Early antibody response and clinical outcome in experimental canine leishmaniasis.

Abstract:

:Infected dogs are the main reservoir of zoonotic visceral leishmaniasis, a widespread parasitic disease caused by Leishmania infantum. Therefore, the control of canine infections is required to reduce the incidence of human cases. Disease outcome in dogs depends on the fine balance between parasite virulence and efficacy of the immune system. Thus, knowledge of early response could yield relevant information for diagnosis and follow-up. In our study, 20 Beagle dogs were intravenously infected with 108 amastigotes of a fresh isolate of L. infantum and monitored along 16 weeks post inoculation. Specific antibody response and clinical evolution of infected animals were highly variable. Immunofluorescence antibody test (IFAT) and enzyme linked immunosorbent assay (ELISA) were useful to assess infection status, although only ELISA with promastigote-coated plates and, particularly, western blotting (WB) allowed an early diagnosis. Prominent antigens were identified by mass peptide fingerprinting. Chaperonin HSP60, 32 and 30 KDa antigens were recognized by all dogs on week 10 post infection. This suggests that these antigens may be valuable for early diagnosis. Advanced infection showed, in addition, reactivity to HSP83 and HSP70. Disease outcome did not show a clear relationship with ELISA or IFAT titers. Correlation between the clinical status and the combined reactivity to some antigens sustains their use for diagnosis and follow-up.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Olías-Molero AI,Corral MJ,Jiménez-Antón MD,Alunda JM

doi

10.1038/s41598-019-55087-w

subject

Has Abstract

pub_date

2019-12-09 00:00:00

pages

18606

issue

1

issn

2045-2322

pii

10.1038/s41598-019-55087-w

journal_volume

9

pub_type

杂志文章
  • MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1.

    abstract::Previous studies have suggested that microRNA-107 (miR-107) regulates cell migration in tumor and promotes Hypoxia Inducible Factor 1α (HIF1α) regulated angiogenesis under hypoxia. We found that miR-107 was strongly expressed in ischemic boundary zone (IBZ) after permanent middle cerebral artery occlusion (pMCAO) in r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13316

    authors: Li Y,Mao L,Gao Y,Baral S,Zhou Y,Hu B

    更新日期:2015-08-21 00:00:00

  • Anti-cancer efficacy of nonthermal plasma dissolved in a liquid, liquid plasma in heterogeneous cancer cells.

    abstract::The therapeutic potential of nonthermal plasma for cancer treatment has been reported recently. The heterogeneity of cancer cells need to be addressed to design effective anticancer treatments. Here, we show that treatment with nonthermal atmospheric-pressure plasma dissolved in a liquid (liquid plasma) induces oxidat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29020

    authors: Nguyen NH,Park HJ,Yang SS,Choi KS,Lee JS

    更新日期:2016-07-01 00:00:00

  • Colonization with the enteric protozoa Blastocystis is associated with increased diversity of human gut bacterial microbiota.

    abstract::Alterations in the composition of commensal bacterial populations, a phenomenon known as dysbiosis, are linked to multiple gastrointestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome, or to infections by diverse enteric pathogens. Blastocystis is one of the most common single-celled euk...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25255

    authors: Audebert C,Even G,Cian A,Blastocystis Investigation Group.,Loywick A,Merlin S,Viscogliosi E,Chabé M

    更新日期:2016-05-05 00:00:00

  • Identification of conserved proteins from diverse shell matrix proteome in Crassostrea gigas: characterization of genetic bases regulating shell formation.

    abstract::The calcifying shell is an excellent model for studying biomineralization and evolution. However, the molecular mechanisms of shell formation are only beginning to be elucidated in Mollusca. It is known that shell matrix proteins (SMPs) play important roles in shell formation. With increasing data of shell matrix prot...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45754

    authors: Feng D,Li Q,Yu H,Kong L,Du S

    更新日期:2017-04-04 00:00:00

  • Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice.

    abstract::Although the search for quantitative trait loci for behaviour remains a considerable challenge, the complicated genetic architecture of quantitative traits is beginning to be understood. The current project utilised heterogeneous stock (HS) male mice (n = 580) to investigate the genetic basis for brain weights, activi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41204

    authors: Janecka M,Marzi SJ,Parsons MJ,Liu L,Paya-Cano JL,Smith RG,Fernandes C,Schalkwyk LC

    更新日期:2017-02-01 00:00:00

  • Estimation of the impact of Fasciola hepatica infection on time taken for UK beef cattle to reach slaughter weight.

