Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression.

abstract：:We propose a hybrid plasmonic device consisting of a planar dielectric waveguide covering a gold nanostripe array fabricated on a gold film and investigate its guiding properties at telecom wavelengths. The fundamental modes of a hybrid device and their dependence on the key geometric parameters are studied. A communi...

journal_title：Scientific reports

authors： Thomas PA,Auton GH,Kundys D,Grigorenko AN,Kravets VG

更新日期：2017-03-24 00:00:00

abstract：:Increasing evidence has confirmed that immunoglobulins (Igs) can be expressed in non-B cells. Our previous work demonstrated that mesangial cells and podocytes express IgA and IgG, respectively. The aim of this work was to reveal whether proximal tubular epithelial cells (PTECs) express Igs. High-throughput single-cel...

journal_title：Scientific reports

authors： Deng Z,Wang X,Liu Y,Tian X,Deng S,Sun Y,Wang S,Zheng D,Cui Z,Pan Y,A L,Yan H,Qiu X,Wang Y

更新日期：2020-11-12 00:00:00

abstract：:Diet composition impacts metabolic and cardiovascular health with high caloric diets contributing to obesity related disorders. Dietary interventions such as caloric restriction exert beneficial effects in the cardiovascular system, but alteration of which specific nutrient is responsible is less clear. This study inv...

journal_title：Scientific reports

authors： Hennig M,Ewering L,Pyschny S,Shimoyama S,Olecka M,Ewald D,Magarin M,Uebing A,Thierfelder L,Jux C,Drenckhahn JD

更新日期：2019-10-22 00:00:00

abstract：:As a two-dimensional material, graphene has attracted increasing attention as heat dissipation material owing to its excellent thermal transport property. In this work, we fabricated sisal nanocrystalline cellulose/functionalized graphene papers (NPGs) with high thermal conductivity by vacuum-assisted self-assembly me...

journal_title：Scientific reports

authors： Ren L,Wang M,Lu S,Pan L,Xiong Z,Zhang Z,Peng Q,Li Y,Yu J

更新日期：2019-03-14 00:00:00

abstract：:Melanoma patients' plasma contains exosomes produced by malignant and normal cells. Plasma exosomes were isolated and separated by immunocapture into two fractions: melanoma cell-derived exosomes (MTEX) and normal cell-derived exosomes (non-MTEX). Immunosuppressive effects of MTEX on primary human immune cells were ev...

journal_title：Scientific reports

authors： Sharma P,Diergaarde B,Ferrone S,Kirkwood JM,Whiteside TL

更新日期：2020-01-09 00:00:00

abstract：:Lipid droplet (LD)-associated hydrolase (LDAH) is a newly identified LD protein abundantly expressed in tissues that predominantly store triacylglycerol (TAG). However, how LDAH regulates TAG metabolism remains unknown. We found that upon oleic acid loading LDAH translocalizes from the ER to newly formed LDs, and indu...

journal_title：Scientific reports

authors： Goo YH,Son SH,Paul A

更新日期：2017-06-02 00:00:00

abstract：:Natural competence for genetic transformation refers to the natural ability of various bacteria to take up exogenous DNA from their surroundings and to incorporate internalized genetic information into their genomes. By promoting bacterial diversification and adaptability, this process represents a major driving force...

journal_title：Scientific reports

authors： Lichev A,Angelov A,Cucurull I,Liebl W

更新日期：2019-07-30 00:00:00

abstract：:The previous performance of the English men's national football team in penalty shootouts has led to the widespread stereotype that English football players are particularly bad at scoring penalties. Research has proposed possible reasons behind this alleged "penalty curse". When looking at these reasons, the question...

journal_title：Scientific reports

authors： Brinkschulte M,Furley P,Memmert D

更新日期：2020-04-27 00:00:00

abstract：:Using census data we identify geographic patterns in residency changes in Lesotho over a decade. Using kriging to spatially interpolate data from 8,510 households we identify regions where households have members temporarily living away from home (divided households). Further, using a multivariate analysis and data fr...

journal_title：Scientific reports

authors： Palk L,Blower S

更新日期：2015-12-02 00:00:00

abstract：:Supported by histological and genetic evidence implicating myelin, neuroinflammation and oligodendrocyte dysfunction in schizophrenia spectrum disorders (SZ), diffusion tensor imaging (DTI) studies have consistently shown white matter (WM) abnormalities when compared to healthy controls (HC). The diagnostic specificit...

journal_title：Scientific reports

authors： Tønnesen S,Kaufmann T,Doan NT,Alnæs D,Córdova-Palomera A,Meer DV,Rokicki J,Moberget T,Gurholt TP,Haukvik UK,Ueland T,Lagerberg TV,Agartz I,Andreassen OA,Westlye LT

