PepT1 Expression Helps Maintain Intestinal Homeostasis by Mediating the Differential Expression of miRNAs along the Crypt-Villus Axis.

abstract：:Phytoplasmas (class, Mollicutes) are insect-transmissible and plant-pathogenic bacteria that multiply intracellularly in both plants and insects through host switching. Our previous study revealed that phytoplasmal sigma factor rpoD of OY-M strain (rpoDOY) could be a key regulator of host switching, because the expres...

journal_title：Scientific reports

authors： Miura C,Komatsu K,Maejima K,Nijo T,Kitazawa Y,Tomomitsu T,Yusa A,Himeno M,Oshima K,Namba S

更新日期：2015-07-07 00:00:00

abstract：:To investigate the safety, cost-effectiveness, and clinical outcomes of simultaneous bilateral total knee arthroplasty (TKA) in hemophilic arthropathy (HA), the requirements for transfusions, complications, costs, hospital stays, Hospital for Special Surgery (HSS) knee scores, knee range of motion (ROM) and revision r...

journal_title：Scientific reports

authors： Jiang C,Zhao Y,Feng B,Zhai J,Bian Y,Qiu G,Weng X

更新日期：2018-01-25 00:00:00

abstract：:Defective hepatic autophagy is observed in obesity and diabetes, whereas autophagy is inhibited by insulin in hepatocytes. Insulin-induced anti-autophagy is mediated by non-canonical Gαi3 signaling via an unknown mechanism. Previously, we identified the anti-autophagic activity of Tnfaip8 via activation of mammalian t...

journal_title：Scientific reports

authors： Kim JS,Park J,Kim MS,Ha JY,Jang YW,Shin DH,Son JH

更新日期：2017-07-24 00:00:00

abstract：:Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN). Alprostadil (Prostaglandin E1, PGE1) had protective effects on renal function. However, it is unknown whether PGE1 inhibited insulin resistance in renal tubule epithelial cells via autophagy, which plays a protecti...

journal_title：Scientific reports

authors： Wei W,An XR,Jin SJ,Li XX,Xu M

更新日期：2018-01-08 00:00:00

abstract：:The aim of this prospective study was to evaluate the changes in stereopsis in patients who underwent vitrectomy for macular hole (MH) and assess the relationship between stereopsis and retinal microstructures. Fifty-two patients who underwent successful vitrectomy for unilateral MH and 20 control participants were re...

journal_title：Scientific reports

authors： Okamoto F,Moriya Y,Sugiura Y,Murakami T,Morikawa S,Hoshi S,Hiraoka T,Oshika T

更新日期：2020-11-11 00:00:00

abstract：:Improving the prevention efficacy of health screening campaigns by increasing their attendance rate represents a challenge that calls for new strategies. This paper analyzes the response to a Pap test screening campaign of 155,000 women over the last decade. Using a mathematical model of statistical physics origins we...

journal_title：Scientific reports

authors： Burioni R,Contucci P,Fedele M,Vernia C,Vezzani A

更新日期：2015-04-23 00:00:00

abstract：:The development of physiologically active semiochemicals is largely limited by the labor-consuming searching process. How to screen active semiochemicals efficiently is of significance to the extension of behavior regulation in pest control. Here pharmacophore modeling and shape-based virtual screening were combined t...

journal_title：Scientific reports

authors： Liu J,Tian Z,Zhang Y

更新日期：2016-10-06 00:00:00

abstract：:We previously demonstrated that ABCD4 does not localize to peroxisomes but rather, the endoplasmic reticulum (ER), because it lacks the NH2-terminal hydrophilic region required for peroxisomal targeting. It was recently reported that mutations in ABCD4 result in a failure to release vitamin B12 from lysosomes. A simil...

journal_title：Scientific reports

authors： Kawaguchi K,Okamoto T,Morita M,Imanaka T

更新日期：2016-07-26 00:00:00

abstract：:Difficulties in the production of lignin from rice straw because of high silica content in the recovered lignin reduce its recovery yield and applications as bio-fuel and aromatic chemicals. Therefore, the objective of this study is to develop a novel method to reduce the silica content in lignin from rice straw more ...

journal_title：Scientific reports

authors： Do NH,Pham HH,Le TM,Lauwaert J,Diels L,Verberckmoes A,Do NHN,Tran VT,Le PK

更新日期：2020-12-04 00:00:00

abstract：:PCTAIRE kinase 3 (PCTK3) is a member of the cyclin dependent kinase family, but its physiological function remains unknown. We previously reported that PCTK3-knockdown HEK293T cells showed actin accumulation at the leading edge, suggesting that PCTK3 is involved in the regulation of actin reorganization. In this study...

journal_title：Scientific reports

authors： Matsuda S,Kawamoto K,Miyamoto K,Tsuji A,Yuasa K

更新日期：2017-03-31 00:00:00

abstract：:The concept of brain circuit disorders has been proposed for a variety of neuropsychiatric diseases, characterized by pathological disturbances of neuronal networks including changes in oscillatory signaling of re-entrant cortico-subcortical loops in the basal ganglia system. Parts of this circuitry play a pivotal rol...

