiography (OLAG) within human skin in vivo. OLAG enables rapid (~seconds) mapping of lym...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21122
更新日期：2016-02-19 00:00:00
abstract：:Breast cancer survivors display altered inflammatory responses to immune challenges relative to cancer-naive controls likely due to previous cancer treatments, stress associated with cancer, and/or tumor physiology. Proper inflammatory responses are necessary for adaptive sickness behaviors (e.g., fatigue, anorexia, a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37334-8
更新日期：2019-01-24 00:00:00
abstract：:This work reports the first study of current-driven magnetization noise in a single, nanometerscale, ferromagnetic (Co) particle, attached to normal metal leads by high-resistance tunneling junctions. As the tunnel current increases at low temperature, the magnetic switching field decreases, its probability distributi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01200
更新日期：2013-01-01 00:00:00
abstract：:To survive and replicate in macrophages Mycobacterium tuberculosis (Mtb) has developed strategies to subvert host defence mechanisms, including autophagy. Autophagy induction has the potential to clear Mtb, but little is known about its effect during controlled tuberculosis and HIV co-infection. Mammalian target of ra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28171
更新日期：2016-06-15 00:00:00
abstract：:Functions of septin cytoskeletal polymers in tumorigenesis are still poorly defined. Their role in the regulation of cytokinesis and cell migration were proposed to contribute to cancer associated aneuploidy and metastasis. Overexpression of Septin 9 (Sept9) promotes migration of cancer cell lines. SEPT9 mRNA and prot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44976
更新日期：2017-03-24 00:00:00
abstract：:We investigated a high-quality MgB2 thin film with a thickness of ~1000 nm on an Al2O3 substrate using optical spectroscopy. We measured the reflectance spectra of the film at various temperatures both below, and above, the superconducting transition temperature, T c [Formula: see text] 40 K. An earlier study showed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09248-4
更新日期：2017-08-21 00:00:00
abstract：:We consider escape from a metastable state of a nonlinear oscillator driven close to triple its eigenfrequency. The oscillator can have three stable states of period-3 vibrations and a zero-amplitude state. Because of the symmetry of period-tripling, the zero-amplitude state remains stable as the driving increases. Ho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66243-y
更新日期：2020-06-26 00:00:00
abstract：:Melon (Cucumis melo L.) is a very important crop throughout the world and has great economic importance, in part due to its nutritional properties. It prefers well-drained soil with low acidity and has a strong demand for water during fruit set. Therefore, a correct water balance-involving aquaporins-is necessary to m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79250-w
更新日期：2020-12-17 00:00:00
abstract：:In this paper, a new type of porous ceramics was prepared using the raw sepiolite mineral. The porous ceramics was shaped by the dry pressing method and sintered in the range of 700 ~ 1200 °C. The temperature-microstructure evolution and the properties of porous sepiolite ceramics were investigated by thermo gravimetr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43918-9
更新日期：2019-05-14 00:00:00
abstract：:Intrinsically disordered proteins are abundant in the eukaryotic proteome, and they are implicated in a range of different diseases. However, there is a paucity of experimental data on molecular details of the coupled binding and folding of such proteins. Two interacting and relatively well studied disordered protein ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02076
更新日期：2013-01-01 00:00:00
abstract：:Contamination by endocrine disrupting compounds (EDCs) concerns the security and sustainability of a drinking water supply system and human exposure via water consumption. This study analyzed the selected EDCs in source (river water, n = 10) and supply (tap water, n = 155) points and the associated risks. A total of 1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74061-5
更新日期：2020-10-20 00:00:00
abstract：:Dibutyl phthalate (DBP) is recognized as an environmental endocrine disruptor that has been detected in fetal and postnatal samples. Recent evidence found that in utero DBP exposure was associated with an increase of adipose tissue weight and serum lipids in offspring, but the precise mechanism is unknown. Here we aim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73477-3
更新日期：2020-10-01 00:00:00
