Abstract:
:Human listeners are able to recognize accurately an impressive range of complex sounds, such as musical instruments or voices. The underlying mechanisms are still poorly understood. Here, we aimed to characterize the processing time needed to recognize a natural sound. To do so, by analogy with the "rapid visual sequential presentation paradigm", we embedded short target sounds within rapid sequences of distractor sounds. The core hypothesis is that any correct report of the target implies that sufficient processing for recognition had been completed before the time of occurrence of the subsequent distractor sound. We conducted four behavioral experiments using short natural sounds (voices and instruments) as targets or distractors. We report the effects on performance, as measured by the fastest presentation rate for recognition, of sound duration, number of sounds in a sequence, the relative pitch between target and distractors and target position in the sequence. Results showed a very rapid auditory recognition of natural sounds in all cases. Targets could be recognized at rates up to 30 sounds per second. In addition, the best performance was observed for voices in sequences of instruments. These results give new insights about the remarkable efficiency of timbre processing in humans, using an original behavioral paradigm to provide strong constraints on future neural models of sound recognition.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Isnard V,Chastres V,Viaud-Delmon I,Suied Cdoi
10.1038/s41598-019-43126-5subject
Has Abstractpub_date
2019-05-29 00:00:00pages
8005issue
1issn
2045-2322pii
10.1038/s41598-019-43126-5journal_volume
9pub_type
杂志文章abstract::Due to limited availability of pharmacological therapies, triple-negative breast cancer (TNBC) is the subtype with worst outcome. We hypothesised that 2-Deoxy-D-Glucose (2-DG), a glucose analogue, may hold potential as a therapy for particularly aggressive TNBC. We investigated 2-DG's effects on TNBC cell line variant...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39789-9
更新日期:2019-03-07 00:00:00
abstract::We have developed an optimized protocol for plasma targeted mRNA sequencing in our previous study. Here, we performed plasma targeted mRNA sequencing for 40 colorectal adenoma patients and 39 colonoscopy-proven normal controls in order to find potential circulating mRNA markers for colorectal adenoma. Results showed t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49445-x
更新日期:2019-09-10 00:00:00
abstract::Potato (Solanum tuberosum) is an important staple crop worldwide, it has been cultivated in the Andean Altiplano under low-input farming practices at high altitudes and under harsh environment for centuries. We analyzed secondary metabolite (SM) gene diversity encoded in the potato rhizosphere microbiome during plant ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02314-x
更新日期:2017-05-24 00:00:00
abstract::Inflammatory and cardiovascular biomarkers have been associated with obesity, but little is known about how they change upon dietary intervention and concomitant weight loss. Further, protein biomarkers might be useful for predicting weight loss in overweight and obese individuals. We performed secondary analyses in t...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-64636-7
更新日期:2020-05-13 00:00:00
abstract::Many organisms faced with seasonally fluctuating abiotic and biotic conditions respond by altering their phenotype to account for the demands of environmental changes. Here we discovered that newts, which switch seasonally between an aquatic and terrestrial lifestyle, grow a complex adhesive system on their tongue pad...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00674-y
更新日期:2017-04-21 00:00:00
abstract::The biodosimetric information is critical for evaluating the human health hazards caused by radon and its progeny. Here, we demonstrated that the formation of phosphorylated histone variant H2AX (γ-H2AX), p53-binding protein 1 (53BP1) and phosphorylated KRAB-associated protein 1 (pKAP-1) foci and their linear tracks i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38295
更新日期:2016-12-06 00:00:00
abstract::Unambiguous identification of trace amounts of biochemical molecules in a complex background using terahertz spectroscopy is extremely challenging owing to the extremely small absorption cross sections of these molecules in the terahertz regime. Herein, we numerically propose a terahertz nonresonant nano-slits structu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60732-w
更新日期:2020-02-28 00:00:00
abstract::Freezing colloidal suspensions widely exists in nature and industry. Interface instability has attracted much attention for the understandings of the pattern formation in freezing colloidal suspensions. However, the interface instability modes, the origin of the ice banding or ice lamellae, are still unclear. In-situ ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23358
更新日期:2016-03-21 00:00:00
abstract::Sexual conflict over parental investment can result in suboptimal reproductive output. A recent hypothesis suggests that equality in investment, and hence conflict resolution, may be reached via coordination of parental activities like alternating nest visits. However, how robust patterns of care within couples are ag...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39139-9
更新日期:2019-02-26 00:00:00
abstract::Bacterial biofilms are particularly problematic since they become resistant to most available antibiotics. Hence, novel potential antagonists to inhibit biofilm formation are urgent. Here the influences of two natural products, ursolic acid and resveratrol, on biofilm of the clinical methicillin-resistant Staphylococc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05467
更新日期:2014-06-27 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-57571-0
更新日期:2020-01-14 00:00:00
abstract::Plant extracts, or phytonutrients, are used in traditional medicine practices as supplements to enhance the immune system and gain resistance to various infectious diseases and are used in animal production as health promoting feed additives. To date, there are no studies that have assessed their mechanism of action a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09253
更新日期:2015-03-19 00:00:00
abstract::We report on the ion beam fabrication of all-carbon multi electrode arrays (MEAs) based on 16 graphitic micro-channels embedded in single-crystal diamond (SCD) substrates. The fabricated SCD-MEAs are systematically employed for the in vitro simultaneous amperometric detection of the secretory activity from populations...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20682
更新日期:2016-02-09 00:00:00