    abstract::Fasciolosis is common in UK beef cattle, but it is unclear at what levels liver fluke burdens cause production losses. This study aimed to address these uncertainties by estimating the impact of liver fluke infection on UK beef cattle productivity and investigating the use of diagnostic tests in a quantitative manner....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07396-1

    authors: Mazeri S,Rydevik G,Handel I,Bronsvoort BMD,Sargison N

    更新日期:2017-08-04 00:00:00

  • Noise-induced switching from a symmetry-protected shallow metastable state.

    abstract::We consider escape from a metastable state of a nonlinear oscillator driven close to triple its eigenfrequency. The oscillator can have three stable states of period-3 vibrations and a zero-amplitude state. Because of the symmetry of period-tripling, the zero-amplitude state remains stable as the driving increases. Ho...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66243-y

    authors: Tadokoro Y,Tanaka H,Dykman MI

    更新日期:2020-06-26 00:00:00

  • Effective Hamiltonian for surface states of topological insulator nanotubes.

    abstract::In this work we derive an effective Hamiltonian for the surface states of a hollow topological insulator (TI) nanotube with finite width walls. Unlike a solid TI cylinder, a TI nanotube possesses both an inner as well as outer surface on which the states localized at each surface are coupled together. The curvature al...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45350

    authors: Siu ZB,Tan SG,Jalil MB

    更新日期:2017-04-03 00:00:00

  • Macroscopic phase separation of superconductivity and ferromagnetism in Sr0.5Ce0.5FBiS2-x Se x revealed by μSR.

    abstract::The compound Sr0.5Ce0.5FBiS2 belongs to the intensively studied family of layered BiS2 superconductors. It attracts special attention because superconductivity at T sc  = 2.8 K was found to coexist with local-moment ferromagnetic order with a Curie temperature T C  = 7.5 K. Recently it was reported that upon replacing...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17637-y

    authors: Nikitin AM,Grinenko V,Sarkar R,Orain JC,Salis MV,Henke J,Huang YK,Klauss HH,Amato A,Visser A

    更新日期:2017-12-12 00:00:00

  • Giant proximity effect in single-crystalline MgB2 bilayers.

    abstract::Although giant proximity effect (GPE) can shed important information on understanding superconducting pairing mechanisms and superconducting electronics, reports on the GPE are few because the fabrication of the junctions with GPE is technologically difficult. Here, we report a GPE in the single-crystalline MgB2 bilay...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40263-9

    authors: Jung SG,Pham D,Park TH,Choi HY,Seo JW,Kang WN,Park T

    更新日期:2019-03-01 00:00:00

  • Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway.

    abstract::The present work aimed to investigate the activities and underlying mechanisms of dioscin against alcoholic liver fibrosis (ALF). In vivo liver fibrosis in mice was induced by an alcoholic liquid diet, and in vitro studies were performed on activated HSC-T6 and LX2 cells treated with lipopolysaccharide. Our results sh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18038

    authors: Liu M,Xu Y,Han X,Yin L,Xu L,Qi Y,Zhao Y,Liu K,Peng J

    更新日期:2015-12-10 00:00:00

  • Significantly enhanced creep resistance of low volume fraction in-situ TiBw/Ti6Al4V composites by architectured network reinforcements.

    abstract::We present a new class of TiBw/Ti6Al4V composites with a network reinforcement architecture that exhibits a significant creep resistance compared to monolithic Ti6Al4V alloys. Creep tests performed at temperatures between 773 K and 923 K and stress range of 100 MPa-300 MPa indicate both a significant improvement of th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40823

    authors: Wang S,Huang LJ,Geng L,Scarpa F,Jiao Y,Peng HX

    更新日期:2017-01-17 00:00:00

  • Quantitative assessment of maternal biomarkers related to one-carbon metabolism and neural tube defects.

    abstract::Periconceptional supplementation with folic acid reduces the occurrence of neural tube defects (NTDs). The association between maternal abnormalities in homocysteine metabolism (e.g., hyperhomocysteinaemia, folate deficiency and low vitamin B12) and the risk of NTDs-affected pregnancies has been widely evaluated in re...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/srep08510

    authors: Tang KF,Li YL,Wang HY

    更新日期:2015-03-02 00:00:00

  • Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients.

    abstract::The loss of retinal pericytes (RPCs) is a hallmark of early stage diabetic retinopathy (DR), but the mechanism underlying RPC death is unclear. Although it was postulated in previous studies using bovine RPCs that autoantibodies against RPCs might develop and induce RPC death, it is unknown whether autoantibodies agai...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20341

    authors: Zhang L,Li Y,Payne J,Srivastava S,Fan X,Fung J,Li X,Kern TS,Lin F

    更新日期:2016-02-03 00:00:00

  • Symbiotic cooperation between freshwater rock-boring bivalves and microorganisms promotes silicate bioerosion.

