Transforming early pharmaceutical assessment of genotoxicity: applying statistical learning to a high throughput, multi end point in vitro micronucleus assay.

abstract：:Microtus fortis exhibits natural resistance against Schistosoma japonicum, and the parasite cannot grow and develop in M. fortis. Extensive research has been carried out, however, the associated mechanism remains unclear. In the present study, we analysed the combined data obtained from a cytokine chip assay, transcri...

journal_title：Scientific reports

authors： Hu Y,Sun L,Yuan Z,Xu Y,Cao J

更新日期：2017-09-12 00:00:00

abstract：:Recent breakthrough of novel hierarchic materials, orchestrated through oriented attachment of crystal subunits, opened questions on what is the mechanism of their self-assembly. Using rutile-type TiO2, synthesized by hydrothermal reaction of Ti(IV)-butoxide in highly acidic aqueous medium, we uncovered the key proces...

journal_title：Scientific reports

authors： Jordan V,Javornik U,Plavec J,Podgornik A,Rečnik A

更新日期：2016-04-11 00:00:00

abstract：:Understanding source-sink dynamics is important for conservation management, particularly when climatic events alter species' distributions. Following a 2011 'marine heatwave' in Western Australia, we observed high recruitment of the endemic fisheries target species Choerodon rubescens, towards the cooler (southern) e...

journal_title：Scientific reports

authors： Cure K,Thomas L,Hobbs JA,Fairclough DV,Kennington WJ

更新日期：2017-08-17 00:00:00

abstract：:The structure and function of cellular membranes were sustained by redox-enzymes. We studied the interaction between the oxidative stress caused by excessive accumulation of ZnO-nanoparticles (ZnO-NPs) in plants and the role of redox-enzymes that can alleviate this stress. The crude callus extract from pomegranate, wh...

journal_title：Scientific reports

authors： Farghaly FA,Radi AA,Al-Kahtany FA,Hamada AM

更新日期：2020-11-12 00:00:00

abstract：:The finding that mature forest ecosystems increase carbon in woody tissues and mineral soils indicates that the original equilibriums are being pushed to a higher state. The final driving forces will probably be increasing CO2 and nitrogen deposition, global warming, and changes to precipitation patterns. However, whi...

journal_title：Scientific reports

authors： Xiao Y,Zhou G,Zhang Q,Wang W,Liu S

更新日期：2014-01-14 00:00:00

abstract：:The public goods game is a famous example illustrating the tragedy of the commons (Hardin in Science 162:1243-1248, 1968). In this game cooperating individuals contribute to a pool, which in turn is distributed to all members of the group, including defectors who reap the same rewards as cooperators without having mad...

journal_title：Scientific reports

authors： Hintze A,Staudacher J,Gelhar K,Pothmann A,Rasch J,Wildegger D

更新日期：2020-12-28 00:00:00

abstract：:Organ regenerative therapy aims to reproduce fully functional organs to replace organs that have been lost or damaged as a result of disease, injury, or aging. For the fully functional regeneration of ectodermal organs, a concept has been proposed in which a bioengineered organ is developed by reproducing the embryoni...

journal_title：Scientific reports

authors： Asakawa K,Toyoshima KE,Ishibashi N,Tobe H,Iwadate A,Kanayama T,Hasegawa T,Nakao K,Toki H,Noguchi S,Ogawa M,Sato A,Tsuji T

更新日期：2012-01-01 00:00:00

abstract：:The Rho-family small GTPase Cdc42 localizes at plasma membrane and Golgi complex and aside from protrusion and migration operates in vesicle trafficking, endo- and exocytosis as well as establishment and/or maintenance of cell polarity. The formin family members FMNL2 and -3 are actin assembly factors established to r...

journal_title：Scientific reports

authors： Kage F,Steffen A,Ellinger A,Ranftler C,Gehre C,Brakebusch C,Pavelka M,Stradal T,Rottner K

更新日期：2017-08-29 00:00:00

abstract：:The influence of the growth conditions of multilayer CdTe/ZnTe quantum dots (QDs) on Si substrate upon their carrier dynamics is studied using intensity integration and broadening photoluminescence. The unusual temperature dependence of the line broadening is explained using a model for interband transitions that invo...

journal_title：Scientific reports

authors： Man MT,Lee HS

更新日期：2015-02-05 00:00:00

abstract：:Danggui Buxue Tang (DBT) is a classic Chinese herbal formula which consists of Astragali mongholici Radix and Angelica sinensis Radix (ASR). For chemical ingredients, HPLC were performed. Results showed compared with single herbs, DBT decoction could promote the dissolution of ingredients such as ferulic acid and caly...

