A dyadic study of psychological well-being of individuals with Parkinson's disease and their caregivers.

Abstract:

:Parkinson's disease (PD) is an incapacitating neurodegenerative disease. Patients with PD and their caregivers may have interactive effects on each other's psychological well-being. This study aimed to assess the dyadic dynamics of resilience, fatigue, and suicidal ideation on the depression severity of PD patients and their caregivers. In total, 175 PD patients and 175 caregivers were recruited at a medical center from August 2018 to May 2020. Structural equation modeling (SEM) was used to examine the actor/partner effects on the psychological well-being of both the PD patients and their caregivers. The most common psychiatric diagnoses of both the PD patients (28.6%) and their caregivers (11.4%) were depressive disorders. The PD patients' and their caregivers' fatigue, suicidal ideation, and lack of resilience were significantly associated with the severity of their depression, respectively. Interactive effects existed between psychological well-being of individuals with PD and their caregivers. Clinicians must be aware of, and manage, these contributing factors between PD patients and their caregivers in order to prevent them from worsening each other's depression.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lee Y,Chiou YJ,Hung CF,Chang YY,Chen YF,Lin TK,Wang LJ

doi

10.1038/s41598-020-79609-z

subject

Has Abstract

pub_date

2021-01-13 00:00:00

pages

957

issue

1

issn

2045-2322

pii

10.1038/s41598-020-79609-z

journal_volume

11

pub_type

杂志文章
  • Individualized fluid administration for critically ill patients with sepsis with an interpretable dynamic treatment regimen model.

    abstract::Fluid strategy is the key to the successful management of patients with sepsis. However, previous studies failed to consider individualized treatment strategy, and clinical trials typically included patients with sepsis as a homogeneous study population. We aimed to develop sequential decision rules for managing fluid...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74906-z

    authors: Zhang Z,Zheng B,Liu N

    更新日期:2020-10-21 00:00:00

  • Retraction Note: Type IV collagen α1-chain noncollagenous domain blocks MMP-2 activation both in-vitro and in-vivo.

    abstract::Editor's Note: this Article has been retracted; the Retraction Note is available at https://www.nature.com/articles/s41598-020-76500-9. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误,撤回出版物

    doi:10.1038/s41598-020-76500-9

    authors: Sudhakar YA,Verma RK,Pawar SC

    更新日期:2020-11-26 00:00:00

  • Past and future potential range changes in one of the last large vertebrates of the Australian continent, the emu Dromaius novaehollandiae.

    abstract::In Australia, significant shifts in species distribution have occurred with the loss of megafauna, changes in indigenous Australian fire regime and land-use changes with European settlement. The emu, one of the last megafaunal species in Australia, has likely undergone substantial distribution changes, particularly ne...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79551-0

    authors: Ryeland J,Derham TT,Spencer RJ

    更新日期:2021-01-13 00:00:00

  • The role of isochrony in speech perception in noise.

    abstract::The role of isochrony in speech-the hypothetical division of speech units into equal duration intervals-has been the subject of a long-standing debate. Current approaches in neurosciences have brought new perspectives in that debate through the theoretical framework of predictive coding and cortical oscillations. Here...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76594-1

    authors: Aubanel V,Schwartz JL

    更新日期:2020-11-11 00:00:00

  • Improving catalytic activity of the Baeyer-Villiger monooxygenase-based Escherichia coli biocatalysts for the overproduction of (Z)-11-(heptanoyloxy)undec-9-enoic acid from ricinoleic acid.

    abstract::Baeyer-Villiger monooxygenases (BVMOs) can be used for the biosynthesis of lactones and esters from ketones. However, the BVMO-based biocatalysts are not so stable under process conditions. Thereby, this study focused on enhancing stability of the BVMO-based biocatalysts. The biotransformation of ricinoleic acid into ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28575-8

    authors: Woo JM,Jeon EY,Seo EJ,Seo JH,Lee DY,Yeon YJ,Park JB

    更新日期:2018-07-06 00:00:00

  • Fast Determination of Flip Angle and T1 in Hyperpolarized Gas MRI During a Single Breath-Hold.

    abstract::MRI of hyperpolarized media, such as (129)Xe and (3)He, shows great potential for clinical applications. The optimal use of the available spin polarization requires accurate flip angle calibrations and T1 measurements. Traditional flip angle calibration methods are time-consuming and suffer from polarization losses du...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25854

    authors: Zhong J,Ruan W,Han Y,Sun X,Ye C,Zhou X

    更新日期:2016-05-12 00:00:00

  • Mechanism of Astragalus membranaceus in the treatment of laryngeal cancer based on gene co-expression network and molecular docking.

