Abstract:
:The lack of a marker of epileptogenesis is an unmet medical need, not only from the clinical perspective but also from the point of view of the pre-clinical research. Indeed, the lack of this kind of marker affects the investigations on the mechanisms of epileptogenesis as well as the development of novel therapeutic approaches aimed to prevent or to mitigate the severity of the incoming epilepsy in humans. In this work, we provide evidence that in an experimental model of epileptogenesis that mimics the alteration of the blood-brain barrier permeability, a key-mechanism that contributes to the development of epilepsy in humans and in animals, the prolonged occurrence in the electrocorticograms (ECoG) of high rates of a nonlinear dynamical regimes known as intermittency univocally characterizes the population of experimental animals which develop epilepsy, hence it can be considered as the first biophysical marker of epileptogenesis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rizzi M,Weissberg I,Milikovsky DZ,Friedman Adoi
10.1038/srep31129subject
Has Abstractpub_date
2016-08-04 00:00:00pages
31129issn
2045-2322pii
srep31129journal_volume
6pub_type
杂志文章abstract::The uncertainty relation is a fundamental limit in quantum mechanics and is of great importance to quantum information processing as it relates to quantum precision measurement. Due to interactions with the surrounding environment, a quantum system will unavoidably suffer from decoherence. Here, we investigate the dyn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01094-8
更新日期:2017-04-21 00:00:00
abstract::Interaction of light with media often occurs with a femtosecond response time. Its measurement by conventional techniques requires the use of femtosecond lasers and sophisticated time-gated optical detection. Here we demonstrate that by exploiting quantum interference of entangled photons it is possible to measure the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11694-z
更新日期:2017-09-13 00:00:00
abstract::The bioactive plant diterpene oridonin displays important pharmacological activities and is widely used in traditional Chinese medicine; however, its molecular mechanism of action is still incompletely described. In vitro and in vivo data have demonstrated anti-tumor activity of oridonin and its ability to interfere w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35088-x
更新日期:2018-11-13 00:00:00
abstract::Hepatitis C virus (HCV) infection of hepatocytes promotes liver fibrosis by activation of hepatic stellate cells (HSCs) and excessive deposition of extracellular matrix in liver tissue. Whether or not host factors released from the HCV-infected hepatocytes play role in HSCs activation is unclear. In this study, HSCs w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04259-7
更新日期:2017-06-30 00:00:00
abstract::To what extent deep-time dispersal limitation shapes present-day biodiversity at broad spatial scales remains elusive. Here, we compiled a continental dataset on the distributions of African lizard species in the reptile subfamily Agaminae (a relatively young, Neogene radiation of agamid lizards which ancestors coloni...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34014
更新日期:2016-09-27 00:00:00
abstract::Shoulder problems are common in patients with a cervical herniated intervertebral disc (HIVD). This study aimed to explore the incidence and risk of shoulder capsulitis/tendonitis following cervical HIVD surgery. We used data from the Taiwan "Longitudinal Health Insurance Database". We identified all patients who were...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26898
更新日期:2016-05-27 00:00:00
abstract::A junction between two boundaries of a topological superconductor (TSC), mediated by localized edge modes of Majorana fermions, is investigated. The tunneling of fermions across the junction depends on the magnetic flux. It breaks the time-reversal symmetry at the boundary of the sample. The persistent current is dete...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07492-2
更新日期:2017-08-02 00:00:00
abstract::We evaluated the in-vitro effect of potassium on CD4+ T cells and the role of urinary potassium as a potential biomarker of disease activity in patients with ulcerative colitis (UC). This prospective observational cohort study included healthy controls (n = 18) and UC patients [n = 30, median age: 40 (IQR: 28-46) year...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18046-x
更新日期:2017-12-22 00:00:00
abstract::Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-α subunits is traditionally associated to post-translational modifications such as hydroxylation, acetylation, ubiquitination, and phosphorylation. H...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12698
更新日期:2015-08-03 00:00:00
abstract::Enhancement of endogenous neurogenesis after ischemic stroke may improve functional recovery. We previously demonstrated that medium B, which is a combination with epidermal growth factor (EGF) and fibronectin, can promote neural stem/progenitor cell (NSPC) proliferation and migration. Here, we showed that medium B pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63598-0
更新日期:2020-04-20 00:00:00
abstract::Low-dimensional behavior of large systems of globally coupled oscillators has been intensively investigated since the introduction of the Ott-Antonsen ansatz. In this report, we generalize the Ott-Antonsen ansatz to second-order Kuramoto models in complex networks. With an additional inertia term, we find a low-dimens...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04783
更新日期:2014-05-02 00:00:00
abstract::Cassava is one of the most important root crops as a reliable source of food and carbohydrates. Carbohydrate metabolism and starch accumulation in cassava storage root is a cascade process that includes large amounts of proteins and cofactors. Here, comparative proteomics were conducted in cassava root at nine develop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19643
更新日期:2016-01-21 00:00:00
abstract::In this paper, for the first time, the switchable two-color quantum dot laser has been realized considering solution process technology, which has both simultaneous and lonely lasing capability exploiting selective energy contacts. Furthermore, both channels can be modulated independently, which is a significant featu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60859-w
更新日期:2020-03-24 00:00:00
abstract::Episodic ataxia is an autosomal dominant ion channel disorder characterized by episodes of imbalance and incoordination. The disease is genetically heterogeneous and is classified as episodic ataxia type 2 (EA2) when it is caused by a mutation in the CACNA1A gene, encoding the α1A subunit of the P/Q-type voltage-gated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02554-x
