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Clinicopathological features and prognostic factors of young breast cancers in Eastern Guangdong of China.

Abstract：

:Breast cancer in young women is typically with higher proportion of adverse pathological features. Breast cancer with BRCA1 mutation is often early-onset, and is usually associated with triple negative phenotpe. In this study, we aim to analyze the clinicopathological characteristics and prognosis in young breast cancer patients (≤35 years old) comparing to non-young patients (>35 years old). A total of 1913 cases of primary breast carcinoma with stage I-III were enrolled, with 283 cases diagnosed as young patients. No significant difference was observed in tumor size, TNM staging, lymph node metastasis, ER, HER-2 or histological grade between young and non-young patients. Multivariate analysis demonstrated that age was an independent prognostic factor for overall survival (OS). In 70 samples of young patients available, BRCA1 was immunohistochemically positive 85.7% in cytoplasm and 41.4% in nuclear. BRCA1 nuclear expression is not significantly associated with clinicopathological characteristics in young breast cancer patients.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wei JT,Huang WH,Du CW,Qiu SQ,Wei XL,Liu J,Zhang GJ

doi

10.1038/srep05360

subject

Has Abstract

pub_date

2014-06-19 00:00:00

pages

5360

issn

2045-2322

pii

srep05360

journal_volume

4

pub_type

杂志文章

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