    abstract::Bioerosion is a process with a high socio-economic impact that contributes to coastal retreat, and likely to increase with climate change. Whereas limestone bioerosion is well explained by a combination of mechanical and chemical pathways, the bioerosion mechanisms of silicates, which are harder and chemically more re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70265-x

    authors: Daval D,Guyot F,Bolotov IN,Vikhrev IV,Kondakov AV,Lyubas AA,Bychkov AY,Yapaskurt VO,Cabié M,Pokrovsky OS

    更新日期:2020-08-07 00:00:00

  • Manipulation of Auxin Response Factor 19 affects seed size in the woody perennial Jatropha curcas.

    abstract::Seed size is a major determinant of seed yield but few is known about the genetics controlling of seed size in plants. Phytohormones cytokinin and brassinosteroid were known to be involved in the regulation of herbaceous plant seed development. Here we identified a homolog of Auxin Response Factor 19 (JcARF19) from a ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40844

    authors: Sun Y,Wang C,Wang N,Jiang X,Mao H,Zhu C,Wen F,Wang X,Lu Z,Yue G,Xu Z,Ye J

    更新日期:2017-01-19 00:00:00

  • Sea-Island-Like Morphology of CuNi Bimetallic Nanoparticles Uniformly Anchored on Single Layer Graphene Oxide as a Highly Efficient and Noble-Metal-Free Catalyst for Cyanation of Aryl Halides.

    abstract::Aryl nitriles are versatile compounds that can be synthesized via transition-metal-mediated cyanation of aryl halides. Most of the supported-heterogeneous catalysts are noble-metals based and there are very limited numbers of efficient non-noble metal based catalysts demonstrated for the cyanation of aryl halides. Her...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57483-z

    authors: Mayakrishnan G,Elayappan V,Kim IS,Chung IM

    更新日期:2020-01-20 00:00:00

  • The role of Snell's law for a magnonic majority gate.

    abstract::In the fifty years since the postulation of Moore's Law, the increasing energy consumption in silicon electronics has motivated research into emerging devices. An attractive research direction is processing information via the phase of spin waves within magnonic-logic circuits, which function without charge transport ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08114-7

    authors: Kanazawa N,Goto T,Sekiguchi K,Granovsky AB,Ross CA,Takagi H,Nakamura Y,Uchida H,Inoue M

    更新日期:2017-08-11 00:00:00

  • A calmodulin like EF hand protein positively regulates oxalate decarboxylase expression by interacting with E-box elements of the promoter.

    abstract::Oxalate decarboxylase (OXDC) enzyme has immense biotechnological applications due to its ability to decompose anti-nutrient oxalic acid. Flammulina velutipes, an edible wood rotting fungus responds to oxalic acid by induction of OXDC to maintain steady levels of pH and oxalate anions outside the fungal hyphae. Here, w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14578

    authors: Kamthan A,Kamthan M,Kumar A,Sharma P,Ansari S,Thakur SS,Chaudhuri A,Datta A

    更新日期:2015-10-12 00:00:00

  • Validation of an apnea and hypopnea detection algorithm implemented in implantable cardioverter defibrillators. The AIRLESS study.

    abstract::Diagnosis of sleep apnea (SA) using simple tools has the potential to improve the efficacy of cardiac implants in the prevention of cardiac arrhythmias. The aim of the present study was to validate a transthoracic impedance sensor for SA diagnosis in patients with cardiac implants. We compared the apnea-hypopnea index...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45255-3

    authors: Defaye P,Mendelson M,Tamisier R,Jacon P,Venier S,Arnol N,Pépin JL

    更新日期:2019-07-03 00:00:00

  • Environment-based preference selection promotes cooperation in spatial prisoner's dilemma game.

    abstract::The impact of environment on individuals is particularly critical. In evolutionary games, adopting the strategy of the neighbor who performs better is nontrivial for the survival and maintenance of cooperation, in that such an action may help the agents to obtain higher benefit and more obvious evolutionary advantages...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34116-0

    authors: Wu Y,Zhang S,Zhang Z

    更新日期:2018-10-23 00:00:00

  • Endogenous emotion generation ability is associated with the capacity to form multimodal internal representations.

    abstract::Training the capacity to self-generate emotions can be a potent "vaccine" against negative stressors and be an effective intervention for affective psychopathology. However, due to a lack of knowledge about sources of individual differences in generation abilities, it is unclear how to optimally design such interventi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-20380-7

    authors: Engen H,Kanske P,Singer T

    更新日期:2018-01-31 00:00:00

  • A Novel PET Imaging Probe for the Detection and Monitoring of Translocator Protein 18 kDa Expression in Pathological Disorders.