abstract：:Crustaceans form the second largest subphylum on Earth, which includes Litopeneaus vannamei (Pacific whiteleg shrimp), one of the most cultured shrimp worldwide. Despite efforts to study the shrimp microbiota, little is known about it from shrimp obtained from the open sea and the role that aquaculture plays in microb...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11805-w
更新日期：2017-09-18 00:00:00
abstract：:Long-read sequencing technologies such as Pacific Biosciences and Oxford Nanopore MinION are capable of producing long sequencing reads with average fragment lengths of over 10,000 base-pairs and maximum lengths reaching 100,000 base- pairs. Compared with short reads, the assemblies obtained from long-read sequencing ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03996-z
更新日期：2017-06-21 00:00:00
abstract：:There is increasing interest in the development of noninvasive diagnostic methods for early cancer detection, to improve the survival rate and quality of life of cancer patients. Identification of volatile metabolic compounds may provide an approach for noninvasive early diagnosis of malignant diseases. Here we analyz...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05196
更新日期：2014-06-06 00:00:00
abstract：:The SLRP opticin (OPTC) has been demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here, we investigated the in vivo effect of OPTC deficiency in OA cartilage. OA was induced in 10-week-old Optc -/- and Optc +/+ mice. Ten weeks post-surgery, cartilage was processed for histology and immu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18047-w
更新日期：2018-01-11 00:00:00
abstract：:The Law of the Minimum is often implemented using t-norm or fuzzy intersection. We propose the use of t-conorm or fuzzy union for climate suitability assessment of a grass species using annual ryegrass (Lolium multiflorum Lam.) as an example and evaluate the performance for alfalfa (Medicago sativa L.) and sorghum (So...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28291-3
更新日期：2018-07-05 00:00:00
abstract：:A neurogenic pathway, involving airway TRPV-1, has been implicated in acute cardiovascular events occurring after peaks of air pollution. We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variabi...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-72062-y
更新日期：2020-09-16 00:00:00
abstract：:Parkinson's disease (PD) is an incapacitating neurodegenerative disease. Patients with PD and their caregivers may have interactive effects on each other's psychological well-being. This study aimed to assess the dyadic dynamics of resilience, fatigue, and suicidal ideation on the depression severity of PD patients an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79609-z
更新日期：2021-01-13 00:00:00
abstract：:Protein aggregation is a common biological phenomenon, observed in different physiological and pathological conditions. Decreased protein solubility and a tendency to aggregate is also observed during physiological aging but the causes are currently unknown. Herein we performed a biophysical separation of aging-relate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19311
更新日期：2016-01-18 00:00:00
abstract：:Keratoconus (KC) is an ectatic corneal disease characterized by progressive thinning and irregular astigmatism, and a leading indication for corneal transplantation. KC-associated changes have been demonstrated for the entire cornea, but the pathological thinning and mechanical weakening is usually localized. We perfo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39182-6
更新日期：2019-02-27 00:00:00
abstract：:TLR4 is implicated in diseases associated with chronic low-grade inflammation, yet homeostatic signaling mechanisms that prevent and/or are affected by chronic TLR4 activation are largely uncharacterized. We recently reported that LPS/TLR4 activates in human leukocytes signaling intermediates (SI), abbreviated TLR4-SI...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43347-8
更新日期：2019-05-07 00:00:00
abstract：:During pregnancy a variety of immunological changes occur to accommodate the fetus. It is unknown whether these changes continue to affect humoral immunity postpartum or how quickly they resolve. IgG levels were measured to P. falciparum and P. vivax antigens in 201 postpartum and 201 controls over 12 weeks. Linear mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32159
更新日期：2016-08-25 00:00:00
abstract：:Biological networks play a key role in determining biological function and therefore, an understanding of their structure and dynamics is of central interest in systems biology. In Boolean models of such networks, the status of each molecule is either "on" or "off" and along with the molecules interact with each other...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20067
更新日期：2016-01-29 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-59134-9
更新日期：2020-02-06 00:00:00