journal_title：Scientific reports

authors： Maurer L,Tang H,Haumesser JK,Altschüler J,Kühn AA,Spranger J,van Riesen C

更新日期：2017-11-14 00:00:00

abstract：:Jasmonates (JAs) are plant-specific key signaling molecules that respond to various stimuli and are involved in the synthesis of secondary metabolites. However, little is known about the JA signal pathway, especially in economically significant medicinal plants. To determine the functions of novel genes that participa...

journal_title：Scientific reports

authors： Ge Q,Zhang Y,Hua WP,Wu YC,Jin XX,Song SH,Wang ZZ

更新日期：2015-09-21 00:00:00

abstract：:Obese individuals can be categorized as "healthy obese" (MHO) and "unhealthy obese" (MUO) based on the presence or absence of metabolic abnormality. This study sets out to assess potential genetic causes behind persistence of healthy metabolic status in individuals categorized as "healthy obese". This study was conduc...

journal_title：Scientific reports

authors： Gharooi Ahangar O,Javanrouh N,Daneshpour MS,Barzin M,Valizadeh M,Azizi F,Hosseinpanah F

更新日期：2020-08-12 00:00:00

abstract：:γ-Oryzanol (OZ), which has a lot of beneficial effects, is a mixture of ferulic acid esters of triterpene alcohols (i.e., triterpene alcohol type of OZ (TTA-OZ)) and ferulic acid esters of plant sterols (i.e., plant sterol type of OZ (PS-OZ)). Although it has been reported that OZ is found in several kinds of cereal t...

journal_title：Scientific reports

authors： Ito J,Sawada K,Ogura Y,Xinyi F,Rahmania H,Mohri T,Kohyama N,Kwon E,Eitsuka T,Hashimoto H,Kuwahara S,Miyazawa T,Nakagawa K

更新日期：2019-08-29 00:00:00

abstract：:Glacial refugia are centers of high biodiversity. Therefore, knowledge on their locations and reactions of associated populations and landscapes to climatic changes is crucial for conservation management. We here investigated the biogeography of a butterfly species linked to open forest habitats. Using mitochondrial a...

journal_title：Scientific reports

authors： Wendt M,Husemann M,Kramp K,Schmitt T

更新日期：2021-01-08 00:00:00

abstract：:The quantification of hepatitis C virus (HCV) is essential for the management of chronic hepatitis C therapy. We have developed a fully automated microfluidic RT-qPCR system for rapid quantitative detection of HCV RNA in human EDTA-plasma and serum, and the performance of the method was assessed. The platform for the ...

journal_title：Scientific reports

authors： Chan SDH,Toyoda H,Sanjeeviraman J,Souppe A,Iwamoto M,Wu W,Eto D,Tada T,Kumada T,Zhang JP

更新日期：2020-04-30 00:00:00

abstract：:Cardiac energy metabolism must cope with early postnatal changes in tissue oxygen tensions, hemodynamics, and cell proliferation to sustain development. Here, we tested the hypothesis that proliferating neonatal cardiomyocytes are dependent on high oxidative energy metabolism. We show that energy-related gene expressi...

journal_title：Scientific reports

authors： de Carvalho AETS,Bassaneze V,Forni MF,Keusseyan AA,Kowaltowski AJ,Krieger JE

更新日期：2017-11-13 00:00:00

abstract：:Organic gases undergoing conversion to form secondary organic aerosol (SOA) during atmospheric aging are largely unidentified, particularly in regions influenced by anthropogenic emissions. SOA dominates the atmospheric organic aerosol burden and this knowledge gap contributes to uncertainties in aerosol effects on cl...

journal_title：Scientific reports

authors： Bruns EA,El Haddad I,Slowik JG,Kilic D,Klein F,Baltensperger U,Prévôt AS

更新日期：2016-06-17 00:00:00

abstract：:Apparently mundane, amorphous nanostructures of carbon have optical properties which are as exotic as their crystalline counterparts. In this work we demonstrate a simple and inexpensive mechano-chemical method to prepare bulk quantities of self-passivated, amorphous carbon dots. Like the graphene quantum dots, the wa...

journal_title：Scientific reports

authors： Siddique AB,Pramanick AK,Chatterjee S,Ray M

更新日期：2018-06-27 00:00:00

abstract：:Knowledge of the ecology of N2-fixing (diazotrophic) plankton is mainly limited to oligotrophic (sub)tropical oceans. However, diazotrophs are widely distributed and active throughout the global ocean. Likewise, relatively little is known about the temporal dynamics of diazotrophs in productive areas. Between February...

journal_title：Scientific reports

authors： Moreira-Coello V,Mouriño-Carballido B,Marañón E,Fernández-Carrera A,Bode A,Sintes E,Zehr JP,Turk-Kubo K,Varela MM

