Abstract：
:Atherosclerosis arises from leukocyte infiltration and thickening of the artery walls and constitutes a major component of vascular disease pathology, but the molecular events underpinning this process are not fully understood. Proteins containing an Asn-Gly-Arg (NGR) motif readily undergo deamidation of asparagine to generate isoDGR structures that bind to integrin αvβ3 on circulating leukocytes. Here we report the identification of isoDGR motifs in human atherosclerotic plaque components including extracellular matrix (ECM) proteins fibronectin and tenascin C, which have been strongly implicated in human atherosclerosis. We further demonstrate that deamidation of NGR motifs in fibronectin and tenascin C leads to increased adhesion of the monocytic cell line U937 and enhanced binding of primary human monocytes, except in the presence of a αvβ3-blocking antibody or the αv-selective inhibitor cilengitide. In contrast, under the same deamidating conditions monocyte-macrophages displayed only weak binding to the alternative ECM component vitronectin which lacks NGR motifs. Together, these findings confirm a critical role for isoDGR motifs in mediating leukocyte adhesion to the ECM via integrin αvβ3 and suggest that protein deamidation may promote the pathological progression of human atherosclerosis by enhancing monocyte recruitment to developing plaques.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Dutta B,Park JE,Kumar S,Hao P,Gallart-Palau X,Serra A,Ren Y,Sorokin V,Lee CN,Ho HH,de Kleijn D,Sze SKdoi
10.1038/s41598-017-06202-2subject
Has Abstractpub_date
2017-07-18 00:00:00pages
5765issue
1issn
2045-2322pii
10.1038/s41598-017-06202-2journal_volume
7pub_type
杂志文章abstract：:Spiral waves anchored to obstacles in cardiac tissues may cause lethal arrhythmia. To unpin these anchored spirals, comparing to high-voltage side-effect traditional therapies, wave emission from heterogeneities (WEH) induced by the uniform electric field (UEF) has provided a low-voltage alternative. Here we provide a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04831
更新日期：2014-04-29 00:00:00
abstract：:Hyperuricemia is an abnormal metabolic condition characterized by an increase in uric acid levels in the blood. It is the cause of gout, manifested by inflammatory arthritis, pain and disability. This study examined the possible ameliorative impacts of parsley (PAR) and celery (CEL) as hypouricemic agents at biochemic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66205-4
更新日期：2020-06-11 00:00:00
abstract：:Standard aquatic toxicity tests of chemicals are often limited by the chemicals' water solubility. Liposomes have been widely used in the pharmaceutical industry to overcome poor pharmacokinetics and biodistribution. In this work, liposomes were synthesized and used in an ecotoxicological context, as a tool to assure ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66694-3
更新日期：2020-06-16 00:00:00
abstract：:Salinization is having a major impact on wetlands and its biota worldwide. Specifically, many migratory animals that rely on wetlands are increasingly exposed to elevated salinity on their nonbreeding grounds. Experimental evidence suggests that physiological challenges associated with increasing salinity may disrupt ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07258-w
更新日期：2017-07-31 00:00:00
abstract：:Multisensory interactions are essential to make sense of the environment by transforming the mosaic of sensory inputs received by the organism into a unified perception. Brain rhythms allow coherent processing within areas or between distant brain regions and could thus be instrumental in functionally connecting remot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47503-y
更新日期：2019-08-02 00:00:00
abstract：:Accurate placement of a coordinate system on the radius is important to quantitatively report 3D surgical planning parameters or joint kinematics using 4D imaging techniques. In clinical practice, the scanned length of the radial shaft varies among scanning protocols and scientific studies. The error in positioning a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65060-7
更新日期：2020-05-15 00:00:00
abstract：:The current assessment of corneal vascularisation (CV) relies on slit-lamp examination, which may be subjective. Dye-based angiographies, like indocyanine green angiography (ICGA), allows for good visualisation of anterior segment blood vessels. However, ICGA is invasive and can be associated with systemic adverse eff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80099-2
更新日期：2021-01-13 00:00:00
