Female Breast Cancer Mortality Clusters in Shandong Province, China: A Spatial Analysis.

abstract：:Cisplatin, a highly effective and widely used chemotherapeutic agent, has a major limitation for its nephrotoxicity. We recently identified a novel strategy for attenuating its nephrotoxicity in chemotherapy by an effective adjuvant via epigenetic modification through targeting HDAC2. Molecular docking and SPR assay f...

journal_title：Scientific reports

authors： Ma T,Huang C,Meng X,Li X,Zhang Y,Ji S,Li J,Ye M,Liang H

更新日期：2016-05-05 00:00:00

abstract：:Cold environments dominate the Earth's biosphere and the resident microorganisms play critical roles in fulfilling global biogeochemical cycles. However, only few studies have examined the molecular basis of thermosensing; an ability that microorganisms must possess in order to respond to environmental temperature and...

journal_title：Scientific reports

authors： Najnin T,Siddiqui KS,Taha T,Elkaid N,Kornfeld G,Curmi PM,Cavicchioli R

更新日期：2016-04-07 00:00:00

abstract：:Ataxia-telangiectasia (AT) and related disorders feature cancer predisposition, neurodegeneration, and immunodeficiency resulting from failure to respond to DNA damage. Hypomorphic mutations in MRE11 cause an AT-like disorder (ATLD) with variable clinical presentation. We have sought to understand how diverse MRE11 mu...

journal_title：Scientific reports

authors： Hartlerode AJ,Regal JA,Ferguson DO

更新日期：2018-07-04 00:00:00

abstract：:Anterior-posterior body axis in all bilaterians is determined by the Hox gene clusters that are activated in a spatio-temporal order. This expression pattern of Hox genes is established and maintained by regulatory mechanisms that involve higher order chromatin structure and Polycomb group (PcG) and trithorax group (t...

journal_title：Scientific reports

authors： Vasanthi D,Nagabhushan A,Matharu NK,Mishra RK

更新日期：2013-10-22 00:00:00

abstract：:Anaerobic digestion is a common technology to biologically stabilize wasted solids produced in municipal wastewater treatment. Its efficiency is usually evaluated by calculating the reduction in volatile solids, which assumes no biomass growth associated with digestion. To determine whether this assumption is valid an...

journal_title：Scientific reports

authors： Mei R,Narihiro T,Nobu MK,Kuroda K,Liu WT

更新日期：2016-09-26 00:00:00

abstract：:To provide a comprehensive analysis of small molecule genotoxic potential we have developed and validated an automated, high-content, high throughput, image-based in vitro Micronucleus (IVM) assay. This assay simultaneously assesses micronuclei and multiple additional cellular markers associated with genotoxicity. Aco...

journal_title：Scientific reports

authors： Wilson A,Grabowski P,Elloway J,Ling S,Stott J,Doherty A

更新日期：2021-01-28 00:00:00

abstract：:The proneural transcription factor Ascl1 is a master regulator of neurogenesis, coordinating proliferation and differentiation in the central nervous system. While its expression is well characterised, post-translational regulation is much less well understood. Here we demonstrate that a population of chromatin-bound ...

journal_title：Scientific reports

authors： Gillotin S,Davies JD,Philpott A

更新日期：2018-03-15 00:00:00

abstract：:Mutations in fused in sarcoma (FUS), a DNA/RNA binding protein, are associated with familial amyotrophic lateral sclerosis (ALS). However, little is known about how ALS-causing mutations alter protein-protein and protein-RNA complexes and contribute to neurodegeneration. In this study, we identified protein arginine m...

journal_title：Scientific reports

authors： Jun MH,Ryu HH,Jun YW,Liu T,Li Y,Lim CS,Lee YS,Kaang BK,Jang DJ,Lee JA

更新日期：2017-01-17 00:00:00

abstract：:Herein, water-oxidation reaction by cobalt(II) phthalocyanine, N,N'-bis (salicylidene) ethylenediamino cobalt(II), nickel(II) Schiff base (N,N'-bis (salicylidene)ethylenediamino nickel(II), nickel(II)) phthalocyanine-tetrasulfonate tetrasodium, manganese(II) phthalocyanine, 5,10,15,20-Tetraphenyl-21H,23H-porphine mang...

journal_title：Scientific reports

authors： Najafpour MM,Feizi H

更新日期：2019-05-16 00:00:00

abstract：:Conventional solid lubricants such as MoS2, graphite, or diamond-like carbon films demonstrate excellent tribological performance but only in specific environments due to their inherent materials properties. This limitation prohibits using these solid lubricants in environments that change dynamically. This study pres...

journal_title：Scientific reports

authors： Ayyagari AV,Mutyala KC,Sumant AV

更新日期：2020-09-21 00:00:00

abstract：:The MADS-box transcription factors play essential roles in many physiological and biochemical processes of plants, especially in fruit ripening. Here, a tomato MADS-box gene, SlCMB1, was isolated. SlCMB1 expression declined with the fruit ripening from immature green to B + 7 (7 days after Breaker) fruits in the wild ...