    abstract::Astragalus membranaceus (HUANG QI, HQ) is a kind of traditional Chinese medicine. Researchers have widely concerned its antitumor effect. At present, there is still a lack of research on the treatment of laryngeal cancer with HQ. In this study, we integrated data from the weighted gene co-expression network of larynge...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68093-0

    authors: Dong KF,Huo MQ,Sun HY,Li TK,Li D

    更新日期:2020-07-07 00:00:00

  • Genetic analysis of the molecular regulation of electric fields-guided glia migration.

    abstract::In a developing nervous system, endogenous electric field (EF) influence embryonic growth. We reported the EF-directed migration of both rat Schwann cells (SCs) and oligodendrocyte precursor cells (OPCs) and explored the molecular mechanism using RNA-sequencing assay. However, previous studies revealed the differentia...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74085-x

    authors: Yao L,Shippy T,Li Y

    更新日期:2020-10-08 00:00:00

  • Hepatocytic parental progenitor cells of rat small hepatocytes maintain self-renewal capability after long-term culture.

    abstract::The liver has a variety of functions for maintaining homeostasis, and hepatocytes play a major role. In contrast with the high regenerative capacity of mature hepatocytes (MHs) in vivo, they have not been successfully expanded ex vivo. Here we demonstrate that CD44-positive cells sorted from small hepatocyte (SH) colo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46177

    authors: Ishii M,Kino J,Ichinohe N,Tanimizu N,Ninomiya T,Suzuki H,Mizuguchi T,Hirata K,Mitaka T

    更新日期:2017-04-11 00:00:00

  • Excited-state fidelity as a signal for the many-body localization transition in a disordered Ising chain.

    abstract::In this work, we use exact matrix diagonalization to explore the many-body localization (MBL) transitions in quantum Ising chains with disordered nearest-neighbour couplings, disordered next-nearest-neighbour couplings and disordered external fields. It is demonstrated that the fidelity can be used to characterize the...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00660-4

    authors: Hu T,Xue K,Li X,Zhang Y,Ren H

    更新日期:2017-04-03 00:00:00

  • Analysis of miRNAs and their target genes associated with lipid metabolism in duck liver.

    abstract::Fat character is an important index in duck culture that linked to local flavor, feed cost and fat intake for costumers. Since the regulation networks in duck lipid metabolism had not been reported very clearly, we aimed to explore the potential miRNA-mRNA pairs and their regulatory roles in duck lipid metabolism. Her...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27418

    authors: He J,Wang W,Lu L,Tian Y,Niu D,Ren J,Dong L,Sun S,Zhao Y,Chen L,Shen J,Li X

    更新日期:2016-06-08 00:00:00

  • Prognostic relevance of UCH-L1 and α-internexin in pancreatic neuroendocrine tumors.

    abstract::Prognostic biomarkers for the pancreatic neuroendocrine tumors are needed. Proteomic study on insulinoma has been rarely reported. We identified the differential expression of proteins between insulinoma and their paired tissues by proteomic analysis, and evaluated the prognostic significance of specific proteins in p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02051-1

    authors: Song YL,Yu R,Qiao XW,Bai CM,Lu CM,Xiao Y,Zhong DR,Chen J,Zhao YP,Zhang TP,Song TT,Gao HL,Wan YH,Shen L,Chen J,Lv B,Hao JJ,Zhang Y,Tang L,Chen YJ

    更新日期:2017-05-19 00:00:00

  • Low temperature synthesis of NbC/C nano-composites as visible light photoactive catalyst.

    abstract::A facile carbothermal route was adopted to obtain niobium carbide nanoparticles (NPs) embedded in carbon network from Nb2O5 to study photocatalytic behavior. Optimization of synthesis parameters to obtain single phase NbC NPs has been successfully done. The phase identification, morphology and nature of carbon were de...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31989-z

    authors: Gupta A,Mittal M,Singh MK,Suib SL,Pandey OP

    更新日期:2018-09-11 00:00:00

  • Linking the oral microbiome and salivary cytokine abundance to circadian oscillations.

    abstract::Saliva has immense potential as a diagnostic fluid for identification and monitoring of several systemic diseases. Composition of the microbiome and inflammation has been associated and reflective of oral and overall health. In addition, the relative ease of collection of saliva further strengthens large-scale diagnos...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81420-3

    authors: Sarkar A,Kuehl MN,Alman AC,Burkhardt BR

    更新日期:2021-01-29 00:00:00

  • The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.