更新日期：2018-09-20 00:00:00

abstract：:Terrestrial microbial ecosystems are exposed to many types of disturbances varying in their spatial and temporal characteristics. The ability to cope with these disturbances is crucial for maintaining microbial ecosystem functions, especially if disturbances recur regularly. Thus, understanding microbial ecosystem dyn...

journal_title：Scientific reports

authors： König S,Worrich A,Banitz T,Centler F,Harms H,Kästner M,Miltner A,Wick LY,Thullner M,Frank K

更新日期：2018-06-22 00:00:00

abstract：:Previous trial evidence suggested potential risk of serious urinary tract infections (UTIs) and genital infections in type 2 diabetes patients using sodium glucose co-transporter-2 inhibitors (SGLT2) inhibitors. We conducted a systematic review and meta-analysis to assess the effects of SGLT2 inhibitors on UTIs and ge...

journal_title：Scientific reports

authors： Liu J,Li L,Li S,Jia P,Deng K,Chen W,Sun X

更新日期：2017-06-06 00:00:00

abstract：:This work reports a facile method for preparing the new photoactive In(2)O(3) films as well as their implementation in photoelectrochemical (PEC) application. We firstly investigated the relationship between oxygen vacancies (V(O)) and PEC performance and revealed a rule between them. We found that the optimized In(2)...

journal_title：Scientific reports

authors： Gan J,Lu X,Wu J,Xie S,Zhai T,Yu M,Zhang Z,Mao Y,Wang SC,Shen Y,Tong Y

更新日期：2013-01-01 00:00:00

abstract：:Quaternized polyacrylic polymer has many applications in water treatment because of its ion exchange effects, but its further industrial applications are largely restricted because of its poor mechanical strength. In this work, a magnetic anion exchange resin with a polyacrylic matrix (MAP) was prepared by incorporati...

journal_title：Scientific reports

authors： Zhang G,Li S,Shuang C,Mu Y,Li A,Tan L

更新日期：2020-03-23 00:00:00

abstract：:Facio-Scapulo Humeral dystrophy (FSHD) is the third most common myopathy, affecting 1 amongst 10,000 individuals (FSHD1, OMIM #158900). This autosomal dominant pathology is associated in 95% of cases with genetic and epigenetic alterations in the subtelomeric region at the extremity of the long arm of chromosome 4 (q ...

journal_title：Scientific reports

authors： Gaillard MC,Broucqsault N,Morere J,Laberthonnière C,Dion C,Badja C,Roche S,Nguyen K,Magdinier F,Robin JD

更新日期：2019-07-17 00:00:00

abstract：:The present study tested whether the LPS/TLR4 signal pathway in endometrial stromal cells is essential for the pathogenesis of adenomyosis. We tested the expression of TLR4, MD2 in the endometrium without adenomyosis (CE), the eutopic endometrium with adenomyosis (EuE) and the ectopic endometrium with adenomyosis (EE)...

journal_title：Scientific reports

authors： Guo J,Chen L,Luo N,Li C,Chen R,Qu X,Liu M,Kang L,Cheng Z

更新日期：2016-02-22 00:00:00

abstract：:Although more than 1,000 androgen receptor (AR) mutations have been identified and these mutants are pathologically important, few theoretical studies have investigated the role of AR protein folding stability in disease and its relationship with the phenotype of the patients. Here, we extracted AR variant data from f...

journal_title：Scientific reports

authors： Chen F,Chen X,Jiang F,Leng F,Liu W,Gui Y,Yu J

更新日期：2020-07-21 00:00:00

abstract：:Adverse events during the prenatal and early postnatal period of life are associated with development of cardiovascular disease in adulthood. Prenatal exposure to excess testosterone (T) in sheep induces adverse reproductive and metabolic programming leading to polycystic ovarian syndrome, insulin resistance and hyper...

journal_title：Scientific reports

authors： Vyas AK,Hoang V,Padmanabhan V,Gilbreath E,Mietelka KA

更新日期：2016-06-22 00:00:00

abstract：:Repeated social defeat stress (R-SDS) induces multiple behavioral changes in mice. However, the relationships between these behavioral changes were not fully understood. In the first experiment, to examine how the social avoidance is related to R-SDS-impaired behavioral flexibility, 10-week-old male C57BL/6N mice rece...

journal_title：Scientific reports

authors： Higashida S,Nagai H,Nakayama K,Shinohara R,Taniguchi M,Nagai M,Hikida T,Yawata S,Ago Y,Kitaoka S,Narumiya S,Furuyashiki T

更新日期：2018-07-11 00:00:00

abstract：:A tunable high-order sideband spectra generation scheme is presented by using a photonic molecule optomechanical system coupled to a waveguide beyond the perturbation regime. The system is coherently driven by a two-tone laser consisting of a continuous-wave control field and a pulsed driving field which propagates th...

