Abstract:
:Continuous subcutaneous insulin infusion (CSII) catheters are considered the weak link of insulin pump therapy. Wear-time considerably varies between patients and the choice of catheter material is based on personal preferences rather than scientific facts. Therefore, we systematically assessed and quantified the inflammatory tissue response to steel versus Teflon CSII catheters over a maximum wear-time of 7 days in swine. Tissue surrounding catheters was analysed using histopathology and quantitative real-time PCR. The area of inflammation increased significantly over time independent of material which was confirmed by an increase in CD68 expression and an increase in mononuclear and neutrophil cell infiltrate around the catheters. We observed substantially higher fibrin deposition (p < 0.05) around steel on day 4 of wear-time. IL-6 gene expression increased within 24 hours after insertion, returned to normal levels around Teflon (p < 0.05) but remained high around steel (p < 0.05). IL-10 and TGF-β levels did not resolve over time, indicating impaired wound healing. In conclusion, there was a major temporal effect in the acute inflammatory response to CSII catheters but we found little difference between materials. This study setup presents a robust tool for the systematic analysis of the tissue response to CSII catheters.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hauzenberger JR,Münzker J,Kotzbeck P,Asslaber M,Bubalo V,Joseph JI,Pieber TRdoi
10.1038/s41598-017-18790-0subject
Has Abstractpub_date
2018-01-18 00:00:00pages
1132issue
1issn
2045-2322pii
10.1038/s41598-017-18790-0journal_volume
8pub_type
杂志文章abstract::The repeated measurements of heart rate variability (HRV) is more relevant than a single HRV measurement in predicting patient prognosis but is less addressed previously. This prospective study aimed to investigate the association between repeated measurements of HRV and long-term mortality in chronic hemodialysis pat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57792-3
更新日期:2020-01-21 00:00:00
abstract::There has been a developing technology in algae with pharmaceuticals wastewater. However, the effect and the underlying mechanism of pharmaceuticals on algae are not well understood. To investigate the effect and mechanism of pharmaceuticalson microalgae, four pharmaceuticals of clofibric acid (CLF), ciprofloxacin (CI...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36609-4
更新日期:2019-02-07 00:00:00
abstract::Difficulties in the production of lignin from rice straw because of high silica content in the recovered lignin reduce its recovery yield and applications as bio-fuel and aromatic chemicals. Therefore, the objective of this study is to develop a novel method to reduce the silica content in lignin from rice straw more ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77867-5
更新日期:2020-12-04 00:00:00
abstract::Modes attenuation of the tube lattice fiber (TLF) is characterized by D/λ, where D is the core diameter and λ is the wavelength. Hence, the TLF is structured with a large core to ensure a low attenuation loss. A small core, on the other hand, facilitates the gas-filled TLF applications, but at the expense of the incre...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01839-5
更新日期:2017-05-09 00:00:00
abstract::Cells grown in three-dimensional (3D) cultures are more likely to have native cell-cell and cell-matrix interactions than in 2D cultures that impose mechanical constraints to cells. However, most 3D cultures utilise gel matrix which, while serving as a scaffold, limits application due to its solid and opaque nature an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21950-5
更新日期:2018-02-26 00:00:00
abstract::For accurate micro-scale quantification of a specific protein in biological fluids, immunoaffinity chromatography (IAC) and isoelectric focusing (IEF) were combined in a single fused-silica capillary. The inner wall of the capillary was coated with an anti-E-tag antibody at the inlet side to form an IAC column, and po...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39221
更新日期:2016-12-15 00:00:00
abstract::In this paper, we evaluated the power of microbiome measures taken at three time points over the growth test period (weaning, 15 and 22 weeks) to foretell growth and carcass traits in 1039 individuals of a line of crossbred pigs. We measured prediction accuracy as the correlation between actual and predicted phenotype...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43031-x
更新日期:2019-04-25 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is an important risk factor for the development of type 2 diabetes mellitus. Interferon gamma-induced protein 10 (IP-10), a proinflammatory chemokine, plays a crucial role in inflammatory diseases. This cross-sectional pilot study investigated whether circulating IP-10 is assoc...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/srep10096
更新日期:2015-05-11 00:00:00
abstract::The effect of intravenous fluids (IVF) has been investigated clinically through the assessment of post-treatment reactions. However, the responses to IVF vary from patient-to-patient. It is important to understand the response of IVF treatment to be able to provide optimal IVF care. Herein, we investigated the impact ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61296-5
更新日期:2020-07-16 00:00:00
abstract::Oxidovanadium complexes with organic ligands are well known to have cytotoxic or differentiating capabilities against a range of cancer cell types. Their limited use in clinical testing though has resulted largely from uncertainties about the long-term toxicities of such complexes, due in part to the speciation to van...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73539-6
更新日期:2020-10-07 00:00:00
abstract::Stable isotope labeling is a standard technique for tracing material transfer in molecular, ecological and biogeochemical studies. The main assumption in this approach is that the enrichment with a heavy isotope has no effect on the organism metabolism and growth, which is not consistent with current theoretical and e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44181
更新日期:2017-03-10 00:00:00
abstract::Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissecti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31298-5
更新日期:2018-08-29 00:00:00
abstract::Editor's Note: this Article has been retracted; the Retraction Note is available at https://www.nature.com/articles/s41598-020-73758-x. ...
