Abstract：
:Transcript levels are the primary factor determining protein levels, but for the majority of genes, fold changes in transcript levels are larger than the corresponding changes in protein levels, a phenomenon that is termed "protein homeostasis". However, this phenomenon is not well characterized in the context of environmental changes. In this study, we sequenced the entire transcriptome and proteome of chicken primary hepatocytes administered three mycotoxin treatments Aflatoxin B1 (AFB1), Ochoratoxin A (OTA) and Zearalenone (ZEN). Each mycotoxin induced unique set of differential expressed transcripts and proteins, suggesting variable cytotoxicity and biochemical action in cell. We found a weak positive correlation between transcript and protein changes, and the transcript changes were higher than the protein changes. Furthermore, we observed pathway-specific protein homeostasis pattern under mycotoxin stress. Specifically, the "Metabolism", "Transcription" and "Translation" pathways (housekeeping pathways) showed lower fold changes in protein/mRNA levels than non-housekeeping pathways such as "Cell growth and death" and "Immune system". Protein molecular weight had a weak negative effect on protein production, and this effect was stronger for non-housekeeping pathways. Overall, we hypothesize housekeeping pathways maintain stable protein production for baseline cellular function, whereas non-housekeeping pathways is associated with the fitness response to environmental stress.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sun Y,Wen J,Chen R,Deng Ydoi
10.1038/s41598-019-44305-0subject
Has Abstractpub_date
2019-05-24 00:00:00pages
7819issue
1issn
2045-2322pii
10.1038/s41598-019-44305-0journal_volume
9pub_type
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