    abstract::Autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication and restricted/repetitive behavior patterns or interests. Antagonists targeting histamine H3 receptor (H3R) are considered potential therapeutic agents for the therapeutic management of different brain...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31385-7

    authors: Eissa N,Jayaprakash P,Azimullah S,Ojha SK,Al-Houqani M,Jalal FY,Łażewska D,Kieć-Kononowicz K,Sadek B

    更新日期:2018-08-30 00:00:00

  • Quinone derivatives isolated from the endolichenic fungus Phialocephala fortinii are Mdr1 modulators that combat azole resistance in Candida albicans.

    abstract::One of the main azole-resistance mechanisms in Candida pathogens is the upregulation of drug efflux pumps, which compromises the efficacy of azoles and results in treatment failure. The combination of azole-antifungal agents with efflux pump inhibitors represents a promising strategy to combat fungal infection. High-t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33687

    authors: Xie F,Chang W,Zhang M,Li Y,Li W,Shi H,Zheng S,Lou H

    更新日期:2016-09-21 00:00:00

  • Ionic direct current modulation evokes spike-rate adaptation in the vestibular periphery.

    abstract::Recent studies have shown that ionic direct current (iDC) can modulate the vestibular system in-vivo, with potential benefits over conventional pulsed stimulation. In this study, the effects of iDC stimulation on vestibular nerve fiber firing rate was investigated using loose-patch nerve fiber recordings in the acutel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55045-6

    authors: Manca M,Glowatzki E,Roberts DC,Fridman GY,Aplin FP

    更新日期:2019-12-12 00:00:00

  • MicroPattern: a web-based tool for microbe set enrichment analysis and disease similarity calculation based on a list of microbes.

    abstract::The microbiota colonized on human body is renowned as "a forgotten organ" due to its big impacts on human health and disease. Recently, microbiome studies have identified a large number of microbes differentially regulated in a variety of conditions, such as disease and diet. However, methods for discovering biologica...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40200

    authors: Ma W,Huang C,Zhou Y,Li J,Cui Q

    更新日期:2017-01-10 00:00:00

  • A marine inducible prophage vB_CibM-P1 isolated from the aerobic anoxygenic phototrophic bacterium Citromicrobium bathyomarinum JL354.

    abstract::A prophage vB_CibM-P1 was induced by mitomycin C from the epipelagic strain Citromicrobium bathyomarinum JL354, a member of the alpha-IV subcluster of marine aerobic anoxygenic phototrophic bacteria (AAPB). The induced bacteriophage vB_CibM-P1 had Myoviridae-like morphology and polyhedral heads (approximately capsid 6...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07118

    authors: Zheng Q,Zhang R,Xu Y,White RA 3rd,Wang Y,Luo T,Jiao N

    更新日期:2014-11-19 00:00:00

  • A controlled double-duration inducible gene expression system for cartilage tissue engineering.

    abstract::Cartilage engineering that combines competent seeding cells and a compatible scaffold is increasingly gaining popularity and is potentially useful for the treatment of various bone and cartilage diseases. Intensive efforts have been made by researchers to improve the viability and functionality of seeding cells of eng...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26617

    authors: Ma Y,Li J,Yao Y,Wei D,Wang R,Wu Q

    更新日期:2016-05-25 00:00:00

  • Global computational mutagenesis of domain structures associated with inherited eye disease.

    abstract::Multidomain proteins account for 70% of the eukaryotic proteome. In genetic disease, multidomain proteins are often affected by numerous mutations, but the effects of these mutations on protein stability and their roles in genetic disease are not well understood. Here, we analyzed protein globular domains to understan...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39905-9

    authors: Ortiz FW,Sergeev YV

    更新日期:2019-03-06 00:00:00

  • mTOR regulates neuroprotective effect of immunized CD4+Foxp3+ T cells in optic nerve ischemia.

    abstract::The therapeutic potential of targeting CD4+Foxp3+ regulatory T cells (Tregs) remains controversial under the condition of neuroinflammation. This study aims to explore the neuroprotective role of Tregs in optic nerve ischemia (ONI) and evaluate the therapeutic strategy of Tregs transfer with a focus on targeting the m...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37805

    authors: Chen G,Tang L,Wei W,Li Z,Li Y,Duan X,Chen H

    更新日期:2016-11-25 00:00:00

  • Large Optical Gain AlInN-Delta-GaN Quantum Well for Deep Ultraviolet Emitters.