更新日期：2019-03-06 00:00:00

abstract：:A better understanding of the mechanisms of action of human adjuvants could inform a rational development of next generation vaccines for human use. Here, we exploited a genome wide transcriptomics analysis combined with a systems biology approach to determine the molecular signatures induced by four clinically tested...

journal_title：Scientific reports

authors： Olafsdottir TA,Lindqvist M,Nookaew I,Andersen P,Maertzdorf J,Persson J,Christensen D,Zhang Y,Anderson J,Khoomrung S,Sen P,Agger EM,Coler R,Carter D,Meinke A,Rappuoli R,Kaufmann SH,Reed SG,Harandi AM

更新日期：2016-12-13 00:00:00

abstract：:This work reports a facile method for preparing the new photoactive In(2)O(3) films as well as their implementation in photoelectrochemical (PEC) application. We firstly investigated the relationship between oxygen vacancies (V(O)) and PEC performance and revealed a rule between them. We found that the optimized In(2)...

journal_title：Scientific reports

authors： Gan J,Lu X,Wu J,Xie S,Zhai T,Yu M,Zhang Z,Mao Y,Wang SC,Shen Y,Tong Y

更新日期：2013-01-01 00:00:00

abstract：:Co-existing infection/inflammation and birth asphyxia potentiate the risk of developing neonatal encephalopathy (NE) and adverse outcome. In a newborn piglet model we assessed the effect of E. coli lipopolysaccharide (LPS) infusion started 4 h prior to and continued for 48 h after hypoxia on brain cell death and syste...

journal_title：Scientific reports

authors： Martinello KA,Meehan C,Avdic-Belltheus A,Lingam I,Ragab S,Hristova M,Tann CJ,Peebles D,Hagberg H,Wolfs TGAM,Klein N,Tachtsidis I,Golay X,Kramer BW,Fleiss B,Gressens P,Robertson NJ

更新日期：2019-07-15 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Capdessus R,King M,Sorbo DD,Duff M,Ridgers CP,McKenna P

更新日期：2019-10-09 00:00:00

abstract：:Two-photon (2P) microscopy is a powerful tool for imaging and exploring label-free biological tissues at high resolution. Although this type of microscopy has been demonstrated in ex vivo ocular tissues of both humans and animal models, imaging the human eye in vivo has always been challenging. This work presents a no...

journal_title：Scientific reports

authors： Ávila FJ,Gambín A,Artal P,Bueno JM

更新日期：2019-07-12 00:00:00

abstract：:COX-2 inhibition may be of benefit in the treatment of tuberculosis (TB) through a number of pathways including efflux pump inhibition (increasing intracellular TB drug levels) and diverse effects on inflammation and the immune response. We investigated celecoxib (a COX-2 inhibitor) alone and with standard anti-tuberc...

journal_title：Scientific reports

authors： Naftalin CM,Verma R,Gurumurthy M,Hee KH,Lu Q,Yeo BCM,Tan KH,Lin W,Yu B,Seng KY,Lee LS,Paton NI

更新日期：2018-09-10 00:00:00

abstract：:Hyperspectral imaging (HSI) is being explored in endoscopy as a tool to extract biochemical information that may improve contrast for early cancer detection in the gastrointestinal tract. Motion artefacts during medical endoscopy have traditionally limited HSI application, however, recent developments in the field hav...

journal_title：Scientific reports

authors： Grigoroiu A,Yoon J,Bohndiek SE

更新日期：2020-03-03 00:00:00

abstract：:Rare individuals remain cognitively intact despite the presence of neuropathology usually associated with fully symptomatic Alzheimer's disease (AD), which we refer to as Non-Demented with Alzheimer's disease Neuropathology (NDAN). Understanding the involved mechanism(s) of their cognitive resistance may reveal novel ...

journal_title：Scientific reports

authors： Briley D,Ghirardi V,Woltjer R,Renck A,Zolochevska O,Taglialatela G,Micci MA

更新日期：2016-06-14 00:00:00

abstract：:Major depression (MDD) has been associated with an altered EEG frontal asymmetry measured in resting state; nevertheless, this association has showed a weak consistency across studies. In the present study, which starts from an evolutionistic view of psychiatric disorders, we investigated frontal asymmetry in MDD, usi...

journal_title：Scientific reports

authors： Spironelli C,Maffei A,Romeo Z,Piazzon G,Padovan G,Magnolfi G,Pasini I,Gomez Homen F,Concari G,Angrilli A

更新日期：2020-05-18 00:00:00

abstract：:Transcript levels are the primary factor determining protein levels, but for the majority of genes, fold changes in transcript levels are larger than the corresponding changes in protein levels, a phenomenon that is termed "protein homeostasis". However, this phenomenon is not well characterized in the context of envi...

journal_title：Scientific reports

authors： Sun Y,Wen J,Chen R,Deng Y

更新日期：2019-05-24 00:00:00