The duration of the interpregnancy interval in multiparous women and maternal weight gain between pregnancies: findings from a UK population-based cohort.

abstract：:Current approaches to predicting a cardiovascular disease (CVD) event rely on conventional risk factors and cross-sectional data. In this study, we applied machine learning and deep learning models to 10-year CVD event prediction by using longitudinal electronic health record (EHR) and genetic data. Our study cohort i...

journal_title：Scientific reports

authors： Zhao J,Feng Q,Wu P,Lupu RA,Wilke RA,Wells QS,Denny JC,Wei WQ

更新日期：2019-01-24 00:00:00

abstract：:The extreme miniaturization of biological and chemical assays in aqueous-droplet compartments enables spatiotemporal control for large-scale parallel experimentation and can thus permit new capabilities for "digitizing" directed molecular evolution methodologies. We report a remarkably facile bulk method to generate m...

journal_title：Scientific reports

authors： Sharma B,Takamura Y,Shimoda T,Biyani M

更新日期：2016-05-20 00:00:00

abstract：:Boron carbide (B4C) coating on diamond particle is synthesized by heating diamond particles in a powder mix of H3BO3 and B in Ar atmosphere. The composition, bond state and coverage fraction of boron carbide coating on diamond particles are investigated. The boron carbide coating favors to grow on diamond (100) surfac...

journal_title：Scientific reports

authors： Sun Y,He L,Zhang C,Meng Q,Liu B,Gao K,Wen M,Zheng W

更新日期：2017-09-06 00:00:00

abstract：:Wildfires burn large parts of the tropics every year, shaping ecosystem structure and functioning. Yet the complex interplay between climate, vegetation and human factors that drives fire dynamics is still poorly understood. Here we show that on all continents, except Australia, tropical fire regimes change drasticall...

journal_title：Scientific reports

authors： Hantson S,Scheffer M,Pueyo S,Xu C,Lasslop G,van Nes EH,Holmgren M,Mendelsohn J

更新日期：2017-10-30 00:00:00

abstract：:Optimal mental workload plays a key role in driving performance. Thus, driver-assisting systems that automatically adapt to a drivers current mental workload via brain-computer interfacing might greatly contribute to traffic safety. To design economic brain computer interfaces that do not compromise driver comfort, it...

journal_title：Scientific reports

authors： Geissler CF,Schneider J,Frings C

更新日期：2021-01-12 00:00:00

abstract：:Cuprizone-induced demyelination in mice is a frequently used model in preclinical multiple sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated a promise as a myelin biomarker in human and animal studies with a particular advantage of ...

journal_title：Scientific reports

authors： Khodanovich MY,Sorokina IV,Glazacheva VY,Akulov AE,Nemirovich-Danchenko NM,Romashchenko AV,Tolstikova TG,Mustafina LR,Yarnykh VL

更新日期：2017-04-24 00:00:00

abstract：:A reliable method for the diagnosis of minimal cardiac ischemia would meet a strong demand for the sensitive diagnosis of coronary artery disease in cardiac stress testing and risk stratification in patients with chest pain but unremarkable ECGs and biomarkers. We hypothesized that platelets accumulate early on in isc...

journal_title：Scientific reports

authors： Ziegler M,Alt K,Paterson BM,Kanellakis P,Bobik A,Donnelly PS,Hagemeyer CE,Peter K

更新日期：2016-12-02 00:00:00

abstract：:The cysteine-rich PLAC8 domain of unknown function occurs in proteins found in most Eukaryotes. PLAC8-proteins play important yet diverse roles in different organisms, such as control of cell proliferation in animals and plants or heavy metal resistance in plants and fungi. Mammalian Onzin can be either pro-proliferat...

journal_title：Scientific reports

authors： Daghino S,Di Vietro L,Petiti L,Martino E,Dallabona C,Lodi T,Perotto S

更新日期：2019-04-29 00:00:00

abstract：:Hypertension is the most common and lethal risk factor for cardiovascular disease (CVD). Numerous variants have been associated with hypertension, however, most of which failed to get replication due to ethnic differences. In this study, we analyzed associations of 10 newly reported single nucleotide polymorphisms (SN...

journal_title：Scientific reports

authors： Yu Q,Sun HP,Chen WQ,Chen XQ,Xu Y,He YH,Kong QP

更新日期：2015-10-21 00:00:00

abstract：:Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with the development of atherosclerosis. We aimed to assess the genetic determinants of Lp-PLA2 activity and mass by genotyping multiple polymorphisms in PLA2G7, the gene encoding Lp-PLA2, among 1258 participants from the Chinese Multi-provincial ...