abstract：:Eucalyptus globulus is an aromatic medicinal plant which known for its 1,8-cineole main pharmacological constituent exhibits as natural analgesic agent. Eucalyptus globulus-loaded micellar nanoparticle was developed via spontaneous emulsification technique and further evaluation for its analgesic efficacy study, in vi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50134-y
更新日期：2019-09-23 00:00:00
abstract：:Neuromuscular impairment requires adherence to a rehabilitation regimen for maximum recovery of motor function. Consumer-grade game controllers have emerged as a viable means to relay supervised physical therapy to patients' homes, thereby increasing their accessibility to healthcare. These controllers allow patients ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59927-y
更新日期：2020-02-28 00:00:00
abstract：:We present a concept and prototype of a memory element based on current driven magneto-impedance (MI) effect that stores the binary data (0, 1) as the orientation of the magnetization. The magnetization orientation in the surface layer with tilted anisotropy easy axis can be switched controllably between two stable st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36180
更新日期：2016-10-26 00:00:00
abstract：:Anomalous transport in porous media is commonly believed to be induced by the highly complex pore space geometry. However, this phenomenon is also observed in porous media with rather simple pore structure. In order to answer how ubiquitous can anomalous transport be in porous media, we in this work systematically inv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39363-3
更新日期：2019-03-14 00:00:00
abstract：:To investigate the concentrations of rare earth elements in cereals and assess human health risk through cereal consumption, a total of 327 cereal samples were collected from rare earth mining area and control area in Shandong, China. The contents of 14 rare earth elements were determined by Inductively Coupled Plasma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10256-7
更新日期：2017-08-29 00:00:00
abstract：:Episodic ataxia is an autosomal dominant ion channel disorder characterized by episodes of imbalance and incoordination. The disease is genetically heterogeneous and is classified as episodic ataxia type 2 (EA2) when it is caused by a mutation in the CACNA1A gene, encoding the α1A subunit of the P/Q-type voltage-gated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02554-x
更新日期：2017-05-31 00:00:00
abstract：:Empirical yield estimation from satellite data has long lacked suitable combinations of spatial and temporal resolutions. Consequently, the selection of metrics, i.e., temporal descriptors that predict grain yield, has likely been driven by practicality and data availability rather than by systematic targetting of cri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51715-7
更新日期：2019-10-31 00:00:00
abstract：:We studied the spin-transfer torque (STT) in graphene based normal-metal/topological-insulator/ferromagnet heterostructures (N/TI/F), which is induced by the helical spin-polarized current in the quantum spin Hall insulator. We found that the STT is comparable in magnitude to the STT in ferromagnetic-normal- ferromagn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22680-4
更新日期：2018-03-12 00:00:00
abstract：:Lack of effective anti-metastatic drugs creates a major hurdle for metastatic lung cancer therapy. For successful lung cancer treatment, there is a strong need of newer therapeutics with metastasis-inhibitory potential. In the present study, we determined the anti-metastatic and anti-angiogenic potential of a natural ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21860
更新日期：2016-02-24 00:00:00
abstract：:Childhood and adolescent overweight and obesity are increasing in China, but limited information is available on its secular trends in Guangzhou. In this cross-sectional study, ten-wave successive data were obtained from the physical fitness surveillance for students in Guangzhou from 2003 to 2012. A total of 2,619,15...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-12094-z
更新日期：2017-09-21 00:00:00
abstract：:Modern DNA sequencing capabilities have led to the discovery of a large number of new bacteriophage genomes, which are a rich source of novel proteins with an unidentified biological role. The genome of Enterobacter cancerogenus bacteriophage Enc34 contains several proteins of unknown function that are nevertheless co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15774-y
更新日期：2017-11-14 00:00:00
abstract：:By moving the alkoxy group on the spacer from position 5 to position 4 to add another protocol for the algorithm for intermolecular and intramolecular hydrogen bonding interactions, highly regioselectivity of noncovalent synthesis of the hydrazide-based cyclic hexamers was achieved: one out of thirteen possible isomer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01059