journal_title：Scientific reports

authors： Lin PL,Li ZC,Xie RF,Wang YH,Zhou X

更新日期：2017-03-22 00:00:00

abstract：:Autotaxin (ATX) is a secreted enzyme metabolized by liver sinusoidal endothelial cells that has been associated with liver fibrosis. We evaluated serum ATX values in 128 treatment-naïve, histologically assessed primary biliary cholangitis (PBC) patients and 80 healthy controls for comparisons of clinical parameters in...

journal_title：Scientific reports

authors： Joshita S,Umemura T,Usami Y,Yamashita Y,Norman GL,Sugiura A,Yamazaki T,Fujimori N,Kimura T,Matsumoto A,Igarashi K,Yoshizawa K,Ota M,Tanaka E

更新日期：2018-05-25 00:00:00

abstract：:MicroRNAs (miRNAs) are important post-transcriptional regulators involved in animal adipogenesis, however, their roles in bovine fat deposition remain poorly understood. In the present study, we conducted a comparative RNA sequencing to identify the key miRNAs involved in beef lipid accumulation by comparing the backf...

journal_title：Scientific reports

authors： Guo Y,Zhang X,Huang W,Miao X

更新日期：2017-03-08 00:00:00

abstract：:The late Ediacaran witnessed an increase in metazoan diversity and ecological complexity, marking the inception of the Cambrian Explosion. To constrain the drivers of this diversification, we combine redox and nutrient data for two shelf transects, with an inventory of biotic diversity and distribution from the Nama G...

journal_title：Scientific reports

authors： Bowyer FT,Shore AJ,Wood RA,Alcott LJ,Thomas AL,Butler IB,Curtis A,Hainanan S,Curtis-Walcott S,Penny AM,Poulton SW

更新日期：2020-02-10 00:00:00

abstract：:Nano/microfibrous structure can induce high cellular activities because of the topological similarity of the extracellular matrix, and thus, are widely used in various tissue regenerative materials. However, the fabrication of a bioceramic (high weight percent)-based 3D microfibrous structure is extremely difficult be...

journal_title：Scientific reports

authors： Kim M,Yun HS,Kim GH

更新日期：2017-06-09 00:00:00

abstract：:Organic-inorganic hybrid perovskite materials have recently been identified as a promising light absorber for solar cells. In the efficient solar cells, the perovskite active layer has generally been fabricated by either vapor deposition or two-step sequential deposition process. Herein, electrochemically deposited Pb...

journal_title：Scientific reports

authors： Huang JH,Jiang KJ,Cui XP,Zhang QQ,Gao M,Su MJ,Yang LM,Song Y

更新日期：2015-10-29 00:00:00

abstract：:Integrin alpha-4 (ITGA4) is a validated therapeutic target for multiple sclerosis (MS) and Natalizumab, an antibody targeting ITGA4 is currently approved for treating MS. However, there are severe side effects related to this therapy. In this study, we report the development of a novel DNAzyme that can efficiently cle...

journal_title：Scientific reports

authors： Chakravarthy M,Aung-Htut MT,Le BT,Veedu RN

更新日期：2017-05-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Chen YP,Yeh CI,Lee TC,Huang JJ,Pei YC

更新日期：2020-06-04 00:00:00

abstract：:Lanzhou lamb rotavirus vaccine (LLR) is an oral live attenuated vaccine first licensed in China in 2000. To date, > 60 million doses of LLR have been distributed to children. However, very little is known about faecal shedding of LLR in children. Therefore, faecal samples (n = 1,184) were collected from 114 children f...

journal_title：Scientific reports

authors： Li JS,Cao B,Gao HC,Li DD,Lin L,Li LL,Liu N,Duan ZJ

更新日期：2018-01-17 00:00:00

abstract：:Accurate estimation of carrier probabilities of cancer susceptibility gene mutations is an important part of pre-test genetic counselling. Many predictive models are available but their applicability in the Asian population is uncertain. We evaluated the performance of five BRCA mutation risk predictive models in a Ch...

journal_title：Scientific reports

authors： Hung FH,Wang YA,Jian JW,Peng HP,Hsieh LL,Hung CF,Yang MM,Yang AS

更新日期：2019-07-15 00:00:00

abstract：:Over 80% of perinatal mortality in Japan is due to stillbirths after 22 weeks of gestation, with one in 300 families experiencing fetal loss every year. This study aimed to assess causes and risk factors for singleton stillbirth in Japan. A retrospective cross-sectional study was conducted using the Japan Society of O...

journal_title：Scientific reports

authors： Haruyama R,Gilmour S,Ota E,Abe SK,Rahman MM,Nomura S,Miyasaka N,Shibuya K

