Abstract:
:Beneficial and deleterious mutations change an organism's fitness but the distribution of these mutational effects on fitness are unknown. Several experimental, theoretical, and computational studies have explored this question but are limited because of experimental restrictions, or disconnect with physiology. Here we attempt to characterize the distribution of fitness effects (DFE) due to mutations in a cellular regulatory motif. We use a simple mathematical model to describe the dynamics of gene expression in the lactose utilization network, and use a cost-benefit framework to link the model output to fitness. We simulate mutations by changing model parameters and computing altered fitness to obtain the DFE. We find beneficial mutations distributed exponentially, but distribution of deleterious mutations seems far more complex. In addition, we find neither the starting fitness, nor the exact location on the fitness landscape, affecting these distributions qualitatively. Lastly, we quantify epistasis in our model and find that the distribution of epistatic effects remains qualitatively conserved across different locations on the fitness landscape. Overall, we present a first attempt at exploring the specific statistical features of the fitness landscape associated with a system, by using the specific mathematical model associated with it.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Brajesh RG,Dutta D,Saini Sdoi
10.1038/s41598-019-46401-7subject
Has Abstractpub_date
2019-07-08 00:00:00pages
9842issue
1issn
2045-2322pii
10.1038/s41598-019-46401-7journal_volume
9pub_type
杂志文章abstract::Rickettsiales are important zoonotic pathogens, causing severe disease in humans globally. Although mosquitoes are an important vector for diverse pathogens, with the exception of members of the genus Wolbachia little is known about their role in the transmission of Rickettsiales. Herein, Rickettsiales were identified...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38770
更新日期:2016-12-09 00:00:00
abstract::Knowledge of the genomic variation among different strains of a pathogenic microbial species can help in selecting optimal candidates for diagnostic assays and vaccine development. Pooled sequencing (Pool-seq) is a cost effective approach for population level genetic studies that require large numbers of samples such ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45771
更新日期:2017-03-31 00:00:00
abstract::We study the time-development processes of spin and charge transport phenomena in a topological Dirac semimetal attached to a ferromagnetic insulator with a precessing magnetization. Compared to conventional normal metals, topological Dirac semimetals manifest a large inverse spin Hall effect when a spin current is pu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55802-7
更新日期:2019-12-23 00:00:00
abstract::High tumor vascular endothelial growth factor (VEGF) levels are associated with poor treatment outcomes in prostate cancer (PCa), and immune deficiency in the PCa microenvironment, especially suppression of dendritic cell (DC) proliferation, has been confirmed. In this study, we (1) investigated whether VEGF participa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06242-8
更新日期:2017-07-18 00:00:00
abstract::The FGFR4-388Arg variant has been related to poor prognosis in several types of cancer, including lung cancer. The mechanism underlying this association has not been addressed in detail in patients with this pathology. Here, we report that this FGFR4 variant induces MAPK and STAT3 activation and causes pro-oncogenic e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20570-3
更新日期:2018-02-05 00:00:00
abstract::Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to exosomes were evaluated. CD4(+) Tconv, CD8(+) T or CD4(+) CD39(+) Treg were isolated from normal donors' peripheral blood and co-incubated with TEX or exosomes iso...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20254
更新日期:2016-02-04 00:00:00
abstract::Spliced leader dependent trans-splicing (SLTS) has been described as an important RNA regulatory process that occurs in different organisms, including the trematode Schistosoma mansoni. We identified more than seven thousand putative SLTS sites in the parasite, comprising genes with a wide spectrum of functional class...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22093-3
更新日期:2018-03-01 00:00:00
abstract::The aim of this systematic review was taken to investigate the efficacy and safety of docetaxel plus thalidomide vs. docetaxel alone for treating androgen-independent prostate cancer (AIPC). Data were collected from different databases independently by three researchers according to the pre-defined inclusion and exclu...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep04818
更新日期:2014-04-28 00:00:00
abstract::Mitochondria play an essential role in bioenergetics and cellular Ca[Formula: see text] handling. The mitochondrial permeability transition pore (mPTP) is a non-specific channel located in the inner mitochondrial membrane. Long-lasting openings of the pore allow the rapid passage of ions and large molecules, which can...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60177-1
更新日期:2020-03-03 00:00:00
abstract::Developing an effective universal influenza vaccine against influenza virus with highly conserved antigenic epitopes could induce a broad-spectrum immune response to prevent infection. The soluble protein M1 that can induce the M1 specific immune response was first confirmed in our previous study. In this study, we ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60783-z
更新日期:2020-03-05 00:00:00
abstract::Abnormal expression of microRNAs (miRNAs) contributes to glioma initiation. However, the expression of miRNAs in tumour tissue or blood of spinal cord glioma (SCG) patients, particularly in high-grade spinal gliomas (Grade IV) known as glioblastoma (GBM), remains largely unknown. In this study we aimed to determine di...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42364-x
更新日期:2019-06-24 00:00:00
abstract::Healthy neonates exhibit a well-functioning haemostatic system despite peculiarities regarding composition of clotting factors and inhibitors as well as impaired platelet aggregation. Thrombocytopenia and severe bleeding events are feared in sick infants. Recombinant factor VIIa (rFVIIa) is a haemostatic agent used as...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44199-y
更新日期:2019-05-29 00:00:00
abstract::Carbon monoxide (CO) monitoring in human breath is the focus of many investigations as CO could possibly be used as a marker of various diseases. Detecting CO in human breath remains a challenge because low concentrations ( journal_title:Scientific reports pub_type: 临床试验,杂志文章 doi:10.1038/s41598-019-48789-8 更新日期:2019-08-22 00:00:00
