Abstract:
:There is increasing interest in the development of noninvasive diagnostic methods for early cancer detection, to improve the survival rate and quality of life of cancer patients. Identification of volatile metabolic compounds may provide an approach for noninvasive early diagnosis of malignant diseases. Here we analyzed the volatile metabolic signature of human breast cancer cell lines versus normal human mammary cells. Volatile compounds in the headspace of conditioned culture medium were directly fingerprinted by secondary electrospray ionization-mass spectrometry. The mass spectra were subsequently treated statistically to identify discriminating features between normal vs. cancerous cell types. We were able to classify different samples by using feature selection followed by principal component analysis (PCA). Additionally, high-resolution mass spectrometry allowed us to propose their chemical structures for some of the most discriminating molecules. We conclude that cancerous cells can release a characteristic odor whose constituents may be used as disease markers.
journal_name
Sci Repjournal_title
Scientific reportsauthors
He J,Sinues PM,Hollmén M,Li X,Detmar M,Zenobi Rdoi
10.1038/srep05196subject
Has Abstractpub_date
2014-06-06 00:00:00pages
5196issn
2045-2322pii
srep05196journal_volume
4pub_type
杂志文章abstract::Conventional concentrators with inhomogeneous coating materials that fully enclose the destined region pose great challenges for fabrication. In this paper, we propose to design an EM concentrator with homogeneous materials. Distinguished from conventional ones, the elaborately designed EM concentrator features a conc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28050-4
更新日期:2018-06-25 00:00:00
abstract::Synesthesia, an anomalous blending of senses in which stimulation of one sensory modality produces sensation in a different modality, provides a unique opportunity to study how multimodal information is represented in the human brain. We investigated how pitch classes (do, re, mi, etc.) are associated with the three d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18150-y
更新日期:2017-12-19 00:00:00
abstract::The cell wall of Mycobacterium tuberculosis (Mtb) consists of peptidoglycan, arabinogalactan and mycolic acids. The cytoplasmic steps in the peptidoglycan biosynthetic pathway, catalyzed by the Mur (A-F) enzymes, involve the synthesis of UDP-n-acetylmuramyl pentapeptide, a key precursor molecule required for the forma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35134
更新日期:2016-10-13 00:00:00
abstract::Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn mRNA levels in the prefrontal cortex (PFC) of LPS-treated mice. PTN is an inhibitor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76415-5
更新日期:2020-11-20 00:00:00
abstract::Knockin (KI) mouse carrying a point mutation has been an invaluable tool for disease modeling and analysis. Genome editing technologies using the CRISPR/Cas system has emerged as an alternative way to create KI mice. However, if the mice carry nucleotide insertions and/or deletions (InDels) in other genes, which could...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34703
更新日期:2016-10-04 00:00:00
abstract::Little is known about the feeding behavior of hematophagous insects that require plant sugar to complete their life cycles. We studied plant feeding of Lutzomyia longipalpis sand flies, known vectors of Leishmania infantum/chagasi parasites, in a Brazilian city endemic with visceral leishmaniasis. The DNA barcode tech...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29742
更新日期:2016-07-20 00:00:00
abstract::Mosquito larvae continuously encounter microbes in their aquatic environment, which serve as food and play a critical role in successful development. In previous work, we isolated a Chromobacterium sp. (C.sp_P) with larvicidal activity from the midgut of dengue vector Aedes mosquitoes in Panama. In this study, we foun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26680-2
更新日期:2018-05-29 00:00:00
abstract::During dental erosion, tooth minerals are dissolved, leading to a softening of the surface and consequently to irreversible surface loss. Components from human saliva form a pellicle on the tooth surface, providing some protection against erosion. To assess the effect of different components and compositions of saliva...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34760
更新日期:2016-10-05 00:00:00
abstract::Nonstructural protein 1 (NS1) is secreted by dengue virus in the first days of infection and acts as an excellent dengue biomarker. Here, the direct electrical detection of NS1 from dengue type 2 virus has been achieved by the measurement of variations in open circuit potential (OCP) between a reference electrode and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07865
更新日期:2015-01-19 00:00:00
abstract::In this contribution, a complete dissertation concerning the behavior of a Long Period Grating (LPG) inscribed in a B-Ge co-doped optical fiber by means of an excimer laser and exposed to proton irradiation during a recent extensive campaign performed at the European Organization for Nuclear Research (CERN) with a flu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58049-9
更新日期:2020-01-28 00:00:00
abstract::Nitrogen-doped hierarchical porous carbons were synthesized successfully by a controllable one-pot method using glucose and dicyandiamide as carbon source and nitrogen source via hydrothermal carbonization process. The nitrogen-doped materials, possessing high nitrogen content (up to 7 wt%), large surface area (>320 m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21365
更新日期:2016-02-25 00:00:00
abstract::Functional diversity is thought to enhance ecosystem resilience, driving research focused on trends in the functional composition of fisheries, most recently with new reconstructions of global catch data. However, there is currently little understanding of how accounting for unreported catches (e.g. small-scale and il...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10723-1
更新日期:2017-09-06 00:00:00
abstract::The high-speed liquid-jet velocity achieved using an injector strongly depends on the piston motion, physical property of the liquid, and container shape of the injector. Herein, we investigate the liquid ejection mechanism and a technique for estimating the ejection velocity of a high-speed liquid jet using a pyro je...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56511-x
更新日期:2019-12-27 00:00:00
