A bulk sub-femtoliter in vitro compartmentalization system using super-fine electrosprays.

abstract：:3D laboratory models of cancer are designed to recapitulate the biochemical and biophysical characteristics of the tumour microenvironment and aim to enable studies of cancer, and new therapeutic modalities, in a physiologically-relevant manner. We have developed an in vitro 3D model comprising a central high-density ...

journal_title：Scientific reports

authors： Azimi T,Loizidou M,Dwek MV

更新日期：2020-07-21 00:00:00

abstract：:Knee osteoarthritis (OA) is the most common musculoskeletal disorder. OA diagnosis is currently conducted by assessing symptoms and evaluating plain radiographs, but this process suffers from subjectivity. In this study, we present a new transparent computer-aided diagnosis method based on the Deep Siamese Convolution...

journal_title：Scientific reports

authors： Tiulpin A,Thevenot J,Rahtu E,Lehenkari P,Saarakkala S

更新日期：2018-01-29 00:00:00

abstract：:We aimed to assess the ankle-brachial index (ABI) in patients with Graves' disease. In the cross-sectional assessments, 81 patients with drug-naïve Graves' disease and 235 with euthyroidism were enrolled. ABI and vascular cell adhesion molecule-1 (VCAM-1) levels were assessed. In the prospective follow-up, 32 patients...

journal_title：Scientific reports

authors： Li YH,Lee IT

更新日期：2020-10-13 00:00:00

abstract：:Continuous subcutaneous insulin infusion (CSII) catheters are considered the weak link of insulin pump therapy. Wear-time considerably varies between patients and the choice of catheter material is based on personal preferences rather than scientific facts. Therefore, we systematically assessed and quantified the infl...

journal_title：Scientific reports

authors： Hauzenberger JR,Münzker J,Kotzbeck P,Asslaber M,Bubalo V,Joseph JI,Pieber TR

更新日期：2018-01-18 00:00:00

abstract：:Mass spectrometry (MS) for the detection of proteins is an indispensable tool for evaluating the biological processes of the proteome. Proteomics frequently requires proteolysis of proteins into peptide fragments. Proteins can be refractory to ideal proteolysis at the sequence level rendering them difficult to analyze...

journal_title：Scientific reports

authors： Reyna C,Mba Medie F,Champion MM,Champion PA

更新日期：2016-09-14 00:00:00

abstract：:Suffering from giant size of objective lenses and infeasible manipulations of distant targets, telescopes could not seek helps from present super-resolution imaging, such as scanning near-field optical microscopy, perfect lens and stimulated emission depletion microscopy. In this paper, local light diffraction shrinka...

journal_title：Scientific reports

authors： Wang C,Tang D,Wang Y,Zhao Z,Wang J,Pu M,Zhang Y,Yan W,Gao P,Luo X

更新日期：2015-12-18 00:00:00

abstract：:Imaging the distribution of sphingomyelin (SM) in membranes is an important issue in lipid-raft research. Recently we developed novel fluorescent SM analogs that exhibit partition and dynamic behaviors similar to native SM, and succeeded in visualizing lateral domain-segregation between SM-rich liquid-ordered (Lo) and...

journal_title：Scientific reports

authors： Kinoshita M,Ano H,Murata M,Shigetomi K,Ikenouchi J,Matsumori N

更新日期：2017-12-01 00:00:00

abstract：:Small molecule based targeted therapies for the treatment of metastatic melanoma hold promise but responses are often not durable, and tumors frequently relapse. Response to adoptive cell transfer (ACT)-based immunotherapy in melanoma patients are durable but patients develop resistance primarily due to loss of antige...

journal_title：Scientific reports

authors： Dextras C,Dashnyam M,Griner LAM,Sundaresan J,Chim B,Yu Z,Vodnala S,Lee CR,Hu X,Southall N,Marugan JJ,Jadhav A,Restifo NP,Acquavella N,Ferrer M,Singh A

更新日期：2020-03-30 00:00:00

abstract：:B cell derived induced pluripotent stem cells (BiPSCs) were recently established from peripheral blood B cells by the simultaneous transfection of Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) and C/EBPα using a Sendai virus vector. Here, using a different method, we established BiPSCs with immunoglobulin heavy chain (...

journal_title：Scientific reports

authors： Kawamura F,Inaki M,Katafuchi A,Abe Y,Tsuyama N,Kurosu Y,Yanagi A,Higuchi M,Muto S,Yamaura T,Suzuki H,Noji H,Suzuki S,Yoshida MA,Sasatani M,Kamiya K,Onodera M,Sakai A

更新日期：2017-05-10 00:00:00

abstract：:Checkpoint kinases are important in cellular surveillance pathways that help cells to cope with DNA damage and protect their genomes. In cycling cells, DNA replication is one of the most sensitive processes and therefore all organisms carefully regulate replication initiation and progression. The checkpoint kinase ATR...