journal_title：Scientific reports

authors： Cao C,Mi SC,Gao YP,He LY,Yang D,Wang TJ,Zhang R,Wang C

更新日期：2016-03-10 00:00:00

abstract：:As the world's oceans are currently threatened by anthropogenic pollution and climate change, coral breeding has become an important conservation method, since it can limit marine organisms' exposure to sub-optimal environment conditions. However, the aquarium environment is inherently different from the ocean, and th...

journal_title：Scientific reports

authors： Lin C,Zhuo JM,Chong G,Wang LH,Meng PJ,Tsai S

更新日期：2018-10-11 00:00:00

abstract：:Nα-acetylation is a naturally occurring irreversible modification of N-termini of proteins catalyzed by Nα-acetyltransferases (NATs). Although present in all three domains of life, it is little understood in bacteria. The functional grouping of NATs into six types NatA - NatF, in eukaryotes is based on subunit require...

journal_title：Scientific reports

authors： Pathak D,Bhat AH,Sapehia V,Rai J,Rao A

更新日期：2016-06-29 00:00:00

abstract：:Recently, there has been increasing interest in strategies to predict neurological recovery in cervical myelopathy (CM) based on clinical images of the cervical spine. In this study, we aimed to explore potential preoperative brain biomarkers that can predict postoperative neurological recovery in CM patients by using...

journal_title：Scientific reports

authors： Takenaka S,Kan S,Seymour B,Makino T,Sakai Y,Kushioka J,Tanaka H,Watanabe Y,Shibata M,Yoshikawa H,Kaito T

更新日期：2019-07-18 00:00:00

abstract：:Stability and integration are the goals for developing photonic devices. Spirooxazines have the property of photoinduced merocyanine-aggregation in polymer matrix, which can be applied to fluorescence emission and stable information storage. Although visible light coherent radiation with UV-assist has been used to ach...

journal_title：Scientific reports

authors： Ji R,Fu S,Zhang X,Han X,Liu S,Wang X,Liu Y

更新日期：2018-02-28 00:00:00

abstract：:One current concept suggests that unchecked proliferation of clonally selected precursors of endothelial cells (ECs) contribute to severe pulmonary arterial hypertension (PAH). We hypothesized that clonally selected ECs expressing the progenitor marker CD117 promote severe occlusive pulmonary hypertension (PH). The re...

journal_title：Scientific reports

authors： Bhagwani AR,Farkas D,Harmon B,Authelet KJ,Cool CD,Kolb M,Goncharova E,Yoder MC,Clauss M,Freishtat R,Farkas L

更新日期：2020-01-24 00:00:00

abstract：:Recent whooping cough (pertussis) outbreaks in many countries highlight the crucial need for a better understanding of the pathogenesis of Bordetella pertussis infection of the respiratory tract. The baboon is a recently described preclinical model for the study of B. pertussis infection and may be ideal for the evalu...

journal_title：Scientific reports

authors： Naninck T,Coutte L,Mayet C,Contreras V,Locht C,Le Grand R,Chapon C

更新日期：2018-08-16 00:00:00

abstract：:A large number of drugs are administered on different mucosal surfaces. However, due to the poor mucoadhesion of the current formulations, their bioavailability is often very low. The development of efficient mucoadhesive drug delivery systems is thus crucial for improving the performance of these drugs. The mucoadhes...

journal_title：Scientific reports

authors： Ouellette M,Masse F,Lefebvre-Demers M,Maestracci Q,Grenier P,Millar R,Bertrand N,Prieto M,Boisselier É

更新日期：2018-09-25 00:00:00

abstract：:Agamococcidians are enigmatic and poorly studied parasites of marine invertebrates with unexplored diversity and unclear relationships to other sporozoans such as the human pathogens Plasmodium and Toxoplasma. It is believed that agamococcidians are not capable of sexual reproduction, which is essential for life cycle...

journal_title：Scientific reports

authors： Miroliubova TS,Simdyanov TG,Mikhailov KV,Aleoshin VV,Janouškovec J,Belova PA,Paskerova GG

更新日期：2020-09-28 00:00:00

abstract：:Previous studies have demonstrated that patients with posttraumatic stress disorder (PTSD) caused by different types of trauma may show divergence in epidemiology, clinical manifestation and treatment outcome. However, it is still unclear whether this divergence has neuroanatomic correlates in PTSD brains. To elucidat...

journal_title：Scientific reports

authors： Meng L,Jiang J,Jin C,Liu J,Zhao Y,Wang W,Li K,Gong Q

更新日期：2016-09-21 00:00:00

abstract：:Carbon-based stationary phases for chromatographic separation have been commercially available since the 1980s. Porous graphitic carbon liquid chromatography columns are known to be highly resistant to aggressive mobile phases and extreme pH values of solvents and eluents, an important advantage compared to convention...

journal_title：Scientific reports

authors： Candelaria L,Frolova LV,Kowalski BM,Artyushkova K,Serov A,Kalugin NG

更新日期：2018-10-03 00:00:00