journal_title:Scientific reports
pub_type: 已发布勘误,撤回出版物
doi:10.1038/s41598-020-73758-x
更新日期:2020-09-29 00:00:00
abstract::We study the coherence trapping of a qubit correlated initially with a non-Markovian bath in a pure dephasing channel. By considering the initial qubit-bath correlation and the bath spectral density, we find that the initial qubit-bath correlation can lead to a more efficient coherence trapping than that of the initia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13359
更新日期:2015-08-25 00:00:00
abstract::Principal research on energy from thermonuclear fusion uses Deuterium-Tritium plasmas magnetically trapped in toroidal devices. As major scientific problem for an economic (i.e., really feasible) reactor, we must understand how to lead strongly heated plasmas to sustain a high fusion gain while large fraction of curre...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27996-9
更新日期:2018-07-09 00:00:00
abstract::We assessed the relationship between the heterogeneity of HCC on preoperative non-contrast-enhanced CT and patient prognosis. The heterogeneity of CT images from 122 patients was assessed and texture feature parameters such as mean, standard deviation (SD), entropy, mean of the positive pixels (MPP), skewness, and kur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12688-7
更新日期:2017-10-04 00:00:00
abstract::Glaucoma is a leading cause of irreversible vision loss predicted to affect more than 100 million people by 2040. Intraocular pressure (IOP) reduction prevents development of glaucoma and vision loss from glaucoma. Glaucoma surgeries reduce IOP by facilitating aqueous humor outflow through a vent fashioned from the wa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69687-4
更新日期:2020-07-31 00:00:00
abstract::The migration of oligodendrocyte progenitor cells (OPCs) to the white matter is an indispensable requirement for an intact brain function. The mechanism of cell migration in general is not yet completely understood. Nevertheless, evidence is accumulating that besides the coordinated rearrangement of the cytoskeleton, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01806
更新日期:2013-01-01 00:00:00
abstract::The potential angiogenic effect of roxarsone, a feed additive widely used to promote animal growth worldwide, was demonstrated recently. We explored the mechanism of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in roxarsone promotion of rat vascular endothelial cells (ECs) and B16F10 mouse xenogr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53870-3
更新日期:2019-11-22 00:00:00
abstract::We demonstrate an ultrahigh-sensitivity gas pressure sensor based on the Fabry-Perot interferometer employing a fiber-tip diaphragm-sealed cavity. The cavity is comprised of a silica capillary and ultrathin silica diaphragm with a thickness of 170 nm, with represents the thinnest silica diaphragm fabricated thus far b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00931-0
更新日期:2017-04-11 00:00:00
abstract::Light-sheet fluorescence microscopy has emerged as a powerful platform for 3-D volumetric imaging in the life sciences. Here, we introduce an important step towards its use deep inside biological tissue. Our new technique, based on digital holography, enables delivery of the light-sheet through a multimode optical fib...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18050
更新日期:2015-12-14 00:00:00
abstract::To better understand the effects of transient thermal stress in an aquatic insect, we first identified static temperatures associated with fitness deficits, and then reared larvae from egg hatch to adulthood under diurnally variable regimens including daily forays into deleterious temperatures. We sampled mature larva...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75064-y
更新日期:2020-11-05 00:00:00
abstract::Short chain fatty acids (SCFAs) are protective against inflammatory diseases. Free fatty acid receptor 2 (FFA2), is a target of SCFAs however, their selectivity for FFA2 over other FFA receptors is limited. This study aimed to functionally characterise 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide (4CMTB) an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36242-1
更新日期:2018-12-13 00:00:00
abstract::Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity of tumor cells by engaging cell surface α9β1 integrins. This interaction mediated by the C-C loop of EDA activates pro-oncogenic signaling pathways leading to epithelial to mesenchymal transition (EMT) of tumor cells,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37151
更新日期:2016-11-16 00:00:00
abstract::Antidepressants have been the object of an international controversy for about thirty years. Some patients are inclined to develop suicidal ideation (SI) at antidepressant onset; this phenomenon is known as Treatment Emergent Suicidal Ideation (TESI), and it has conducted regulatory bodies to prompt warnings on antide...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/s41598-019-39622-3
更新日期:2019-02-22 00:00:00
abstract::Advanced structural characterisation techniques which are rapid to use, non-destructive and structurally definitive on the nanoscale are in demand, especially for a detailed understanding of extended-defects and their influence on the properties of materials. We have applied the electron backscatter diffraction (EBSD)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11187-z
更新日期:2017-09-07 00:00:00
abstract::PDCD4, the protein encoded by the tumor suppressor gene PDCD4 (programmed cell death 4) has been implicated in the control of cellular transcription and translation by modulating the activity of specific transcription factors and suppressing the translation of mRNAs with structured 5'-UTRs. Most studies of human PDCD4...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59678-w
更新日期:2020-02-17 00:00:00
abstract::Nanomaterials are being extensively produced and applied in society. Human and environmental exposures are, therefore, inevitable and so increased attention is being given to nanotoxicity. While silica nanoparticles (NP) are one of the top five nanomaterials found in consumer and biomedical products, their toxicity pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37145
更新日期:2016-11-22 00:00:00
abstract::Tissue microarray (TMA) core images are a treasure trove for artificial intelligence applications. However, a common problem of TMAs is multiple sectioning, which can change the content of the intended tissue core and requires re-labelling. Here, we investigate different ensemble methods for colorectal tissue classifi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81352-y
更新日期:2021-01-27 00:00:00
abstract::Xenotransplantation of human cancers into immunodeficient mice is a very useful approach for studying human tumor biology. However, the occasional occurrence of lymphomagenesis in some mice can spoil the model and must be investigated in detail. We found that a high percentage (32.5%, 26/80) of cancer patient-derived ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09447
更新日期:2015-03-30 00:00:00