journal_title：Scientific reports

authors： Bøe CA,Håland TW,Boye E,Syljuåsen RG,Grallert B

更新日期：2018-05-02 00:00:00

abstract：:Several cobalt-based Heusler alloys have been predicted to exhibit Weyl Semimetal behavior due to time reversal symmetry breaking. Co2TiGe is one of the predicted ferromagnetic Weyl semimetals. In this work, we report weak localization and small anomalous Hall conductivity in half-metallic Co2TiGe thin films grown by ...

journal_title：Scientific reports

authors： Dulal RP,Dahal BR,Forbes A,Bhattarai N,Pegg IL,Philip J

更新日期：2019-03-04 00:00:00

abstract：:In this article, the interaction between bovine serum albumin (BSA) and the cationic 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) at the air-buffer interface was investigated at different subphase's pH values (pH = 3, 5 and 10). Surface pressure measurements (π - A) and penetration kinetics process (π - t) were ca...

journal_title：Scientific reports

authors： Xu G,Hao C,Zhang L,Sun R

更新日期：2018-01-10 00:00:00

abstract：:There is a pressing need for novel and innovative therapeutic strategies to address infections caused by intracellular pathogens. Peptide nucleic acids (PNAs) present a novel method to target intracellular pathogens due to their unique mechanism of action and their ability to be conjugated to cell penetrating peptides...

journal_title：Scientific reports

authors： Abushahba MF,Mohammad H,Thangamani S,Hussein AA,Seleem MN

更新日期：2016-02-10 00:00:00

abstract：:Bruton tyrosine kinase (BTK) is a key enzyme in B-cell development whose improper regulation causes severe immunodeficiency diseases. Design of selective BTK therapeutics would benefit from improved, in-silico structural modeling of the kinase's solution ensemble. However, this remains challenging due to the immense c...

journal_title：Scientific reports

authors： Sultan MM,Denny RA,Unwalla R,Lovering F,Pande VS

更新日期：2017-11-15 00:00:00

abstract：:Strain engineering is a widespread strategy used to enhance performance of devices based on semiconductor thin films. In ferroelectrics strain engineering is used to control the domain pattern: When an epitaxial film is biaxially compressed, e.g. due to lattice mismatch with the substrate, the film displays out-of-pla...

journal_title：Scientific reports

authors： Yamada T,Ito D,Sluka T,Sakata O,Tanaka H,Funakubo H,Namazu T,Wakiya N,Yoshino M,Nagasaki T,Setter N

更新日期：2017-07-12 00:00:00

abstract：:A dusty thermal vacuum chamber (DTVC) containing a regolith simulant bed is essential for testing equipment and techniques related to lunar surface exploration. Space agencies have been reluctant to operate a DTVC because of the challenge of controlling soil disturbance of the lunar regolith simulant bed during pumpin...

journal_title：Scientific reports

authors： Go GH,Lee J,Chung T,Ryu BH,Jin H,Zhuang L,Shin HS,Kim JH,Yun TS

更新日期：2021-01-21 00:00:00

abstract：:The occurrence of microplastics (MPs) in saltwater bodies is relatively well studied, but nothing is known about their presence in most of the commercial salts that are widely consumed by humans across the globe. Here, we extracted MP-like particles larger than 149 μm from 17 salt brands originating from 8 different c...

journal_title：Scientific reports

authors： Karami A,Golieskardi A,Keong Choo C,Larat V,Galloway TS,Salamatinia B

更新日期：2017-04-06 00:00:00

abstract：:Protein S-sulfenylation, which results from oxidation of free thiols on cysteine residues, has recently emerged as an important post-translational modification that regulates the structure and function of proteins involved in a variety of physiological and pathological processes. By altering the size and physiochemica...

journal_title：Scientific reports

authors： Al-Barakati HJ,McConnell EW,Hicks LM,Poole LB,Newman RH,Kc DB

更新日期：2018-07-26 00:00:00

abstract：:The objective of our in vivo study was to compare the effects of the osteotomy on the thermal alterations, the bone healing and count of polymorphonuclear cells, comparing the drill design (cylindrical or conical) using continuous or intermittent movement. Twelve rabbits were used, which were made four osteotomies (n ...

journal_title：Scientific reports

authors： Gehrke SA,Treichel TLE,Aramburú Júnior J,de Aza PN,Prados-Frutos JC

更新日期：2020-11-26 00:00:00

abstract：:DNA-stabilized silver clusters (Ag-DNA) show excellent promise as a multi-functional nanoagent for molecular investigations in living cells. The unique properties of these fluorescent nanomaterials allow for intracellular optical sensors with tunable cytotoxicity based on simple modifications of the DNA sequences. Thr...

journal_title：Scientific reports

authors： Bossert N,de Bruin D,Götz M,Bouwmeester D,Heinrich D

更新日期：2016-11-30 00:00:00

abstract：:Coenzyme engineering that changes NAD(P) selectivity of redox enzymes is an important tool in metabolic engineering, synthetic biology, and biocatalysis. Here we developed a high throughput screening method to identify mutants of 6-phosphogluconate dehydrogenase (6PGDH) from a thermophilic bacterium Moorella thermoace...

