Abstract:
:The success of mesenchymal stem cell transplantation is highly dependent on their survival and controlled fate regulation. This study demonstrates that dual-delivery of connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) from a core-shell fiber of Silk Fibroin/poly(L-lactic acid-co-ε-caprolactone)-polyethylene oxide (SF/PLCL-PEO) enhanced fibrogenic lineage differentiation of MSCs. The core-shell structure was confirmed by transmission electron microscopy (TEM), fluorescence microscopy and attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectroscopy. A sequential release of FGF-2 and CTGF was successfully achieved in this manner. FGF-2 plays an important role in stem cell proliferation and, meanwhile when accompanied with CTGF, has a slightly additive effect on fibrogenic differentiation of MSCs, whereas CTGF promotes fibrogenesis and alleviates osteogenesis, chondrogenesis and adipogenesis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xu R,Zhao H,Muhammad H,Dong M,Besenbacher F,Chen Mdoi
10.1038/s41598-017-08226-0subject
Has Abstractpub_date
2017-08-17 00:00:00pages
8509issue
1issn
2045-2322pii
10.1038/s41598-017-08226-0journal_volume
7pub_type
杂志文章abstract::Biological validation of new radiotherapy modalities is essential to understand their therapeutic potential. Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellular DNA damage and relative biological effectiveness (RBE) of a cl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01770
更新日期:2013-01-01 00:00:00
abstract::Insulin signaling governs many processes including glucose homeostasis and metabolism, and is therapeutically used to treat hyperglycemia in diabetes. We demonstrated that insulin-induced Akt activation enhances the sensitivity to TGF-β by directing an increase in cell surface TGF-β receptors from a pool of intracellu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53490-x
更新日期:2019-11-18 00:00:00
abstract::The aim is to design a patient-specific instrument (PSI) for multilevel cervical pedicle screw placement from C2 to C7, as well as verifying reliability and reproducibility. Computed tomography (CT) scans were obtained from 7 cadaveric cervical spines. Using Mimics software, semiautomatic segmentation was performed fo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51936-w
更新日期:2019-10-30 00:00:00
abstract::We investigate instability mechanisms in amorphous In-Ga-Zn-O transistors based on bias and illumination stress-recovery experiments coupled with analysis using stretched exponentials and inverse Laplace transform to retrieve the distribution of activation energies associated with metastable oxygen defects. Results sh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14902
更新日期:2015-10-08 00:00:00
abstract::We extend an agent-based multiscale model of vascular tumour growth and angiogenesis to describe transarterial chemoembolisation (TACE) therapies. The model accounts for tumour and normal cells that are both nested in a vascular system that changes its structure according to tumour-related growth factors. Oxygen promo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65012-1
更新日期:2020-06-29 00:00:00
abstract::Chronic stress and prolonged activation of defence pathways have deleterious consequences for the cell. Dietary restriction is believed to be beneficial as it induces the cellular stress response machinery. We report here that although the phenomenon is beneficial in a wild-type cell, dietary restriction leads to an i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33433
更新日期:2016-09-16 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-54276-x
更新日期:2019-11-20 00:00:00
abstract::It is essential to understand how the loss of biodiversity impacts both ecosystem function (EF) and multifunctionality (EMF). Previous studies have mostly focused on predicting how species richness (SR) impacts EMF, while the effect of functional diversity (FD) on EMF remains unclear. Specifically, we know little abou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43475-1
更新日期:2019-05-06 00:00:00
abstract::Habitats along linear infrastructure, such as roads and electrical transmission lines, can have high local biodiversity. To determine whether these habitats also contribute to landscape-scale biodiversity, we estimated species richness, evenness and phylogenetic diversity of plant, butterfly and bumblebee communities ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78090-y
更新日期:2020-12-07 00:00:00
abstract::Here we demonstrate that aerosols of host directed therapies [HDT] administered during a chronic Mycobacterium tuberculosis (Mtb) infection have bactericidal effect. The pulmonary bacterial load of C57BL/6 mice chronically infected with Mtb was reduced by 1.7 and 0.6 log10CFU after two weeks of treatment via aerosol d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35023-0
更新日期:2018-11-09 00:00:00
abstract::Large classes of electronic, photonic, and acoustic crystals and quasi-crystals have been predicted to support topological wave-modes. Some of these modes are stabilized by certain symmetries but others occur as pure wave phenomena, hence they can be observed in many other media that support wave propagation. Surface ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21462-2
更新日期:2018-02-20 00:00:00
abstract::For the application of formic acid as a liquid organic hydrogen carrier, development of efficient catalysts for dehydrogenation of formic acid is a challenging topic, and most studies have so far focused on the composition of metals and supports, the size effect of metal nanoparticles, and surface chemistry of support...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33502
更新日期:2016-09-26 00:00:00
abstract::The dorsal anterior cingulate cortex (dACC) has been identified as a core region affected by many disorders, representing a promising target for neuromodulation. High Definition-transcranial Direct Current Stimulation (HD-tDCS) is a non-invasive neuromodulation technique that has already shown promising outcomes and h...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-018-22730-x
更新日期:2018-03-13 00:00:00
abstract::Riverine and atmospheric inputs are often considered as the main terrestrial sources of dissolved inorganic nitrogen (DIN), phosphorus (DIP), and silicon (DSi) in the ocean. However, the fluxes of nutrients via submarine groundwater discharge (SGD) often exceed riverine inputs in different local and regional scale set...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20806-2
更新日期:2018-02-05 00:00:00
