Abstract：
:Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) represent naive and primed pluripotency states, respectively, and are maintained in vitro by specific signalling pathways. Furthermore, ESCs cultured in serum-free medium with two kinase inhibitors (2i-ESCs) are thought to be the ground naïve pluripotent state. Here, we present a comparative study of the epigenetic and transcriptional states of pericentromeric heterochromatin satellite sequences found in these pluripotent states. We show that 2i-ESCs are distinguished from other pluripotent cells by a prominent enrichment in H3K27me3 and low levels of DNA methylation at pericentromeric heterochromatin. In contrast, serum-containing ESCs exhibit higher levels of major satellite repeat transcription, which is lower in 2i-ESCs and even more repressed in primed EpiSCs. Removal of either DNA methylation or H3K9me3 at PCH in 2i-ESCs leads to enhanced deposition of H3K27me3 with few changes in satellite transcript levels. In contrast, their removal in EpiSCs does not lead to deposition of H3K27me3 but rather removes transcriptional repression. Altogether, our data show that the epigenetic state of PCH is modified during transition from naive to primed pluripotency states towards a more repressive state, which tightly represses the transcription of satellite repeats.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tosolini M,Brochard V,Adenot P,Chebrout M,Grillo G,Navia V,Beaujean N,Francastel C,Bonnet-Garnier A,Jouneau Adoi
10.1038/s41598-018-23822-4subject
Has Abstractpub_date
2018-04-10 00:00:00pages
5776issue
1issn
2045-2322pii
10.1038/s41598-018-23822-4journal_volume
8pub_type
杂志文章abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-26716-7
更新日期：2018-06-18 00:00:00
abstract：:Mandrill (Mandrillus sphinx) is a primate species, which belongs to the Old World monkey (Cercopithecidae) family. It is closely related to human, serving as a model for human health related research. However, the genetic studies on and genomic resources of mandrill are limited, especially in comparison to other prima...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59110-3
更新日期：2020-02-12 00:00:00
abstract：:Plants deploy several ammonium transporter (AMT) and nitrate transporter (NRT) genes to acquire NH4+ and NO3- from the soil into the roots and then transport them to other plant organs. Coding sequences of wheat genes obtained from ENSEMBL were aligned to known AMT and NRT sequences of Arabidopsis, barley, maize, rice...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25430-8
更新日期：2018-05-04 00:00:00
abstract：:Negative hemodynamic response has been widely reported in blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging studies, however its origin is still controversial. Optical intrinsic signal (OIS) imaging can be used to study brain activity by simultaneously recording hemodynamic signals at diff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21627
更新日期：2016-02-10 00:00:00
abstract：:The present study was undertaken to determine the prevalence of endplate junction failure in a smaller cohort of Danish patients with lumbar disk herniation and compare this to the previously published data from India. Consecutive patients seen in a large regional hospital spine-care unit, with a clinical presentation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74690-w
更新日期：2020-10-19 00:00:00
abstract：:Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence of monodominance in a massive, basin-wide database of forest-inv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50323-9
更新日期：2019-09-25 00:00:00
abstract：:The regular rise and fall of the sun resulted in the development of 24-h rhythms in virtually all organisms. In an evolutionary heartbeat, humans have taken control of their light environment with electric light. Humans are highly sensitive to light, yet most people now use light until bedtime. We evaluated the impact...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75622-4
更新日期：2020-11-05 00:00:00
abstract：:Management of curable sexually-transmitted infections (STI) such as Chlamydia can be revolutionized by highly sensitive nucleic acid testing that is deployable at the point-of-care (POC). Here we report the development of a mobile nucleic acid amplification testing (mobiNAAT) platform utilizing a mobile phone and drop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04781-8
更新日期：2017-07-03 00:00:00
abstract：:Recent studies have linked appearance of Paneth cells in colorectal adenomas to adenoma burden and male gender. However, the clinical importance of Paneth cells' associations with synchronous advanced adenoma (AA) and colorectal carcinoma (CRC) is currently unclear. We performed a comprehensive case-control study usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26129
更新日期：2016-05-18 00:00:00
abstract：:Multi-phenotype analysis has drawn increasing attention to high-throughput genomic studies, whereas only a few applications have justified the use of multivariate techniques. We applied a recently developed multi-trait analysis method on a small set of bacteria hypersensitive response phenotypes and identified a singl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45281
更新日期：2017-03-24 00:00:00
abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68106-y
更新日期：2020-07-14 00:00:00
abstract：:Diffuse myocardial fibrosis is a key pathophysiologic feature in heart failure and can be quantified by cardiac magnetic resonance (CMR) T1 mapping. However, increases in myocardial free water also prolong native T1 times and may impact fibrosis quantification. Thus far, the impact of systemic patient volume status re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23868-4
更新日期：2018-04-03 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58429-1
更新日期：2020-01-27 00:00:00
abstract：:HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To find strategies toward an HIV cure, detailed understandings of the molecular mechanisms underlying establishment and persistence of the reservoirs are needed. The cellular transcription factor KAP1 is known as a potent repre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82164-w
更新日期：2021-01-29 00:00:00
