Rational engineering of a virulence gene from Mycobacterium tuberculosis facilitates proteomic analysis of a natural protein N-terminus.

abstract：:Antimicrobial peptides (AMPs) are peptide antibiotics with a broad spectrum of antimicrobial activities. Activity prediction of AMPs from their amino acid sequences is of great therapeutic importance but imposes challenges on prediction methods due to label interactions. In this paper we propose a novel multi-label le...

journal_title：Scientific reports

authors： Wang P,Ge R,Liu L,Xiao X,Li Y,Cai Y

更新日期：2017-05-19 00:00:00

abstract：:Different classical theories are commonly applied in various branches of physics to describe the relativistic dynamics of electrons by coupled equations for the orbital motion and spin precession. Exemplarily, we benchmark the Frenkel model and the classical Foldy-Wouthuysen model with spin-dependent forces (Stern-Ger...

journal_title：Scientific reports

authors： Wen M,Bauke H,Keitel CH

更新日期：2016-08-22 00:00:00

abstract：:The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary a...

journal_title：Scientific reports

authors： Liu W,Ling S,Sun W,Liu T,Li Y,Zhong G,Zhao D,Zhang P,Song J,Jin X,Xu Z,Song H,Li Q,Liu S,Chai M,Dai Q,He Y,Fan Z,Zhou YJ,Li Y

更新日期：2015-11-05 00:00:00

abstract：:The human pyruvate dehydrogenase complex (PDC) comprises four multidomain components, E1, E3, E2 and an E3-binding protein (E3BP), the latter two forming the core as E2·E3BP sub-complex. Pyruvate flux through PDC is regulated via phosphorylation (inactivation) at E1 by four PDC kinases (PDKs), and reactivation by two ...

journal_title：Scientific reports

authors： Guevara EL,Yang L,Birkaya B,Zhou J,Nemeria NS,Patel MS,Jordan F

更新日期：2017-02-23 00:00:00

abstract：:Graphene has been identified as an emerging horizon for a nanoscale photonic platform because the Fermi level of intrinsic graphene can be engineered to support surface plasmons (SPs). The current solid back electrical gating and chemical doping methods cannot facilitate the demonstration of graphene SPs at the near-i...

journal_title：Scientific reports

authors： Zhang Q,Li X,Hossain MM,Xue Y,Zhang J,Song J,Liu J,Turner MD,Fan S,Bao Q,Gu M

更新日期：2014-10-09 00:00:00

abstract：:The Middle East is one of the most water stressed regions in the world, receiving the majority of its hydrological input during the winter, in the form of highly variable and scattered precipitation. The persistence of wintertime anticyclonic conditions over the region can deflect storm tracks and result in extended s...

journal_title：Scientific reports

authors： Kumar KN,Molini A,Ouarda TBMJ,Rajeevan MN

更新日期：2017-09-26 00:00:00

abstract：:The microRNA (miR)-183/96/182 cluster plays important roles in the development and functions of sensory organs, including the inner ear. Point-mutations in the seed sequence of miR-96 result in non-syndromic hearing loss in both mice and humans. However, the lack of a functionally null mutant has hampered the evaluati...

journal_title：Scientific reports

authors： Geng R,Furness DN,Muraleedharan CK,Zhang J,Dabdoub A,Lin V,Xu S

更新日期：2018-12-21 00:00:00

abstract：:Ge-monopnictides (GeAs) plays critical role in high-tech industry, especially in the field of advanced optical devices and infrared. As a secondary material, coal fly ash could be further recycled to retrieve germanium and prepare GeAs material with high added values. Hence, the aim of this paper is to propose a one-p...

journal_title：Scientific reports

authors： Zhang L,Xu Z

更新日期：2017-06-16 00:00:00

abstract：:The salamander chytrid fungus (Batrachochytrium salamandrivorans [Bsal]) is causing massive mortality of salamanders in Europe. The potential for spread via international trade into North America and the high diversity of salamanders has catalyzed concern about Bsal in the U.S. Surveillance programs for invading patho...

journal_title：Scientific reports

authors： Waddle JH,Grear DA,Mosher BA,Grant EHC,Adams MJ,Backlin AR,Barichivich WJ,Brand AB,Bucciarelli GM,Calhoun DL,Chestnut T,Davenport JM,Dietrich AE,Fisher RN,Glorioso BM,Halstead BJ,Hayes MP,Honeycutt RK,Hossack BR,Kle

更新日期：2020-08-03 00:00:00

abstract：:Novel activated boron nitride (BN) as an effective adsorbent for pollutants in water and air has been reported in the present work. The activated BN was synthesized by a simple structure-directed method that enabled us to control the surface area, pore volume, crystal defects and surface groups. The obtained BN exhibi...