journal_title：Scientific reports

authors： Qi Y,Zhao D,Jia Z,Wang W,Wang M,Sun J,Liu J,Li Y,Xie W,Liu J

更新日期：2016-12-01 00:00:00

abstract：:Evidence suggest that overexpression of hypoxia-inducible factor-1α (HIF-1α) is linked to multidrug resistance of epilepsy. Here we explored whether aberrant expression of HIF-1α is regulated by miRNAs. Genome-wide microRNA expression profiling was performed on temporal cortex resected from mesial temporal lobe epilep...

journal_title：Scientific reports

authors： Li Y,Huang C,Feng P,Jiang Y,Wang W,Zhou D,Chen L

更新日期：2016-08-24 00:00:00

abstract：:Legionella pneumophila is a ubiquitous, pathogenic, Gram-negative bacterium responsible for legionellosis. Like many other amoeba-resistant microorganisms, L. pneumophila resists host clearance and multiplies inside the cell. Through its Dot/Icm type IV secretion system, the bacterium injects more than three hundred e...

journal_title：Scientific reports

authors： Mengue L,Régnacq M,Aucher W,Portier E,Héchard Y,Samba-Louaka A

更新日期：2016-11-02 00:00:00

abstract：:Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the destruction of interlobular biliary ductules, which progressively leads to cholestasis, hepatic fibrosis, cirrhosis, and eventually liver failure. Several mouse models have been used to clarify the pathogenesis of PBC and are general...

journal_title：Scientific reports

authors： Ma WT,Liu QZ,Yang JB,Yang YQ,Zhao ZB,Ma HD,Gershwin ME,Lian ZX

更新日期：2017-11-10 00:00:00

abstract：:The activity of the ubiquitin proteasome system (UPS) is downregulated in aggregation diseases such as Alzheimer's disease (AD). In this study, we investigated the therapeutic potential of the Agouti-related peptide (AgRP), which is secreted by human mesenchymal stem cells (MSCs), in terms of its effect on the regulat...

journal_title：Scientific reports

authors： Lee NK,Park SE,Kwon SJ,Shim S,Byeon Y,Kim JH,Na DL,Chang JW

更新日期：2017-01-04 00:00:00

abstract：:By eliminating the spherical aberrations of microsphere we derived a simple but useful formula on the focusing of dielectric microsphere. On basis of this formula, not only can researchers determine the parameters of an optical microsphere system with super-resolution, but they can also perform parameter transformatio...

journal_title：Scientific reports

authors： Xia T,Guo H,Hu J,Zhuang S

更新日期：2017-07-18 00:00:00

abstract：:Chronic stress and prolonged activation of defence pathways have deleterious consequences for the cell. Dietary restriction is believed to be beneficial as it induces the cellular stress response machinery. We report here that although the phenomenon is beneficial in a wild-type cell, dietary restriction leads to an i...

journal_title：Scientific reports

authors： Bhadra AK,Das E,Roy I

更新日期：2016-09-16 00:00:00

abstract：:The focus of this study is to evaluate the efficacy of Machine Learning (ML) algorithms in the long-lead prediction of El Niño (La Niña) Modoki (ENSO Modoki) index (EMI). We evaluated two widely used non-linear ML algorithms namely Support Vector Regression (SVR) and Random Forest (RF) to forecast the EMI at various l...

journal_title：Scientific reports

authors： Pal M,Maity R,Ratnam JV,Nonaka M,Behera SK

更新日期：2020-01-15 00:00:00

abstract：:With land privatization and fencing of thousands of hectares of communal grazing areas, East Africa is struggling with one of the most radical cultural and environmental changes in its history. The 668,500-hectare Greater Mara is of crucial importance for the great migrations of large mammals and for Maasai pastoralis...

journal_title：Scientific reports

authors： Løvschal M,Bøcher PK,Pilgaard J,Amoke I,Odingo A,Thuo A,Svenning JC

更新日期：2017-01-25 00:00:00

abstract：:We investigated the ocular surface (OS) system modifications after completely successful glaucoma surgery in thirty-eight patients undergoing trabeculectomy (surgical group), using laser scanning confocal microscopy (LSCM) and impression cytology (IC). Twenty-six medically controlled glaucomatous patients served as co...

journal_title：Scientific reports

authors： Agnifili L,Brescia L,Oddone F,Sacchi M,D'Ugo E,Di Marzio G,Perna F,Costagliola C,Mastropasqua R

更新日期：2019-08-05 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) plays a crucial role in breakdown of the blood-retinal barrier due to hyperpermeability in diabetic retinopathy (DR). However, the distinct signaling driven by VEGF and PlGF in the pathogenesis of DR remains unclear. In this study, we investi...