更新日期：2013-01-01 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. We prospectively evaluated endothelial function by assessing flow-mediated dilatation (FMD) of the brachial artery in patients with biopsy-proven NAFLD. This prospective study included 139 patients (50 healthy controls, 47 patients wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65835-y
更新日期：2020-06-01 00:00:00
abstract：:Mammalian cytokinetic abscission is mediated by the ESCRT membrane fission machinery. While much has been clarified on the topology and kinetics of abscission through high-resolution microscopy, key questions regarding the mechanism of abscission remain open. Here we apply cryogenic soft-X-ray tomography to elucidate ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27629
更新日期：2016-06-10 00:00:00
abstract：:Low intensity transcranial focused ultrasound (LIFU) is a promising method of non-invasive neuromodulation that uses mechanical energy to affect neuronal excitability. LIFU confers high spatial resolution and adjustable focal lengths for precise neuromodulation of discrete regions in the human brain. Before the full p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62265-8
更新日期：2020-03-27 00:00:00
abstract：:Some neural network can be trained by transfer learning, which uses a pre-trained neural network as the source task, for a small target task's dataset. The performance of the transfer learning depends on the knowledge (i.e., layers) selected from the pre-trained network. At present, this knowledge is usually chosen by...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64165-3
更新日期：2020-05-18 00:00:00
abstract：:Although biophysical yield responses to local warming have been studied, we know little about how crop yield growth-a function of climate and technology-responds to global temperature and socioeconomic changes. Here, we present the yield growth of major crops under warming conditions from preindustrial levels as simul...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-017-08214-4
更新日期：2017-08-10 00:00:00
abstract：:It is generally believed that anthropogenic aerosols cool the atmosphere; therefore, they offset the global warming resulting from greenhouse gases to some extent. Reduction in sulphate, a primary anthropogenic aerosol, is necessary for mitigating air pollution, which causes atmospheric warming. Here, the changes in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78805-1
更新日期：2020-12-10 00:00:00
abstract：:The predictions for a warmer and drier climate and for increased likelihood of climate extremes raise high concerns about the possible collapse of dryland ecosystems, and about the formation of new drylands where native species are less tolerant to water stress. Using a dryland-vegetation model for plant species that ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56080-z
更新日期：2019-12-20 00:00:00
abstract：:Animals can adjust their behaviour according to previous experience gained during foraging. In parasitoids, experience plays a key role in host location, a hierarchical process in which air-borne and substrate-borne semiochemicals are used to find hosts. In nature, chemical traces deposited by herbivore hosts when wal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27098
更新日期：2016-06-02 00:00:00
abstract：:The replication-incompetent adenovirus (Ad) vector is one of the most promising vectors for gene therapy; however, systemic administration of Ad vectors results in severe hepatotoxicities, partly due to the leaky expression of Ad genes in the liver. Here we show that nuclear factor-kappa B (NF-κB) mediates the leaky e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19922
更新日期：2016-01-27 00:00:00
abstract：:This study was aimed at elucidating the changes of mandible symmetry in a rabbit model with low estrogen levels induced by ovariectomy (OVX) combined with temporomandibular joint (TMJ) anterior disc displacement without reduction (ADDWoR). 32 growing rabbits were randomly allocated into 4 groups; OVX group, ADDWoR gro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34023-4
更新日期：2018-10-23 00:00:00
abstract：:Mesenchymal stem cells (MSC) are osteoblasts progenitors and a variety of studies suggest that they may play an important role for the health in the field of bone regeneration. Magnesium supplementation is gaining importance as adjuvant treatment to improve osteogenesis, although the mechanisms involving this process ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08379-y
更新日期：2017-08-10 00:00:00
