Immune interconnectivity of anatomically distant tumors as a potential mediator of systemic responses to local therapy.

abstract：:Microorganisms associated with plants are highly diverse and can produce a large number of secondary metabolites, with antimicrobial, anti-parasitic and cytotoxic activities. We are particularly interested in exploring endophytes from medicinal plants found in the Pantanal, a unique and widely unexplored wetland in Br...

journal_title：Scientific reports

authors： Savi DC,Shaaban KA,Gos FMWR,Ponomareva LV,Thorson JS,Glienke C,Rohr J

更新日期：2018-02-15 00:00:00

abstract：:The N-methyl-D-aspartate subfamily of ionotropic glutamate receptors (NMDARs) is well known for its important roles in the central nervous system (CNS), e.g. learning and memory formation. Besides the CNS, NMDARs are also expressed in numerous peripheral tissues including the pancreas, kidney, stomach, and blood cells...

journal_title：Scientific reports

authors： Koch A,Bonus M,Gohlke H,Klöcker N

更新日期：2019-07-11 00:00:00

abstract：:A hematite photoanode showing a stable, record-breaking performance of 4.32 mA/cm² photoelectrochemical water oxidation current at 1.23 V vs. RHE under simulated 1-sun (100 mW/cm²) irradiation is reported. This photocurrent corresponds to ca. 34% of the maximum theoretical limit expected for hematite with a band gap o...

journal_title：Scientific reports

authors： Kim JY,Magesh G,Youn DH,Jang JW,Kubota J,Domen K,Lee JS

更新日期：2013-01-01 00:00:00

abstract：:Sleep has been hypothesised to maintain a close relationship with metabolism. Here we focus on the brain structure that triggers slow-wave sleep, the ventrolateral preoptic nucleus (VLPO), to explore the cellular and molecular signalling pathways recruited by an increase in glucose concentration. We used infrared vide...

journal_title：Scientific reports

authors： Scharbarg E,Daenens M,Lemaître F,Geoffroy H,Guille-Collignon M,Gallopin T,Rancillac A

更新日期：2016-01-12 00:00:00

abstract：:The Antarctic silverfish (Pleuragramma antarctica) is a critically important forage species with a circumpolar distribution and is unique among other notothenioid species for its wholly pelagic life cycle. Previous studies have provided mixed evidence of population structure over regional and circumpolar scales. The a...

journal_title：Scientific reports

authors： Caccavo JA,Papetti C,Wetjen M,Knust R,Ashford JR,Zane L

更新日期：2018-12-14 00:00:00

abstract：:In wild animal conservation, knowing the age of an individual animal is extremely beneficial. However, estimating the age is difficult for many species. Recently, epigenetics-based methods of estimating age have been reported. These studies were predominantly on humans with few reports on other animals, especially wil...

journal_title：Scientific reports

authors： Ito H,Udono T,Hirata S,Inoue-Murayama M

更新日期：2018-07-03 00:00:00

abstract：:The human microbiome plays a key role in maintaining host homeostasis and is influenced by age, geography, diet, and other factors. Traditionally, India has an established convention of extended family arrangements wherein three or more generations, bound by genetic relatedness, stay in the same household. In the pres...

journal_title：Scientific reports

authors： Chaudhari DS,Dhotre DP,Agarwal DM,Gaike AH,Bhalerao D,Jadhav P,Mongad D,Lubree H,Sinkar VP,Patil UK,Salvi S,Bavdekar A,Juvekar SK,Shouche YS

更新日期：2020-03-30 00:00:00

abstract：:The brain effortlessly recognizes objects even when the visual information belonging to an object is widely separated, as well demonstrated by the Kanizsa-type illusory contours (ICs), in which a contour is perceived despite the fragments of the contour being separated by gaps. Such large-range visual completion has l...

journal_title：Scientific reports

authors： Wu X,Zhou L,Qian C,Gan L,Zhang D

更新日期：2015-02-10 00:00:00

abstract：:Parkinson's disease (PD) is a degenerative disorder that affects the central nervous system. PD-related alterations in structural and functional neuroimaging have not been fully explored. This study explored multi-modal PD neuroimaging and its application for predicting clinical scores on the Movement Disorder Society...

journal_title：Scientific reports

authors： Son SJ,Kim M,Park H

更新日期：2016-11-30 00:00:00

abstract：:State of the art clinical hand prostheses are controlled in a simple and limited way that allows the activation of one function at a time. More advanced laboratory approaches, based on machine learning, offer a significant increase in functionality, but their clinical impact is limited, mainly due to lack of reliabili...

journal_title：Scientific reports

authors： Hahne JM,Markovic M,Farina D

更新日期：2017-06-30 00:00:00

abstract：:Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial pharmacological target for several central nervous system disorders. In this study, we aimed to monitor in vivo regional changes of mGluR1 related to neuroinflammation in the brains of rats after pilocarpine-induced status epilepticus (PISE) using longitu...

