Abstract：
:Demand for clinical decision support systems in medicine and self-diagnostic symptom checkers has substantially increased in recent years. Existing platforms rely on knowledge bases manually compiled through a labor-intensive process or automatically derived using simple pairwise statistics. This study explored an automated process to learn high quality knowledge bases linking diseases and symptoms directly from electronic medical records. Medical concepts were extracted from 273,174 de-identified patient records and maximum likelihood estimation of three probabilistic models was used to automatically construct knowledge graphs: logistic regression, naive Bayes classifier and a Bayesian network using noisy OR gates. A graph of disease-symptom relationships was elicited from the learned parameters and the constructed knowledge graphs were evaluated and validated, with permission, against Google's manually-constructed knowledge graph and against expert physician opinions. Our study shows that direct and automated construction of high quality health knowledge graphs from medical records using rudimentary concept extraction is feasible. The noisy OR model produces a high quality knowledge graph reaching precision of 0.85 for a recall of 0.6 in the clinical evaluation. Noisy OR significantly outperforms all tested models across evaluation frameworks (p < 0.01).
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rotmensch M,Halpern Y,Tlimat A,Horng S,Sontag Ddoi
10.1038/s41598-017-05778-zsubject
Has Abstractpub_date
2017-07-20 00:00:00pages
5994issue
1issn
2045-2322pii
10.1038/s41598-017-05778-zjournal_volume
7pub_type
杂志文章abstract：:Antidepressants have been the object of an international controversy for about thirty years. Some patients are inclined to develop suicidal ideation (SI) at antidepressant onset; this phenomenon is known as Treatment Emergent Suicidal Ideation (TESI), and it has conducted regulatory bodies to prompt warnings on antide...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-019-39622-3
更新日期：2019-02-22 00:00:00
abstract：:Catharanthus roseus is a commercial source for anti-cancer terpenoid indole alkaloids (TIAs: vincristine and vinblastine). Inherent levels of these TIAs are very low, hence research studies need to focus on enhancing their levels in planta. Since primary metabolism provides precursors for specialized-metabolism, eleva...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33415-w
更新日期：2018-10-10 00:00:00
abstract：:As part of an ongoing study of new insulin mimetic agents from medicinal plants, the 70% EtOH extract of Symplocos cochinchinensis was found to have a stimulatory effect on glucose uptake in 3T3-L1 adipocyte cells. The intensive targeted isolation of this active extract resulted in ten new hydroxyoleoside-type compoun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38013-4
更新日期：2019-02-19 00:00:00
abstract：:One of the most important goals of condensed matter physics is materials by design, i.e. the ability to reliably predict and design materials with a set of desired properties. A striking example is the deterministic enhancement of the superconducting properties of materials. Recent experiments have demonstrated that t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34140
更新日期：2016-09-23 00:00:00
abstract：:Natural and anthropogenic stressors can cause phase shifts from coral-dominated to algal-dominated states. In the Caribbean, over-fishing of large herbivorous fish and disease among the long-spined urchin, Diadema, have facilitated algal growth on degraded reefs. We found that diminutive species of urchin and parrotfi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39670
更新日期：2017-01-05 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-017-18751-7
更新日期：2018-01-08 00:00:00
abstract：:The human foot and ankle system is equipped with structures that can produce mechanical work through elastic (e.g., Achilles tendon, plantar fascia) or viscoelastic (e.g., heel pad) mechanisms, or by active muscle contractions. Yet, quantifying the work distribution among various subsections of the foot and ankle can ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15218-7
更新日期：2017-11-13 00:00:00
abstract：:Single-photon emission computed tomography combined with micro-CT (SPECT/μCT) imaging using Nanobodies against complement receptor of the Ig superfamily (CRIg), found on tissue macrophages such as synovial macrophages, has promising potential to visualize joint inflammation in experimental arthritis. Here, we further ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35966
更新日期：2016-10-25 00:00:00
abstract：:Gentamicin may cause acute kidney injury. The pathogenesis of gentamicin nephrotoxicity is unclear. Autophagy is a highly conserved physiological process involved in removing damaged or aged biological macromolecules and organelles from the cytoplasm. The role of autophagy in the pathogenesis of gentamicin nephrotoxic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11256
更新日期：2015-06-08 00:00:00
abstract：:Forest fragmentation threatens the ecosystem carbon (C) storage. The distribution patterns of ecosystem C density are poorly documented for fragmented forests of differing patch size. The objectives of this study were to examine C density in these forest ecosystems and the influence of edge effects on C density. Allom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13598-4
更新日期：2017-10-13 00:00:00
abstract：:In June 2016, a disease characterised by intestinal haemorrhage with a mortality rate of approximately 5% was observed in a duck farm in Shandong province, China. Here, we report the isolation and characterisation of a reovirus from duck tissue samples by inoculating duck embryos and duck embryo fibroblasts (DEF). The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44178-3
更新日期：2019-05-23 00:00:00
abstract：:The therapeutic effects of C16, which is an inhibitor of RNA-dependent protein kinase (PKR), on growth of hepatocellular carcinoma (HCC) cells and tumor progression in vitro and in vivo were evaluated. Huh7 cells, a human HCC cell line, were used. The effects of C16 on cell viability were evaluated with the MTT assay,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61579-x
更新日期：2020-03-20 00:00:00
abstract：:Separation of CO2 from other gasses offers environmental benefits since CO2 gas is the main contributor to global warming. Recently, graphene oxide (GO) based gas separation membranes are of interest due to their selective barrier properties. However, maintaining selectivity without sacrificing permeance is still chal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00433-z
更新日期：2017-03-28 00:00:00
