Lamina Cribrosa Morphology Predicts Progressive Retinal Nerve Fiber Layer Loss In Eyes with Suspected Glaucoma.

abstract：:Environmental pollution by emerging contaminants, e.g. pharmaceuticals, has become a matter of widespread concern in recent years. We investigated the membrane transport of diclofenac and its toxic effects on gene expression and the development of zebrafish embryos. The association of diclofenac with the embryos confo...

journal_title：Scientific reports

authors： Chen JB,Gao HW,Zhang YL,Zhang Y,Zhou XF,Li CQ,Gao HP

更新日期：2014-05-02 00:00:00

abstract：:Demand for clinical decision support systems in medicine and self-diagnostic symptom checkers has substantially increased in recent years. Existing platforms rely on knowledge bases manually compiled through a labor-intensive process or automatically derived using simple pairwise statistics. This study explored an aut...

journal_title：Scientific reports

authors： Rotmensch M,Halpern Y,Tlimat A,Horng S,Sontag D

更新日期：2017-07-20 00:00:00

abstract：:Phagocytosis is a process in which target cells or particles are engulfed and taken up by other cells, typically professional phagocytes; this process is crucial in many physiological processes and disease states. The detection of targets for phagocytosis is directed by a complex repertoire of cell surface receptors. ...

journal_title：Scientific reports

authors： Schulz D,Severin Y,Zanotelli VRT,Bodenmiller B

更新日期：2019-02-13 00:00:00

abstract：:Following facial nerve axotomy, nerve function is not fully restored even after reconstruction. This may be attributed to axon degeneration/neuronal death and sustained neuroinflammation. CD38 is an enzyme that catalyses the hydrolysis of nicotinamide adenine dinucleotide (NAD+) and is a candidate molecule for regulat...

journal_title：Scientific reports

authors： Takaso Y,Noda M,Hattori T,Roboon J,Hatano M,Sugimoto H,Brenner C,Yamamoto Y,Okamoto H,Higashida H,Ito M,Yoshizaki T,Hori O

更新日期：2020-10-20 00:00:00

abstract：:Fluorescence lifetime imaging microscopy (FLIM) is a key technology that provides direct insight into cell metabolism, cell dynamics and protein activity. However, determining the lifetimes of different fluorescent proteins requires the detection of a relatively large number of photons, hence slowing down total acquis...

journal_title：Scientific reports

authors： Zickus V,Wu ML,Morimoto K,Kapitany V,Fatima A,Turpin A,Insall R,Whitelaw J,Machesky L,Bruschini C,Faccio D,Charbon E

更新日期：2020-12-02 00:00:00

abstract：:Languages may differ in terms of the functional units of word-form encoding used in spoken word production. It is widely accepted that segments are the primary units used in Indo-European languages. However, it is controversial what the functional units (syllables or segments) in Chinese spoken word production are. In...

journal_title：Scientific reports

authors： Feng C,Yue Y,Zhang Q

更新日期：2019-08-13 00:00:00

abstract：:The mechanism underlying tissue fusion mediated by laser irradiation remains unclear. We clarify the mechanisms underlying laser-mediated tissue fusion using a novel model. Microscopic examinations of morphological changes within the adventitia of a bovine carotid artery and a collagen sheet prepared from bovine dermi...

journal_title：Scientific reports

authors： Sasaki S,Ikeda T,Okihara SI,Nishimura S,Nakadate R,Saeki H,Oki E,Mori M,Hashizume M,Maehara Y

更新日期：2019-06-28 00:00:00

abstract：:The effect of initial evenness on the temporal trajectory of synthetic communities in comprehensive, low-volume microcosm studies remains unknown. We used flow cytometric fingerprinting and 16S rRNA gene amplicon sequencing to assess the impact of time on community structure in one hundred synthetic ecosystems of fixe...

journal_title：Scientific reports

authors： Ehsani E,Hernandez-Sanabria E,Kerckhof FM,Props R,Vilchez-Vargas R,Vital M,Pieper DH,Boon N

更新日期：2018-01-10 00:00:00

abstract：:Heavy metal sequestration from industrial wastes and agricultural soils is a long-standing challenge. This is more critical for copper since copper pollution is hazardous both for the environment and for human health. In this study, we applied an integrated approach of Darwin's theory of natural selection with bacteri...

journal_title：Scientific reports

authors： Gahlot DK,Taheri N,Mahato DR,Francis MS

更新日期：2020-11-23 00:00:00

abstract：:PP2A is a master controller of multiple inflammatory signaling pathways. It is a target in asthma; however the molecular mechanisms by which PP2A controls inflammation warrant further investigation. In A549 lung epithelial cells in vitro we show that inhibition of basal PP2A activity by okadaic acid (OA) releases rest...

