Abstract：
:The risk of Helicobacter pylori infection is highest in childhood, but the colonization process of the stomach mucosa is poorly understood. We used anesthetized Mongolian gerbils to study the initial stages of H. pylori colonization. Prandial and postprandial gastric conditions characteristic of humans of different ages were simulated. The fraction of bacteria that reached the deep mucus layer varied strongly with the modelled postprandial conditions. Colonization success was weak with fast gastric reacidification typical of adults. The efficiency of deep mucus entry was also low with a slow pH decrease as seen in pH profiles simulating the situation in babies. Initial colonization was most efficient under conditions simulating the postprandial reacidification and pepsin activation profiles in young children. In conclusion, initial H. pylori colonization depends on age-related gastric physiology, providing evidence from an in vivo infection model that suggests an explanation why the bacterium is predominantly acquired in early childhood.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bücker R,Azevedo-Vethacke M,Groll C,Garten D,Josenhans C,Suerbaum S,Schreiber Sdoi
10.1038/srep00994subject
Has Abstractpub_date
2012-01-01 00:00:00pages
994issn
2045-2322journal_volume
2pub_type
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