更新日期：2018-03-07 00:00:00

abstract：:Pancreatic cancer (PC), as the leading cause of cancer death worldwide, is one of the deadliest tumors with a very low 5-year survival rate. Therefore, it is urgent to seek new biomarkers of PC for more accurate and reliable treatments. To identify the differentially expressed miRNAs (DEM) in PC tissues, we performed ...

journal_title：Scientific reports

authors： Wang HL,Zhou R,Liu J,Chang Y,Liu S,Wang XB,Huang MF,Zhao Q

更新日期：2017-09-13 00:00:00

abstract：:To evaluate the corneal spherical aberrations in cataract patients with and without high myopia, we conducted a retrospective case series of 502 cataract eyes with high myopia and 1500 age-related cataract eyes and measure their corneal biometric data and axial length using Pentacam and IOLMaster. Both the anterior an...

journal_title：Scientific reports

authors： Zhang M,Qian D,Jing Q,Chen J,Jiang Y

更新日期：2019-02-05 00:00:00

abstract：:Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare disease, characterised by the aplasia of vagina and uterus in women with a 46,XX karyotype. Most cases are sporadic, but familial recurrence has also been described. Herein, we investigated an Italian cohort of 36 unrelated MRKH patients to explore the presence ...

journal_title：Scientific reports

authors： Pontecorvi P,Bernardini L,Capalbo A,Ceccarelli S,Megiorni F,Vescarelli E,Bottillo I,Preziosi N,Fabbretti M,Perniola G,Benedetti Panici P,Pizzuti A,Grammatico P,Marchese C

更新日期：2021-01-11 00:00:00

abstract：:Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B lymphocyte responses is largely unexplored. Here, we show that chronic B cell depletion (Ba...

journal_title：Scientific reports

authors： Ponnuswamy P,Joffre J,Herbin O,Esposito B,Laurans L,Binder CJ,Tedder TF,Zeboudj L,Loyer X,Giraud A,Zhang Y,Tedgui A,Mallat Z,Ait-Oufella H

更新日期：2017-06-23 00:00:00

abstract：:Glycolipids had received increasing attention because of their uses in various industries like cosmetics, pharmaceuticals, food and machinery manufacture. Microalgae were competitive organisms to accumulate metabolic substance. However, using microalgae to produce glycolipid was rare at present. In this study, glycoli...

journal_title：Scientific reports

authors： Wang X,Shen Z,Miao X

更新日期：2016-07-21 00:00:00

abstract：:Superdirective antennas developed over the last century have received renewed interest in recent years from the development of metamaterials. These arrays of electromagnetic resonators (or meta-atoms) carrying short wavelength electro- and/or magneto-inductive waves support current distributions with very high spatial...

journal_title：Scientific reports

authors： Vallecchi A,Radkovskaya A,Li L,Faulkner G,Stevens CJ,Shamonina E

更新日期：2020-01-14 00:00:00

abstract：:The exploitation of surface plasmon polaritons has been mostly limited to the visible and near infrared range, due to the low frequency limit for coherent plasmon excitation and the reduction of confinement on the metal surface for lower energies. In this work we show that 3D--out of plane--nanostructures can consider...

journal_title：Scientific reports

authors： Malerba M,Alabastri A,Miele E,Zilio P,Patrini M,Bajoni D,Messina GC,Dipalo M,Toma A,Proietti Zaccaria R,De Angelis F

更新日期：2015-11-10 00:00:00

abstract：:Moyamoya disease is an idiopathic human cerebrovascular disorder that is characterized by progressive stenosis and abnormal collateral vessels. We recently identified mysterin/RNF213 as its first susceptibility gene, which encodes a 591-kDa protein containing enzymatically active P-loop ATPase and ubiquitin ligase dom...

journal_title：Scientific reports

authors： Morito D,Nishikawa K,Hoseki J,Kitamura A,Kotani Y,Kiso K,Kinjo M,Fujiyoshi Y,Nagata K

更新日期：2014-03-24 00:00:00

abstract：:The widely used mood stabilizer valproate (VPA) causes perturbation of energy metabolism, which is implicated in both the therapeutic mechanism of action of the drug as well as drug toxicity. To gain insight into these mechanisms, we determined the effects of VPA on energy metabolism in yeast. VPA treatment increased ...

journal_title：Scientific reports

authors： Salsaa M,Pereira B,Liu J,Yu W,Jadhav S,Hüttemann M,Greenberg ML

更新日期：2020-07-16 00:00:00

abstract：:Cell-based assays are growing in importance for screening drugs and investigating their mechanisms of action. Most of the assays use so-called "normal" cell strain because it is difficult to produce cell lines in which the disease conditions are reproduced. In this study, we used a cell-resealing technique, which reve...

journal_title：Scientific reports

authors： Kano F,Noguchi Y,Murata M

更新日期：2017-11-09 00:00:00