journal_title：Scientific reports

authors： Zhang J,Hu Z,Yao Q,Guo X,Nguyen V,Li F,Chen G

更新日期：2018-02-21 00:00:00

abstract：:Here we present a set of measurements using Differential Scanning Fluorimetry (DSF) as an inexpensive, high throughput screening method to investigate the folding of silk protein molecules as they abandon their first native melt conformation, dehydrate and denature into their final solid filament conformation. Our fir...

journal_title：Scientific reports

authors： Vollrath F,Hawkins N,Porter D,Holland C,Boulet-Audet M

更新日期：2014-07-09 00:00:00

abstract：:Formic acid (FA) has been used for decades to control Varroa destructor, one of the most important parasites of the western honey bee, Apis mellifera. The rather unselective molecular mode of action of FA and its possible effects on honeybees have long been a concern of beekeepers, as it has undesirable side effects t...

journal_title：Scientific reports

authors： Genath A,Sharbati S,Buer B,Nauen R,Einspanier R

更新日期：2020-12-14 00:00:00

abstract：:Analyzing drug-drug interactions may unravel previously unknown drug action patterns, leading to the development of new drug discovery tools. We present a new approach to analyzing drug-drug interaction networks, based on clustering and topological community detection techniques that are specific to complex network sc...

journal_title：Scientific reports

authors： Udrescu L,Sbârcea L,Topîrceanu A,Iovanovici A,Kurunczi L,Bogdan P,Udrescu M

更新日期：2016-09-07 00:00:00

abstract：:Left ventricular mass index (LVMI) increase has been described in hypertension (HTN), but less is known about its association with type 2 diabetes (T2DM). As these conditions frequently co-exist, we investigated the association of T2DM, HTN and both with echocardiographic parameters, and hypothesized that patients wit...

journal_title：Scientific reports

authors： Seferovic JP,Tesic M,Seferovic PM,Lalic K,Jotic A,Biering-Sørensen T,Giga V,Stankovic S,Milic N,Lukic L,Milicic T,Macesic M,Gajovic JS,Lalic NM

更新日期：2018-01-17 00:00:00

abstract：:Dark septate endophytes (DSE) are a form-group of root endophytic fungi with elusive functions. Here, the genomes of two common DSE of semiarid areas, Cadophora sp. and Periconia macrospinosa were sequenced and analyzed with another 32 ascomycetes of different lifestyles. Cadophora sp. (Helotiales) and P. macrospinosa...

journal_title：Scientific reports

authors： Knapp DG,Németh JB,Barry K,Hainaut M,Henrissat B,Johnson J,Kuo A,Lim JHP,Lipzen A,Nolan M,Ohm RA,Tamás L,Grigoriev IV,Spatafora JW,Nagy LG,Kovács GM

更新日期：2018-04-20 00:00:00

abstract：:Breast cancer in young women is typically with higher proportion of adverse pathological features. Breast cancer with BRCA1 mutation is often early-onset, and is usually associated with triple negative phenotpe. In this study, we aim to analyze the clinicopathological characteristics and prognosis in young breast canc...

journal_title：Scientific reports

authors： Wei JT,Huang WH,Du CW,Qiu SQ,Wei XL,Liu J,Zhang GJ

更新日期：2014-06-19 00:00:00

abstract：:Case-control genetic association studies typically ignore possible later disease onset in currently healthy subjects and assume that subjects with diseases equally contribute to the likelihood for inference, regardless of their onset age. Therefore, we used an event-history with risk-free model to simultaneously chara...

journal_title：Scientific reports

authors： Yang HC,Chen IC,Tsay YC,Li ZR,Chen CH,Hwu HG,Chen CH

更新日期：2017-05-16 00:00:00

abstract：:Electrochemically active bacteria (EAB) are ubiquitous in environment and have important application in the fields of biogeochemistry, environment, microbiology and bioenergy. However, rapid and sensitive methods for EAB identification and evaluation of their extracellular electron transfer ability are still lacking. ...

journal_title：Scientific reports

authors： Yuan SJ,He H,Sheng GP,Chen JJ,Tong ZH,Cheng YY,Li WW,Lin ZQ,Zhang F,Yu HQ

更新日期：2013-01-01 00:00:00

abstract：:In neuroblastoma (NB), one of the most common paediatric solid tumours, activation of anaplastic lymphoma kinase (ALK) is often associated with poor outcomes. Although genetic studies have identified copy number alteration and nonsynonymous mutations of ALK, the regulatory mechanism of ALK signalling at protein levels...

journal_title：Scientific reports

authors： Satoh S,Takatori A,Ogura A,Kohashi K,Souzaki R,Kinoshita Y,Taguchi T,Hossain MS,Ohira M,Nakamura Y,Nakagawara A

