Inhibition of the Rho/Rho kinase pathway prevents lipopolysaccharide-induced hyperalgesia and the release of TNF-α and IL-1β in the mouse spinal cord.

abstract：:Protein phosphorylation is an important type of post-translational modification that is involved in a variety of biological activities. Most phosphorylation events occur on serine, threonine and tyrosine residues in eukaryotes. In recent years, many phosphorylation sites have been identified as a result of advances in...

journal_title：Scientific reports

authors： Xiao Q,Miao B,Bi J,Wang Z,Li Y

更新日期：2016-04-19 00:00:00

abstract：:Upwelling off Vietnam in the South China Sea (SCS) and the Sumatra-Java upwelling in the Indian Ocean significantly modulate regional variation in climate. Although located in different hemispheres, these upwellings nearly concur during the boreal summer; both are the result of wind-induced Ekman divergence. Beyond se...

journal_title：Scientific reports

authors： Wu CR,Wang LC,Wang YL,Lin YF,Chiang TL,Hsin YC

更新日期：2019-03-06 00:00:00

abstract：:Age-hardening in Al alloys has been used for over a century to improve its mechanical properties. However, the lack of direct observation limits our understanding of the dynamic nature of the evolution of nanoprecipitates during age-hardening. Using in-situ (scanning) transmission electron microscopy (S/TEM) while hea...

journal_title：Scientific reports

authors： Liu C,Malladi SK,Xu Q,Chen J,Tichelaar FD,Zhuge X,Zandbergen HW

更新日期：2017-05-19 00:00:00

abstract：:The resistance-nodulation-cell division (RND)-type xenobiotic efflux system plays a major role in the multidrug resistance of gram-negative bacteria. The only constitutively expressed RND system of Escherichia coli consists of the inner membrane transporter AcrB, the membrane fusion protein AcrA, and the outer membran...

journal_title：Scientific reports

authors： Yamamoto K,Tamai R,Yamazaki M,Inaba T,Sowa Y,Kawagishi I

更新日期：2016-02-26 00:00:00

abstract：:High salt intake leads to an increase in some proinflammatory cytokines and neurotransmitters involved in the pathogenesis of hypertension. The purpose of this work was to know if oral administration of anti-oxidant and free-radical scavenger CoQ10 may attenuate high salt-induced hypertension via regulating neurotrans...

journal_title：Scientific reports

authors： Gao HL,Yu XJ,Qi J,Yi QY,Jing WH,Sun WY,Cui W,Mu JJ,Yuan ZY,Zhao XF,Liu KL,Zhu GQ,Shi XL,Liu JJ,Kang YM

更新日期：2016-07-25 00:00:00

abstract：:Vascular leakage is a life-threatening complication of dengue virus (DENV) infection. Previously, association between "paracellular" endothelial hyperpermeability and plasma leakage had been extensively investigated. However, whether "transcellular" endothelial leakage is involved in dengue hemorrhagic fever (DHF) and...

journal_title：Scientific reports

authors： Chanthick C,Kanlaya R,Kiatbumrung R,Pattanakitsakul SN,Thongboonkerd V

更新日期：2016-08-22 00:00:00

abstract：:Immersive virtual reality has become increasingly popular to improve the assessment and treatment of health problems. This rising popularity is likely to be facilitated by the availability of affordable headsets that deliver high quality immersive experiences. As many health problems are more prevalent in older adults...

journal_title：Scientific reports

authors： Huygelier H,Schraepen B,van Ee R,Vanden Abeele V,Gillebert CR

更新日期：2019-03-14 00:00:00

abstract：:V2O5 based materials are attractive cathode alternatives due to the many oxidation state switches of vanadium bringing about a high theoretical specific capacity. However, significant capacity losses are eminent for crystalline V2O5 phases related to the irreversible phase transformations and/or vanadium dissolution s...

journal_title：Scientific reports

authors： Afyon S,Krumeich F,Mensing C,Borgschulte A,Nesper R

更新日期：2014-11-19 00:00:00

abstract：:Although the cognitive impairment in Alzheimer's disease (AD) is believed to be caused by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have reported cognitive normal subjects with AD brain pathology. As the mechanism underlying these discrepancies has not been clarified, we foc...

journal_title：Scientific reports

authors： Kobayashi E,Nakano M,Kubota K,Himuro N,Mizoguchi S,Chikenji T,Otani M,Mizue Y,Nagaishi K,Fujimiya M

更新日期：2018-01-26 00:00:00

abstract：:A better understanding of functional changes in the intervertebral disc (IVD) and interaction with endplate is essential to elucidate the pathogenesis of IVD degeneration disease (IDDD). To date, the simultaneous depiction of 3D micro-architectural changes of endplate with aging and interaction with IVD remains a tech...

