De novo yeast genome assemblies from MinION, PacBio and MiSeq platforms.

abstract：:Protein synthesis is traditionally associated with specific cytoplasmic compartments. We now show that OFD1, a centrosomal/basal body protein, interacts with components of the Preinitiation complex of translation (PIC) and of the eukaryotic Initiation Factor (eIF)4F complex and modulates the translation of specific mR...

journal_title：Scientific reports

authors： Iaconis D,Monti M,Renda M,van Koppen A,Tammaro R,Chiaravalli M,Cozzolino F,Pignata P,Crina C,Pucci P,Boletta A,Belcastro V,Giles RH,Surace EM,Gallo S,Pende M,Franco B

更新日期：2017-04-27 00:00:00

abstract：:Climate change is expected to have profound, partly unforeseeable effects on the composition of functional traits of complex ecosystems, such as coral reefs, and some ecosystem properties are at risk of disappearing. This study applies a novel spatially explicit, individual-based model to explore three critical life h...

journal_title：Scientific reports

authors： Kubicek A,Breckling B,Hoegh-Guldberg O,Reuter H

更新日期：2019-03-06 00:00:00

abstract：:Quantum key distribution involving decoy-states is a significant application of quantum information. By using three-intensity decoy-states of single-photon-added coherent sources, we propose a practically realizable scheme on quantum key distribution which approaches very closely the ideal asymptotic case of an infini...

journal_title：Scientific reports

authors： Wang D,Li M,Guo GC,Wang Q

更新日期：2015-10-14 00:00:00

abstract：:We perform this meta-analysis to compare the efficacy and safety of cryoablation versus radiofrequency ablation for patients with cavotricuspid valve isthmus dependent atrial flutter. By searching EMBASE, MEDLINE, PubMed and Cochrane electronic databases from March 1986 to September 2014, 7 randomized clinical trials ...

journal_title：Scientific reports

authors： Chen YH,Lin H,Xie CL,Zhang XT,Li YG

更新日期：2015-06-03 00:00:00

abstract：:Intracellular calcium ([Ca2+]i) signaling is an essential universal secondary messenger in articular chondrocytes. However, little is known about its spatiotemporal features in the context of osteoarthritis (OA). Herein, by examining the cartilage samples collected from patients undergoing knee arthroscopic surgery, w...

journal_title：Scientific reports

authors： Gong X,Xie W,Wang B,Gu L,Wang F,Ren X,Chen C,Yang L

更新日期：2017-12-06 00:00:00

abstract：:Thioflavin T (ThT) is standardly used as a fluorescent marker to detect aggregation of amyloid fibrils by conventional fluorescence microscopy, including polarization resolved imaging that brings information on the orientational order of the fibrils. These techniques are however diffraction limited and cannot provide ...

journal_title：Scientific reports

authors： Shaban HA,Valades-Cruz CA,Savatier J,Brasselet S

更新日期：2017-10-02 00:00:00

abstract：:GSK3α has been identified as a new target in the treatment of acute myeloid leukemia (AML). However, most GSK3 inhibitors lack specificity for GSK3α over GSK3β and other kinases. We have previously shown in lung cancer cells that GSK3α and to a lesser extent GSK3β are inhibited by the advanced clinical candidate tivan...

journal_title：Scientific reports

authors： Kuenzi BM,Remsing Rix LL,Kinose F,Kroeger JL,Lancet JE,Padron E,Rix U

更新日期：2019-01-24 00:00:00

abstract：:Incorporation of Zn atoms into a nanosize Cu lattice is known to alter the electronic properties of Cu, improving catalytic performance in a number of industrially important reactions. However the structural influence of Zn on the Cu phase is not well studied. Here, we show that Cu nano-clusters modified with increasi...

journal_title：Scientific reports

authors： Li MM,Zheng J,Qu J,Liao F,Raine E,Kuo WC,Su SS,Po P,Yuan Y,Tsang SC

更新日期：2016-02-09 00:00:00

abstract：:Without any root contact with the soil, epiphytic bryophytes must experience and explore poor, patchy, and heterogeneous habitats; while, the nitrogen (N) uptake and use strategies of these organisms remain uncharacterized, which obscures their roles in the N cycle. To investigate the N sources, N preferences, and res...

journal_title：Scientific reports

authors： Song L,Lu HZ,Xu XL,Li S,Shi XM,Chen X,Wu Y,Huang JB,Chen Q,Liu S,Wu CS,Liu WY

更新日期：2016-07-27 00:00:00

abstract：:Light regulates cGMP concentration in the photoreceptor cytoplasm by activating phosphodiesterase (PDE) molecules through a G-protein signalling cascade. Spontaneous PDE activity is present in rod outer segments even in darkness. This basal PDE activity (βdark) has not been determined in wild type mammalian photorecep...

journal_title：Scientific reports

authors： Turunen TT,Koskelainen A

更新日期：2019-02-04 00:00:00

abstract：:Ocean acidification and global warming have been shown to significantly affect the physiological performances of marine calcifiers; however, the underlying mechanisms remain poorly understood. In this study, the transcriptome and biomineralization responses of Pinctada fucata to elevated CO2 (pH 7.8 and pH 7.5) and te...