journal_title：Scientific reports

authors： Yamasaki T,Fujinaga M,Mori W,Zhang Y,Wakizaka H,Nengaki N,Xie L,Hatori A,Zhang MR

更新日期：2017-11-02 00:00:00

abstract：:Although it is clear that lipids are responsible for insulin resistance, it is poorly understood what types of lipids are involved. In this study, we verified the characteristic lipid species in skeletal muscle of a chronic exercise training model and a high-fat induced-obesity model. Three different lipidomics analys...

journal_title：Scientific reports

authors： Goto-Inoue N,Yamada K,Inagaki A,Furuichi Y,Ogino S,Manabe Y,Setou M,Fujii NL

更新日期：2013-11-20 00:00:00

abstract：:Antimicrobial peptides (AMPs) exhibit broad-spectrum antimicrobial activity, and have promise as new therapeutic agents. While the adult North American bullfrog (Rana [Lithobates] catesbeiana) is a prolific source of high-potency AMPs, the aquatic tadpole represents a relatively untapped source for new AMP discovery. ...

journal_title：Scientific reports

authors： Helbing CC,Hammond SA,Jackman SH,Houston S,Warren RL,Cameron CE,Birol I

更新日期：2019-02-06 00:00:00

abstract：:We aimed to establish a highly sensitive method for measuring visual function using spatial-sweep steady-state pattern electroretinography (swpPERG). Overall, 35 eyes of 35 healthy adults (18 men; mean age, 32.3 years) were examined using swpPERG, and the data were recorded using spatial-patterned and contrast-reverse...

journal_title：Scientific reports

authors： Minami S,Nagai N,Suzuki M,Kurihara T,Sonobe H,Watanabe K,Shinoda H,Takagi H,Tsubota K,Ozawa Y

更新日期：2019-12-02 00:00:00

abstract：:Decrease in blood concentration of branched-chain amino acids, especially leucine, is known to promote liver carcinogenesis in patients with chronic liver disease, but the mechanism is unclear. We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9 system, and elucid...

journal_title：Scientific reports

authors： Mizuno Y,Shimada S,Akiyama Y,Watanabe S,Aida T,Ogawa K,Ono H,Mitsunori Y,Ban D,Kudo A,Arii S,Yamaoka S,Tanabe M,Tanaka S

更新日期：2018-01-08 00:00:00

abstract：:The 37 currently recognized Bemisia tabaci cryptic species are economically important species and contain both primary and secondary endosymbionts, but their diversity has never been mapped systematically across the group. To achieve this, PacBio sequencing of full-length bacterial 16S rRNA gene amplicons was carried ...

journal_title：Scientific reports

authors： Wang HL,Lei T,Xia WQ,Cameron SL,Liu YQ,Zhang Z,Gowda MMN,De Barro P,Navas-Castillo J,Omongo CA,Delatte H,Lee KY,Patel MV,Krause-Sakate R,Ng J,Wu SL,Fiallo-Olivé E,Liu SS,Colvin J,Wang XW

更新日期：2019-04-25 00:00:00

abstract：:Papillary thyroid carcinoma (PTC) displays strong but so far largely uncharacterized heritability. Here we studied genetic predisposition in a family with six affected individuals. We genotyped all available family members and conducted whole exome sequencing of blood DNA from two affected individuals. Haplotype analy...

journal_title：Scientific reports

authors： Tomsic J,He H,Akagi K,Liyanarachchi S,Pan Q,Bertani B,Nagy R,Symer DE,Blencowe BJ,de la Chapelle A

更新日期：2015-07-02 00:00:00

abstract：:Lipoprotein associated phospholipase A2 (Lp-PLA2) has been characterized for its interfacial activation as well as inhibition by detergent micelles and lipoprotein particles. The enzyme has been shown to bind on the surfaces of hydrophobic aggregates, such as detergent micelles, lipoprotein particles and even polystyr...

journal_title：Scientific reports

authors： Zhuo S,Yuan C

更新日期：2020-10-14 00:00:00

abstract：:Profiling immune repertoires by high throughput sequencing enhances our understanding of immune system complexity and immune-related diseases in humans. Previously, cloning and Sanger sequencing identified limited numbers of T cell receptor (TCR) nucleotide sequences in rhesus monkeys, thus their full immune repertoir...

journal_title：Scientific reports

authors： Li Z,Liu G,Tong Y,Zhang M,Xu Y,Qin L,Wang Z,Chen X,He J

更新日期：2015-05-11 00:00:00

abstract：:The metal-to-insulator transition (MIT) closest to room temperature of 68-70 °C as shown by vanadium oxide (VO2), compared with other transition metal oxides, makes it a potential candidate for smart window coating. We have successfully fabricated a potential smart window device after the optimum design of a multilaye...