journal_title：Scientific reports

authors： Cao Y,Liao S,Zeng H,Ni S,Tintani F,Hao Y,Wang L,Wu T,Lu H,Duan C,Hu J

更新日期：2017-03-07 00:00:00

abstract：:Dyslipidemia in pregnancy are associated with risk of adverse outcomes. As an adverse pregnancy outcome, small-for-gestational-age has been extensively studied in Western countries. However, similar studies have rarely been conducted in Asian countries. Data were derived from 5695 pairs of non-diabetic mothers and neo...

journal_title：Scientific reports

authors： Chen Q,Chen H,Xi F,Sagnelli M,Zhao B,Chen Y,Yang M,Xu D,Jiang Y,Chen G,Luo Q

更新日期：2020-11-16 00:00:00

abstract：:Anti-mucin1 (MUC1) antibodies have long been used clinically in cancer diagnosis and therapy and specific bindings of some of them are known to be dependent on the differential glycosylation of MUC1. However, a systematic comparison of the binding specificities of anti-MUC1 antibodies was not previously conducted. Her...

journal_title：Scientific reports

authors： Yoshimura Y,Denda-Nagai K,Takahashi Y,Nagashima I,Shimizu H,Kishimoto T,Noji M,Shichino S,Chiba Y,Irimura T

更新日期：2019-11-12 00:00:00

abstract：:Exploration of macroscopic quantum entanglement is of great interest in both fundamental science and practical application. We investigate a hybrid quantum system that consists of two nitrogen-vacancy centers ensembles (NVE) coupled to a superconducting coplanar waveguide resonator (CPWR). The collective magnetic coup...

journal_title：Scientific reports

authors： Liu Y,You J,Hou Q

更新日期：2016-02-23 00:00:00

abstract：:Transport of tissue-derived lymphatic fluid and clearance by draining lymph nodes are pivotal for maintenance of fluid homeostasis in the body and for immune-surveillance of the self- and non-self-proteomes. Yet a quantitative analysis of nodal filtration of the tissue-derived proteome present in lymphatic fluid has n...

journal_title：Scientific reports

authors： Clement CC,Wang W,Dzieciatkowska M,Cortese M,Hansen KC,Becerra A,Thangaswamy S,Nizamutdinova I,Moon JY,Stern LJ,Gashev AA,Zawieja D,Santambrogio L

更新日期：2018-07-26 00:00:00

abstract：:The voluntary control of movement is often tested by using the countermanding, or stop-signal task that sporadically requires the suppression of a movement in response to an incoming stop-signal. Neurophysiological recordings in monkeys engaged in the countermanding task have shown that dorsal premotor cortex (PMd) is...

journal_title：Scientific reports

authors： Pani P,Giarrocco F,Giamundo M,Montanari R,Brunamonti E,Ferraina S

更新日期：2018-09-24 00:00:00

abstract：:Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary conservation of the 60...

journal_title：Scientific reports

authors： Di Giglio MG,Muttenthaler M,Harpsøe K,Liutkeviciute Z,Keov P,Eder T,Rattei T,Arrowsmith S,Wray S,Marek A,Elbert T,Alewood PF,Gloriam DE,Gruber CW

更新日期：2017-02-01 00:00:00

abstract：:Despite dedicated research has been carried out to adequately map the distribution of the sperm whale in the Mediterranean Sea, unlike other regions of the world, the species population status is still presently uncertain. The analysis of two years of continuous acoustic data provided by the ANTARES neutrino telescope...

journal_title：Scientific reports

authors： André M,Caballé A,van der Schaar M,Solsona A,Houégnigan L,Zaugg S,Sánchez AM,Castell JV,Solé M,Vila F,Djokic D,Adrián-Martínez S,Albert A,Anghinolfi M,Anton G,Ardid M,Aubert JJ,Avgitas T,Baret B,Barrios-Martí J,Ba

更新日期：2017-04-12 00:00:00

abstract：:Drug delivery by micro- and nano-carriers enables controlled transport of pharmaceuticals to targeted sites. Even though carrier fabrication has made much progress recently, the delivery including controlled particle distribution and adhesion within the body remains a great challenge. The adhesion of carriers is stron...

journal_title：Scientific reports

authors： Müller K,Fedosov DA,Gompper G

更新日期：2014-05-02 00:00:00

abstract：:We investigate the behaviour of the recently proposed Quantum PageRank algorithm, in large complex networks. We find that the algorithm is able to univocally reveal the underlying topology of the network and to identify and order the most relevant nodes. Furthermore, it is capable to clearly highlight the structure of...

journal_title：Scientific reports

authors： Paparo GD,Müller M,Comellas F,Martin-Delgado MA

更新日期：2013-10-04 00:00:00

abstract：:Carbon-based nanomaterials such as single-walled carbon nanotubes and reduced graphene oxide are currently being evaluated for biomedical applications including in vivo drug delivery and tumor imaging. Several reports have studied the toxicity of carbon nanomaterials, but their effects on human male reproduction have ...

journal_title：Scientific reports

authors： Asghar W,Shafiee H,Velasco V,Sah VR,Guo S,El Assal R,Inci F,Rajagopalan A,Jahangir M,Anchan RM,Mutter GL,Ozkan M,Ozkan CS,Demirci U