journal_title：Scientific reports

authors： Li S,Liu C,Huang J,Liu Y,Zhang S,Zheng G,Xie L,Zhang R

更新日期：2016-01-06 00:00:00

abstract：:The human brain has evolved specialised mechanisms to enable the rapid detection of threat cues, including emotional face expressions (e.g., fear and anger). However, contextual cues - such as gaze direction - influence the ability to recognise emotional expressions. For instance, anger paired with direct gaze, and fe...

journal_title：Scientific reports

authors： Caruana N,Inkley C,Zein ME,Seymour K

更新日期：2019-11-07 00:00:00

abstract：:Insertion sequences (ISs) are ubiquitous and abundant mobile genetic elements in prokaryotic genomes. ISs often encode only one protein, the transposase, which catalyzes their transposition. Recent studies have shown that transposases of many different IS families interact with the β sliding clamp, a DNA replication f...

journal_title：Scientific reports

authors： Díaz-Maldonado H,Gómez MJ,Moreno-Paz M,San Martín-Úriz P,Amils R,Parro V,López de Saro FJ

更新日期：2015-08-26 00:00:00

abstract：:Anti-VEGF drugs are as the first-line therapies for diabetic macular edema (DME). In this study, we investigated the association between hyperreflective foci in the outer retinal layers and functional efficacy in DME patients who received intravitreal ranibizumab (IVR) injections. We retrospectively reviewed 77 eyes o...

journal_title：Scientific reports

authors： Yoshitake T,Murakami T,Suzuma K,Dodo Y,Fujimoto M,Tsujikawa A

更新日期：2020-01-21 00:00:00

abstract：:The relationship among the single nucleotide polymorphisms (SNPs) of the C-X-C motif chemokine ligand 12 gene (CXCL12) and the serum lipid profiles in the Chinese population has rarely been described, especially in somewhat old-fashioned and isolated Maonan minority. The goal of the current study was to elucidate the ...

journal_title：Scientific reports

authors： Qiu L,Yin RX,Nie RJ,Hu XJ,Khounphinith E,Zhang FH

更新日期：2019-12-20 00:00:00

abstract：:Histone acetylation has been linked to cardiac hypertrophy and heart failure. However, the pathological implications of changes in histone methylation and the effects of interventions with histone methyltransferase inhibitors for heart failure have not been fully clarified. Here, we focused on H3K9me3 status in the he...

journal_title：Scientific reports

authors： Ono T,Kamimura N,Matsuhashi T,Nagai T,Nishiyama T,Endo J,Hishiki T,Nakanishi T,Shimizu N,Tanaka H,Ohta S,Suematsu M,Ieda M,Sano M,Fukuda K,Kaneda R

更新日期：2017-01-04 00:00:00

abstract：:The importance of evaluating physical cues in cancer research is gradually being realized. Assessment of cancer cell physical appearance, or phenotype, may provide information on changes in cellular behavior, including migratory or communicative changes. These characteristics are intrinsically different between malign...

journal_title：Scientific reports

authors： Ware MJ,Tinger S,Colbert KL,Corr SJ,Rees P,Koshkina N,Curley S,Summers HD,Godin B

更新日期：2015-07-13 00:00:00

abstract：:Coccolithophores are single-celled photosynthesizing marine algae, responsible for half of the calcification in the surface ocean, and exert a strong influence on the distribution of carbon among global reservoirs, and thus Earth's climate. Calcification in the surface ocean decreases the buffering capacity of seawate...

journal_title：Scientific reports

authors： McClelland HL,Barbarin N,Beaufort L,Hermoso M,Ferretti P,Greaves M,Rickaby RE

更新日期：2016-09-28 00:00:00

abstract：:Lung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored. Thus, we investigated the frequency of EGFR and KRAS mutations in a l...

journal_title：Scientific reports

authors： Leal LF,de Paula FE,De Marchi P,de Souza Viana L,Pinto GDJ,Carlos CD,Berardinelli GN,Miziara JE,da Silva CM,Silva ECA,Pereira R,de Oliveira MA,Scapulatempo-Neto C,Reis RM

更新日期：2019-03-01 00:00:00

abstract：:Vortices are essential to angular momentum in quantum systems such as ultracold atomic gases. The existence of quantized vorticity in bosonic systems stimulated the development of the Gross-Pitaevskii mean-field approximation. However, the true dynamics of angular momentum in finite, interacting many-body systems like...

journal_title：Scientific reports

authors： Weiner SE,Tsatsos MC,Cederbaum LS,Lode AU

更新日期：2017-01-16 00:00:00

abstract：:Given that many fundamental questions in neuroscience are still open, it seems pertinent to explore whether the brain might use other physical modalities than the ones that have been discovered so far. In particular it is well established that neurons can emit photons, which prompts the question whether these biophoto...

