Abstract：
:Carbon-based nanomaterials such as single-walled carbon nanotubes and reduced graphene oxide are currently being evaluated for biomedical applications including in vivo drug delivery and tumor imaging. Several reports have studied the toxicity of carbon nanomaterials, but their effects on human male reproduction have not been fully examined. Additionally, it is not clear whether the nanomaterial exposure has any effect on sperm sorting procedures used in clinical settings. Here, we show that the presence of functionalized single walled carbon nanotubes (SWCNT-COOH) and reduced graphene oxide at concentrations of 1-25 μg/mL do not affect sperm viability. However, SWCNT-COOH generate significant reactive superoxide species at a higher concentration (25 μg/mL), while reduced graphene oxide does not initiate reactive species in human sperm. Further, we demonstrate that exposure to these nanomaterials does not hinder the sperm sorting process, and microfluidic sorting systems can select the sperm that show low oxidative stress post-exposure.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Asghar W,Shafiee H,Velasco V,Sah VR,Guo S,El Assal R,Inci F,Rajagopalan A,Jahangir M,Anchan RM,Mutter GL,Ozkan M,Ozkan CS,Demirci Udoi
10.1038/srep30270subject
Has Abstractpub_date
2016-08-19 00:00:00pages
30270issn
2045-2322pii
srep30270journal_volume
6pub_type
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