journal_title：Scientific reports

authors： Rahman MM,Rumzhum NN,Morris JC,Clark AR,Verrills NM,Ammit AJ

更新日期：2015-05-18 00:00:00

abstract：:Principal research on energy from thermonuclear fusion uses Deuterium-Tritium plasmas magnetically trapped in toroidal devices. As major scientific problem for an economic (i.e., really feasible) reactor, we must understand how to lead strongly heated plasmas to sustain a high fusion gain while large fraction of curre...

journal_title：Scientific reports

authors： Cardinali A,Castaldo C,Cesario R,Amicucci L,Galli A,Napoli F,Panaccione L,Riccardi C,Santini F,Schettini G,Tuccillo AA

更新日期：2018-07-09 00:00:00

abstract：:Identification of loci or genes under natural selection is important for both understanding the genetic basis of local adaptation and practical applications, and genome scans provide a powerful means for such identification purposes. In this study, genome-wide simple sequence repeats markers (SSRs) were used to scan f...

journal_title：Scientific reports

authors： Song Z,Zhang M,Li F,Weng Q,Zhou C,Li M,Li J,Huang H,Mo X,Gan S

更新日期：2016-10-17 00:00:00

abstract：:Fusion transcripts can contribute to diversity of molecular networks in the human cortex. In this study, we explored the occurrence of fusion transcripts in normal human cortex along with single neurons and astrocytes. We identified 1305 non-redundant fusion events from 388 transcriptomes representing 59 human cortice...

journal_title：Scientific reports

authors： Mehani B,Narta K,Paul D,Raj A,Kumar D,Sharma A,Kaurani L,Nayak S,Dash D,Suri A,Sarkar C,Mukhopadhyay A

更新日期：2020-01-28 00:00:00

abstract：:Animal coloration is a poorly-understood aspect of phenotypic variability. Here I expand initial studies of the colour gamut of birds by providing the first quantitative description of the colour variation of an entire avifauna: Australian landbirds (555 species). The colour of Australian birds occupies a small fracti...

journal_title：Scientific reports

authors： Delhey K

更新日期：2015-12-18 00:00:00

abstract：:We have demonstrated a proof-of-principle experiment of reference-frame-independent phase coding quantum key distribution (RFI-QKD) over an 80-km optical fiber. After considering the finite-key bound, we still achieve a distance of 50 km. In this scenario, the phases of the basis states are related by a slowly time-va...

journal_title：Scientific reports

authors： Liang WY,Wang S,Li HW,Yin ZQ,Chen W,Yao Y,Huang JZ,Guo GC,Han ZF

更新日期：2014-01-09 00:00:00

abstract：:Enzymes that cleave polysaccharides in lignocellulose, i. e., cellulases, xylanases, and accessory enzymes, play crucial roles in the natural decomposition of plant-derived biomass and its efficient and sustainable processing into biofuels or other bulk chemicals. The analysis of open reading frame cthe_2195 from the ...

journal_title：Scientific reports

authors： Heinze S,Mechelke M,Kornberger P,Liebl W,Schwarz WH,Zverlov VV

更新日期：2017-09-11 00:00:00

abstract：:The recent reported trapped "rainbow" storage of light using metamaterials and plasmonic graded surface gratings has generated considerable interest for on-chip slow light. The potential for controlling the velocity of broadband light in guided photonic structures opens up tremendous opportunities to manipulate light ...

journal_title：Scientific reports

authors： Hu H,Ji D,Zeng X,Liu K,Gan Q

更新日期：2013-01-01 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Choi S,Rogers DJ,Sandana EV,Bove P,Teherani FH,Nenstiel C,Hoffmann A,McClintock R,Razeghi M,Look D,Gentle A,Phillips MR,Ton-That C

更新日期：2017-11-16 00:00:00

abstract：:EEG is known to contain considerable inter-trial and inter-subject variability, which poses a challenge in any group-level EEG analyses. A true experimental effect must be reproducible even with variabilities in trials, sessions, and subjects. Extracting components that are reproducible across trials and subjects bene...

journal_title：Scientific reports

authors： Tanaka H

更新日期：2020-01-09 00:00:00

abstract：:L-Ascorbic acid (vitamin C, AA) exhibits anti-cancer effects with high-dose treatment through the generation of reactive oxygen species (ROS) and selective damage to cancer cells. The anti-cancer effects of L-ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a transporter of L-ascorbic...

journal_title：Scientific reports

authors： Cho S,Chae JS,Shin H,Shin Y,Song H,Kim Y,Yoo BC,Roh K,Cho S,Kil EJ,Byun HS,Cho SH,Park S,Lee S,Yeom CH