abstract::To evaluate the diagnostic accuracy of combined computed tomography colonography (CTC) and dual-energy iodine map imaging for detecting colorectal masses using high-pitch dual-source CT, compared with optical colonography (OC) and histopathologic findings. Twenty-eight consecutive patients were prospectively enrolled ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22188-x
更新日期:2018-02-28 00:00:00
abstract::Immunotherapies demand for predictive biomarkers to avoid unnecessary adverse effects and costs. Analytic morphomics is the technique to use body composition measures as imaging biomarkers for underlying pathophysiology to predict prognosis or outcome to therapy. We investigated different body composition measures to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46189-6
更新日期:2019-07-05 00:00:00
abstract::The development of physiologically active semiochemicals is largely limited by the labor-consuming searching process. How to screen active semiochemicals efficiently is of significance to the extension of behavior regulation in pest control. Here pharmacophore modeling and shape-based virtual screening were combined t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34600
更新日期:2016-10-06 00:00:00
abstract::Staphylococci are common causes of healthcare-associated and community-associated infections. However, limited data are available on the prevalence, phenotypes and molecular characteristics of Staphylococci in metro system around the world. 320 surface samples were collected from the Guangzhou metro system to isolate ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16087
更新日期:2015-10-29 00:00:00
abstract::Phasins or PhaPs are a group of amphiphilic proteins that are found attached to the surface of microbial polyhydroxyalkanoate (PHA) granules. They have both structural and regulatory functions and can affect intracellular PHA accumulation and mediate protein folding. The molecular basis for the diverse functions of th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39424
更新日期:2016-12-23 00:00:00
abstract::The suprachiasmatic nucleus (SCN) central clock comprises two coupled oscillators, with light entraining the retinorecipient vasoactive intestinal peptide (VIP)-positive ventrolateral oscillator, which then entrains the arginine vasopressin (AVP)-positive dorsomedial oscillator. While glucose availability is known to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00699-3
更新日期:2017-04-04 00:00:00
abstract::microRNAs (miRNAs) are small double stranded RNA molecules consisting of two complementary strands called the 5p and 3p arms. Following imprecise processing and/or addition of nucleotides at the ends, miRNA biogenesis can give rise to variants called isomiRs. Exosomes are small vesicles released by cells. They have at...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56593-7
更新日期:2019-12-27 00:00:00
abstract::The inactivation of pathogens in liquids has broad applications, ranging from water disinfection to food pasteurization. However, common cell inactivation methods (e.g., chlorination, ultraviolet radiation and thermal treatment) have significant drawbacks such as carcinogenic byproduct formation, energy intensiveness ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34027-0
更新日期:2018-10-25 00:00:00
abstract::Although early diagnosis and treatment reduce the risk of blindness from glaucoma, the decision on whether or not to begin treatment in patients with suspected glaucoma is often a dilemma because the majority of patients never develop definite glaucoma. A growing body of evidences suggests that posterior bowing of the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17843-8
更新日期:2018-01-15 00:00:00
abstract::Pertuzumab is an antihuman HER2 antibody developed for HER2 positive breast cancer. Glycosylation profiles are always the important issue for antibody based therapy. Previous findings have suggested the impact of glycosylation profiles on the function of antibodies, like pharmacodynamics, antibody-dependent cellular c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46347
更新日期:2017-04-11 00:00:00
abstract::An unresolved mystery in the field of spinal muscular atrophy (SMA) is why a reduction of the ubiquitously expressed Smn protein causes defects mostly in motoneurons. We addressed the possibility that this restricted vulnerability stems from elevated Smn expression in motoneurons. To explore this, we established an ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27470
更新日期:2016-06-07 00:00:00
abstract::Nicotine is the psychoactive agent involved in nicotine dependence. However, nicotine as a drug, and its effects on human psychology are largely under-investigated in genetic studies. In this study, we recruited 208 current non-smokers to evaluate the effect of nicotine and its relationship to genetic risks to nicotin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09521
更新日期:2015-03-31 00:00:00
abstract::Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR) in juvenile rats on gut-derived ghrelin and related hypothalamic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02843-5
更新日期:2017-06-02 00:00:00
abstract::Individuals with Angelman syndrome (AS) are characterized by severe cognitive impairments alongside an enhanced drive for social engagement. As knowledge on imitation skills in this population is limited, we conducted the first controlled study of imitation in AS. We examined how 23 individuals with AS and 21 typicall...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72079-3
更新日期:2020-10-02 00:00:00
abstract::Accidental introduction through ballast water and biofouling are currently the main factors responsible for spreading non-indigenous species in the marine realm. In the Southwestern Atlantic, two scleractinian corals, Tubastraea coccinea and T. tagusensis, have been introduced by opportunistic colonization in 1980 and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50442-3
更新日期:2019-09-27 00:00:00
abstract::Although it has been reported that uterine signal transducer and activator of transcription 3 (STAT3) is essential for embryo implantation, the exact roles of uterine epithelial and stromal STAT3 on embryo implantation have not been elucidated. To address this issue, we generated Stat3-floxed/Ltf-iCre (Stat3-eKO), Sta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72640-0
更新日期:2020-09-23 00:00:00
abstract::Damnacanthal, an anthraquinone present in noni plants, targets several tyrosine kinases and has antitumoral effects. This study aims at getting additional insight on the potential of damnacanthal as a natural antitumor compound. The direct effect of damnacanthal on c-Met was tested by in vitro activity assays. Additio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08021
更新日期:2015-01-26 00:00:00