    abstract::The optical gain and spontaneous emission characteristics of low In-content AlInN-delta-GaN quantum wells (QWs) are analyzed for deep ultraviolet (UV) light emitting diodes (LEDs) and lasers. Our analysis shows a large increase in the dominant transverse electric (TE) polarized spontaneous emission rate and optical ga...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22983

    authors: Tan CK,Sun W,Borovac D,Tansu N

    更新日期:2016-03-10 00:00:00

  • DoGMP1 from Dendrobium officinale contributes to mannose content of water-soluble polysaccharides and plays a role in salt stress response.

    abstract::GDP-mannose pyrophosphorylase (GMP) catalyzed the formation of GDP-mannose, which serves as a donor for the biosynthesis of mannose-containing polysaccharides. In this study, three GMP genes from Dendrobium officinale (i.e., DoGMPs) were cloned and analyzed. The putative 1000 bp upstream regulatory region of these DoG...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41010

    authors: He C,Yu Z,Teixeira da Silva JA,Zhang J,Liu X,Wang X,Zhang X,Zeng S,Wu K,Tan J,Ma G,Luo J,Duan J

    更新日期:2017-02-08 00:00:00

  • Multiple dimensions of biodiversity drive human interest in tide pool communities.

    abstract::Activities involving observation of wild organisms (e.g. wildlife watching, tidepooling) can provide recreational and learning opportunities, with biologically diverse animal assemblages expected to be more stimulating to humans. In turn, more diverse communities may enhance human interest and facilitate provisioning ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33155-x

    authors: Fairchild TP,Fowler MS,Pahl S,Griffin JN

    更新日期:2018-10-15 00:00:00

  • Electric-double-layer p-i-n junctions in WSe2.

    abstract::While p-n homojunctions in two-dimensional transition metal dichalcogenide materials have been widely reported, few show an ideality factor that is constant over more than a decade in current. In this paper, electric double layer p-i-n junctions in WSe2 are shown with substantially constant ideality factors (2-3) over...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69523-9

    authors: Fathipour S,Paletti P,Fullerton-Shirey SK,Seabaugh AC

    更新日期:2020-07-30 00:00:00

  • Female Breast Cancer Mortality Clusters in Shandong Province, China: A Spatial Analysis.

    abstract::This study aimed to detect the spatial distribution and high-risk clusters of female breast cancer mortality for the years 2011 to 2013 in Shandong Province, China. The urban-rural difference in the spatial distribution and clusters of disease mortality were also examined. Breast cancer mortality data were obtained fr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00179-8

    authors: Chu J,Zhou C,Guo X,Sun J,Xue F,Zhang J,Lu Z,Fu Z,Xu A

    更新日期:2017-03-07 00:00:00

  • Giant photoluminescence emission in crystalline faceted Si grains.

    abstract::Empowering an indirect band-gap material like Si with optical functionalities, firstly light emission, represents a huge advancement constantly pursued in the realization of any integrated photonic device. We report the demonstration of giant photoluminescence (PL) emission by a newly synthesized material consisting o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02674

    authors: Faraci G,Pennisi AR,Alberti A,Ruggeri R,Mannino G

    更新日期:2013-01-01 00:00:00

  • The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice.

    abstract::There are more than 2300 genes that are predominantly expressed in mouse testes. The role of hundreds of these genes has been studied in mouse spermatogenesis but still there are many genes whose function is unknown. Gene knockout (KO) strategy in mice is widely used for in vivo study of gene function. The present stu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23176-x

    authors: Khan M,Jabeen N,Khan T,Hussain HMJ,Ali A,Khan R,Jiang L,Li T,Tao Q,Zhang X,Yin H,Yu C,Jiang X,Shi Q

    更新日期:2018-03-21 00:00:00

  • Three-dimensional HepaRG spheroids as a liver model to study human genotoxicity in vitro with the single cell gel electrophoresis assay.

    abstract::Many efforts have been made in the last 30 years to develop more relevant in vitro models to study genotoxic responses of drugs and environmental contaminants. While 2D HepaRG cells are one of the most promising models for liver toxicology, a switch to 3D cultures that integrate both in vivo architecture and cell-cell...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47114-7

    authors: Mandon M,Huet S,Dubreil E,Fessard V,Le Hégarat L

    更新日期:2019-07-22 00:00:00