更新日期：2018-07-27 00:00:00

abstract：:Streptococcus pneumoniae (pneumococcus) is a principal cause of bacterial middle ear infections, pneumonia, and meningitis. Capsule-targeted pneumococcal vaccines have likely contributed to increased carriage of nonencapsulated S. pneumoniae (NESp). Some NESp lineages are associated with highly efficient DNA uptake an...

journal_title：Scientific reports

authors： Bradshaw JL,Rafiqullah IM,Robinson DA,McDaniel LS

更新日期：2020-11-03 00:00:00

abstract：:Solute segregating to grain boundary can stabilize the microstructure of nanocrystalline materials, but a lot of solutes also cause embrittlement effect on interfacial strength. Therefore, uncovering the solute effect on grain boundary strength is very important for nanocrystalline alloys design. In this work, we have...

journal_title：Scientific reports

authors： Huang Z,Wang P,Chen F,Shen Q,Zhang L

更新日期：2020-10-08 00:00:00

abstract：:Hepadnaviruses, including human hepatitis B virus (HBV), replicate their tiny DNA genomes by protein-primed reverse transcription of a pregenomic (pg) RNA. Replication initiation as well as pgRNA encapsidation depend on the interaction of the viral polymerase, P protein, with the ε RNA element, featuring a lower and a...

journal_title：Scientific reports

authors： Gajer M,Dörnbrack K,Rösler C,Schmid B,Beck J,Nassal M

更新日期：2017-08-02 00:00:00

abstract：:Cu removal by a novel multi-amines decorated resin (PAMD) from wastewater in the absence or presence of citric acid (CA) was examined. Adsorption capacity of Cu onto PAMD markedly increased by 186% to 5.07 mmol/g in the presence of CA, up to 7 times of that onto four commercial resins under the same conditions. Preloa...

journal_title：Scientific reports

authors： Ling C,Liu F,Pei Z,Zhang X,Wei M,Zhang Y,Zheng L,Zhang J,Li A,Xing B

更新日期：2015-05-12 00:00:00

abstract：:The impact of reperfusion therapies on cognition has been poorly explored and little knowledge exists. We explored the influence of endovascular treatment (EVT) on cognitive outcome in patients with anterior circulation ischemic stroke. Patients presenting with ischemic stroke due to anterior large vessel occlusion wh...

journal_title：Scientific reports

authors： Lattanzi S,Coccia M,Pulcini A,Cagnetti C,Galli FL,Villani L,Campa S,Dobran M,Polonara G,Ceravolo MG,Silvestrini M

更新日期：2020-10-28 00:00:00

abstract：:Glioblastoma multiforme (GBM), an extremely invasive and high-grade (grade IV) glioma, is the most common and aggressive form of brain cancer. It has a poor prognosis, with a median overall survival of only 11 months in the general GBM population and 14.6 to 21 months in clinical trial participants with standard GBM t...

journal_title：Scientific reports

authors： Akay M,Hite J,Avci NG,Fan Y,Akay Y,Lu G,Zhu JJ

更新日期：2018-10-18 00:00:00

abstract：:MicroRNAs (miRNAs) are noncoding RNAs which control gene expression by the suppression of translation or the degradation of mRNAs. Dre-miR-21 (miR-21) has been reported to impact cardiac valvulogenesis in zebrafish embryos. However, the target genes of miR-21 are still largely unknown. Here a tandem isobaric mass tag ...

journal_title：Scientific reports

authors： Wu Y,Lou QY,Ge F,Xiong Q

更新日期：2017-06-22 00:00:00

abstract：:Modern microbial mats can provide key insights into early Earth ecosystems, and Shark Bay, Australia, holds one of the best examples of these systems. Identifying the spatial distribution of microorganisms with mat depth facilitates a greater understanding of specific niches and potentially novel microbial interaction...

journal_title：Scientific reports

authors： Wong HL,Smith DL,Visscher PT,Burns BP

更新日期：2015-10-26 00:00:00

abstract：:The sensitivity of many ion channels to phosphatidylinositol-4,5-bisphosphate (PIP2) levels in the cell membrane suggests that PIP2 fluctuations are important and general signals modulating neuronal excitability. Yet the PIP2 dynamics of central neurons in their native environment remained largely unexplored. Here, we...

journal_title：Scientific reports

authors： Hackelberg S,Oliver D

更新日期：2018-08-28 00:00:00

abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...

journal_title：Scientific reports

authors： Lopes-Marques M,Serrano C,Cardoso AR,Salazar R,Seixas S,Amorim A,Azevedo L,Prata MJ

更新日期：2020-07-14 00:00:00