    abstract::A new fluorine-substituted ligand, compound 1 (CB251), with a very high affinity (Ki = 0.27 ± 0.09 nM) and selectivity for the 18-kDa translocator protein (TSPO), is presented as an attractive biomarker for the diagnosis of neuroinflammation, neurodegeneration and tumour progression. To test compound 1 as a TSPO PET i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20422

    authors: Perrone M,Moon BS,Park HS,Laquintana V,Jung JH,Cutrignelli A,Lopedota A,Franco M,Kim SE,Lee BC,Denora N

    更新日期:2016-02-08 00:00:00

  • Silver Nanowires Modified with PEDOT: PSS and Graphene for Organic Light-Emitting Diodes Anode.

    abstract::Silver nanowires (AgNWs) networks are promising candidates for the replacement of indium tin oxide (ITO). However, the surface roughness of the AgNWs network is still too high for its application in optoelectronic devices. In this work, we have reduced the surface roughness of the AgNWs networks to 6.4 nm, compared to...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45392

    authors: Xu Y,Wei X,Wang C,Cao J,Chen Y,Ma Z,You Y,Wan J,Fang X,Chen X

    更新日期:2017-03-28 00:00:00

  • The high-affinity metal Transporters NRAMP1 and IRT1 Team up to Take up Iron under Sufficient Metal Provision.

    abstract::Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in Arabidopsis thaliana. The molecular bases for low affinity transport however remained unknown. Since IRT1 and NRAMP1 have a broad range of subst...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37222

    authors: Castaings L,Caquot A,Loubet S,Curie C

    更新日期:2016-11-16 00:00:00

  • Author Correction: Comprehensive analysis of correlations among codon usage bias, gene expression, and substitution rate in Arachis duranensis and Arachis ipaënsis orthologs.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-60582-6

    authors: Song H,Gao H,Liu J,Tian P,Nan Z

    更新日期:2020-02-27 00:00:00

  • Population structure of an orchid mycorrhizal fungus with genus-wide specificity.

    abstract::Fundamental life history processes of mycorrhizal fungi with inconspicuous fruiting bodies can be difficult to elucidate. In this study we investigated the species identities and life history of the orchid mycorrhizal Tulasnella fungi, which associate with the south eastern Australia orchid genus Chiloglottis. Tulasne...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05855-3

    authors: Ruibal MP,Triponez Y,Smith LM,Peakall R,Linde CC

    更新日期:2017-07-17 00:00:00

  • Footprints reveal direct evidence of group behavior and locomotion in Homo erectus.

    abstract::Bipedalism is a defining feature of the human lineage. Despite evidence that walking on two feet dates back 6-7 Ma, reconstructing hominin gait evolution is complicated by a sparse fossil record and challenges in inferring biomechanical patterns from isolated and fragmentary bones. Similarly, patterns of social behavi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28766

    authors: Hatala KG,Roach NT,Ostrofsky KR,Wunderlich RE,Dingwall HL,Villmoare BA,Green DJ,Harris JW,Braun DR,Richmond BG

    更新日期:2016-07-12 00:00:00

  • Safety of Ligation of Aberrant Left Hepatic Artery Originating from Left Gastric Artery in Laparoscopic Gastrectomy for Gastric Cancer.

    abstract::There are still lot of controversies whether aberrant left hepatic artery (ALHA) originating from left gastric artery should be ligated or preserved during gastric cancer (GC) surgery. We aimed to investigate this issue. We reviewed ALHA cases who had laparoscopic gastrectomy for gastric cancer at Seoul National Unive...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62587-7

    authors: Ang RRG,Lee HJ,Bae JS,Zhu CC,Berlth F,Kim TH,Park SH,Suh YS,Kong SH,Kim SH,Yang HK

    更新日期:2020-04-03 00:00:00

  • Natural killer cells impede the engraftment of cardiomyocytes derived from induced pluripotent stem cells in syngeneic mouse model.

    abstract::Transplantation of cardiomyocytes derived from induced pluripotent stem cell (iPSC-CMs) is a promising approach for increasing functional CMs during end-stage heart failure. Although major histocompatibility complex (MHC) class I matching between donor cells and recipient could reduce acquired immune rejection, innate...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47134-3

    authors: Nakamura Y,Miyagawa S,Yoshida S,Sasawatari S,Toyofuku T,Toda K,Sawa Y

    更新日期:2019-07-25 00:00:00