abstract：:Altered metabolism is considered as a hallmark of cancer. Here we investigated expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) 2 lyase (HMGCL), an essential enzyme in ketogenesis, which produces ketone bodies by the breakdown of fatty acids to supply energy, in nasopharyngeal carcinoma (NPC). The express...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11025-2
更新日期：2017-09-20 00:00:00
abstract：:We investigate the impact of borders on the topology of spatially embedded networks. Indeed territorial subdivisions and geographical borders significantly hamper the geographical span of networks thus playing a key role in the formation of network communities. This is especially important in scientific and technologi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04546
更新日期：2014-04-01 00:00:00
abstract：:Brain-computer interfaces enable active communication and execution of a pre-defined set of commands, such as typing a letter or moving a cursor. However, they have thus far not been able to infer more complex intentions or adapt more complex output based on brain signals. Here, we present neuroadaptive generative mod...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71287-1
更新日期：2020-09-07 00:00:00
abstract：:The clinical associations and correlations with other virulence factors such as cag pathogenicity island (PAI) of the Integrating Conjugative Elements Helicobacter pylori TFSS (ICEHptfs), a new type IV secretion system (TFSS) in H. pylori has not been described. Among 103 studied strains from Indonesia, almost all str...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24406-y
更新日期：2018-04-17 00:00:00
abstract：:Emergence of a highly pathogenic avian influenza (HPAI) H5N8 virus in Asia and its spread to Europe and North America has caused great concern for human health. Although the H5N8 virus has been only moderately pathogenic to mammalian hosts, virulence can still increase. We evaluated the pathogenic potential of several...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40667
更新日期：2017-01-17 00:00:00
abstract：:Because of the unique selection rule, hyper-Raman scattering (HRS) can provide spectral information that linear Raman and infrared spectroscopy cannot obtain. However, the weak signal is the key bottleneck that restricts the application of HRS technique in study of the molecular structure, surface or interface behavio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30331-x
更新日期：2018-08-08 00:00:00
abstract：:Changes in litterfall dynamics and soil properties due to anthropogenic or natural perturbations have important implications to soil carbon (C) and nutrient cycling via microbial pathway. Here we determine soil microbial responses to contrasting types of litter inputs (leaf vs. fine woody litter) and nitrogen (N) depo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19536
更新日期：2016-01-14 00:00:00
abstract：:The stochastic tunneling-basin hopping method (STUN-BH) was utilized to obtain the most stable peptide S7 configuration (Ac-Ser-Ser-Phe-Pro-Gln-Pro-Asn-CONH2) adsorbed on Au(111) facet. After the most stable S7 configuration was found, molecular dynamics (MD) simulation was conducted to investigate the thermal stabili...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59144-7
更新日期：2020-02-07 00:00:00
abstract：:A body with mechanical sensors may remotely detect particles suspended in the surrounding fluid via controlled agitation. Here we propose a sensory mode that relies on generating unsteady flow and sensing particle-induced distortions in the flow field. We demonstrate the basic physical principle in a simple analytical...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58880-0
更新日期：2020-02-14 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-28601-9
更新日期：2018-07-04 00:00:00
abstract：:Onychomycosis (OM) is a common nail disease. Although controversial, vascular diseases are considered independent predictors of OM and vice versa. Sequential pattern mining (SPM) has not been previously used for statistical analysis in dermatology, but it is an efficient method for identifying frequent association rul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35909-z
更新日期：2018-12-14 00:00:00
abstract：:Antibiotics are unable to remove biofilms from surgical implants. This high antibiotic tolerance is related to bacterial persisters, a sub-population of bacteria phenotypically tolerant to antibiotics secondary to a reduced metabolic state. WLBU2 is an engineered cationic amphipathic peptide designed to maximize antim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17780-6
更新日期：2017-12-22 00:00:00
abstract：:Spin fluctuations are widely believed to play an important role in the superconducting mechanisms of unconventional high temperature superconductors. Spin fluctuations have been observed in iron-based superconductors as well. However, in some iron-based superconductors such as LaFePO0.9, they have not been observed by...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33878-x
更新日期：2018-11-05 00:00:00
abstract：:The variation in mortality-to-incidence ratios (MIRs) among countries reflects the clinical outcomes and the available interventions for colorectal cancer treatments. The association between MIR of prostate cancer and cancer care disparities among countries is an interesting issue that is rarely investigated. For the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40003
更新日期：2017-01-04 00:00:00
abstract：:Machine learning methods provide powerful tools to map physical measurements to scientific categories. But are such methods suitable for discovering the ground truth about psychological categories? We use the science of emotion as a test case to explore this question. In studies of emotion, researchers use supervised ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77117-8
更新日期：2020-11-20 00:00:00
abstract：:Protein kinases are frequently mutated in human cancers, which leads to altered signaling pathways and contributes to tumor growth and progression. ERK3 is an atypical mitogen-activated protein kinase (MAPK) containing an S-E-G activation motif rather than the conserved T-X-Y motif in conventional MAPKs such as ERK1/2...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15135-9
更新日期：2017-11-03 00:00:00