更新日期：2016-08-19 00:00:00

abstract：:Over the history of carbon, it is generally acknowledged that Bernal AB stacking of the sp2 carbon layers is the unique crystalline form of graphite. The universal graphite structure is synthesized at 2,600~3,000 °C and exhibits a micro-polycrystalline feature. In this paper, we provide evidence for a metastable form ...

journal_title：Scientific reports

authors： Lee JK,Kim JG,Hembram KP,Kim YI,Min BK,Park Y,Lee JK,Moon DJ,Lee W,Lee SG,John P

更新日期：2016-12-21 00:00:00

abstract：:In eye movement perimetry (EMP), the saccadic reaction time (SRT) to 'seen' visual stimuli are delayed in glaucoma. Evaluating SRT behaviour in hemi-field sectors could refine its clinical implication. The development phase included 60 controls retrospectively and for the test cohort in evaluation phase, another 30 he...

journal_title：Scientific reports

authors： Mazumdar D,Meethal NSK,George R,Pel JJM

更新日期：2021-01-29 00:00:00

abstract：:Optical elastography is undergoing extensive development as an imaging tool to map mechanical contrast in tissue. Here, we present a new platform for optical elastography by generating sub-millimetre-scale mechanical contrast from a simple digital camera. This cost-effective, compact and easy-to-implement approach ope...

journal_title：Scientific reports

authors： Sanderson RW,Fang Q,Curatolo A,Adams W,Lakhiani DD,Ismail HM,Foo KY,Dessauvagie BF,Latham B,Yeomans C,Saunders CM,Kennedy BF

更新日期：2020-09-29 00:00:00

abstract：:Seeds of tomato were magnetoprimed at 100 mT for 30 min followed by imbibition for 12 and 24 h, respectively, at 20 °C, to examine the biochemical and molecular changes involved in homeostasis of hydrogen peroxide (H2O2) and its signaling associated with hormone interactions for promoting vigor. The relative transcrip...

journal_title：Scientific reports

authors： Anand A,Kumari A,Thakur M,Koul A

更新日期：2019-06-19 00:00:00

abstract：:CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications. Typically, sgRNA is constitutively expressed relying on RNA polymerase III promoters. Polymerase II promoters initiate transcription in a flexible manner, but sgRNAs generated by RNA polymerase II promoter lost their nuclease ...

journal_title：Scientific reports

authors： Xie C,Chen YL,Wang DF,Wang YL,Zhang TP,Li H,Liang F,Zhao Y,Zhang GY

更新日期：2017-07-19 00:00:00

abstract：:We report abnormal magnetic field effects on electrogenerated chemiluminescence (MFEECL) based on triplet emission from the Ru(bpy)3Cl2-TPrA electrochemical system: the appearance of MFEECL after magnetic field ceases. In early studies the normal MFEECL have been observed from electrochemical systems during the applic...

journal_title：Scientific reports

authors： Pan H,Shen Y,Wang H,He L,Hu B

更新日期：2015-03-16 00:00:00

abstract：:LytR-cpsA-Psr (LCP) domain containing proteins fulfil important functions in bacterial cell wall synthesis. In Mycobacterium tuberculosis complex (Mtbc) strains, the causative agents of tuberculosis (TB), the genes Rv3484 and Rv3267 encode for LCP proteins which are putatively involved in arabinogalactan transfer to p...

journal_title：Scientific reports

authors： Malm S,Maaß S,Schaible UE,Ehlers S,Niemann S

更新日期：2018-03-02 00:00:00

abstract：:Bronchoconstrictive airway disorders such as asthma are characterized by inflammation and increases in reactive oxygen species (ROS), which produce a highly oxidative environment. β2-adrenergic receptor (β2AR) agonists are a mainstay of clinical therapy for asthma and provide bronchorelaxation upon inhalation. We have...

journal_title：Scientific reports

authors： Rambacher KM,Moniri NH

更新日期：2020-02-19 00:00:00

abstract：:A growing proportion of head and neck cancers (HNC) result from HPV infection. Between HNC aetiological groups (HPV positive and HPV negative) clinical evidence demonstrates significantly better treatment response among HPV positive cancers. Cancer stem cells (CSCs) are identified in HNC tumour populations as agents o...

journal_title：Scientific reports

authors： Reid P,Staudacher AH,Marcu LG,Olver I,Moghaddasi L,Brown MP,Bezak E

更新日期：2020-02-17 00:00:00

abstract：:Autografts tend to be unreliable in older patients. Some of these age-related skeletal changes appear to be attributable to a decline in endogenous WNT signaling. We used a functional in vivo transplantation assay to demonstrate that the bone-forming capacity of an autograft can be traced back to a Wnt-responsive cell...

journal_title：Scientific reports

authors： Chen T,Li J,Córdova LA,Liu B,Mouraret S,Sun Q,Salmon B,Helms J

更新日期：2018-01-08 00:00:00