journal_title：Scientific reports

authors： Jiao W,Ji JF,Xu W,Bu W,Zheng Y,Ma A,Zhao B,Fan Q

更新日期：2019-10-25 00:00:00

abstract：:The Expanded Susceptibility to Smoking Index (ESSI) is based on the combination of susceptibility to smoking and curiosity about smoking. The ESSI can identify young people who are at risk of starting to smoke cigarettes and related products. The objective of this study was to analyse the ESSI results and to examine f...

journal_title：Scientific reports

authors： Santano-Mogena E,Franco-Antonio C,Chimento-Díaz S,Rico-Martín S,Cordovilla-Guardia S

更新日期：2021-01-21 00:00:00

abstract：:Ultrasonic mating signals in moths are argued to have evolved via exploitation of the receivers' sensory bias towards bat echolocation calls. We have demonstrated that female moths of the Asian corn borer are unable to distinguish between the male courtship song and bat calls. Females react to both the male song and b...

journal_title：Scientific reports

authors： Nakano R,Takanashi T,Surlykke A,Skals N,Ishikawa Y

更新日期：2013-01-01 00:00:00

abstract：:In this prospective pilot study, we aimed to evaluate the ability of cardiac magnetic resonance imaging (CMR) parameters of right ventricular function and pulmonary artery stiffness to identify pulmonary hypertension (PH), predict major adverse cardiovascular events (MACEs) in patients with secondary PH due to chronic...

journal_title：Scientific reports

authors： Agoston-Coldea L,Lupu S,Mocan T

更新日期：2018-09-27 00:00:00

abstract：:Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca(2+) imaging, and electrophys...

journal_title：Scientific reports

authors： Yang NN,Shi H,Yu G,Wang CM,Zhu C,Yang Y,Yuan XL,Tang M,Wang ZL,Gegen T,He Q,Tang K,Lan L,Wu GY,Tang ZX

更新日期：2016-05-10 00:00:00

abstract：:Ancient human remains of paleopathological interest typically contain highly degraded DNA in which pathogenic taxa are often minority components, making sequence-based metagenomic characterization costly. Microarrays may hold a potential solution to these challenges, offering a rapid, affordable, and highly informativ...

journal_title：Scientific reports

authors： Devault AM,McLoughlin K,Jaing C,Gardner S,Porter TM,Enk JM,Thissen J,Allen J,Borucki M,DeWitte SN,Dhody AN,Poinar HN

更新日期：2014-03-06 00:00:00

abstract：:Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors. Progesterone affects cell proliferation and survival via non-genomic effects. In ...

journal_title：Scientific reports

authors： Kasubuchi M,Watanabe K,Hirano K,Inoue D,Li X,Terasawa K,Konishi M,Itoh N,Kimura I

更新日期：2017-07-12 00:00:00

abstract：:A central challenge in designing and administering effective anticoagulants is achieving the proper therapeutic window and dosage for each patient. The Hill coefficient, nH, which measures the steepness of a dose-response relationship, may be a useful gauge of this therapeutic window. We sought to measure the Hill coe...

journal_title：Scientific reports

authors： Chang JB,Quinnies KM,Realubit R,Karan C,Rand JH,Tatonetti NP

更新日期：2016-07-21 00:00:00

abstract：:microRNAs are an abundant class of small non-coding RNAs that control gene expression post-transcriptionally. Importantly, microRNA activity participates in the regulation of cellular processes and is a potentially valuable source of biomarkers in the diagnosis and prognosis of human diseases. Here we introduce miQPCR...

journal_title：Scientific reports

authors： Benes V,Collier P,Kordes C,Stolte J,Rausch T,Muckentaler MU,Häussinger D,Castoldi M

更新日期：2015-06-25 00:00:00

abstract：:The functionalization of graphene remains an important challenge for numerous applications expected by this fascinating material. To keep advantageous properties of graphene after modification or functionalization of its structure, local approaches are a promising road. A novel technique is reported here that allows p...

journal_title：Scientific reports

authors： Li H,Daukiya L,Haldar S,Lindblad A,Sanyal B,Eriksson O,Aubel D,Hajjar-Garreau S,Simon L,Leifer K

更新日期：2016-01-29 00:00:00

abstract：:The interplay between structure and function is critical in the understanding of complex systems, their dynamics and their behavior. We investigated the interplay between structural and functional networks by means of the differential identifiability framework, which here quantifies the ability of identifying a partic...

journal_title：Scientific reports

authors： Vera-Ávila VP,Sevilla-Escoboza R,Goñi J,Rivera-Durón RR,Buldú JM

更新日期：2020-09-04 00:00:00