abstract：:Efficient interventions to reduce blood triglycerides are few; newer and more tolerable intervention targets are needed. Understanding the molecular mechanisms underlying blood triglyceride levels variation is key to identifying new therapies. To explore the role of epigenetic mechanisms on triglyceride levels, a bloo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09552-z
更新日期：2017-09-11 00:00:00
abstract：:Vitamin D deficiency, a major public-health worldwide, is associated with hyperuricemia but casual association is questioned. The study was conducted to determine potential causal associations between 25-hydroxy vitamin D (25(OH)D) and uric acid (UA). A cross-sectional study of the Electricity Generating Authority of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14528
更新日期：2015-09-29 00:00:00
abstract：:Glutamate is an indispensable neurotransmitter, triggering postsynaptic signals upon recognition by postsynaptic receptors. We questioned the phylogenetic position and the molecular details of when and where glutamate recognition arose in the glutamate-gated chloride channels. Experiments revealed that glutamate recog...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08558
更新日期：2015-02-24 00:00:00
abstract：:We present measurements of the outdoor stability of PCDTBT:PC71BM based bulk heterojunction organic solar cells for over the course of a year. We find that the devices undergo a burn-in process lasting 450 hours followed by a TS80 lifetime of up to 6200 hours. We conclude that in the most stable devices, the observed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21632
更新日期：2016-02-09 00:00:00
abstract：:The purpose of this work is to make a case for epidemiological models with fractional exponent in the contribution of sub-populations to the incidence rate. More specifically, we question the standard assumption in the literature on epidemiological models, where the incidence rate dictating propagation of infections i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77849-7
更新日期：2020-11-30 00:00:00
abstract：:In nature Siberian hamsters utilize the decrement in day length following the summer solstice to implement physiological adaptations in anticipation of the forthcoming winter, but also exploit an intrinsic interval timer to initiate physiological recrudescence following the winter solstice. However, information is lac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29689
更新日期：2016-07-11 00:00:00
abstract：:The spectral distribution of light emitted from a scanning tunnelling microscope junction not only bears its intrinsic plasmonic signature but is also imprinted with the characteristics of optical frequency fluc- tuations of the tunnel current. Experimental spectra from gold-gold tunnel junctions are presented that sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03766-x
更新日期：2017-06-14 00:00:00
abstract：:Energetic ions have been widely used to evaluate the irradiation tolerance of structural materials for nuclear power applications and to modify material properties. It is important to understand the defect production, annihilation and migration mechanisms during and after collision cascades. In this study, single crys...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19994
更新日期：2016-02-01 00:00:00
abstract：:Skin ageing is an inevitable consequence of life and accelerated by exposure to ultraviolet (UV) rays. Senescence is an irreversible growth arrest and senescent cells accumulate in ageing tissues, at sites of age-related pathologies and in pre-neoplastic lesions. Conventionally, senescent cells have been detected by s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15901-9
更新日期：2017-11-15 00:00:00
abstract：:Copper is an essential trace metal that has been implicated in angiogenesis, the formation of new blood vessels. As tumor growth relies on establishing a functional capillary network for blood supply, copper chelation therapy may hold promise as an anti-cancer strategy by suppressing angiogenesis. To test the anti-ang...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50494-5
更新日期：2019-10-01 00:00:00
abstract：:This paper investigates the possibility of saving a network that is predicted to have a cascading failure that will eventually lead to a total collapse. We model cascading failures using the recently proposed KQ model. Then predict an impending total collapse by monitoring critical slowing down indicators and subseque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25591-6
更新日期：2018-05-10 00:00:00
abstract：:Crystalline atomic layers on solid surfaces are composed of a single building block, unit cell, that is copied and stacked together to form the entire two-dimensional crystal structure. However, it appears that this is not an unique possibility. We report here on synthesis and characterization of the one-atomic-layer-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19446
更新日期：2016-01-19 00:00:00
abstract：:High Refractive Index (HRI) dielectric nanoparticles have been proposed as an alternative to metallic ones due to their low absorption and magnetodielectric response in the VIS and NIR ranges. For the latter, important scattering directionality effects can be obtained. Also, systems constituted by dimers of HRI dielec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11401-y
更新日期：2017-09-11 00:00:00
abstract：:The early diverged Magnoliaceae shows a historical temperate-tropical distribution among lineages indicating divergent evolution, yet which ecophysiological traits are phylogenetically conserved, and whether these traits are involved in correlated evolution remain unclear. Integrating phylogeny and 20 ecophysiological...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12246
更新日期：2015-07-16 00:00:00
abstract：:Glucocorticoids (GC) display pleiotropic effects on the immune system. Macrophages are a major target for GC action. Here we show that dexamethasone (DEX), a synthetic GC, decreased viability of naïve bone marrow-derived macrophages (BMDM), involving an apoptotic mechanism. Administration of DEX together with lipopoly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04323
更新日期：2014-03-10 00:00:00
abstract：:Diet composition impacts metabolic and cardiovascular health with high caloric diets contributing to obesity related disorders. Dietary interventions such as caloric restriction exert beneficial effects in the cardiovascular system, but alteration of which specific nutrient is responsible is less clear. This study inv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51654-3
更新日期：2019-10-22 00:00:00
abstract：:Complex interactions occur between tumor and host immune system at each site in the metastatic setting, the outcome of which can determine behavior ranging from dormancy to rapid growth. An additional layer of complexity arises from the understanding that cytotoxic T cells can traffic through the host circulatory syst...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27718-1
更新日期：2018-06-21 00:00:00