abstract::Single-photon emission computed tomography combined with micro-CT (SPECT/μCT) imaging using Nanobodies against complement receptor of the Ig superfamily (CRIg), found on tissue macrophages such as synovial macrophages, has promising potential to visualize joint inflammation in experimental arthritis. Here, we further ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35966
更新日期:2016-10-25 00:00:00
abstract::Fatty acid oxidation is the major energy pathway used by the kidney, although glycolysis becomes more important in the low oxygen environment of the medulla. Fatty acid oxidation appears to be reduced in renal fibrosis, and drugs that reverse this improve fibrosis. Expression of glycolytic genes is more variable, but ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71475-z
更新日期:2020-09-03 00:00:00
abstract::Drug-induced cholestasis is a leading cause of drug withdrawal. However, the use of primary human hepatocytes (PHHs), the gold standard for predicting cholestasis in vitro, is limited by their high cost and batch-to-batch variability. Mature hepatocyte characteristics have been observed in human induced hepatocytes (h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38694
更新日期:2016-12-09 00:00:00
abstract::Neoadjuvant systemic treatment is increasingly being integrated in the standard treatment of pancreatic ductal adenocarcinoma (PDAC) patients to improve oncological outcomes. Current available imaging techniques remain unreliable in assessing response to therapies, as they cannot distinguish between (vital) tumor tiss...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73242-6
更新日期:2020-10-01 00:00:00
abstract::Advanced structural characterisation techniques which are rapid to use, non-destructive and structurally definitive on the nanoscale are in demand, especially for a detailed understanding of extended-defects and their influence on the properties of materials. We have applied the electron backscatter diffraction (EBSD)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11187-z
更新日期:2017-09-07 00:00:00
abstract::Leaf senescence provides a unique window to explore the age-dependent programmed degradation at organ label in plants. Here, spectral domain optical coherence tomography (SD-OCT) has been used to study in vivo senescing leaf microstructural changes in the deciduous plant Acer serrulatum Hayata. Hayata leaves show autu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38165-3
更新日期:2019-02-04 00:00:00
abstract::Direct visualization and assessment of the iridocorneal angle (ICA) region with high resolution is important for the clinical evaluation of glaucoma. However, the current clinical imaging systems for ICA do not provide sufficient structural details due to their poor resolution. The key challenges in achieving high qua...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30844
更新日期:2016-07-29 00:00:00
abstract::A silica gel coated microsphere resonator is proposed and experimentally demonstrated for measurements of ammonia (NH3) concentration in air with ultra-high sensitivity. The optical properties of the porous silica gel layer change when it is exposed to low (parts per million (ppm)) and even ultra-low (parts per billio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20025-9
更新日期:2018-01-26 00:00:00
abstract::Disease associated genetic variations often cause intracellular enzyme inactivation, dysregulation and instability. However, allosteric communication of mutational effects to distant functional sites leading to loss-of-function remains poorly understood. We characterize here interdomain site-to-site communication by w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44532
更新日期:2017-03-14 00:00:00
abstract::Diabetes mellitus accelerates vascular calcification (VC) and increases the risk of end-stage renal disease (ESRD). Nevertheless, the impact of VC in renal disease progression in type 2 diabetes mellitus (T2DM) is poorly understood. We addressed the effect of VC and mechanisms involved in renal dysfunction in a murine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55501-3
更新日期:2020-01-09 00:00:00
abstract::Comparison of kinetic and thermodynamic properties of IRP1 (iron regulatory protein1) binding to FRT (ferritin) and ACO2 (aconitase2) IRE-RNAs, with or without Mn2+, revealed differences specific to each IRE-RNA. Conserved among animal mRNAs, IRE-RNA structures are noncoding and bind Fe2+ to regulate biosynthesis rate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09093-5
更新日期:2017-08-17 00:00:00
abstract::Studies on the evolution of parental care have focused primarily on the costs and benefits of parental care and the life-history attributes that favour it. However, once care evolves, offspring in some taxa appear to become increasingly dependent on their parents. Although offspring dependency is a central theme in fa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29323
更新日期:2016-07-05 00:00:00
abstract::Gestational diabetes mellitus (GDM) is a hyperglycaemic imbalance first recognized during pregnancy, and affects up to 22% of pregnancies worldwide, bringing negative maternal-fetal consequences in the short- and long-term. In order to better characterize GDM in pregnant women, 100 blood plasma samples (50 GDM and 50 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75539-y
更新日期:2020-11-06 00:00:00
abstract::Heterocyclic amines (HCAs) are formed by cooking protein-rich foods, for instance, meat and fish, and are listed as possible human carcinogens. In the present study, the presence of five potential HCAs (IQ, MeIQ, MeIQx, 4,8-DiMeIQx, and PhIP) in cooked camel meat burgers was analyzed for the first time. The analysis w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01968-x
更新日期:2017-05-10 00:00:00
abstract::Breast cancer survivors display altered inflammatory responses to immune challenges relative to cancer-naive controls likely due to previous cancer treatments, stress associated with cancer, and/or tumor physiology. Proper inflammatory responses are necessary for adaptive sickness behaviors (e.g., fatigue, anorexia, a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37334-8
更新日期:2019-01-24 00:00:00
abstract::Despite advances in renovascular disease (RVD) research, gaps remain between experimental and clinical outcomes, translation of results, and the understanding of pathophysiological mechanisms. A predictive tool to indicate support (or lack of) for biological findings may aid clinical translation of therapies. We creat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57386-8
更新日期:2020-01-16 00:00:00