abstract::Changes in climate and atmospheric CO2 and nitrogen (N) over the last several decades have induced significant effects on forest carbon (C) cycling. However, contributions of individual factors are largely unknown because of the lack of long observational data and the undifferentiating between intrinsic factors and ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04461
更新日期:2014-03-25 00:00:00
abstract::Monolayer germanene, a novel graphene-like germanium allotrope akin to silicene has been recently grown on metallic substrates. Lying directly on the metal surfaces the reconstructed atom-thin sheets are prone to lose the massless Dirac fermion character and unique associated physical properties of free standing germa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20714
更新日期:2016-02-10 00:00:00
abstract::Currently, blueberry bruising is evaluated by either human visual/tactile inspection or firmness measurement instruments. These methods are destructive, time-consuming, and subjective. The goal of this paper was to develop a non-destructive approach for blueberry bruising detection and quantification. Experiments were...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35679
更新日期:2016-10-21 00:00:00
abstract::Analysing the link between terrestrial ecosystem productivity (i.e., Net Primary Productivity: NPP) and extreme climate conditions is vital in the context of increasing threats due to climate change. To reveal the impact of changing extreme conditions on NPP, a copula-based probabilistic model was developed, and the s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55067-0
更新日期:2019-12-12 00:00:00
abstract::To provide a comprehensive analysis of small molecule genotoxic potential we have developed and validated an automated, high-content, high throughput, image-based in vitro Micronucleus (IVM) assay. This assay simultaneously assesses micronuclei and multiple additional cellular markers associated with genotoxicity. Aco...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82115-5
更新日期:2021-01-28 00:00:00
abstract::The whale shark (Rhincodon typus) is an endangered species with a declining global population. The South Ari Atoll Marine Protected Area (SAMPA), Maldives, is one of few locations globally where year-long residency of individuals occurs. This SAMPA aggregation appears to consist almost exclusively of immature males. D...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79101-8
更新日期:2021-01-13 00:00:00
abstract::Rice bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most destructive rice diseases worldwide. Therefore, in addition to breeding disease-resistant rice cultivars, it is desirable to develop effective biocontrol agents against Xoo. Here, we report that a soil bacterium Pseudomonas taiwanen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32950
更新日期:2016-09-08 00:00:00
abstract::The correlations between early responses and the variations in physical density and primary tumor volume (TV) according to cone-beam computed tomography (CBCT) during chemoradiotherapy for non-small cell lung cancer (NSCLC) patients were investigated. 54 patients with inoperable and locally advanced NSCLC were include...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14548-w
更新日期:2017-11-07 00:00:00
abstract::Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39688
更新日期:2017-01-03 00:00:00
abstract::Antimicrobial resistant infections are a serious public health threat worldwide. Whole genome sequencing approaches to rapidly identify pathogens and predict antibiotic resistance phenotypes are becoming more feasible and may offer a way to reduce clinical test turnaround times compared to conventional culture-based m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18972-w
更新日期:2018-01-11 00:00:00
abstract::Recent studies suggest that spatial training can maintain associative memory capacity in Tg2576 mice, but it is not known whether the beneficial effects can be inherited from the trained fathers to their offspring. Here, we exposed male wild-type and male 3XTg Alzheimer disease (AD) mice (3-m old) respectively to spat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01811-3
更新日期:2017-05-08 00:00:00
abstract::Antenna systems serve to absorb light and to transmit excitation energy to the reaction center (RC) in photosynthetic organisms. As the emitted (bacterio)chlorophyll fluorescence competes with the photochemical utilization of the excitation, the measured fluorescence yield is informed by the migration of the excitatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70966-3
更新日期:2020-08-19 00:00:00
abstract::Crystallization is the bottleneck in macromolecular crystallography; even when a protein crystallises, crystal packing often influences ligand-binding and protein-protein interaction interfaces, which are the key points of interest for functional and drug discovery studies. The human hypoxia-inducible factor prolyl hy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76307-8
更新日期:2020-12-15 00:00:00
abstract::To begin studies on reproduction in common bed bug, Cimex lectularius, we identified three genes coding for vitellogenin (Vg, a protein required for the reproductive success of insects) and studied their hormonal regulation. RNA interference studied showed that expression of Vg3 gene in the adult females is a prerequi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35546
更新日期:2016-10-20 00:00:00
abstract::Targeted antineoplastic agents show great promise in the treatment of cancer, having the ability to impart cytotoxicity only to specific tumor types. However, these therapies do not experience uniform uptake throughout tumors, leading to sub-lethal cell killing that can impart treatment resistance, and cause problemat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13803-4
更新日期:2017-10-17 00:00:00
abstract::Silicon, the workhorse of semiconductor industry, is being exploited for various functional applications in numerous fields of nanotechnology. In this paper, we report the fabrication of depth controllable amorphous silicon (a-Si) layers under 80 keV Ar+ ion sputtering at off-normal ion incidences of 30°, 40° and 50° ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68873-8
更新日期:2020-07-17 00:00:00
abstract::Disturbances in calcium metabolism are common in individuals with chronic kidney disease (CKD), but whether they are associated with subsequent kidney function decline is less clear. In a CKD 3-5 cohort of 15,755 adult citizens of Stockholm with creatinine tests taken during 2006-2011 and concurrent calcium testing at...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23500-5
更新日期:2018-03-26 00:00:00