journal_title：Scientific reports

authors： Kumar S,Boone K,Tuszyński J,Barclay P,Simon C

更新日期：2016-11-07 00:00:00

abstract：:To date, there is only scarce evidence for a considerable association of subjective and objective stress measures, which might be attributable to method bias (e.g., confounding) and/or asynchrony of their temporal changes. To validate different subjective stress measures by a physiological measure of long-term stress ...

journal_title：Scientific reports

authors： Weckesser LJ,Dietz F,Schmidt K,Grass J,Kirschbaum C,Miller R

更新日期：2019-01-31 00:00:00

abstract：:Since the discovery of nuclear gamma-rays, its imaging has been limited to pseudo imaging, such as Compton Camera (CC) and coded mask. Pseudo imaging does not keep physical information (intensity, or brightness in Optics) along a ray, and thus is capable of no more than qualitative imaging of bright objects. To attain...

journal_title：Scientific reports

authors： Tanimori T,Mizumura Y,Takada A,Miyamoto S,Takemura T,Kishimoto T,Komura S,Kubo H,Kurosawa S,Matsuoka Y,Miuchi K,Mizumoto T,Nakamasu Y,Nakamura K,Parker JD,Sawano T,Sonoda S,Tomono D,Yoshikawa K

更新日期：2017-02-03 00:00:00

abstract：:Human activating signal cointegrator homology (ASCH) domain-containing proteins are widespread and diverse but, at present, the vast majority of those proteins have no function assigned to them. This study demonstrates that the 103-amino acid Escherichia coli protein YqfB, previously identified as hypothetical, is a u...

journal_title：Scientific reports

authors： Stanislauskienė R,Laurynėnas A,Rutkienė R,Aučynaitė A,Tauraitė D,Meškienė R,Urbelienė N,Kaupinis A,Valius M,Kaliniene L,Meškys R

更新日期：2020-01-21 00:00:00

abstract：:Although various function of chemerin have been suggested, its physiological role remains to be elucidated. Here we show that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue. The glucose intolerance was mainly due to increased hepatic glucose ...

journal_title：Scientific reports

authors： Takahashi M,Okimura Y,Iguchi G,Nishizawa H,Yamamoto M,Suda K,Kitazawa R,Fujimoto W,Takahashi K,Zolotaryov FN,Hong KS,Kiyonari H,Abe T,Kaji H,Kitazawa S,Kasuga M,Chihara K,Takahashi Y

更新日期：2011-01-01 00:00:00

abstract：:The present work focuses on the postseismic deformation observed in the region of L'Aquila (central Italy) following the Mw 6.3 earthquake that occurred on April 6, 2009. A new, 16-month-long dataset of COSMO-SkyMed SAR images was analysed using the Persistent Scatterer Pairs interferometric technique. The analysis re...

journal_title：Scientific reports

authors： Albano M,Barba S,Saroli M,Moro M,Malvarosa F,Costantini M,Bignami C,Stramondo S

更新日期：2015-11-10 00:00:00

abstract：:Infectious bronchitis virus (IBV), a member of the Coronaviridae family, causes serious losses to the poultry industry. Intestinal microbiota play an important role in chicken health and contribute to the defence against colonization by invading pathogens. The aim of this study was to investigate the link between the ...

journal_title：Scientific reports

authors： Xu P,Shi Y,Liu P,Yang Y,Zhou C,Li G,Luo J,Zhang C,Cao H,Hu G,Guo X

更新日期：2020-02-26 00:00:00

abstract：:One strategy to address new potential dangers is to generate defensive responses to stimuli that remind learned threats, a phenomenon called fear generalization. During a threatening experience, the brain encodes implicit and explicit memory traces. Nevertheless, there is a lack of studies comparing implicit and expli...

journal_title：Scientific reports

authors： Manassero E,Mana L,Concina G,Renna A,Sacchetti B

更新日期：2019-09-16 00:00:00

abstract：:Pheromones are odoriferous volatile chemical cues produced by animals for communication among conspecifics so as to regulate their social behaviors. In general, the odor compounds are recognized by receptors in the nasal cavity. Odorant-binding protein (OBP), a lipocalin family protein, mediates the air-borne odor cue...

journal_title：Scientific reports

authors： Muthukumar S,Rajesh D,Selvam RM,Saibaba G,Suvaithenamudhan S,Akbarsha MA,Padmanabhan P,Gulyas B,Archunan G

更新日期：2018-06-19 00:00:00

abstract：:Donor-specific CD4+CD127-CD25+FOXP3+ regulatory T cells (AgTregs) have the potential to induce clinical transplant tolerance; however, their expansion ex vivo remains challenging. We optimized a novel expansion protocol to stimulate donor-specific Tregs using soluble 4-trimer CD40 ligand (CD40L)-activated donor B cell...

journal_title：Scientific reports

authors： Mathew JM,Voss JH,McEwen ST,Konieczna I,Chakraborty A,Huang X,He J,Gallon L,Kornbluth RS,Leventhal JR

更新日期：2018-01-18 00:00:00