更新日期:2017-05-31 00:00:00
abstract::Proteomics studies of fungal systems have progressed dramatically based on the availability of more fungal genome sequences in recent years. Different proteomics strategies have been applied toward characterization of fungal proteome and revealed important gene functions and proteome dynamics. Presented here is the ap...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10132-4
更新日期:2017-09-12 00:00:00
abstract::Recovering the position of a source from the fluxes of diffusing particles through small receptors allows a biological cell to determine its relative position, spatial localization and guide it to a final target. However, how a source can be recovered from point fluxes remains unclear. Using the Narrow Escape approach...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19355-5
更新日期:2018-01-17 00:00:00
abstract::Marine crabs inhabit shallow coastal/estuarine habitats particularly sensitive to climate change, and yet we know very little about the diversity of their responses to environmental change. We report the effects of a rarely studied, but increasingly prevalent, combination of environmental factors, that of near-future ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34089-0
更新日期:2018-10-23 00:00:00
abstract::Sapphirinid copepods, which are marine zooplankton, exhibit tunable structural colors originating from a layered structure of guanine crystal plates. In the present study, the coloring portion of adult male of a sapphirinid copepod, Sapphirina nigromaculata, under the dorsal body surface was characterized to clarify t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59090-4
更新日期:2020-02-10 00:00:00
abstract::Today, despite decades of developments in medicine and the growing interest in precision healthcare, vast majority of diagnoses happen once patients begin to show noticeable signs of illness. Early indication and detection of diseases, however, can provide patients and carers with the chance of early intervention, bet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62922-y
更新日期:2020-04-28 00:00:00
abstract::CD4(+)CD25(+) T cells are critical for maintenance of immunologic self-tolerance. We measured the number of CD4(+)CD25(+) cells in the patients with primary malignant hypertension related kidney injury, to explore the molecular pathogenesis of this disease. We selected 30 patients with primary malignant hypertension r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27659
更新日期:2016-06-09 00:00:00
abstract::In the jejunum, PepT1 is particularly enriched in the well-differentiated absorptive epithelial cells in the villi. Studies of expression and function of PepT1 along the crypt-villus axis demonstrated that this protein is crucial to the process of di/tripeptide absorption. We recently exhibited that PepT1 plays an imp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27119
更新日期:2016-06-01 00:00:00
abstract::Electrochemically active bacteria (EAB) are ubiquitous in environment and have important application in the fields of biogeochemistry, environment, microbiology and bioenergy. However, rapid and sensitive methods for EAB identification and evaluation of their extracellular electron transfer ability are still lacking. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01315
更新日期:2013-01-01 00:00:00
abstract::We report comparative indoor and outdoor stability testing of organic solar cells based on a blend between a donor-acceptor polyfluorene copolymer and a fullerene derivative. The outdoor testing was conducted for a period over 12,000 hours in Sheffield, England, with a Ts80 lifetime determined in excess of 10,000 hour...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01505-w
更新日期:2017-05-02 00:00:00
abstract::Exploiting new, low-cost and efficient electrocatalysts for hydrogen evolution reaction (HER) is important to resolve the energy crisis and environment pollution. In this work, graphene decorated with Ni nanoparticles (NPs) were synthesized via one-pot reduction using graphene oxide (GO, the obtained composite was den...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10589
更新日期:2015-06-12 00:00:00
abstract::The hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. HAS2 is a key enzyme required for HA synthesis and is the key factor in this pathway. However, the regulation of HAS2 and the HAS2-mediated pathway by microRNAs in GCs is poorly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21197
更新日期:2016-02-18 00:00:00
abstract::Adding fluoride into bioactive glasses leads to fluorapatite formation and a decrease in glass transition temperature. Recently, chloride has been introduced into glasses as an alternative to fluoride. The presence of the large chloride ion lowers glass crystallisation tendency and increases glass molar volume, which ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19544-2
更新日期:2018-01-22 00:00:00
abstract::The generation of novelty is central to any creative endeavor. Novelty generation and the relationship between novelty and individual hedonic value have long been subjects of study in social psychology. However, few studies have utilized large-scale datasets to quantitatively investigate these issues. Here we consider...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02758
更新日期:2013-09-26 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is a chronic disease with several degrees of histological features which may progress to cirrhosis. Obesity is an important risk factor and although NAFLD has no specific pharmacological treatment, bariatric surgery has been associated with NAFLD regression in severely obese p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65556-2
更新日期:2020-05-22 00:00:00
abstract::Lassa virus (LASV) is the causative agent of Lassa fever (LF), an often-fatal hemorrhagic disease. LF is endemic in Nigeria, Sierra Leone and other West African countries. Diagnosis of LASV infection is challenged by the genetic diversity of the virus, which is greatest in Nigeria. The ReLASV Pan-Lassa Antigen Rapid T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65736-0
更新日期:2020-05-26 00:00:00
abstract::G-proteins are implicated in plant productivity, but their genome-wide roles in regulating agronomically important traits remain uncharacterized. Transcriptomic analyses of rice G-protein alpha subunit mutant (rga1) revealed 2270 differentially expressed genes (DEGs) including those involved in C/N and lipid metabolis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81824-1
更新日期:2021-01-27 00:00:00