journal_title：Scientific reports

authors： Huang R,Chen H,Zhong C,Kim JE,Zhang YH

更新日期：2016-09-02 00:00:00

abstract：:Receptor-mediated endocytosis is an essential process in signalling pathways for activation of intracellular signalling cascades. One example is the Wnt signalling pathway that seems to depend on endocytosis of the ligand-receptor complex for initiation of Wnt signal transduction. To date, the roles of different endoc...

journal_title：Scientific reports

authors： Bandmann V,Mirsanaye AS,Schäfer J,Thiel G,Holstein T,Mikosch-Wersching M

更新日期：2019-09-10 00:00:00

abstract：:There are approximately 1 million cryptococcal infections per year among HIV+ individuals, resulting in nearly 625,000 deaths. Cryptococcus neoformans and Cryptococcus gattii are the two most common species that cause human cryptococcosis. These two species of Cryptococcus have differences in pathogenicity, diagnosis,...

journal_title：Scientific reports

authors： Hu S,Gu F,Chen M,Wang C,Li J,Yang J,Wang G,Zhou Z,Yang Y

更新日期：2020-07-27 00:00:00

abstract：:Bacterial blight and bacterial leaf streak are serious, economically damaging, diseases of rice caused by the bacteria Xanthomonas oryzae pv. oryzae and X. oryzae pv. oryzicola. Bacillus amyloliquefaciens FZB42 was shown to possess biocontrol activity against these Xanthomonas strains by producing the antibiotic compo...

journal_title：Scientific reports

authors： Wu L,Wu H,Chen L,Yu X,Borriss R,Gao X

更新日期：2015-08-13 00:00:00

abstract：:Concurrent chemoradiation therapy (CCRT) is the treatment of choice for locally advanced non-small cell lung cancer (LA-NSCLC). Several clinical trials that combine programmed cell death 1 (PD-1) axis inhibitors with radiotherapy are in development for patients with LA-NSCLC. However, the effect of CCRT on programmed ...

journal_title：Scientific reports

authors： Fujimoto D,Uehara K,Sato Y,Sakanoue I,Ito M,Teraoka S,Nagata K,Nakagawa A,Kosaka Y,Otsuka K,Imai Y,Hamakawa H,Takahashi Y,Kokubo M,Tomii K

更新日期：2017-09-12 00:00:00

abstract：:The Andaman day gecko (Phelsuma andamanensis) is endemic to the Andaman Archipelago, located ~ 6000 km away from Madagascar where the genus Phelsuma likely evolved. We complemented existing phylogenetic data with additional markers to show that this species consistently branches off early in the evolution of the genus...

journal_title：Scientific reports

authors： Mohan AV,Orozco-terWengel P,Shanker K,Vences M

更新日期：2020-07-16 00:00:00

abstract：:The effects of climate change on the taste and textural attributes of foods remain largely unknown, despite much public interest. On the basis of 30-40 years of records, we provide evidence that the taste and textural attributes of apples have changed as a result of recent global warming. Decreases in both acid concen...

journal_title：Scientific reports

authors： Sugiura T,Ogawa H,Fukuda N,Moriguchi T

更新日期：2013-01-01 00:00:00

abstract：:Low intensity transcranial focused ultrasound (LIFU) is a promising method of non-invasive neuromodulation that uses mechanical energy to affect neuronal excitability. LIFU confers high spatial resolution and adjustable focal lengths for precise neuromodulation of discrete regions in the human brain. Before the full p...

journal_title：Scientific reports

authors： Legon W,Adams S,Bansal P,Patel PD,Hobbs L,Ai L,Mueller JK,Meekins G,Gillick BT

更新日期：2020-03-27 00:00:00

abstract：:Risk of hospital readmission and cardiac mortality increases with atmospheric pollution for patients with heart failure. The underlying mechanisms are unclear. Carbon monoxide (CO) a ubiquitous environmental pollutant could be involved. We explored the effect of daily exposure of CO relevant to urban pollution on post...

journal_title：Scientific reports

authors： Reboul C,Boissière J,André L,Meyer G,Bideaux P,Fouret G,Feillet-Coudray C,Obert P,Lacampagne A,Thireau J,Cazorla O,Richard S

更新日期：2017-01-03 00:00:00

abstract：:We discovered a technical solution of such outstanding importance that it can trigger new approaches in silicon wet etching processing and, in particular, photovoltaic cell manufacturing. The so called inverted pyramid arrays, outperforming conventional pyramid textures and black silicon because of their superior ligh...

journal_title：Scientific reports

authors： Wang Y,Yang L,Liu Y,Mei Z,Chen W,Li J,Liang H,Kuznetsov A,Xiaolong D

更新日期：2015-06-02 00:00:00