journal_title：Scientific reports

authors： Li J,Xiao X,Xu X,Lin J,Huang Y,Xue Y,Jin P,Zou J,Tang C

更新日期：2013-11-13 00:00:00

abstract：:The ancient harbour of Pisa, Portus Pisanus, was one of Italy's most influential seaports for many centuries. Nonetheless, very little is known about its oldest harbour and the relationships between environmental evolution and the main stages of harbour history. The port complex that ensured Pisa's position as an econ...

journal_title：Scientific reports

authors： Kaniewski D,Marriner N,Morhange C,Vacchi M,Sarti G,Rossi V,Bini M,Pasquinucci M,Allinne C,Otto T,Luce F,Van Campo E

更新日期：2018-08-23 00:00:00

abstract：:Successful establishment of invasive species is often related to the existence of vacant niches. Competition occurs when invaders use the same limiting resources as members of the recipient community, which will be reflected in some overlap of their trophic niches. The concept of isotopic niche has been used to study ...

journal_title：Scientific reports

authors： Karlson AM,Gorokhova E,Elmgren R

更新日期：2015-05-19 00:00:00

abstract：:Virus production in the deep-sea environment has been found to be high, and viruses have been suggested to play significant roles in the overall functioning of this ecosystem. Nevertheless, little is known about these viruses, including the mechanisms that control their production, which makes them one of the least un...

journal_title：Scientific reports

authors： Jian H,Xiong L,Xu G,Xiao X,Wang F

更新日期：2016-02-22 00:00:00

abstract：:To assess the correlation between penile hypersensitivity and premature ejaculation (PE), a total of 420 consecutive subjects attending our andrologic clinic for suspected PE were enrolled. The entire cohort was asked to complete the self-report intravaginal ejaculation latency time (IELT) by stopwatch. According to t...

journal_title：Scientific reports

authors： Guo L,Liu Y,Wang X,Yuan M,Yu Y,Zhang X,Zhao S

更新日期：2017-09-05 00:00:00

abstract：:Cisplatin is a highly effective anti-cancer chemotherapeutic agent; however, its clinical use is severely limited by serious side effects, of which nephrotoxicity is the most important. In this study, we investigated whether Qiong-Yu-Gao (QYG), a popular traditional Chinese medicinal formula described 840 years ago, e...

journal_title：Scientific reports

authors： Teng ZY,Cheng XL,Cai XT,Yang Y,Sun XY,Xu JD,Lu WG,Chen J,Hu CP,Zhou Q,Wang XN,Li SL,Cao P

更新日期：2015-10-29 00:00:00

abstract：:Recent advances in RNA-seq methodologies from limiting amounts of mRNA have facilitated the characterization of rare cell-types in various biological systems. So far, however, technical variations in these methods have not been adequately characterized, vis-à-vis sensitivity, starting with reduced levels of mRNA. Here...

journal_title：Scientific reports

authors： Bhargava V,Head SR,Ordoukhanian P,Mercola M,Subramaniam S

更新日期：2014-01-14 00:00:00

abstract：:Studies of personality have suggested that dissimilarities in ability to cope with stressful situations results in differing tendency to develop addictive behaviors. The present study used selectively bred stress-resilient, socially-dominant (Dom) and stress-vulnerable, socially-submissive (Sub) mice to investigate th...

journal_title：Scientific reports

authors： Yanovich C,Kirby ML,Michaelevski I,Yadid G,Pinhasov A

更新日期：2018-01-29 00:00:00

abstract：:Administration of lipopolysaccharide (LPS) by various routes produces profound inflammatory pain hypersensitivity. However, the molecular events that induce this response remain largely uncharacterized. In the present study, we sought to elucidate the role of the Rho/Rho kinase (ROCK) pathway in the release of tumor n...

journal_title：Scientific reports

authors： Wang C,Song S,Zhang Y,Ge Y,Fang X,Huang T,Du J,Gao J

更新日期：2015-09-29 00:00:00

abstract：:Invasive motor Cortex Stimulation (iMCS) was introduced in the 1990's for the treatment of chronic neuropathic orofacial pain (CNOP), although its effectiveness remains doubtful. However, CNOP is known to be a heterogeneous group of orofacial pain disorders, which can lead to different responses to iMCS. Therefore, th...

journal_title：Scientific reports

authors： Henssen D,Kurt E,van Walsum AVC,Kozicz T,van Dongen R,Bartels R

更新日期：2020-04-28 00:00:00

abstract：:Electron-hole exchange interaction in semiconductor quantum dots (QDs) splits the band-edge exciton manifold into optically active ("bright") and passive ("dark") states, leading to a complicated exciton fine structure. In the present work, we resolve by atomistic million-atom many-body pseudopotential calculations th...

