Abstract:
:The nervous system controls most rhythmic behaviors, with a remarkable exception. In Caenorhabditis elegans periodic defecation rhythm does not appear to involve the nervous system. Such oscillations are studied in detail with genetic and molecular biology tools. The small size of C. elegans cells impairs the use of standard electrophysiological methods. We studied a similar rhythmic pacemaker in the noticeably larger gut cells of Heterorhabditis megidis nematode. H. megidis defecation cycle is driven by a central pattern generator (CPG) associated with unusual all-or-none hyper-polarization "action potential". The CPG cycle period depends on the membrane potential and CPG cycling also persisted in experiments where the membrane potential of gut cells was continuously clamped at steady voltage levels. The usual excitable tissue description does not include the endoderm or imply the generation of hyper-polarization spikes. The nematode gut cells activity calls for a reevaluation of the excitable cells definition.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kuznetsov VP,Slivko-Koltchik GA,Voronov DA,Panchin YVdoi
10.1038/s41598-017-18118-ysubject
Has Abstractpub_date
2017-12-19 00:00:00pages
17834issue
1issn
2045-2322pii
10.1038/s41598-017-18118-yjournal_volume
7pub_type
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