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High genetic burden of type 2 diabetes can promote the high prevalence of disease: a longitudinal cohort study in Iran.

Abstract：

:Type 2 diabetes (T2D) is emerging as one of the serious public health issues in both developed and developing counties. Here, we surveyed the worldwide population differentiation in T2D-associated variants and assessed the genetic burden of the disease in an ongoing Tehran Cardio-Metabolic Genetic Study (TCGS) cohort represented the Iranian population. We found multiple SNPs that were significantly depleted or enriched in at least one of the five populations of 1,000 Genome Project (African, American, East Asian, European, and South Asian) as well as the Iranian population. Interestingly, TCF7L2, a well-known associated gene with T2D, harbors the highest number of enriched risk alleles almost in all populations except for East Asian, where this gene embraces the largest number of significantly depleted risk alleles. The polygenic risk score (PRS) of the enriched risk alleles was calculated for 1,867 diabetic and 2,855 non-diabetic participants in the TCGS cohort, interestingly demonstrating that the risk of developing T2D was almost two times higher in top PRS quintile compared with the lowest quintile after adjusting for other known risk factors.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Moazzam-Jazi M,Najd Hassan Bonab L,Zahedi AS,Daneshpour MS

doi

10.1038/s41598-020-70725-4

subject

Has Abstract

pub_date

2020-08-19 00:00:00

pages

14006

issue

1

issn

2045-2322

pii

10.1038/s41598-020-70725-4

journal_volume

10

pub_type

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