journal_title：Scientific reports

authors： Baskoutas S,Zeng Z,Garoufalis CS,Bester G

更新日期：2017-08-24 00:00:00

abstract：:Nanomedicine development currently suffers from a lack of efficient tools to predict pharmacokinetic behavior without relying upon testing in large numbers of animals, impacting success rates and development costs. This work presents dendPoint, the first in silico model to predict the intravenous pharmacokinetics of d...

journal_title：Scientific reports

authors： Kaminskas LM,Pires DEV,Ascher DB

更新日期：2019-10-29 00:00:00

abstract：:We investigated the clinical characteristics of cilioretinal arteries (CAs) and cilioretinal veins (CVs) in eyes with pathologic myopia. Ninety-five eyes with pathologic myopia and CAs were studied. The retrobulbar vessels from which the CAs originated were identified by indocyanine green angiography (ICGA). The resul...

journal_title：Scientific reports

authors： Watanabe T,Kasahara K,Futagami S,Fang Y,Du R,Moriyama M,Uramoto K,Yokoi T,Onishi Y,Yoshida T,Kamoi K,Jonas JB,Ohno-Matsui K

更新日期：2019-02-21 00:00:00

abstract：:Si and Ge nanocrystals in oxides are of a large interest for photo-effect applications due to the fine-tuning of the optical bandgap by quantum confinement in nanocrystals. In this work, dense Ge nanocrystals suitable for enhanced photoconduction were fabricated from 60% Ge in TiO2 amorphous layers by low temperature ...

journal_title：Scientific reports

authors： Lepadatu AM,Slav A,Palade C,Dascalescu I,Enculescu M,Iftimie S,Lazanu S,Teodorescu VS,Ciurea ML,Stoica T

更新日期：2018-03-20 00:00:00

abstract：:Responses of ecosystems to human-induced stress vary in space and time, because both stressors and ecosystem vulnerabilities vary in space and time. Presently, ecosystem impact assessments mainly take into account variation in stressors, without considering variation in ecosystem vulnerability. We developed a method t...

journal_title：Scientific reports

authors： Zijp MC,Huijbregts MAJ,Schipper AM,Mulder C,Posthuma L

更新日期：2017-08-24 00:00:00

abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...

journal_title：Scientific reports

authors： Lopes-Marques M,Serrano C,Cardoso AR,Salazar R,Seixas S,Amorim A,Azevedo L,Prata MJ

更新日期：2020-07-14 00:00:00

abstract：:Yield-phenology relation is a critical issue affecting rainfed maize field productivity in semiarid east African Plateau (EAP). We first introduced Chinese ridge-furrow mulching (RFM) system to EAP, using three maize cultivars with early-, mid- and late-maturing traits as test materials. A two-year field experiment wa...

journal_title：Scientific reports

authors： Mo F,Wang JY,Li FM,Nguluu SN,Ren HX,Zhou H,Zhang J,Kariuki CW,Gicheru P,Kavagi L,Cheruiyot WK,Xiong YC

更新日期：2017-06-12 00:00:00

abstract：:Beneficial and deleterious mutations change an organism's fitness but the distribution of these mutational effects on fitness are unknown. Several experimental, theoretical, and computational studies have explored this question but are limited because of experimental restrictions, or disconnect with physiology. Here w...

journal_title：Scientific reports

authors： Brajesh RG,Dutta D,Saini S

更新日期：2019-07-08 00:00:00

abstract：:Gastroenterologists are still unable to differentiate between some of the most ordinary disorders of the gut and consequently patients are misdiagnosed. We have developed a swallowable gas sensor capsule for addressing this. The gases of the gut are the by-product of the fermentation processes during digestion, affect...

journal_title：Scientific reports

authors： Ou JZ,Cottrell JJ,Ha N,Pillai N,Yao CK,Berean KJ,Ward SA,Grando D,Muir JG,Harrison CJ,Wijesiriwardana U,Dunshea FR,Gibson PR,Kalantar-Zadeh K

更新日期：2016-09-16 00:00:00

abstract：:Cardiac magnetic resonance (CMR) has emerged as a powerful tool for in vivo assessments of cardiac parameters in experimental animal models of cardiovascular diseases, but its reproducibility in this setting remains poorly explored. To address this issue, we investigated the test-retest reproducibility of preclinical ...

journal_title：Scientific reports

authors： Joubert M,Tager P,Legallois D,Defourneaux E,Le Guellec B,Gerber B,Morello R,Manrique A

更新日期：2017-07-27 00:00:00

abstract：:Charge separation is a critical process for achieving high efficiencies in organic photovoltaic cells. The initial tightly bound excitonic electron-hole pair has to dissociate fast enough in order to avoid photocurrent generation and thus power conversion efficiency loss via geminate recombination. Such process takes ...

journal_title：Scientific reports

authors： Oviedo-Casado S,Urbina A,Prior J

更新日期：2017-06-27 00:00:00