Abstract：
:Gastroenterologists are still unable to differentiate between some of the most ordinary disorders of the gut and consequently patients are misdiagnosed. We have developed a swallowable gas sensor capsule for addressing this. The gases of the gut are the by-product of the fermentation processes during digestion, affected by the gut state and can consequently provide the needed information regarding the health of the gut. Here we present the first study on gas sensor capsules for revealing the effect of a medical supplement in an animal (pig) model. We characterise the real-time alterations of gastric-gas in response to environmental heat-stress and dietary cinnamon and use the gas profiles for understanding the bio-physiological changes. Under no heat-stress, feeding increases gastric CO2 concentration, while dietary cinnamon reduces it due to decrease in gastric acid and pepsin secretion. Alternatively, heat-stress leads to hyperventilation in pigs, which reduces CO2 concentration and with the cinnamon treatment, CO2 diminishes even more, resulting in health improvement outcomes. Overall, a good repeatability in gas profiles is also observed. The model demonstrates the strong potential of real-time gas profiler in providing new physiological information that will impact understanding of therapeutics, presenting a highly reliable device for monitoring/diagnostics of gastrointestinal disorders.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ou JZ,Cottrell JJ,Ha N,Pillai N,Yao CK,Berean KJ,Ward SA,Grando D,Muir JG,Harrison CJ,Wijesiriwardana U,Dunshea FR,Gibson PR,Kalantar-Zadeh Kdoi
10.1038/srep33387subject
Has Abstractpub_date
2016-09-16 00:00:00pages
33387issn
2045-2322pii
srep33387journal_volume
6pub_type
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