Abstract：
:The human microbiome plays a key role in maintaining host homeostasis and is influenced by age, geography, diet, and other factors. Traditionally, India has an established convention of extended family arrangements wherein three or more generations, bound by genetic relatedness, stay in the same household. In the present study, we have utilized this unique family arrangement to understand the association of age with the microbiome. We characterized stool, oral and skin microbiome of 54 healthy individuals from six joint families by 16S rRNA gene-based metagenomics. In total, 69 (1.03%), 293 (2.68%) and 190 (8.66%) differentially abundant OTUs were detected across three generations in the gut, skin and oral microbiome, respectively. Age-associated changes in the gut and oral microbiome of patrilineal families showed positive correlations in the abundance of phyla Proteobacteria and Fusobacteria, respectively. Genera Treponema and Fusobacterium showed a positive correlation with age while Granulicatella and Streptococcus showed a negative correlation with age in the oral microbiome. Members of genus Prevotella illustrated high abundance and prevalence as a core OTUs in the gut and oral microbiome. In conclusion, this study highlights that precise and perceptible association of age with microbiome can be drawn when other causal factors are kept constant.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chaudhari DS,Dhotre DP,Agarwal DM,Gaike AH,Bhalerao D,Jadhav P,Mongad D,Lubree H,Sinkar VP,Patil UK,Salvi S,Bavdekar A,Juvekar SK,Shouche YSdoi
10.1038/s41598-020-62195-5subject
Has Abstractpub_date
2020-03-30 00:00:00pages
5685issue
1issn
2045-2322pii
10.1038/s41598-020-62195-5journal_volume
10pub_type
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