journal_title：Scientific reports

authors： Behera MK,Williams LC,Pradhan SK,Bahoura M

更新日期：2020-02-04 00:00:00

abstract：:The success of mesenchymal stem cell transplantation is highly dependent on their survival and controlled fate regulation. This study demonstrates that dual-delivery of connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) from a core-shell fiber of Silk Fibroin/poly(L-lactic acid-co-ε-caprolac...

journal_title：Scientific reports

authors： Xu R,Zhao H,Muhammad H,Dong M,Besenbacher F,Chen M

更新日期：2017-08-17 00:00:00

abstract：:Although recent studies focused on traditional Chinese medicine (TCM) for the treatment of refractory schizophrenia have reported that it may be beneficial, there is still lack of convincing evidence and critical meta-analytic work regarding its effectiveness as an adjunctive therapy. Therefore, we performed a meta-an...

journal_title：Scientific reports

authors： Wei YY,Lin WF,Zhang TH,Tang YX,Wang JJ,Zhong MF

更新日期：2018-04-18 00:00:00

abstract：:A better understanding of functional changes in the intervertebral disc (IVD) and interaction with endplate is essential to elucidate the pathogenesis of IVD degeneration disease (IDDD). To date, the simultaneous depiction of 3D micro-architectural changes of endplate with aging and interaction with IVD remains a tech...

journal_title：Scientific reports

authors： Cao Y,Liao S,Zeng H,Ni S,Tintani F,Hao Y,Wang L,Wu T,Lu H,Duan C,Hu J

更新日期：2017-03-07 00:00:00

abstract：:Frataxin is a highly conserved protein encoded by the frataxin (FXN) gene. The full-length 210-amino acid form of protein frataxin (1-210; isoform A) expressed in the cytosol of cells rapidly translocates to the mitochondria, where it is converted to the mature form (81-210) by mitochondrial processing peptidase. Matu...

journal_title：Scientific reports

authors： Guo L,Wang Q,Weng L,Hauser LA,Strawser CJ,Mesaros C,Lynch DR,Blair IA

更新日期：2018-11-19 00:00:00

abstract：:In this work, we address the ubiquitous phenomenon of Fano resonances in bilayer graphene. We consider that this phenomenon is as exotic as other phenomena in graphene because it can arise without an external extended states source or elaborate nano designs. However, there are not theoretical and/or experimental studi...

journal_title：Scientific reports

authors： Briones-Torres JA,Rodríguez-Vargas I

更新日期：2017-12-01 00:00:00

abstract：:Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) represent naive and primed pluripotency states, respectively, and are maintained in vitro by specific signalling pathways. Furthermore, ESCs cultured in serum-free medium with two kinase inhibitors (2i-ESCs) are thought to be the ground naïve pluripote...

journal_title：Scientific reports

authors： Tosolini M,Brochard V,Adenot P,Chebrout M,Grillo G,Navia V,Beaujean N,Francastel C,Bonnet-Garnier A,Jouneau A

更新日期：2018-04-10 00:00:00

abstract：:Channelopathy mutations prove informative on disease causing mechanisms and channel gating dynamics. We have identified a novel heterozygous mutation in the KCNA1 gene of a young proband displaying typical signs and symptoms of Episodic Ataxia type 1 (EA1). This mutation is in the S4 helix of the voltage-sensing domai...

journal_title：Scientific reports

authors： Hasan S,Bove C,Silvestri G,Mantuano E,Modoni A,Veneziano L,Macchioni L,Hunter T,Hunter G,Pessia M,D'Adamo MC

更新日期：2017-07-04 00:00:00

abstract：:Ion pumps and channels are responsible for a wide variety of biological functions. Ion pumps transport only one ion during each stimulus-dependent reaction cycle, whereas ion channels conduct a large number of ions during each cycle. Ion pumping rhodopsins such as archaerhodopsin-3 (Arch) are often utilized as light-d...

journal_title：Scientific reports

authors： Yamanashi T,Maki M,Kojima K,Shibukawa A,Tsukamoto T,Chowdhury S,Yamanaka A,Takagi S,Sudo Y

更新日期：2019-05-27 00:00:00

abstract：:Recent studies showed that anomalous dry conditions and limited moisture supply roughly between 1998 and 2008, especially in the Southern Hemisphere, led to reduced vegetation productivity and ceased growth in land evapotranspiration (ET). However, natural variability of Earth's climate system can degrade capabilities...

journal_title：Scientific reports

authors： Zhang K,Kimball JS,Nemani RR,Running SW,Hong Y,Gourley JJ,Yu Z

更新日期：2015-10-30 00:00:00

abstract：:Establishing the architecture of gene regulatory networks (GRNs) relies on chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-Seq) methods that provide genome-wide transcription factor binding sites (TFBSs). ChIP-Seq furnishes millions of short reads that, after alignment, describe the genom...

journal_title：Scientific reports

authors： Ouma WZ,Mejia-Guerra MK,Yilmaz A,Pareja-Tobes P,Li W,Doseff AI,Grotewold E

更新日期：2015-03-02 00:00:00