更新日期：2016-09-08 00:00:00

abstract：:Preterm infants are susceptible to inflammation-induced white matter injury but the exposures that lead to this are uncertain. Histologic chorioamnionitis (HCA) reflects intrauterine inflammation, can trigger a fetal inflammatory response, and is closely associated with premature birth. In a cohort of 90 preterm infan...

journal_title：Scientific reports

authors： Anblagan D,Pataky R,Evans MJ,Telford EJ,Serag A,Sparrow S,Piyasena C,Semple SI,Wilkinson AG,Bastin ME,Boardman JP

更新日期：2016-12-01 00:00:00

abstract：:Clinical benefit from trastuzumab and other anti-human epidermal growth factor receptor-2 (HER2) therapies in patients with HER2-positive gastric cancer (GC) remains limited by primary or acquired resistance. We aimed to investigate the impact of concomitant molecular alterations to HER2 amplification on the clinical ...

journal_title：Scientific reports

authors： Lee JY,Hong M,Kim ST,Park SH,Kang WK,Kim KM,Lee J

更新日期：2015-03-19 00:00:00

abstract：:Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor in the rectoanal incontinence (RI). To determine the pathogenesis of AADI, we investigated the effect of aging on GPCR activation and related downstream signaling. We particularly investigated two GPCRs that characterize IAS ...

journal_title：Scientific reports

authors： Mohanty I,Singh J,Rattan S

更新日期：2019-05-01 00:00:00

abstract：:It is widely acknowledged that transcriptional diversity largely contributes to biological regulation in eukaryotes. Since the advent of second-generation sequencing technologies, a large number of RNA sequencing studies have considerably improved our understanding of transcriptome complexity. However, it still remain...

journal_title：Scientific reports

authors： Chen SY,Deng F,Jia X,Li C,Lai SJ

更新日期：2017-08-09 00:00:00

abstract：:Our study focused on quantifying the alterations of streamflow at a weir site due to the construction of a mini-hydropower plant in the Gurugoda Oya (Sri Lanka), and evaluating the spatial responses of benthic macroinvertebrates to altered flow regime. The HEC-HMS 3.5 model was applied to the Gurugoda Oya sub-catchmen...

journal_title：Scientific reports

authors： Munasinghe DSN,Najim MMM,Quadroni S,Musthafa MM

更新日期：2021-01-12 00:00:00

abstract：:Plant-specific TEOSINTE-BRANCHED1/CYCLOIDEA/PCF (TCP) transcription factors play versatile functions in multiple aspects of plant growth and development. However, no systematical study has been performed in cotton. In this study, we performed for the first time the genome-wide identification and expression analysis of...

journal_title：Scientific reports

authors： Ma J,Wang Q,Sun R,Xie F,Jones DC,Zhang B

更新日期：2014-10-16 00:00:00

abstract：:Boulders are ubiquitously found on the surfaces of small rocky bodies in the inner solar system and their spatial and size distributions give insight into the geological evolution and collisional history of the parent bodies. Using images acquired by the Chang'e-2 spacecraft, more than 200 boulders have been identifie...

journal_title：Scientific reports

authors： Jiang Y,Ji J,Huang J,Marchi S,Li Y,Ip WH

更新日期：2015-11-02 00:00:00

abstract：:Species-centric approaches to biodiversity in ecological research are limited in their ability to reflect the evolutionary history and functional diversity of community assembly. Recently, the introduction of alternative facets of biodiversity, such as phylogenetic and functional diversity, has shed light on this prob...

journal_title：Scientific reports

authors： Chun JH,Lee CB

更新日期：2018-02-12 00:00:00

abstract：:In this study, we describe a web-based resource, developed for assisting the scientific community in designing an effective therapeutics against the Ebola virus. Firstly, we predicted and identified experimentally validated epitopes in each of the antigens/proteins of the five known ebolaviruses. Secondly, we generate...

journal_title：Scientific reports

authors： Dhanda SK,Chaudhary K,Gupta S,Brahmachari SK,Raghava GP

更新日期：2016-04-26 00:00:00

abstract：:Solid solutions of Zr(Mo,W)2O7(OH,Cl)2∙2H2O with a preset ratio of components were prepared by a hydrothermal method. The chemical composition of the solutions was determined by energy dispersive X-ray spectroscopy (EDX). For all the samples of ZrMoxW2-xO7(OH,Cl)2∙2H2O (x = 0.0, 0.2, 0.4, 0.6, 0.8, 1.0, 1.2, 1.4, 1.6,...

journal_title：Scientific reports

authors： Petrushina MY,Dedova ES,Filatov EY,Plyusnin PE,Korenev SV,Kulkov SN,Derevyannikova EA,Sharafutdinov MR,Gubanov AI

更新日期：2018-03-28 00:00:00