abstract::The cool sensor transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia, playing a key role in cold hypersensitivity associated to different peripheral neuropathies. Moreover, these channels are aberrantly expressed in different cancers, and seem to participa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70691-x
更新日期:2020-08-25 00:00:00
abstract::Cognitive impairment is one of the most common problem saffecting older adults. In this study, we investigated whether Tai Chi Chuan and Baduanjin practice can modulate mental control functionand the resting state functional connectivity (rsFC) of the cognitive control network in older adults. Participants in the two ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41581
更新日期:2017-02-07 00:00:00
abstract::Duckweed species have a great potential to develop into fast-growing crops for water remediation and bioenergy production. Seed production and utilization of hybrid vigour are essential steps in this process. However, even in the extensively-studied duckweed species, Lemna gibba, flower primordia were often aborted pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03240-8
更新日期:2017-06-08 00:00:00
abstract::There is lack of consensus regarding the prognostic significance of primary tumor location of upper tract urothelial carcinoma(UTUC). We performed a meta-analysis to evaluate the impact of primary tumor location on prognosis in patients with UTUC who had undergone radical nephroureterectomy(RNU). We included eligible ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep06361
更新日期:2014-09-15 00:00:00
abstract::Saliva, as a non-invasive and easily accessible biofluid, has been shown to contain RNA biomarkers for prediction and diagnosis of several diseases. However, systematic analysis done by our group identified two problematic issues not coherently described before: (1) most of the isolated RNA originates from the oral mi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67825-6
更新日期:2020-07-07 00:00:00
abstract::We consider synchronization properties of arrays of spin-torque nano-oscillators coupled via an RC load. We show that while the fully synchronized state of identical oscillators may be locally stable in some parameter range, this synchrony is not globally attracting. Instead, regimes of different levels of composition...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04918-9
更新日期:2017-07-05 00:00:00
abstract::A detailed molecular understanding of botulinum neurotoxin (BoNT)/host-cell-receptor interactions is fundamental both for developing strategies against botulism and for generating improved BoNT variants for medical applications. The X-ray crystal structure of the receptor-binding domain (HC) of BoNT/A1 in complex with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43588
更新日期:2017-03-02 00:00:00
abstract::The ovules and egg cells are well developed to be fertilized at anthesis in many flowering plants. However, ovule development is triggered by pollination in most orchids. In this study, we characterized the function of a Bsister gene, named PeMADS28, isolated from Phalaenopsis equestris, the genome-sequenced orchid. S...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79877-9
更新日期:2021-01-13 00:00:00
abstract::Peripheral nerve long gap defects are a clinical challenge in the regeneration field. Despite the wide variety of surgical techniques and therapies, autografting is the "gold standard" for peripheral nerve gap reconstruction. The pathological process of Wallerian degeneration from the time of acute injury to efficient...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39828
更新日期:2016-12-23 00:00:00
abstract::Bimetallic Pd1-x Pt x solid-solution nanoparticles (NPs) display charging/discharging of hydrogen gas, which has relevance for fuel cell technologies; however, the constituent elements are immiscible in the bulk phase. We examined these material systems using high-energy synchrotron X-ray diffraction, X-ray absorption...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14494-7
更新日期:2017-11-06 00:00:00
abstract::Peptides derived from the N-terminal heptad repeat (NHR) of HIV-1 gp41 can be potent inhibitors against viral entry when presented in a nonaggregating trimeric coiled-coil conformation via the introduction of exogenous trimerization motifs and intermolecular disulfide bonds. We recently discovered that crosslinking is...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32161
更新日期:2016-08-26 00:00:00
abstract::Memristive synapses, the most promising passive devices for synaptic interconnections in artificial neural networks, are the driving force behind recent research on hardware neural networks. Despite significant efforts to utilize memristive synapses, progress to date has only shown the possibility of building a neural...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10123
更新日期:2015-05-05 00:00:00
abstract:ABSTARCT:This work explores a new class of vortex/magnetite/iron oxide nanoparticles designed for magnetic hyperthermia applications. These nanoparticles, named Vortex Iron oxide Particles (VIPs), are an alternative to the traditional Superparamagnetic Iron Oxide Nanoparticles (SPIONs), since VIPs present superior heat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14633-0
更新日期:2017-11-01 00:00:00
abstract::Feedback information is essential for us to adapt appropriately to the environment. The feedback-related negativity (FRN), a frontocentral negative deflection after the delivery of feedback, has been found to be larger for outcomes that are worse than expected, and it reflects a reward prediction error derived from th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34032
更新日期:2016-10-03 00:00:00
abstract::An industrial waste, 1,2,3-trichloropropane (TCP), is toxic and extremely recalcitrant to biodegradation. To date, no natural TCP degraders able to mineralize TCP aerobically have been isolated. In this work, we engineered a biosafety Pseudomonas putida strain KT2440 for aerobic mineralization of TCP by implantation o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07435-x
更新日期:2017-08-01 00:00:00
abstract::The knowledge of diffusion processes in semiconducting alloys is very important both technologically and from a theoretical point of view. Here we show that, self-diffusion in Si1-x Ge x alloys as a function of temperature and Ge concentration can be described by the cBΩ thermodynamic model. This model connects the ac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01301-6
更新日期:2017-05-02 00:00:00
abstract::The theoretical optimal olfactory search strategy is to move cross-wind. Empirical evidence supporting wind-associated directionality among carnivores, however, is sparse. We examined satellite-linked telemetry movement data of adult female polar bears (Ursus maritimus) from Hudson Bay, Canada, in relation to modelled...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46332
更新日期:2017-04-12 00:00:00